Clinical trials: Disease, Acute
Acute Coronary Syndrome, Non-ST Elevation (NSTEMI) Myocardial Infarction
An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction
The use of supplemental oxygen in the setting of suspected acute myocardial infarction (AMI) is manifested in international treatment guidelines and established in prehospital and hospital clinical routine throughout the world.
- Conditions
- Acute Coronary Syndrome, Non-ST Elevation (NSTEMI) Myocardial Infarction, Acute ST Segment Elevation Myocardial Infarction, Angina, Unstable
- Trial name
- DETO2X-AMI (NCT01787110)
- Testing
- Oxygen
- Where
- 34 sites in Sweden
- Volunteers
- 6,629 people
- Sponsor
- Karolinska Institutet
Acute Renal Failure
Carnitine, Aclycarnitine, Myocardial Function, and CRRT
Carnitine is essential for the transport of fatty acids into the mitochondria and energy production in different muscles, including the myocardium.
- Trial name
- NCT01941823
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Asha Moudgil
Hemorrhagic Stroke, Acute
Predictive Value of Human Microbiome and Serological Markers for Clinical Outcome of Cerebral Hemorrhage
Objective: To explore the predictive value of characteristic disorder of intestinal flora for clinical prognosis in patients with intracerebral hemorrhage.
- Conditions
- Hemorrhagic Stroke, Acute, Outcomes, Metabolites
- Trial name
- NCT05551923
- Testing
- intestinal flora disturbance
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Renal Colic, Ureteric Stone
Parecoxib vs Paracetamol in the Treatment of Acute Renal Colic
This study will be conducted to compare the efficacy and safety of Parecoxib versus Paracetamol for treatment of acute renal colic due to ureteric stones.
- Trial name
- NCT03704623
- Testing
- Paracetamol, Parecoxib
- Where
- Kuwait
- Volunteers
- 200 people
- Sponsor
- Mansoura University
Acute Lymphoblastic Leukemia in Remission, B Acute Lymphoblastic Leukemia
Combination Chemotherapy and Inotuzumab Ozogamicin in Treating Patients With B Acute Lymphoblastic Leukemia
This phase II trial studies how well combination chemotherapy and inotuzumab ozogamicin work in treating patients with B acute lymphoblastic leukemia.
- Conditions
- Acute Lymphoblastic Leukemia in Remission, B Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
- Trial name
- NCT03488225
- Testing
- Cyclophosphamide, Cytarabine, Dexamethasone
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- M.D. Anderson Cancer Center
Kidney Failure, Acute, Critical Illness
Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)
Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated.
- Trial name
- NCT00316576
- Testing
- Blood sampling for PCR
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Caen
Acute Myelogenous Leukemia
Phase II Study of Clofarabine in Adult Patients With Refractory or Relapsed Acute Myelogenous Leukemia
Clofarabine (injection) is approved by the Food and Drug Administration (FDA) for the treatment of pediatric patients 1 to 21 years old with relapsed acute lymphoblastic leukemia (ALL) who have had at least 2 prior treatment…
- Trial name
- NCT00044889
- Testing
- clofarabine (IV formulation)
- Where
- 12 sites in United States
- Volunteers
- 40 people
- Sponsor
- Genzyme, a Sanofi Company
ECG, Pharmacokinetics
Evaluating QTc, PK, Safety of Gemtuzumab Ozogamicin (GO) in Patients With CD33+ R/R AML
This is a single-arm, open-label, Phase 4 study evaluating the effect of GO on the QTc, pharmacokinetics, safety, and immunogenicity of GO as a single-agent monotherapy in adult and pediatric patients with relapsed or refractory…
- Conditions
- ECG, Pharmacokinetics, Safety
- Trial name
- NCT03727750
- Testing
- Gemtuzumab Ozogamicin
- Where
- 24 sites in United States, Canada and 4 more
- Volunteers
- 51 people
- Sponsor
- Pfizer
Ischemic Stroke, Intracranial Hemorrhage
Registry of Acute Stroke Under New Oral Anticoagulants -Pilot (RASUNOA-Pilot)
The registry of acute stroke under new oral anticoagulants (RASUNOA) is a German multicenter, prospective, observational registry performed at about 50 study centers covering about 50.000 acute ischemic strokes and 6000 acute…
- Trial name
- RASUNOA (NCT01850797)
- Where
- Germany
- Volunteers
- 353 people
- Sponsor
- University Hospital Heidelberg
Cardiovascular Diseases
Patients With Acute Myocardial Infarction
Aims and objectives The aim of this study was to determine whether planned discharge training given by the nurse has an impact on beliefs about cardiovascular disease risk factors knowledge level, compliance to drug therapy…
- Trial name
- NCT03985397
- Testing
- discharge training
- Volunteers
- 100 people
- Sponsor
- Manisa Celal Bayar University
Leukemia, Myelodysplastic Syndromes
Treosulfan and Fludarabine in Treating Younger Patients Who Are Undergoing a Donor Stem Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome
RATIONALE: Drugs used in chemotherapy, such as treosulfan and fludarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00253513
- Testing
- fludarabine, treosulfan, allogeneic blood or bone marrow transplantation
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- OHSU Knight Cancer Institute
Agitation
Treating Acutely Agitated Patients With Asenapine Sublingual Tablets
Our proposal is to administer asenapine to patients who are clinically agitated and in need of immediate intervention. At present there are no controlled studies that we know of that explores the use of asenapine for this…
- Trial name
- NCT01400113
- Testing
- Asenapine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Tinnitus
Manual Acupuncture for Acute Primary Tinnitus
This clinical trial aims to assess the efficacy of manual acupuncture for patients with acute primary tinnitus.
- Trial name
- NCT07515482
- Testing
- Manual acupuncture, Usaual care
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Dan Bing
Stroke
An AI-Based CDSS for Integrated Management of Patients With Acute Ischemic Stroke(GOLDEN BRIDGE II)
This study will conduct a cluster randomized controlled trial to evaluate the impact of an artificial intelligence-based clinical decision support system for the integrated management of patients with acute ischemic stroke on the…
- Trial name
- NCT04524624
- Testing
- AI-based CDSS
- Where
- China
- Volunteers
- 21,689 people
- Sponsor
- Beijing Tiantan Hospital
Bronchiolitis, Virus
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis
The innate immune response of children with acute viral bronchiolitis (AVB) caused by respiratory syncytial virus (RSV) in the acute phase and in the resolution phase, is marked by variations in inflammatory and anti-inflammatory…
- Conditions
- Bronchiolitis, Virus, Virus Disease
- Trial name
- NCT06396624
- Testing
- Intervention Group photobiomodulation, Control Group
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Universidade Norte do Paraná
Medium Vessel Occlusion, Ischemic Stroke, Acute
Intra-arterial Thrombolysis For Acute Ischemic Stroke With Medium Vessel Occlusion
A multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) phase III trial is planned to evaluate the efficacy and safety of intra-arterial thrombolysis (IAT) in patients with acute ischemic stroke caused by…
- Trial name
- IAT-MEVO (NCT07668323)
- Testing
- Recombinant Tissue Plasminogen Activator (rt-PA), Intra-arterial Thrombolysis, Best Medical Management
- Where
- China
- Volunteers
- 372 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Acute-graft-versus-host Disease
Cannabidiol for the Treatment of Severe (Grades III/IV) Acute Graft-versus-host Disease
Graft-versus-host-disease (GVHD) is a major obstacle to successful allogeneic hematopoietic cell transplantation (alloHCT). Cannabidiol (CBD), a non-psychotropic ingredient of Cannabis sativa possesses potent anti-inflammatory…
- Trial name
- NCT02392780
- Testing
- Cannabidiol, Methylprednisolone, Calcineurin inhibitor
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- moshe yeshurun
Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive)
A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Hematologic Malignancies
The purpose of this trial is to assess the efficacy, safety, tolerability, biologic activity, and pharmacokinetics of AMN107 in six groups of patients with one of the following conditions: Relapsed/refractory Ph+ Acute…
- Conditions
- Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive), Hypereosinophilic Syndrome, Systemic Mastocytosis
- Trial name
- NCT00109707
- Testing
- Nilotinib
- Where
- 101 sites in United States, Australia and 20 more
- Volunteers
- 507 people
- Sponsor
- Novartis Pharmaceuticals
Angina Pectoris, Acute Myocardial Infarction
Evaluation of iFR vs FFR in Stable Angina or Acute Coronary Syndrome
Previous trials have demonstrated that the use of physiological assessment of stenosis severity using fractional flow reserve (FFR) is superior to angiographic assessment in percutaneous coronary intervention (PCI) and improves…
- Trial name
- iFR Swedeheart (NCT02166736)
- Testing
- iFR, FFR
- Where
- 14 sites in Denmark, Iceland and 1 more
- Volunteers
- 2,037 people
- Sponsor
- Uppsala University
Long COVID, Chronic Fatigue Syndrome
Telerehabilitation for Post COVID-19 Condition
Telerehabilitation is a great alternative to offering care during a global pandemic. 85% of patients with COVID-19 report persistent symptoms up to 8 months after the infection.
- Trial name
- Telecovie (NCT05973136)
- Testing
- Telerehabilitation program based on cardiorespiratory principles
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Université de Sherbrooke
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