Clinical trials: Disease Exacerbation
Lung Diseases, Bronchitis, Chronic
Intermittent Moxifloxacin Therapy For The Prevention Of Acute Exacerbations In Patients With Chronic Bronchitis
Moxifloxacin, is being tested at approximately 60 study centres in 15 countries to determine if this drug, when taken periodically in addition to the patients normal treatment, is effective at reducing the number of flare-ups of…
- Trial name
- NCT00473460
- Testing
- Avelox (Moxifloxacin, BAY12-8039)
- Where
- 78 sites in United States, Andorra and 13 more
- Volunteers
- 1,404 people
- Sponsor
- Bayer
COPD Exacerbation, PTE - Pulmonary Thromboembolism
The Appropriate Anticoagulation Duration for Chronic Obstructive Pulmonary Disease With Pulmonary Thromboembolism
Anticoagulation is the most important treatment for pulmonary thromboembolism (PTE). The thromboembolism risk is especially high in patients with chronic obstructive pulmonary disease (COPD) exacerbations.
- Trial name
- NCT03185845
- Testing
- Warfarin
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Myasthaenia Gravis, Myasthenia
Myasthenia Gravis Foundation of America Global MG Patient Registry
The goal of this observational study is to learn about the experiences of people living with Myasthenia Gravis (MG) in the United States.
- Conditions
- Myasthaenia Gravis, Myasthenia, Myasthenia Gravis Associated with Thymoma, Myasthenia Gravis Crisis
- Trial name
- MGFAPR (NCT06617741)
- Where
- United States
- Volunteers
- 3,800 people
- Sponsor
- Myasthenia Gravis Foundation of America
Idiopathic Pulmonary Fibrosis, Acute Fatal Form
Autoantibody Reduction for Acute Exacerbations of Idiopathic Pulmonary Fibrosis
Acute exacerbations (AE) are a dreaded manifestation of idiopathic pulmonary fibrosis (IPF) that presents with rapidly worsening respiratory function over days to weeks.
- Trial name
- STRIVE-IPF (NCT03286556)
- Testing
- Autoantibody Reductive Therapy, Treatment as Usual (TAU)
- Where
- 7 sites in United States
- Volunteers
- 82 people
- Sponsor
- University of Alabama at Birmingham
Asthma
A Study to Determine the Clinical Characteristics, Comorbidities, Treatment Status and Exacerbations of Asthma Patients
This is a prospective cohort study that aims to determine the current demographics, clinical characteristics, comorbidities, treatment status and exacerbations of asthma patients.
- Trial name
- NCT03239431
- Testing
- asthmatic exacerbation
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- Chinese University of Hong Kong
Pneumonia, COPD Asthma
Development and Evaluation of Clinical Pharmacy Services in Respiratory Diseases
Clinical pharmacists in the healthcare system are experts in therapeutics and the use of drugs. They routinely provide medication reviews and recommendations to patients and healthcare professionals.
- Conditions
- Pneumonia, COPD Asthma, COPD Exacerbation
- Trial name
- NCT05564156
- Testing
- Intervention groups
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Bezmialem Vakif University
COPD
Evaluation Of The Efficacy Of Corticosteroids In Patients With An Acute Exacerbation Of Chronic Obstructive Pulmonary Disease Receiving Ventilator Support
Clinical practice guidelines for the management of chronic obstructive pulmonary disease (COPD) recommend treatment with systemic corticosteroids during acute exacerbations.
- Trial name
- NCT01281748
- Testing
- intravenous methylprednisolone, intravenous normal saline solution
- Where
- Spain
- Volunteers
- 83 people
- Sponsor
- Hospital Universitario Getafe
Chronic Obstructive Pulmonary Disease (COPD)
Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT06892210
- Testing
- Methylprednisolone (drug), Hydrocortisone
- Where
- 14 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Copenhagen Respiratory Research
Chronic Obstructive Pulmonary Disease
A COPD Quality Improvement Program（QIP）
QIP(Quality Improvement Programme) is a COPD quality improvement program in China. The initial step of this program is to set up the Quality Standards(QS) of COPD management in clinical practice, then embed Quality Standards into…
- Trial name
- QIP (NCT05638646)
- Testing
- Intervention group, control group
- Where
- China
- Volunteers
- 1,107 people
- Sponsor
- Shenzhen People's Hospital
Acute Heart Failure, COPD Exacerbation
Valsalva Manœuvre in the Diagnosis of Left Ventricular Failure in Chronic Obstructive Pulmonary Disease Exacerbation
Left ventricular failure (LVF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis .
- Trial name
- NCT01619540
- Testing
- Valsalva maneuver
- Where
- 4 sites in Tunisia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Schizophrenia
A Study to Test the Safety and Efficacy of MK-8998 in Acutely Psychotic Participants With Schizophrenia (MK-8998-004)
A study to evaluate the safety and efficacy of treatment with MK-8998 as compared to placebo and olanzapine for acutely psychotic patients with schizophrenia.
- Trial name
- NCT00827918
- Testing
- MK-8998, Comparator: Olanzapine
- Volunteers
- 216 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes, Chronic Obstructive Pulmonary Disease
Corticosteroids and Hemoglobin A1C Levels in Diabetic Patients With COPD Exacerbation
Corticosteroid treatment in diabetic patients admitted for COPD exacerbation are expected to significantly increase hemoglobin A1C levels
- Trial name
- NCT01798420
- Where
- Israel
- Volunteers
- 42 people
- Sponsor
- The Nazareth Hospital, Israel
Pulmonary Disease, Chronic Obstructive, Respiratory Tract Infections
Viral Infections in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
The objectives of the study are to determine the prevalence of respiratory virus infections in COPD patients, during and outside acute exacerbation to explore the impact of these viral infections on the outcome of these patients…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Tract Infections, Virus Diseases, Lung Diseases, Obstructive
- Trial name
- VICE (NCT00448604)
- Where
- Switzerland
- Volunteers
- 86 people
- Sponsor
- University Hospital, Geneva
COVID, Corona Virus Infection
Dipyridamole to Prevent Coronavirus Exacerbation of Respiratory Status (DICER) in COVID-19
The most severe manifestations of COVID-19 include respiratory failure, coagulation problems, and death. Inflammation and blood clotting are believed to play an important role in these manifestations.
- Conditions
- COVID, Corona Virus Infection, Covid-19, SARS-CoV-2 Infection
- Trial name
- DICER (NCT04391179)
- Testing
- Dipyridamole 100 Milligram(mg)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of Michigan
COPD Exacerbation
Respiratory Support in Severe Chronic Obstructive Pulmonary Disease Exacerbation
Preliminary studies have shown that NPPV can avoid tracheal intubation in 40% to 60% patients who have severe exacerbation of COPD.
- Trial name
- NCT03020394
- Where
- China
- Volunteers
- 208 people
- Sponsor
- China-Japan Friendship Hospital
Pulmonary Disease, Chronic Obstructive
Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
This is a multicenter, prospective, randomized, double-blind, placebo-controlled trial that will enroll 1028 patients with at least moderately severe COPD over a three year period and follow them at regular intervals for one…
- Trial name
- NCT02587351
- Testing
- Metoprolol succinate
- Where
- 27 sites in United States
- Volunteers
- 532 people
- Sponsor
- University of Minnesota
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Effects of High Flow Nasal Cannula on Sputum Clearance in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Acute exacerbation of COPD usually presents with more sputum production leading to worsening airflow obstruction. Often patients complain of sensation of sputum (phlegm) stuck in throat, which leads to worsening cough and…
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD Exacerbation, Airflow Obstruction
- Trial name
- NCT04217746
- Testing
- High Flow Nasal Cannula
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Tufts Medical Center
Pulmonary Disease, Chronic Obstructive
A Study Comparing the Efficacy, Safety and Tolerability of Fixed Dose Combination (FDC) of FF/UMEC/VI With the FDC of FF/VI and UMEC/VI; Administered Once-daily Via a Dry Powder Inhaler (DPI) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The study evaluates the efficacy of fluticasone furoate/umeclidinium bromide/vilanterol (FF/UMEC/VI) to reduce the annual rate of moderate and severe exacerbations compared with dual therapy of FF/VI or UMEC/VI in subjects with…
- Trial name
- NCT02164513
- Testing
- fluticasone furoate (FF), vilanterol (VI), umeclidinium bromide (UMEC)
- Where
- 998 sites in United States, Argentina and 35 more
- Volunteers
- 10,355 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Hyaluronic Acid in Acute Exacerbation of COPD - Duration Of Noninvasive Assistance
The objective of this study is to test the effect of High Molecular Weight Hyaluronic Acid (HMW-HA) on Non Invasive Ventilation (NIV) effectiveness in patients admitted to a sub-intensive care unit for respiratory failure due to…
- Trial name
- HAEC-DONA (NCT02674880)
- Testing
- HMW-HA
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- Campus Bio-Medico University
COPD Exacerbation, Pulmonary Disease, Chronic Obstructive
The Oral Microbiota as Reservoir for Systemic Opportunistic Pathogens
Small pilot studies with approximately 20 people per group support that eradication of the oral flora causes fewer exacerbations in chronic obstructive pulmonary disease (COPD) patients.
- Conditions
- COPD Exacerbation, Pulmonary Disease, Chronic Obstructive, Dental Plaque
- Trial name
- NCT02619903
- Testing
- Dental cleaning
- Where
- 2 sites in Sweden
- Volunteers
- 101 people
- Sponsor
- Malmö University
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