Clinical trials: Disease Exacerbation
Acute Exacerbation of COPD
Randomized Controlled Study of Programmed Weaning From NIV for AECOPD
Purpose of research:to explore a reasonable programmed withdrawal process of noninvasive ventilation and thereby reduce the duration of noninvasive mechanical ventilation in patients with acute exacerbations of chronic…
- Trial name
- NCT06014034
- Testing
- Programmed Weaning From Noninvasive Mechanical Ventilation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Asthma
Asthma Exacerbation Study
Asthma is a clinical syndrome that is well recognized by health care practitioners, yet asthma pathogenesis still remains poorly understood.
- Trial name
- NCT00853411
- Testing
- prednisone
- Sponsor
- University of Pittsburgh
Pulmonary Disease, Chronic Obstructive
A Study to Evaluate the Safety, Efficacy and Changes in Induced Sputum and Blood Biomarkers Following Daily Repeat Doses of Inhaled GSK2269557 in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Acute Exacerbation
The purpose of this study is to evaluate specific alterations in immune cell mechanisms related to neutrophil function as detected by PI3Kdelta-dependent changes in messenger ribonucleic acid (mRNA) extracted from induced sputum…
- Trial name
- NCT02522299
- Testing
- GSK2269557, DISKUS, ELLIPTA
- Where
- 6 sites in Canada, Denmark
- Volunteers
- 44 people
- Sponsor
- GlaxoSmithKline
Asthma Exacerbation
Treatment of Acute Asthma in ER With Combination of Systemic Steroids and Inhaled Steroids
We assume that the combination of systemic steroids and inhaled steroid in the first hour of treatment in the ER will decrease the admission rate and improve faster the pulmonary function.
- Trial name
- NCT00397267
- Testing
- inhalation of corticosteroids
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Soroka University Medical Center
Asthma Acute, Asthma Attack
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations
The goal of this clinical trial is to learn if nebulized ketamine helps treat moderate to severe asthma attacks in adults in the emergency department.
- Conditions
- Asthma Acute, Asthma Attack, Asthma Exacerbations
- Trial name
- KET-AIR (NCT07112456)
- Testing
- Nebulized ketamine (0.5 mg/kg in normal saline to a total volume of 5ml) plus standard asthma excaerbationcare
- Where
- Oman
- Volunteers
- 100 people
- Sponsor
- Oman Medical Speciality Board
Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease Exacerbation
Wearable Devices in the Recovery Phase of Acute Exacerbations of COPD (AECOPDs)
The purpose the study is to successfully characterize the recovery phase of acute exacerbations of COPD in the outpatient setting using remotely captured physiologic data from wearable devices, to compare this with patient…
- Trial name
- NCT05776654
- Testing
- Biometric wearable devices
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Bronchitis
A Trial To Evaluate Two Antibiotics For The Treatment Of Acute Exacerbation Of Chronic Bronchitis (AECB)
This trial is a research drug study to compare the effects of two antibiotics for the treatment of acute exacerbation of chronic bronchitis
- Trial name
- NCT00254566
- Testing
- Moxifloxacin, Azithromycin SR
- Where
- 34 sites in China, Malaysia and 4 more
- Volunteers
- 398 people
- Sponsor
- Pfizer
COPD Exacerbation Acute, COPD Exacerbation
PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPD
Acute exacerbation of chronic obstructive pulmonary disease (COPD) is defined acute worsening of respiratory symptoms requiring additional therapy.
- Trial name
- PAINT-COPD (NCT06160687)
- Testing
- PSV mode during NIV, ASV intellisync
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Telerehabilitation, COPD
Long-term Home-based Exercise for Patients With COPD: the COPDtoParis Project
This randomised controlled trial (RCT) aims to investigate the effect of long-term, interactive home-based cycle-exercise on patients with Chronic Obstructive Pulmonary Disease (COPD) after a COPD exacerbation requiring…
- Conditions
- Telerehabilitation, COPD, Quality of Life, Mobility Limitation
- Trial name
- COPDtoParis (NCT06235502)
- Testing
- Home-based cycle-exercise for COPD patients, Standard of Care
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aalborg University Hospital
COPD Exacerbation
COPD Care Model on Clinical and Patient-Reported Outcomes
This study is the first to evaluate a unique integrated care model for COPD which uses a validated clinical frailty indicator to set care goals and guide health care in hospital and in the community.
- Trial name
- NCT03332394
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Ottawa Hospital Research Institute
Asthma
Initiation of Chronic Asthma Care Regimens in the Pediatric Emergency Department
Hypothesis: Initiating chronic management treatment plans in conjunction with an asthma educational intervention in the pediatric Emergency Department (ED) with anti-inflammatory medication will result in an improvement of ED…
- Trial name
- IRUSBUPR0045 (NCT00388739)
- Testing
- Intervention: Budesonide, Usual care: albuterol + systemic steroids
- Where
- United States
- Sponsor
- Baylor College of Medicine
Chronic Obstructive Pulmonary Disease
CareCOPD - COPD Home Monitoring Study
This is a pilot study to demonstrate early validation of objective home-monitoring of Chronic obstructive pulmonary disease (COPD) patients by combining accurate and relevant patient data of medication and lung function (lung…
- Trial name
- NCT04918095
- Testing
- CareCOPD Platform
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cognita Labs LLC
COPD
Early Supported Discharge and Enhanced Homecare After Emergency Department Admission for Acute Exacerbation of COPD
The prevalence of chronic obstructive pulmonary disease (COPD) is between 8 and 15% of the adult population in 2010. This prevalence is expected to increase over the coming decades as the population ages and exposure to the risk…
- Trial name
- EXADOM (NCT03474575)
- Testing
- Prevention
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Grenoble
Schizophrenia
Study Evaluating Safety and Tolerability of Vabicaserin in Patients With Sudden Worsening of Schizophrenia
This study will evaluate the clinical safety and tolerability of vabicaserin in Japanese subjects that have a sudden worsening of their symptoms of schizophrenia.
- Trial name
- NCT00768612
- Testing
- SCA-136 50mg/day, SCA-136 150 mg/day, SCA-136 300mg/day
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
COPD, Chronic Obstructive Pulmonary Disease
The PALP™-COPD Trial (Low-Flow CO2-Removal (ECCO2-R) in Exacerbated COPD)
A Multicenter, Randomized, Controlled Trial to Determine Safety and Efficacy of Pump Assisted Lung Protection (PALP™) for Low Flow Carbon Dioxide (CO2) Removal in Conjunction with Liberation from Mechanical Ventilation Compared…
- Trial name
- PALP-COPD (NCT02107222)
- Testing
- CO2-Removal (PALP-Device/MaquetCP)
- Where
- Germany
- Sponsor
- Maquet Cardiopulmonary GmbH
COPD
Effects of Low-Dose Theophylline During Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
Molecular mechanisms of COPD exacerbations and the modulating effect of low dose theophylline on that inflammation are elucidated in this project.
- Trial name
- NCT00671151
- Testing
- Theophylline
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Son Dureta
Chronic Obstructive Pulmonary Disease
Clinical Presentation and Outcome of COPD Patients With Acute Exacerbation Attending Sohag University Hospital
Chronic obstructive pulmonary disease (COPD) is a worldwide public health challenge because of high prevalence and related disability and mortality (1).
- Trial name
- NCT06684353
- Volunteers
- 200 people
- Sponsor
- Sohag University
Dyspnea
Dyspnea in COPD: Relationship With Exacerbations Frequency
The perception of breathlessness varies significantly among COPD patients with similar severity of airflow limitation; those with poorer perception report less exacerbations as compared to those with frequent exacerbations.
- Trial name
- DPE (NCT02113839)
- Testing
- Spirometry, CO Exhaled breath, P01
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Hospital Clinic of Barcelona
COPD
This is a Multicenter, Prospective and Retrospective and Descriptive Epidemiology Study in Patients With Chronic Obstructive Pulmonary Disease (COPD) in Korea
This study is designed as a multicenter, prospective and retrospective and descriptive epidemiology study. This study is planned to evaluate 2 years of exacerbation in COPD patients and to investigate correlation of COPD disease…
- Trial name
- EPOCH (NCT01419379)
- Where
- 14 sites in South Korea
- Volunteers
- 1,118 people
- Sponsor
- Takeda
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of COPD
Negative Pressure Ventilation-rehabilitation on Acute Exacerbation of Chronic Obstructive Pulmonary Disease
This investigator-initiated, prospective, single center, randomized, controlled clinical trial enrolled patients with stable Global Initiative for Chronic Obstructive Lung Disease stage II-IV chronic obstruction pulmonary…
- Trial name
- NCT04843696
- Testing
- cuirass ventilator (cuirass diameter 21 cm or 34 cm, Dima Italia Srl.,Bologna, Italy), breathing training, and an educational program (relaxation techniques and a home pacing walking exercise)
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
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