Clinical trials: Disease Exacerbation
Schizophrenia, Schizoaffective Disorder
Prediction of Relapse in Schizophrenia/Schizoaffective Disorder With Smartphones and On-body Sensors
This study is dedicated to achieving a better understanding of how to identify patterns that indicate someone might be at high risk for relapse in schizophrenia or schizoaffective disorder.
- Trial name
- NCT02224430
- Testing
- schizophrenia/schizoaffective disorder.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Asthma, Vitamin D Deficiency
Vitamin D Deficiency and Asthma Exacerbation
The study aim is in two phases. First phase: to evaluate the influence of vitamin D deficiency on asthma severity, degree of airway obstruction and frequency of asthma exacerbations.
- Conditions
- Asthma, Vitamin D Deficiency, Disease Exacerbation
- Trial name
- AVD (NCT02661191)
- Testing
- oral cholecalciferol
- Volunteers
- 119 people
- Sponsor
- University of Turin, Italy
COPD Exacerbation
Anti-ST2 (MSTT1041A) in COPD (COPD-ST2OP)
Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity and mortality worldwide. In contrast to other chronic diseases, COPD is increasing in prevalence and is projected to be the third-leading cause of…
- Trial name
- COPD-ST2OP (NCT03615040)
- Testing
- MSTT1041A
- Where
- United Kingdom
- Volunteers
- 81 people
- Sponsor
- University of Leicester
Shortness of Breath, Chest Pain
Checklists Resuscitation Emergency Department
The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.
- Conditions
- Shortness of Breath, Chest Pain, Abdominal Pain, Altered Mental Status
- Trial name
- NCT05649891
- Testing
- Emergency Manual
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Chronic Obstructive Pulmonary Disease
Assessment Of Different Scores In Predicting Outcome In AECOPD Patients In Emergency Department
evaluate the value of different scores in predicting hospital mortality and Need for MV In patients presented to ED with AECOPD.
- Trial name
- NCT05793697
- Volunteers
- 139 people
- Sponsor
- Assiut University
Asthma
Retrospective Review on Patients With Recurrent Asthmatic Attacks Requiring Hospitalizations
Asthma is a common respiratory disease. around the world. Asthma exacerbation is one of the major sequelae and associated with various morbidity and mortality.
- Trial name
- NCT04479501
- Testing
- Asthma exacerbation related hospitalization
- Where
- Hong Kong
- Volunteers
- 2,280 people
- Sponsor
- Chinese University of Hong Kong
Copd, COPD Exacerbation
Telehealth and Onsite Maintenance Exercise in Chronic Lung Disease
The goal of this pilot clinical trial is to compare telehealth and onsite supervised maintenance exercise program for adults with Chronic Lung Disease.
- Conditions
- Copd, COPD Exacerbation, COPD Bronchitis, Emphysema or COPD
- Trial name
- CLD (NCT06304207)
- Testing
- Onsite Maintenance Exercise Training, Telehealth Maintenance Exercise
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- MGH Institute of Health Professions
Asthma Attack
Phenotyping and Classifying Asthma Exacerbations
An observational study in patients between 12 and 70 years old with an acute asthma exacerbation, to determine the relation between phenotypical characteristics and the treatment response.
- Trial name
- ExCluSieF (NCT05304039)
- Testing
- Questionnaires, Spirometry, Fractional Exhaled Nitric Oxide (FeNO)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Franciscus Gasthuis
Chronic Obstructive Pulmonary Disease
Vibratory PEP Device and Hospital Length of Stay for Acute Exacerbation of COPD
This study is evaluating the use of a respiratory device, the Acapella Vibratory Positive Expiratory Pressure (PEP) Therapy device, in patients admitted to the hospital with a chronic obstructive pulmonary disease (COPD)…
- Trial name
- NCT03094806
- Testing
- Acapella Vibratory PEP Therapy Device plus usual care
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
COPD, Chronic Bronchitis
Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
The purpose of this study is to show that one form of mechanical airway clearance techniques, High Frequency Chest Wall Oscillation (HFCWO)using a pneumatic vest, will diminish exacerbations of COPD which will improve respiratory…
- Conditions
- COPD, Chronic Bronchitis, Emphysema
- Trial name
- NCT00181207
- Testing
- pneumatic vest
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Bronchiectasis
The Role of Viral Infection in Acute Exacerbations of Non-cystic Fibrosis Bronchiectasis in Adults
Bronchiectasis is clinically characterized by irreversible dilation of the bronchi and bronchioles leading to persistent cough, purulent sputum, and airway flow limitation, which may be accompanied by recurrent exacerbations.It…
- Trial name
- NCT01801657
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Chronic Obstructive Pulmonary Disease
Analysis of the Dynamics of the Lung Microbiota During Acute Exacerbation of COPD Requiring Admission to Intensive Care Unit
This study aims to investigate the correlation between pulmonary microbiota dynamics (including bacteria, fungi and viruses) and COPD exacerbation for COPD patients admitted to ICU
- Trial name
- ADMiRE (NCT03641235)
- Testing
- Sputum collection
- Where
- France
- Volunteers
- 29 people
- Sponsor
- University Hospital, Bordeaux
Asthma
Effects of Omalizumab Compared to Non-Omalizumab Treatment in Asthma Patients
The purpose of this study is effects of Omalizumab compared to non-Omalizumab treatment in the propensity-matched group on asthma exacerbation in asthma patients in Korea: a retrospective cohort in real world.
- Trial name
- NCT02921178
- Testing
- Omalizumab
- Volunteers
- 124 people
- Sponsor
- Ajou University School of Medicine
Schizophrenia
A Study of the Efficacy and Safety of Asenapine in Participants With an Acute Exacerbation of Schizophrenia (P05688)
The purpose of this trial is to assess the effect of asenapine 2.5 and 5 mg sublingually twice daily (BID) compared with placebo in the treatment of schizophrenia (overall symptoms) as measured by the Positive and Negative…
- Trial name
- NCT01617187
- Testing
- Asenapine, Olanzapine
- Volunteers
- 360 people
- Sponsor
- Organon and Co
Chronic Obstructive Pulmonary Disease, COPD
OPUS Study: Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease (BY217/M2-111)
The purpose of this study is to determine whether roflumilast is effective in the treatment of exacerbations in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00076089
- Testing
- Roflumilast
- Where
- 40 sites in United States, Canada and 4 more
- Volunteers
- 1,100 people
- Sponsor
- AstraZeneca
Asthma
Airway Temperature
Airway irritation, cough and bronchial spasm are common symptoms in patients with airway inflammatory diseases such as asthma. The primary focus of this exploratory study is to determine if there is an increase in tissue…
- Trial name
- RATE (NCT02401074)
- Testing
- Segmental Bronchoprovocation with Allergen (SBP-Ag)
- Where
- United States
- Sponsor
- Lu Yuan Lee
Pulmonary Cystic Fibrosis
Standardized Treatment of Pulmonary Exacerbations II
Cystic fibrosis (CF), a life-shortening genetic disease, is marked by acute episodes during which symptoms of lung infection increase and lung function decreases.
- Trial name
- STOP2 (NCT02781610)
- Testing
- Standard of care IV antibiotic(s)
- Where
- 58 sites in United States, Canada
- Volunteers
- 982 people
- Sponsor
- Chris Goss
COPD
Mucin Concentration in Sputum From COPD Patients During a Pulmonary Exacerbation
chronic obstructive pulmonary disease (COPD) is typically associated with mucus hypersecretion in the airways. In health, mucin is the major macromolecular component and is responsible for the protective and clearance properties…
- Trial name
- mucinCOPDex (NCT01848093)
- Testing
- sputum collection
- Where
- 2 sites in Germany
- Sponsor
- Philipps University Marburg
Cardiac Failure
Link-HF: Multisensor Non-invasive Telemonitoring System for Prediction of Heart Failure Exacerbation
This is a multi-center, non-randomized, non-interventional study to evaluate the accuracy of a remote monitoring and analytical platform for prediction of heart failure exacerbation.
- Trial name
- LINK-HF (NCT03037710)
- Testing
- HealthPatch
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Josef Stehlik
COPD, COPD Exacerbation Acute
The Italian Registry of Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a treatable but debilitating medical condition associated with persistent symptoms and chronic airflow obstruction.
- Conditions
- COPD, COPD Exacerbation Acute, Comorbid Chronic Lung Disease on Heart Failure, Mortality
- Trial name
- ICoRe (NCT06652776)
- Testing
- Pharmacological treatment
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Milan
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