Clinical trials: Disease, Acute
Skin Diseases, Bacterial
Safety and Efficacy of CEM-102 Compared to Linezolid in Acute Bacterial Skin Infections
The purpose of this study is to determine the safety and efficacy of CEM-102 compared to Linezolid in the treatment of acute bacterial skin structure infections (ABSSIs).
- Trial name
- NCT00948142
- Testing
- CEM-102, Linezolid
- Where
- 16 sites in United States
- Volunteers
- 198 people
- Sponsor
- Arrevus Inc.
Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia
Use of Decitabine in Myelodysplastic Syndrome (MDS) Following Azacitidine (AZA) Failure
The purpose of this study is to assess the response rate at 6 months in Myelodysplastic Syndrome (MDS) patients, Chronic Myelomonocytic Leukaemia (CMML-2) patients, and Acute Myeloid Leukaemia (AML) patients with up to 30% bone…
- Conditions
- Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndrome
- Trial name
- DEC-MDS (NCT01133886)
- Testing
- Decitabine
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College London
Diabetes Mellitus, Hypoglycemia Unawareness
Prevention Through Intervention: Telehealth Solution to Deter 911 Calls Due to Hypoglycemia
This study aims to standardize and evaluate the benefits of the Prevention to Intervention program offered by the Birmingham Fire and Rescue Service.
- Conditions
- Diabetes Mellitus, Hypoglycemia Unawareness, Hypoglycemia, Hypoglycemia Acute
- Trial name
- NCT03665870
- Testing
- Hypoglycemia Education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Acute Pancreatitis
Treatment of Acute Pancreatitis With Ketorolac
Patients with acute pancreatitis will be randomly assigned in either study group to receive oral (injection) Ketorolac or the control group. In patients who cannot tolerate oral medications, ketorolac injection will be used.
- Trial name
- NCT02885441
- Testing
- Ketorolac
- Where
- Iran
- Volunteers
- 56 people
- Sponsor
- Ilam University of Medical Sciences
Pneumothorax, Pulmonary Contusion
Electrical Impedance Imaging of Patients on Mechanical Ventilation
The goal of this study is to evaluate the sensitivity and specificity of Electrical Impedance Tomography (EIT) as a bedside diagnostic tool for lung pathologies in patients who are mechanically ventilated.
- Conditions
- Pneumothorax, Pulmonary Contusion, Pleural Effusion, Pulmonary Edema
- Trial name
- NCT02232841
- Testing
- Mechanical Ventilation, CT Scan
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Colorado State University
Intervertebral Disc Compression, Muscle Atrophy
50% Body Weight Reverses Stature, Lumbar Disc Expansion and Vertebral Compliance by Hyper-Buoyancy Floatation.
Study with the aim to see the effect on a space ground analogue , Hyper-Buoyancy Floatation (HBF) on lumbar column and the effect of a supplementary 50% of an axial load.
- Conditions
- Intervertebral Disc Compression, Muscle Atrophy, Spine Injury
- Trial name
- NCT05590754
- Testing
- Hyper-buoyancy Floatation (HBF), Axial Load after 4h of HBF
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Intracerebral Infarcts, Ischemic Stroke
Discharge Educational Strategies for Reduction of Vascular Events
DESERVE is a discharge education study using health workers to enroll and randomly assign 800 subjects diagnosed with TIA, or mild stroke to either risk factor education or usual care.
- Conditions
- Intracerebral Infarcts, Ischemic Stroke, Hemorrhagic Strokes, TIA's
- Trial name
- DESERVE (NCT01836354)
- Testing
- DESERVE education
- Where
- 3 sites in United States
- Volunteers
- 552 people
- Sponsor
- NYU Langone Health
HBV Related Acute-on-chronic Liver Failure, HBV-related Liver Cirrhosis
Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure
This study aims to investigate the methylomic features of patients with hepatitis B-related acute-on-chronic liver failure and establish and validate a prognostic risk prediction classification model.
- Conditions
- HBV Related Acute-on-chronic Liver Failure, HBV-related Liver Cirrhosis, HBV (Hepatitis B Virus)
- Trial name
- NCT07275554
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Migraine With Aura, Migraine Without Aura
Evaluation of the Efficacy of Diclofenac Potassium and Rimegepant for the Acute Treatment of Migraine
In a real-world population of adults with migraine, the investigators would like to investigate whether 50 mg diclofenac potassium is non-inferior to 75 mg rimegepant in terms of pain freedom at 2 hours after drug intake.
- Trial name
- ATOM (NCT05211154)
- Testing
- Diclofenac Potassium 50Mg/Pkt Oral Pwdr, Rimegepant 75 MG
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Danish Headache Center
Acute Coronary Syndrome, Tobacco Use
Integrated Smoking Cessation and Mood Management for ACS Patients
Quitting smoking following acute coronary syndrome can reduce mortality up to 50%. However, depression and smoking are highly co-morbid and depressed mood may interfere with cessation and independently predicts mortality.
- Trial name
- PACES (NCT03029923)
- Testing
- Experimental: Behavioral Activation Treatment for Cardiac Smokers (BAT-CS), Smoking cessation plus Health and Wellness
- Where
- United States
- Sponsor
- The Miriam Hospital
Traumatic Brain Injury, Acute Brain Injuries
Vagus Nerve Stimulation to Treat Moderate Traumatic Brain Injury
The purpose of this single-center, prospective, randomized (1:1), double-blind, sham-controlled parallel-arm pilot study is to provide initial evidence of use of the noninvasive vagus nerve stimulator for treatment in patients…
- Trial name
- NCT02974959
- Testing
- gammaCore active device
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- CentraCare
Type 2 Diabetes Mellitus
Effects of Triacylglycerol Structure on Gut Hormones and Haemostatic Markers
Type 2 diabetes mellitus (T2DM) is a chronic disorder determined by lifestyle and genes. It is associated with chronic hyperglycaemia along with other metabolic abnormalities.
- Trial name
- NCT01906359
- Testing
- Native palm olein (IV56), Chemically interesterified palm olein (IV56), High oleic sunflower oil
- Where
- 5 sites in Malaysia
- Volunteers
- 23 people
- Sponsor
- Malaysia Palm Oil Board
Acute Graft Versus Host Disease
Multicenter Study Of Natalizumab Plus Standard Steroid Treatment For High Risk Acute Graft-Versus-Host Disease
This research trial is designed to study the safety and effectiveness of combining the study drug, Natalizumab (Tysabri®) with the standard treatment, the use of steroids, as a new treatment for acute graft versus host disease…
- Trial name
- NCT02133924
- Testing
- natalizumab, steroids
- Where
- 12 sites in United States
- Volunteers
- 76 people
- Sponsor
- John Levine
Hematologic Diseases, Acute Leukemia in Remission
Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation
The purpose of this study is to determine the recommended phase 2 dose of the drug Vorinostat in children, adolescents and young adults following allogeneic blood or marrow transplant (BMT) and determine whether the addition of…
- Conditions
- Hematologic Diseases, Acute Leukemia in Remission, Chronic Myelogenous Leukemia - Chronic Phase, Chronic Myelogenous Leukemia, Accelerated Phase
- Trial name
- NCT03842696
- Testing
- Vorinostat, Blood and Marrow Transplant (BMT), Tacrolimus (or cyclosporine)
- Where
- 7 sites in United States
- Volunteers
- 43 people
- Sponsor
- University of Michigan Rogel Cancer Center
Obesity, Appetite Regulation
ProSat - Effect of Probiotics on Satiety
The aim of the ProSat study is to examine the effects of a probiotic capsule containing one of two doses (low and high dose) of Lb.
- Trial name
- ProSat (NCT00826761)
- Testing
- probiotic
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Hemianopia, Stroke
Combined tDCS and Vision Restoration Training in Post-acute Stroke: an Exploratory Efficacy and Safety Study
The purpose of this Study is to determine whether non-invasive transcranial direct current stimulation (tDCS) is effective in increasing rehabilitation effects after stroke in visual Cortex.
- Trial name
- NCT02703870
- Testing
- verum tDCS, VRT
- Where
- 2 sites in Austria, Germany
- Volunteers
- 19 people
- Sponsor
- University of Magdeburg
Acute Lymphoblastic Leukemia (ALL)
A Pilot Study of Allopurinol As A Modifier of 6-MP Metabolism in Pediatric ALL
This research is being done to determine if allopurinol can change the metabolism of the oral chemotherapeutic medication 6-mercaptopurine (6-MP) in children with acute lymphoblastic leukemia (ALL).
- Trial name
- NCT02046694
- Testing
- Allopurinol
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Schizophrenia, Schizoaffective Disorder
A Study of the Efficacy and Safety of Ziprasidone in Patients With Acute Exacerbation of Schizophrenia or Schizoaffective Disorder
The purpose of this study is to evaluate the efficacy and safety of ziprasidone in acute exacerbation of schizophrenia or schizoaffective disorder, including patients with recent onset of symptoms
- Trial name
- NCT00645229
- Testing
- Ziprasidone
- Where
- Portugal
- Volunteers
- 1 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Acute Respiratory Distress Syndrome, Electrical Impedance Tomography
Evaluate the Effect of Prone Ventilation on Ventilated-blood Flow Ratio in Patients With ARDS by EIT
Patients with ARDS often suffer a gravity-dependent alveolar collapse, resulting in a reduction of tidal volume, residual alveolar excessive distension, and ventilator-related lung injury(VILI) induced by unreasonable ventilator…
- Conditions
- Acute Respiratory Distress Syndrome, Electrical Impedance Tomography, Prone Position Ventilation, Ventilation Perfusion Mismatch
- Trial name
- NCT06181539
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Acute Myeloid Leukemia
A Phase 2 Study of MAX-40279 Combined With Venetoclax and Azacitidine in Unfit Newly Diagnosed Acute Myeloid Leukemia
This is a prospective, multicenter, phase Ⅱ study consisting of dose escalation and ex-pansion stages in unfit newly diagnosed AML.
- Trial name
- NCT07743112
- Testing
- MAX-40279, Azacitidine, Venetoclax
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Maxinovel Pty., Ltd.
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