Clinical trials: Disease, Adnexal
Fallopian Tube Cancer, Ovarian Cancer
A Phase IIclinical Trial of Carboplatin and Paclitaxel or Carboplatin and Gemcitabine in Platinum-sensitive, Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancer
purpose Primary endpoint To evaluate the 24 month disease free survival Second endpoints To evaluate the 24 month overall survival To analyze the toxicity and the quality of life
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cancer
- Trial name
- NCT01570582
- Testing
- carboplatin and paclitaxel
- Where
- South Korea
- Volunteers
- 314 people
- Sponsor
- Korean Gynecologic Oncology Group
Ovarian Cancer
Efficacy Study of Chemotherapy to Treat Ovarian Cancer Recurrence by Prolonging the Platinum Free Interval
This study aims to test the hypothesis that the artificial prolongation of the platinum-free interval with a non-platinum treatment will improve the effectiveness of overall therapy in patients with ovarian cancer progression…
- Trial name
- MITO-8 (NCT00657878)
- Testing
- stealth liposomal doxorubicin, carboplatin, paclitaxel
- Where
- 40 sites in Belgium, Germany and 1 more
- Volunteers
- 215 people
- Sponsor
- National Cancer Institute, Naples
Fallopian Tube Cancer, Ovarian Cancer
Imatinib Mesylate in Treating Patients With Refractory or Relapsed Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer, or Ovarian Low Malignant Potential Tumor
RATIONALE: Imatinib mesylate may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth. PURPOSE: Phase II trial to determine the effectiveness of imatinib mesylate in treating patients who have…
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00039585
- Testing
- imatinib mesylate
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Lynch Syndrome, Endometrial Neoplasms
Universal Screening for Lynch Syndrome in Women With Endometrial and Non-Serous Ovarian Cancer
This study will maximize identification of women with Lynch Syndrome using an enhanced screening strategy to identify those at risk.
- Conditions
- Lynch Syndrome, Endometrial Neoplasms, Ovarian Neoplasms, Colorectal Neoplasms
- Trial name
- LS2 (NCT02494791)
- Testing
- Questionnaire, Educational Material
- Where
- Canada
- Volunteers
- 886 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Cancer, Tyrosine Kinase Mutation
LIVInG With chrONic Cancer TrEatments (LONGEVITI) Study
People with advanced chronic cancers are now living for many years as a result of new targeted anti-cancer treatments. Many of these treatments are quite new and people may take them for months, even years, as long as the…
- Conditions
- Cancer, Tyrosine Kinase Mutation, Breast Cancer, Melanoma
- Trial name
- LONGEVITI (NCT05645510)
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- University of Alberta
Burning Pain, Impaired Balance
Feasibility Study of New Method of Diagnostic and Prediction of Painful CIPN
This clinical trial studies how well Diode laser fiber type Selective Stimulator (DLss) works in predicting pain development in patients with ovarian cancer who are receiving chemotherapy.
- Conditions
- Burning Pain, Impaired Balance, Malignant Ovarian Neoplasm, Numbness
- Trial name
- NCT03206216
- Testing
- Diode Laser fiber type Selective Stimulator (DLss)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Lung Cancer, Liver Cancer
Triplex Checkpoint Inhibitors Therapy for Advanced Solid Tumors
This trial is designed to investigate the safety, response rates and survival outcomes of patients with advanced solid tumors by infusion of CTLA4, PD1 and PDL1 antibodies combination through venous (IV), artery (IA) or…
- Conditions
- Lung Cancer, Liver Cancer, Colorectal Cancer, Pancreas Cancer
- Trial name
- NCT05187338
- Testing
- ipilimumab +pembrolizumab +durvalumab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Polycystic Ovary Syndrome
IVF Outcome in Polycystic Ovary Syndrome Patients
1. To investigate the circulating concentrations of phoenixin and their associations with BMI, the concentrations of sex hormones including (LH), (FSH), (E2), (P4), (TT) and steroid hormones enzyme in PCOS patients. 2.
- Trial name
- NCT04104958
- Testing
- qRTPCR (mRNA level).
- Volunteers
- 100 people
- Sponsor
- Assiut University
Ovarian Cancer
Efficacy of Neoadjuvant Therapy With Cisplatin Plus Mitomycin C in BRCA1-Mutated Ovarian Cancer
This study was designed to assess the safety and efficacy of neoadjuvant therapy with mitomycin C plus cisplatin (MP) in BRCA1-mutated ovarian cancer versus standard regimen (paclitaxel plus carboplatin (TP)).
- Trial name
- NCT04747717
- Testing
- chemotherapy/surgery
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Hereditary Breast and Ovarian Cancer
Efficacy of Lifestyle Intervention in BRCA1/2 Mutation Carriers
The hypothesis of this 3 year, prospective randomized multicenter efficacy trial is that a structured life-style intervention program with exercise training and mediterranean diet is effective regarding increased adherence to a…
- Trial name
- LIBRE-2 (NCT02516540)
- Testing
- Structured exercise training plus mediterranean diet
- Where
- 19 sites in Germany
- Volunteers
- 600 people
- Sponsor
- Technical University of Munich
Ovarian Cancer, Fallopian Tube Cancer
Phase 1 Study of a Cancer Vaccine to Treat Patients With Advanced Stage Ovarian, Fallopian or Peritoneal Cancer
Immunotherapy is a novel way to treat cancer and does so by targeting the immune system to destroy tumor cells. Many different therapeutic vaccines have been evaluated in phase 1, 2, and even phase 3 trials.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- NCT01416038
- Testing
- DPX-Survivac, low dose cyclophosphamide (oral)
- Where
- 7 sites in United States, Canada
- Volunteers
- 19 people
- Sponsor
- ImmunoVaccine Technologies, Inc. (IMV Inc.)
Pancreatic Cancer, Breast Cancer
Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors
Study of NGM831 as Monotherapy and in Combination with Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors
- Conditions
- Pancreatic Cancer, Breast Cancer, Gastric Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT05215574
- Testing
- NGM831, NGM831 plus pembrolizumab (KEYTRUDA®), NGM831 and NGM438 plus pembrolizumab (KEYTRUDA®)
- Where
- 9 sites in United States
- Volunteers
- 130 people
- Sponsor
- NGM Biopharmaceuticals, Inc
Microbiota, Ovarian Neoplasms
Pelvic Microbiomes of Benign and Malignant Ovarian Diseases
This case-control study aims to compare the pelvic microbiomes of benign ovarian diseases and ovarian malignancies by 16s RNA techniques and culture.
- Conditions
- Microbiota, Ovarian Neoplasms, Ribosome Alteration
- Trial name
- MTBOD-1 (NCT03388996)
- Testing
- microbiomes
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Lei Li
Epithelial Ovarian Cancer
Torvutatug Samrotecan Plus Bevacizumab as First-line Maintenance in Homologous Recombination Deficiency (HRD) Negative Advanced Epithelial Ovarian Cancer
This study will evaluate the efficacy, safety and tolerability of Torvutatug samrotecan (torvu-sam) in combination with bevacizumab compared with bevacizumab monotherapy as first line maintenance treatment in patients with…
- Trial name
- TREVI-OC-02 (NCT07851025)
- Testing
- Torvutatug samrotecan, Bevacizumab
- Where
- 186 sites in United States, Argentina and 22 more
- Volunteers
- 950 people
- Sponsor
- AstraZeneca
Ovarian Cancer, Fallopian Tube Cancer
The Activity of TroVax® Versus Placebo in Relapsed Asymptomatic Ovarian Cancer
The purpose of this trial is to assess the effectiveness of TroVax® compared to placebo in extending the time to progression in patients with asymptomatic relapsed platinum resistant ovarian, fallopian tube or primary peritoneal…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- TRIOC (NCT01556841)
- Testing
- TroVax®
- Where
- 12 sites in United Kingdom
- Volunteers
- 94 people
- Sponsor
- University College, London
Advanced Solid Tumor, Advanced Lymphoma
Study of SNX281 in Subjects With Advanced Solid Tumors and Lymphoma
This clinical trial is evaluating a drug called SNX281 given by itself and in combination with pembrolizumab (KEYTRUDA®) in participants with advanced solid tumors and lymphoma.
- Trial name
- NCT04609579
- Testing
- SNX281, pembrolizumab
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Stingthera, Inc.
Epithelial Ovarian Cancer
Microscopic Peritoneal Metastases After Complete Macroscopic Cytoreductive Surgery for Epithelial Ovarian Cancer
The objective of the cytoreductive surgery carried out for the management of ovarian cancers is to obtain a complete macroscopic cytoreduction. This means that all visible peritoneal metastases must be resected.
- Trial name
- MicroPCI (NCT03754569)
- Testing
- Peritoneal biopsies after complete macroscopic cytoreduction
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HER2-positive, Adenocarcinoma
CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors
Phase 1, first-in-human, open label study of CAR macrophages in HER2 overexpressing solid tumors.
- Conditions
- HER2-positive, Adenocarcinoma, Bile Duct Cancer, Biliary Tract Cancer
- Trial name
- NCT04660929
- Testing
- CT-0508, Pembrolizumab
- Where
- 7 sites in United States
- Volunteers
- 48 people
- Sponsor
- Carisma Therapeutics Inc
Fallopian Tube Cancer, Ovarian Cancer
Laboratory Study in Predicting Tumor Response to Chemotherapy in Patients With Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
RATIONALE: Collecting samples of tissue from patients with cancer to study in the laboratory may help doctors predict how well patients will respond to treatment with certain chemotherapy drugs and plan the best treatment.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00897039
- Testing
- flow cytometry, immunohistochemistry staining method
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Southeastern Gynecologic Oncology
Polycystic Ovary, Obesity
Polycystic Ovary Syndrome and BETATROPHIN
This is an original study giving an information about the association body mass index, polycystic ovary syndrome and betatrophin.
- Trial name
- NCT04448730
- Testing
- serum marker levels
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Hatice Akkaya
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