Clinical trials: Disease Exacerbation
COPD Exacerbation
COPD Aerosol Study Comparing the Efficacy of Nebulizers Versus Dry Powder Inhalers
The purpose of this study is to compare drug delivery and lung function after treatment with formoterol from a nebulizer versus a dry powder inhaler (DPI) in patients recovering from severe exacerbations of COPD.
- Trial name
- NCT02291016
- Testing
- Formoterol
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Asthma
Identification of Plasma miRNAs as Potential Biomarkers in Asthma Exacerbation
We hypothesize that there is a statistically significant difference in miRNA profiling and expression of subjects with asthma upon its exacerbation compared to patient's baseline level or following effective treatment of an…
- Trial name
- NCT01631760
- Testing
- no intervention
- Where
- 2 sites in United States
- Sponsor
- University of South Florida
COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD
Survey on NIV Settings in the Intensive Care Unit for Acute Exacerbation of COPD
Introduction Chronic obstructive pulmonary disease (COPD) is a common condition and the fourth leading cause of death worldwide.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD, Hypercapnic Respiratory Failure, COPD
- Trial name
- NIV-ICU (NCT06888180)
- Testing
- Non interventional study
- Volunteers
- 976 people
- Sponsor
- University Hospital, Caen
Schizophrenia
A Study to Test the Safety and Efficacy of MK-8998 in Acutely Psychotic Participants With Schizophrenia (MK-8998-004)
A study to evaluate the safety and efficacy of treatment with MK-8998 as compared to placebo and olanzapine for acutely psychotic patients with schizophrenia.
- Trial name
- NCT00827918
- Testing
- MK-8998, Comparator: Olanzapine
- Volunteers
- 216 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Obstructive Pulmonary Disease
Efficacy of Helium/Oxygen Compared to Air/Oxygen in Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of the study is to evaluate the efficacy of Helium/Oxygen (He/O2) 78%/22% compared to a conventional Air/O2 mixture in reducing endotracheal intubation rate and mortality in patients with severe hypercapnic…
- Trial name
- ECHO/ICU (NCT01155310)
- Testing
- Helium/Oxygen 78%/22%, Air/Oxygen
- Where
- 16 sites in Belgium, France and 4 more
- Volunteers
- 446 people
- Sponsor
- Air Liquide Santé International
Heart Failure; With Decompensation, Lower Extremity Edema
Above-Knee-High Application of Lower Limb Compression and Its Impact on Clinical Outcome in Patients Hospitalized With Heart Failure Exacerbation.
Heart failure (HF) remains one of the most common causes of hospitalization with high morbidity and mortality, and its worldwide prevalence is increasing.
- Conditions
- Heart Failure; With Decompensation, Lower Extremity Edema, Heart Failure，Congestive
- Trial name
- A-KHALIFE (NCT05467735)
- Testing
- Application of compression to bilateral lower extremities of patients using appropriately-sized elastic compression stockings.
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Hepatitis B, Hepatocellular Carcinoma
The Risk of Exacerbation of Chronic Hepatitis B After Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma
This study aim to find out the risk of exacerbation of chronic hepatitis B after percutaneous radiofrequency ablation (RFA) or hepatectomy for HCC, and it's effect to treatment outcome.
- Trial name
- HBV-HCC (NCT00720668)
- Testing
- radiofrequency ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
Acute Exacerbation of COPD, Lung Diseases
Antibiotic Stewardship in AECOPD Through CRP-Guided Management
Objectives: To determine whether CRP-guided antibiotic treatment for managing AECOPD in adult patients attending Emergency Departments leads to reduced antibiotic duration, without non-inferior COPD health status with usual care.
- Conditions
- Acute Exacerbation of COPD, Lung Diseases, Lung Diseases, Obstructive, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT05286918
- Testing
- The intervention (CRP-guided) group
- Where
- Hong Kong
- Volunteers
- 1,184 people
- Sponsor
- The University of Hong Kong
Acute Exacerbation of COPD, Corticosteroid
Treatment Efficacy of Systemic Corticosteroids in AECOPD Patients With Higher Blood Eosinophil Levels
Chronic Obstructive Pulmonary Disease (COPD) is one of the top three causes of death worldwide now. Acute exacerbations (AEs) of COPD are a risk factor for lung function deterioration, poor quality of life, longer…
- Conditions
- Acute Exacerbation of COPD, Corticosteroid, Morality, Lung Diseases, Obstructive
- Trial name
- NCT05059873
- Testing
- Prednisone
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Capital Medical University
Respiratory Infection (for Example, Pneumonia, Bronchitis), Respiratory Infection Virus
Kinetics and Metabolism of Nicotinamide Provided as a Dietary Supplementation
The diet of patients with reduced tryptophan serum levels that are either hospitalized for acute respiratory infection or treated for chronic inflammatory diseases such as inflammatory bowel diseases (in- or outpatients) is…
- Conditions
- Respiratory Infection (for Example, Pneumonia, Bronchitis), Respiratory Infection Virus, Community Acquired Pneumonia (CAP), COPD Acute Exacerbation
- Trial name
- CICR-NAM_PK (NCT07156929)
- Testing
- Controlled-ileocolonic-release nicotinamide (CICR-NAM): 500 mg/d, Controlled-ileocolonic-release nicotinamide (CICR-NAM): 1000 mg/d
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- University Hospital Schleswig-Holstein
Bronchitis, Chronic
A Multicentre, Randomised, Open-Label Study To Compare The Efficacy And Safety Of Azithromycin For 5 Days With Those Of Amoxicillin-Clavulanic Acid In Patients With Chronic Bronchitis
This study compared the clinical efficacy and safety of azithromycin with that of amoxicillin-clavulanic acid, in patients between the ages of 35 and 75 years, presenting with an exacerbation of chronic bronchitis.
- Trial name
- NCT00649831
- Testing
- Amoxicillin/clavulinic acid, Azithromycin
- Where
- 31 sites in France
- Volunteers
- 250 people
- Sponsor
- Pfizer
Congestive Heart Failure, Copd
A Mobile Integrated Health Intervention to Manage Congestive Health Failure and Chronic Obstructive Pulmonary Disease
Episodic and disjointed medical care for older, community-dwelling adults with chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) leave them vulnerable to adverse events such as worsening disease…
- Trial name
- NCT05540158
- Testing
- Mobile Integrated Health Intervention
- Sponsor
- University of Massachusetts, Worcester
COPD Exacerbation, COPD
Telemonitoring System for Early Diagnosis of COPD Exacerbations.
A tailored management of COPD patients would obviously allow to reduce costs for hospitalizations and improve quality of life. This management could benefit of the Information and Comunication Technology support, which can offer…
- Trial name
- NCT03739957
- Testing
- BPCO Media Kit
- Where
- 3 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Laboratori di Informatica Applicata
Asthma
PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study
The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to 16 week…
- Trial name
- NCT04129931
- Testing
- MCT, Clazakizumab, Broncho-Vaxom
- Where
- 29 sites in United States
- Volunteers
- 950 people
- Sponsor
- University of North Carolina, Chapel Hill
Cystic Fibrosis
Muco Smartphone Exacerbation
Exacerbation in cystic fibrosis play an important role in terms of mortality and morbidity. Exacerbation frequencies is relatedto FEV1 decline and mortality.
- Trial name
- MUSE (NCT02122289)
- Testing
- Application of Smartphone, No application Smartphone
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Montpellier
Premenstrual Dysphoric Disorder, Premenstrual Exacerbation of Mood Disorder
Adapting and Piloting Acceptance and Commitment Therapy (ACT) for Severe Premenstrual Mood Symptoms
In the weeks prior to menstruation, many individuals experience mood and physical symptoms that negatively impact their quality of life and functioning.
- Trial name
- ACT-PM (NCT06462391)
- Testing
- Acceptance and Commitment Therapy (ACT) Group
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Women's College Hospital
CAP, COPD Exacerbation
Project to Improve the Diagnosis and Treatment Ability of Adult Severe Community Acquired Lower Respiratory Tract Infection
1. Objective to understand the proportion of atypical pathogens in the pathogens of SCAP and AECOPD in urban hospitals in China. 2.
- Trial name
- NCT04959955
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
COPD, COPD Exacerbation
Pulmonary Rehabilitation for COPD Patients: Can Performance Predict Exacerbation?
The aim of pulmonary rehabilitation is to improve exercise capacity and reduce dyspnoea. As well as improving the patient's overall condition, pulmonary rehabilitation provides a means to monitor the patient regularly.
- Conditions
- COPD, COPD Exacerbation, Pulmonary Rehabilitation
- Trial name
- PREDICT (NCT05492149)
- Testing
- Performance follow-up
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Groupe Hospitalier du Havre
Chronic Obstructive Pulmonary Disease Exacerbation, COPD Exacerbation
The Addition of Inhaled Furosemide to Standard Treatment of COPD Exacerbation
The goal of this randomized controlled trial is to determine the effect of adding inhaled furosemide to the known treatment of patient with Chronic obstructive pulmonary disease (COPD) exacerbation.
- Trial name
- FUROSCOPE (NCT05769738)
- Testing
- Furosemide, Normal saline
- Volunteers
- 200 people
- Sponsor
- American University of Beirut Medical Center
Schizophrenia
Safety and Efficacy of Cariprazine in Patients With Schizophrenia
The objective of this study is to evaluate the efficacy, safety, and tolerability of cariprazine relative to placebo for the treatment of acute exacerbation of schizophrenia.
- Trial name
- NCT01104766
- Testing
- Cariprazine, Aripiprazole
- Where
- 58 sites in United States, Romania and 2 more
- Volunteers
- 617 people
- Sponsor
- Forest Laboratories
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