Clinical trials: Disease, Adnexal
Bulky Stage IIIC and IV Epithelial Ovarian Cancer, Fallopian Tube Cancer
First-line Intraperitoneal Cisplatin and Etoposide Chemotherapy for Ovarian Cancer
The purpose of this study is to evaluate the role of an additional intraperitoneal chemotherapy with cisplatin and etoposide in bulky advanced epithelial ovarian cancer.
- Conditions
- Bulky Stage IIIC and IV Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- AICE (NCT01669226)
- Testing
- PEip (weekly) and TCiv, TCiv
- Where
- 7 sites in China
- Volunteers
- 215 people
- Sponsor
- Shanghai Gynecologic Oncology Group
Carcinoma, Ovarian Epithelial, Ovarian Neoplasms
Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery
Study to compare the safety and efficacy of oregovomab versus placebo, administered in combination with specific cycles of a standard six-cycle chemotherapy regimen (paclitaxel and carboplatin), for the treatment of subjects with…
- Conditions
- Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma
- Trial name
- FLORA-5 (NCT04498117)
- Testing
- Oregovomab, Paclitaxel, Carboplatin
- Where
- 148 sites in United States, Argentina and 12 more
- Volunteers
- 615 people
- Sponsor
- CanariaBio Inc.
Polycystic Ovary Syndrome (PCOS) Women
Meal Timing on Glucose and Hyperandrogenism in PCOS Women
The objective of this study is to investigate the effects of two isocaloric maintenance diets with different meal timing distribution on insulin resistance hyperandrogenism and cytochrome P450c17 alpha activity in lean PCOS…
- Trial name
- MealTimePCOS (NCT01711476)
- Testing
- Active Comparator: Lifestyle counseling ARM 1
- Where
- Venezuela
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas Caracas
Adnexal Torsion, Laparoscopy
ADnexal TOrsion Markers Study
Adnexal torsion , is a severe, though uncommon gynecological emergency, with a prevalence of 2.7-3%. The need for prompt diagnosis and treatment in order to save ovarian tissue has been realized a long time ago.
- Trial name
- ATOMS (NCT01659489)
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Advanced Solid Tumor, Advanced Malignant Neoplasm
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
The Phase 2 monotherapy portion of this study is currently enrolling and will evaluate the efficacy and safety of PC14586 (INN rezatapopt) in participants with locally advanced or metastatic solid tumors harboring a TP53 Y220C…
- Conditions
- Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor
- Trial name
- NCT04585750
- Testing
- rezatapopt, pembrolizumab
- Where
- 76 sites in United States, Australia and 7 more
- Volunteers
- 300 people
- Sponsor
- PMV Pharmaceuticals, Inc
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
Treatment Outcome and Quality of Life in Patients With Pediatric Extra-Cranial Germ Cell Tumors Previously Treated on Clinical Trial CCLG-GC-1979-01 or CCLG-GC-1989-01
RATIONALE: Treatment for pediatric extracranial germ cell tumors may cause side effects and secondary cancers later in life. A study that evaluates patients after receiving combination chemotherapy or surgery may help doctors…
- Conditions
- Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Gastrointestinal Complications, Infertility
- Trial name
- NCT00436774
- Testing
- assessment of therapy complications, quality-of-life assessment
- Where
- 13 sites in Ireland, United Kingdom
- Volunteers
- 60 people
- Sponsor
- Children's Cancer and Leukaemia Group
Ovarian Cancer, Liquid Biopsy
Setting Up ctDNA Analysis on Archived Plasma Samples
This study (DARE part 1) is a single-center, retrospective, observational feasibility study promoted by the Fondazione Policlinico Universitario Agostino Gemelli IRCCS and co-funded by Fondazione AIRC, aimed at evaluating the…
- Trial name
- DARE-part1 (NCT07546578)
- Testing
- ctDNA
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma
Bevacizumab With or Without Everolimus in Treating Patients With Recurrent or Persistent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
This randomized phase II trial studies how well bevacizumab with or without everolimus works in treating patients with recurrent or persistent ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer.
- Conditions
- Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma
- Trial name
- NCT00886691
- Testing
- Bevacizumab, Everolimus, Laboratory Biomarker Analysis
- Where
- 45 sites in United States
- Volunteers
- 150 people
- Sponsor
- GOG Foundation
Ovarian Hyperstimulation Syndrome, Frozen-thawed Embryo Transfers
Association Between Live Birth Rate and Serum Progesterone During Hormonal Replacement Therapy
Nowadays, frozen-thawed embryo transfers (FET) are expending. This practice avoids risk of ovarian hyperstimulation syndrome (OHSS), as well as allowing better synchronization between endometrium and embryo, which is fundamental…
- Trial name
- PROGEVOL (NCT05588635)
- Testing
- Identification of predictive factors
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Premature Ovarian Failure
Human Amniotic Epithelial Cells Treatment for Ovarian Insufficiency
This project will investigate the safety and effectiveness of human amniotic epithelial cells in primary ovarian insufficiency patients and provide a new cell therapy against infertility.
- Trial name
- NCT03207412
- Testing
- hAECs, Minimally invasive implantation
- Volunteers
- 20 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Ovarian Neoplasms, Recurrent Ovarian Carcinoma
Efficacy and Safety of SBRT in Oligo-metastatic/Persistent/Recurrent Ovarian Cancer
This is a prospective, multicenter, Phase II study aimed at defining the activity and safety of SBRT in MPR-OC. Clinical and imaging data as well as SBRT parameters would be analyzed with the aim to identify potential predictors…
- Conditions
- Ovarian Neoplasms, Recurrent Ovarian Carcinoma, Oligometastatic Disease
- Trial name
- MITO-RT3/RAD (NCT04593381)
- Testing
- Stereotactic body radiotherapy
- Where
- 14 sites in Italy
- Volunteers
- 376 people
- Sponsor
- Gemelli Molise Hospital
Endometritis, Vaginal Cleansing
Vaginal Cleansing With Chlorhexidine Versus Iodine for Prevention of Endometritis
Povidone has been approved for vaginal cleansing in the prevention of endometritis postcaesarean section. chlorhexidine solution which is cheap and readily available as shown to prevent endometritis.The aim of this study is to…
- Conditions
- Endometritis, Vaginal Cleansing, Post Caesarean
- Trial name
- NCT06936475
- Testing
- Povidone-Iodine, Chlorhexidine Gluconate
- Where
- Nigeria
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Federal Teaching Hospital Abakaliki
Polycystic Ovary Syndrome
Anti-Mullerian Hormone as Predictor of Ovarian Responce to Clomiphene Citrate in PCOS
Polycystic ovary syndrome (PCOS) is found in 5% to 6% of women of reproductive age. It affects women's reproductive capability; thus patients have risks of infertility, miscarriage, and complicated pregnancy.
- Trial name
- NCT03316469
- Testing
- Clomiphene Citrate, Follicular growth
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Breast Carcinoma, Colon Carcinoma
Experimental PET Imaging Scans Before Cancer Surgery to Study the Amount of PET Tracer Accumulated in Normal and Cancer Tissues
This phase I trial studies a new imaging technique called FAPi PET/CT to determine where and to which degree the FAPI tracer (68Ga-FAPi-46) accumulate in normal and cancer tissues in patients with non-prostate cancer.
- Conditions
- Breast Carcinoma, Colon Carcinoma, Esophageal Carcinoma, Gastric Carcinoma
- Trial name
- NCT04147494
- Testing
- Computed Tomography, Gallium Ga 68 FAPi-46, Gallium Ga 68-labeled PSMA-11
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Ovarian Cancer
The Assessment of Mesothelin Antigen Specific Immunologic Assays in Ovarian Cancer Patients
Ovarian cancer is the first in mortality rate of the gynecologic malignancies and the overall 5-year survival rate of ovarian cancer is only 20-30%. Besides, the incidence of ovarian cancer increased in recent years in Taiwan.
- Trial name
- NCT00173394
- Where
- Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Ovarian Cancer
Adjuvant Whole Abdominal Intensity Modulated Radiotherapy (IMRT) for High Risk Stage FIGO III Patients With Ovarian Cancer
The prognosis for patients with advanced epithelial ovarian cancer remains poor despite aggressive surgical resection and platinum-based chemotherapy.
- Trial name
- OVAR-IMRT-01 (NCT00527631)
- Testing
- whole abdomen irradiation using IMRT
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Heidelberg University
Breast Cancer, Colon Cancer
CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors
Background: The p53 gene normally helps to stop cancer cells from growing. However, when the p53 gene is mutated or damaged, cancer cells may grow unchecked.
- Conditions
- Breast Cancer, Colon Cancer, Pancreatic Cancer, Sarcoma
- Trial name
- NCT01386502
- Testing
- p53: 264-272 peptide, CT-011
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Epithelial Ovarian Cancer
Tinzaparin And Biomarkers After Neoadjuvant Treatment of Ovarian Cancer
Background: Previous findings have indicated antineoplastic properties of tinzaparin (Innohep®), a commonly used anti-coagulant.
- Trial name
- NCT05284552
- Testing
- Tinzaparin Injectable Solution
- Where
- 8 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- University Hospital, Linkoeping
Polycystic Ovary Syndrome (PCOS), Female Infertility
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
- Trial name
- PPOS-PCOS-IVF (NCT07394530)
- Testing
- Progestin-Primed Ovarian Stimulation (PPOS), GnRH Antagonist Protocol
- Where
- Vietnam
- Volunteers
- 400 people
- Sponsor
- Hanoi General Hospital (Vietnam)
Breast Neoplasm Female, Early Detection of Cancer
The FYI on MRI: A Multilevel Decision Support Intervention for Screening Breast MRI
The purpose of this study is to test the impact of a multilevel decision support intervention on informed decisions about breast MRI among high-risk Black and Latina women.
- Conditions
- Breast Neoplasm Female, Early Detection of Cancer, Hereditary Breast and Ovarian Cancer Syndrome, Magnetic Resonance Imaging
- Trial name
- NCT06892275
- Testing
- Enhanced Usual Care, Decision Support
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Georgetown University
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