Clinical trials: Disease, Acute
Acute Myeloid Leukemia
Idarubicin Overcomes MDR1 Induced Chemoresistance With Higher Induction Remission Rate and Quality Than Daunorubicin in Acute Myeloid Leukemia Patients
Whether Idarubicin can overcomes multidrug resistant 1 induced chemoresistance with higher induction remission rate than daunorubicin in de novo acute myeloid leukemia patients.Whether induction therapy with IA regimen has a…
- Trial name
- NCT01889407
- Testing
- Idarubicin
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Aortic Syndrome
Additive Anti-inflammatory Action for Aortopathy & Arteriopathy
Acute aortic syndrome (AAS) is a life-threatening condition. Inflammation plays a key role in the pathogenesis, development and progression of AAS, and is associated with significant mortality and morbidity.
- Trial name
- NCT04398992
- Testing
- observation
- Where
- 34 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Nanjing Medical University
HIV Infections
The Biology of HIV Transmission
The purpose of this study is to look at the amount of HIV in the blood, genital fluid, and saliva of the partners of patients with early HIV infection.
- Trial name
- NCT00001092
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Ischemic Stroke, Cerebral Infarction
Early Antiplatelet Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT)
Stroke is the second leading cause of death worldwide, and ischemic stroke is the most frequent type. Intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 hours of symptom onset is the most effective…
- Trial name
- TREND-IVT (NCT06548971)
- Testing
- Aspirin, Best medical management
- Where
- 119 sites in China
- Volunteers
- 1,184 people
- Sponsor
- Capital Medical University
Acute Myeloid Leukemia
Study of Chidamide Combined With Cladribine in Refractory/Relapsed Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is highly heterogeneous, the efficacy of the individual varies greatly, and the risk of recurrence is high.
- Trial name
- NCT05330364
- Testing
- Chidamide, Cladribine
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Ge Zheng
Head Trauma, Image, Body
Rapid MRI for Acute Pediatric Head Trauma
Pediatric head trauma is a leading cause of morbidity and mortality for children/adolescents. The current standard of care regarding imaging modality when concerned for an acute head injury is CT.
- Trial name
- NCT03291964
- Testing
- Rapid Brain MRI
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Oregon Health and Science University
Chronic Obstructive Pulmonary Disease Exacerbation
Evaluation of Oxygen Delivery Methods in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
To examine the effects of oxygen therapy methods applied as indicated in COPD acute exacerbations on blood gas results and spirometric measurements.
- Trial name
- NCT06561464
- Testing
- EzPAP®, Non-invasive mechanical ventilation (NIMV)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Acute Pancreatitis
Exploring the Mechanism of Severe Acute Pancreatitis Based on Metagenomics, Metabolomics and Proteomics
The goal of this observational study is to learn about the biomarkers and mechanisms of severe acute pancreatitis in 30 healthy controls, 30 patients of mild acute pancreatitis, 30 patients of moderately severe acute…
- Trial name
- NCT06230432
- Where
- China
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Nanchang University
Concussion, Mild
The Combined Effect of Chronic Cannabis Use and Subconcussive Head Impacts on Brain Health
The purpose of this pilot study is to better understand the effects of chronic cannabis (THC) use on the neural responses to subconcussive head impacts, as a form of repetitive soccer headings.
- Trial name
- NCT04641832
- Testing
- Soccer heading
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Indiana University
Spinal Cord Trauma, Pain
Study of Pregabalin in the Prevention of Central Neuropathic Pain in Acute Spinal Cord Injury
This research study will test to see if people who receive pregabalin after their spinal cord injury will develop less nerve damage pain than people who do not receive it.
- Trial name
- NCT00879021
- Testing
- Lyrica
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Nova Scotia Health Authority
Elastography, Chronic Kidney Diseases
Shear Wave Elastography in Differentiating Acute or Chronic Kidney Disease
Chronic kidney disease is a common global public health issue and its prevalence increased year by year. Early diagnosis and intervention can prevent further complications and comorbidities of long-term dialysis, cardiovascular…
- Trial name
- CKD-SWE (NCT04404114)
- Testing
- Shear wave elastography to distinguish AKI from normal kidney, Shear wave elastography to distinguish AKI from CKD, Shear wave elastography to distinguish CKD from normal kidney
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- National Taiwan University Hospital
Traumatic Spinal Cord Injury
Early Pharmacological Treatment of Acute Spasticity After Spinal Cord Injury
The objective of this clinical trial is to evaluate if early detection of spasticity and immediate treatment with oral baclofen during acute care prevents problematic spasticity and improves neurofunctional recovery after tSCI.
- Trial name
- NCT06564714
- Testing
- Early baclofen Intervention, Usual routine care
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Acute Myeloid Leukemia (AML)
Injection of Lymphocytes From Haplo-identical Donor Following Chemotherapy in Patients With High-risk Acute Myeloblastic Leukemia Not Eligible for an Allogeneic Hematopoietic Stem Cell Transplantation
Patients with high risk AML non eligible for an intensive treatment and for an allogeneic transplantation will be treated with azacitidine and venetoclax.
- Trial name
- ILDA (NCT04886206)
- Testing
- DLI
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Nantes University Hospital
Acute Ischemic Stroke
Evaluate the Efficacy and Safety of TTYP01 Tablets in the Treatment of Acute Ischemic Stroke
The study is designed as a multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy and safety of TTYP01 tablets in the treatment of acute ischemic stroke.
- Trial name
- NCT06648304
- Testing
- TTYP01 tablets
- Where
- China
- Volunteers
- 614 people
- Sponsor
- Shanghai Auzone Biological Technology Co., Ltd.
Acute Upper Gastrointestinal Non Variceal Hemorrhage
Endoscopic Diagnosis and Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding
Acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) is a common critical disease in gastroenterology. Due to the development of modern medical technology, the incidence rate of ANVUGIB has been decreasing in recent years…
- Trial name
- NCT04895904
- Testing
- No intervention
- Volunteers
- 3,200 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Spinal Cord Injuries
Exoskeleton Use in Acute Rehab Post Spinal Cord Injury; a Safety and Feasibility Study
This study will examine the safety and feasibility of using an exoskeleton in subjects who are less than 6 months post spinal cord injury (SCI).
- Trial name
- NCT03144830
- Testing
- Exoskeleton
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of Calgary
Venous Thromboembolism
RE-COVERY DVT/PE: Global Study on Treatment Secondary Prevention of Acute Venous Thromboembolism
RE-COVERY is a large, multi-national, multi-center observational study based on new data collection. The study will enroll and characterize patients within 30 days of being diagnosed with an acute DVT and/or PE.
- Trial name
- NCT02596230
- Where
- 222 sites in United States, Argentina and 35 more
- Volunteers
- 7,797 people
- Sponsor
- Boehringer Ingelheim
Breast Cancer, Chronic Myeloproliferative Disorders
Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors
RATIONALE: Interleukin-12 may kill tumor cells by stopping blood flow to the tumor and by stimulating a person's white blood cells to kill cancer cells.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Kidney Cancer
- Trial name
- NCT00003107
- Testing
- recombinant interleukin-12
- Where
- United States
- Sponsor
- Indiana University
Relapsed/Refractory Acute Myeloid Leukemia
Safety and Efficacy of NK520 to Treat Relapsed/Refractory Acute Myeloid Leukemia
This study will evaluate the safety and efficacy of NK520 in the treatment of relapsed/refractory acute myeloid leukemia. NK520 will be administered by intravenous injection.
- Trial name
- NCT06541444
- Testing
- NK520
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Base Therapeutics (Shanghai) Co., Ltd.
Acute Pancreatitis
Simvastatin in Reducing Pancreatitis in Patients With Recurrent, Acute or Chronic Pancreatitis
This randomized phase II trial studies how well simvastatin works in reducing pancreatitis (the inflammation of the pancreas) in patients with pancreatitis that occurs more than once (recurrent), has worsened quickly (acute), or…
- Trial name
- NCT02743364
- Testing
- Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- National Cancer Institute (NCI)
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