Clinical trials: Disease, Acute
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
Choline Magnesium Trisalicylate and Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia
This randomized phase II trial studies how well choline magnesium trisalicylate with idarubicin and cytarabine works in treating patients with acute myeloid leukemia.
- Conditions
- Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b)
- Trial name
- NCT02144675
- Testing
- choline magnesium trisalicylate, idarubicin, cytarabine
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Rutgers, The State University of New Jersey
Myelodysplastic Syndrome, Leukemia
FTS Study in Patients With Advanced Hematologic Malignancies
Primary Objective: Determining the maximum tolerated dose (MTD) and pharmacokinetics (PK) of FTS (S-Trans, Trans-Farnesylthiosalicylic Acid) after daily oral administration on Days 1 through 21 of a 28-Day cycle to patients with…
- Trial name
- NCT00867230
- Testing
- FTS
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Insomnia (Disorder)
INvestigating the Value of Early Sleep Therapy
Twenty percent of breast cancer survivors have insomnia, which is defined as persistent trouble falling and/or staying asleep that results in difficulty functioning during the day.
- Trial name
- INVEST (NCT06294041)
- Testing
- Sleep Restriction Therapy (SRT), Sleep Hygiene Education (SHE)
- Volunteers
- 50 people
- Sponsor
- University of Strathclyde
Drug Use, Alcohol Use
Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions
This study will assess Specialized Community Disease Management (SCDM), an intervention which employs various evidence-based strategies to engage substance using co-morbid patients while in the hospital and follow them into the…
- Conditions
- Drug Use, Alcohol Use, Congestive Heart Failure, Pneumonia
- Trial name
- NCT02059005
- Testing
- Specialized Community Disease Management, Treatment As Usual
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Treatment Research Institute
Falls (Accidents) in Old Age
GAPcare: The Geriatric Acute & Post-acute Care Coordination Program for Fall Prevention in the Emergency Department
GAPcare (Geriatric Acute \& Post-acute Care Coordination Program for Fall Prevention) is an early stage investigation that enrolls older adults who present to the Emergency Department after a fall to determine the feasibility of…
- Trial name
- GAPcare (NCT03360305)
- Testing
- GAPcare intervention
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Rhode Island Hospital
Long COVID
Development of Voice Biomarkers of Frequent COVID-19 and Long Covid-related Symptoms Based on Data From Users of the Long COVID Companion App
The LIH DDP research team focuses its research topics on vocal biomarkers and Long COVID, among others. Voice is indeed a promising tool to monitor health, as it contains many information on our health and is easy to collect.
- Trial name
- EVO-LC (NCT07156994)
- Testing
- No Intervention: Observational Cohort
- Where
- Luxembourg
- Volunteers
- 300 people
- Sponsor
- Luxembourg Institute of Health
Hypothermia, Induced, Rewarming
Hypothermia as an Adjunctive Therapy to Percutaneous Intervention in Patients With Acute Myocardial Infarction
To evaluate and improve the safety and efficacy of hypothermia as an adjunctive therapy to percutaneous coronary intervention in patients with acute myocardial infarction.
- Conditions
- Hypothermia, Induced, Rewarming, Myocardial Infarction, Percutaneous Cornonary Intervention
- Trial name
- COOL-MI InCor (NCT02664194)
- Testing
- Proteus® Cooling System, Primary Percutaneous Coronary Intervention
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- University of Sao Paulo General Hospital
Long COVID, COVID-19 Pandemic
Long COVID and Its Associations With Health Outcomes in Older Adults
The Peking University Health Cohort in Anning, Yunnan (PKUHC-AN) is a prospective cohort study carried out in Anning, Yunnan. The primary aim of this study is to investigate the impact of COVID-19 on older adults' health, and to…
- Conditions
- Long COVID, COVID-19 Pandemic, Elderly Infection, Vaccine Reaction
- Trial name
- NCT05825651
- Testing
- no interventions
- Where
- China
- Volunteers
- 11,527 people, healthy volunteers welcome
- Sponsor
- Peking University
Acute Coronary Syndrome (ACS), Reactive Hyperemia
Effect of Olive Leaf Extracts on Endothelial Dysfunction in Patients With Acute Coronary Syndrome
the study aims to examine the short-term (30 days) effects of olive leaf extract on endothelial function in patients with acute coronary syndrome (ACS).
- Conditions
- Acute Coronary Syndrome (ACS), Reactive Hyperemia, Endothelial Dysfunction
- Trial name
- ACS_ATHEROLIV (NCT06723002)
- Testing
- Atherolive 500mg/day, Atherolive 1000/day, Placbo_Atherolive
- Volunteers
- 300 people
- Sponsor
- University of Monastir
Cortisol
Effect of MIST on Esophageal Sensitivity: Pilot Study
Influence of placing the esophageal probe on the cortisol response. Number of cortisol (non)responders and association of heart rate and subjective perception of stress with cortisol levels.
- Trial name
- PilotMIST (NCT05760872)
- Testing
- Placing esophageal probe
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Idiopathic Pulmonary Fibrosis
Inspiratory Effort and Respiratory Mechanics in Spontaneously Breathing Patients With Acute Exacerbation of Idiopathic Pulmonary Fibrosis: a Matched Control Study
Idiopathic pulmonary fibrosis is a life-threatening lung disease characterized by progressive deterioration of lung function and a median survival time of 3-5 years from diagnosis.
- Trial name
- IERATIC (NCT05313672)
- Volunteers
- 20 people
- Sponsor
- Roberto Tonelli
Acute Respiratory Failure (ARF), Nitric Oxide
Modified Inhaled Nitric Oxide in Ventilated Patients With Acute Respiratory Failure
Pneumonia is the main cause of ICU admission in patients with acute respiratory failure (ARF). Severe pneumonia is a serious lung infection caused by bacteria, fungi, viruses, and other pathogens.
- Conditions
- Acute Respiratory Failure (ARF), Nitric Oxide, Pneumonia
- Trial name
- NCT07892001
- Testing
- Modified iNO
- Where
- China
- Volunteers
- 424 people
- Sponsor
- Southeast University, China
COVID-19, Respiratory Failure
Characteristics and Outcomes of Patients With COVID-19 Treated With HFNO and Prone Positioning
A subset of patients with COVID-19 develops acute respiratory failure and acute respiratory distress syndrome (ARDS) (1). The use of invasive mechanical ventilation for the treatment of these conditions is associated with high…
- Conditions
- COVID-19, Respiratory Failure, Prone Position, Endotracheal Intubation
- Trial name
- AW-PP_Covid (NCT05178212)
- Where
- Argentina
- Volunteers
- 600 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive)
A Phase l/ll Study of AMN107 in Adult Patients With Glivec-intolerant CML or Relapsed-refractory Ph+ALL
This study will investigate if nilotinib provides an improved safety and efficacy profile over that seen in patients receiving Imatinib.
- Trial name
- NCT00384228
- Testing
- Nilotinib
- Where
- Japan
- Volunteers
- 42 people
- Sponsor
- Novartis Pharmaceuticals
Spinal Cord Injury
Intrathecal Transplantation of UC-MSC in Patients With Sub-Acute Spinal Cord Injury
This study aim to evaluate the safety and efficacy of intrathecal transplantation of allogeneic umbilical cord derived mesenchymal stem cells (UC-MSC) for treatment of different phrases of spinal cord injury.
- Trial name
- NCT03521336
- Testing
- Umbilical Cord Mesenchymal Stem Cells
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Acute Ischemic Stroke
Extending the Time Window for Intravenous Tenecteplase in Patients With Distal Medium Vessel Occlusions Stroke
To assess the safety and efficacy of beyond time window TNK intravenous thrombolysis for distal Medium Vessel Occlusion (MeVO) related stroke in a prospective randomized clinical trial.
- Trial name
- NCT06559436
- Testing
- Intravenous thrombolysis, Standard medical management
- Where
- China
- Volunteers
- 560 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Safety & Activity of Controllable PRAME-TCR Therapy in Previously Treated AML/MDS or Metastatic Uveal Melanoma
The purpose of this study is to evaluate the safety and activity of BPX-701 in participants with relapsed AML, previously treated MDS, or metastatic uveal melanoma expressing high levels of PReferentially expressed Antigen in…
- Conditions
- Acute Myeloid Leukemia, Myelodysplastic Syndrome, Uveal Melanoma
- Trial name
- NCT02743611
- Testing
- BPX-701, Rimiducid
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- Bellicum Pharmaceuticals
Acute Kidney Failure
Protocol to Assess the Severity of Acute Kidney Injury
The principal objective is to safely determine if we can identify the severity of Acute Kidney Injury (AKI) early in the course of the disease. Once enrolled, we will draw blood and urine for relevant biomarkers.
- Trial name
- AKI (NCT00673244)
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- George Washington University
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Treosulfan-based Conditioning for Transplantation in AML/MDS
The study hypotheses is that the introduction of dose escalated treosulfan, in substitution to busulfan, will reduce toxicity after allogeneic transplantation while improving myeloablation and and disease control in patients with…
- Trial name
- NCT00491634
- Testing
- treosulfan
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Dr. Avichai Shimoni MD
Parkinson Disease, Parkinsonism
Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD
Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies.
- Trial name
- NCT07674264
- Testing
- Acute intermittent hypercapnic hypoxia (AIHH), Acute intermittent hypercapnic normoxia (AIHN)
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Florida
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