Clinical trials: Disease Exacerbation
Asthma Exacerbation
Reduction in Clinical Variance Using Targeted Design Changes in Computerized Provider Order Entry Order (CPOE) Sets
Selective redesign of order sets using different ways to frame the order and physician decision-making in a computerized provider order entry system could increase adherence to evidence-based care and reduce population-specific…
- Trial name
- NCT00952471
- Testing
- Evidence Based Intervention to order set
- Where
- United States
- Volunteers
- 458 people
- Sponsor
- Brian Jacobs
COPD
Randomized Trial of the FreeAspire Versus PEP-bottle After Acute Exacerbation in COPD Patients
BACKGROUND: Studies have shown that COPD patients with bronchial hypersecretion have increased risk of acute exacerbations. FREE ASPIRE is an electro-medical device which removes bronchopulmonary secretions noninvasively, without…
- Trial name
- NCT02640430
- Testing
- standard treatment, Free Aspire
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 40 people
- Sponsor
- Maugeri Foundation
COPD Exacerbation Acute
Combination Antibiotic Therapy Compared to Monotherapy in the Treatment of Acute COPD
The investigators hypothesized that the empirical use of fluoroquinolones together with beta-lactam antibiotics will change their therapeutic success in patients with acute exacerbations of COPD compared to that in patients in…
- Trial name
- COPD (NCT04879030)
- Testing
- Beta-Lactams, Fluoroquinolone
- Where
- Vietnam
- Volunteers
- 170 people
- Sponsor
- Haiphong University of Medicine and Pharmacy
Heart Failure
Genetic and Immunity in Heart Failure
Heart failure is a major health problem with serious consequences on mortality and morbidity worldwide. In chronic heart failure an alteration of the inflammatory state occur.
- Trial name
- GISCO (NCT06758128)
- Testing
- Evaluation of HS1,2 polymorphisms
- Where
- 2 sites in Italy
- Volunteers
- 215 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
COPD, Chronic Bronchitis
Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
The purpose of this study is to show that one form of mechanical airway clearance techniques, High Frequency Chest Wall Oscillation (HFCWO)using a pneumatic vest, will diminish exacerbations of COPD which will improve respiratory…
- Conditions
- COPD, Chronic Bronchitis, Emphysema
- Trial name
- NCT00181207
- Testing
- pneumatic vest
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Acute Exacerbation Copd
Impact of Air Quality on Exacerbations of COPD in the Somme
All COPD patients with a diagnosis of acute exacerbation in emergency room in University Hospital of Amiens-Picardie between 01/01/2017 and 31/12/2017.
- Trial name
- PolluBPCO (NCT03079661)
- Where
- France
- Volunteers
- 179 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
COPD Exacerbation
Low-dose CT for Diagnosis of Pneumonia in COPD Exacerbations and Comparison of the Inflammatory Profile.
Hypothesis: There is an underdiagnosis of pneumonia in COPD (Chronic Obstructive Pulmonary Disease) exacerbations which could be demonstrated by performing low-dose chest CT.
- Trial name
- NCT02264483
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Acute Gastritis, Gastric Ulcer
Efficacy and Safety of Teprenone in Patients With Acute Gastritis, Acute Gastric Lesion of Chronic Gastritis With Acute Exacerbation or Gastric Ulcer
This is a self-controlled, open, multiple-center clinical trial.
- Trial name
- NCT01190657
- Testing
- Selbex
- Where
- 26 sites in China
- Volunteers
- 1,184 people
- Sponsor
- Eisai Co., Ltd.
COPD, COPD Exacerbation
A Retrospective rEal-life daTa Study to Assess the exaceRbations and Lung functIon in Chronic Obstructive Pulmonary Disease ( COPD ) patiEnts receiVing Fluticasone/Salmeterol Comparing to Those Εscalating in Open-triple Fluticasone/Salmeterol, Long Acting Muscarinic Antagonist (LAMA) Combination
Inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA) combination is commonly prescribed to treat COPD; we will perform a retrospective analysis on the effect of adding a long-acting muscarinic receptor antagonist (LAMA) to…
- Trial name
- RETRIEVE (NCT03858348)
- Where
- Greece
- Volunteers
- 1,000 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
COPD, COPD Exacerbation
Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)
To demonstrate the additional benefit of roflumilast when added on to fixed-dose combination (FDC) LABA/ICS in the reduction of exacerbations in subjects with severe to very severe COPD.
- Conditions
- COPD, COPD Exacerbation, Lung Diseases, Respiratory Disorders
- Trial name
- NCT01443845
- Testing
- Roflumilast
- Where
- 338 sites in United States, Argentina and 15 more
- Volunteers
- 2,354 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Infectious Etiology of Acute Exacerbations of COPD
To assess the infectious etiology related to acute exacerbation of COPD in Hong Kong
- Trial name
- NCT00441389
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Clinical Practice of AECOPD Management in China
The purpose of this study is observe clinical practice including glucocorticoids treatment in AECOPD in China.
- Trial name
- NCT02051166
- Where
- 13 sites in China
- Volunteers
- 5,095 people
- Sponsor
- AstraZeneca
COPD Exacerbation, PTE - Pulmonary Thromboembolism
The Appropriate Anticoagulation Duration for Chronic Obstructive Pulmonary Disease With Pulmonary Thromboembolism
Anticoagulation is the most important treatment for pulmonary thromboembolism (PTE). The thromboembolism risk is especially high in patients with chronic obstructive pulmonary disease (COPD) exacerbations.
- Trial name
- NCT03185845
- Testing
- Warfarin
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD
Remote Monitoring of COPD Patients Experiencing an Acute Exacerbation Through Health Evaluations Using Wearable Mobile Technology
Chronic obstructive pulmonary disease (COPD) causes about 3 million deaths annually and significantly burdens healthcare systems, costing the EU 38.6 billion euros, largely due to frequent hospitalizations triggered by acute…
- Trial name
- COPD-BREATHE (NCT06890767)
- Testing
- Wearable mobile device, CAT Questionnaire, DHRQ Questionnaire
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- David Ruttens
Chronic Obstructive Pulmonary Disease Exacerbation, Obstructive Sleep Apnea Exacerbation
Non-invasive Ventilation or CPAP in OSA-COPD Following Admission for an Acute Hypercapnic Respiratory Failure
Chronic obstructive pulmonary disease (COPD) is a major public health problem with 212.3 million prevalent cases of COPD worldwide and 3.3 million deaths related to COPD in 2019.
- Trial name
- NCT07047092
- Testing
- Non-invasive Ventilation (NIV), Continous Positive Airway Pressure (CPAP)
- Where
- France
- Volunteers
- 386 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Prevention of Asthma Relapse After Discharge From Emergency
The purpose of this study is to compare the Symbicort® Turbuhaler® to both Pulmicort® Turbuhaler® and Bricanyl® Turbuhaler® for the treatment of asthma after discharge from the emergency room
- Trial name
- PARADE (NCT00326053)
- Testing
- Budesonide/formoterol
- Where
- 20 sites in Canada
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Idiopathic Pulmonary Fibrosis
Heart Rate Variability and Nocturnal Blood Oxygen Saturation in Patients With Idiopathic Pulmonary Fibrosis
The goal of this observational study is to compare the overnight heart rate variability (HRV) and nocturnal oxygen saturation (SpO2) in patients with idiopathic pulmonary fibrosis (IPF).
- Trial name
- NCT06027372
- Testing
- "LARGAN" ECG Holter
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Asthma, Asthma Attack
The Effect of Asthma Flare-up Clinic After Exacerbation
The goal of this interventional study is to examine the effect of asthma flare-up clinic follow-up in adult subjects after an asthma flare-up. This study aim to answer the following questions: 1.
- Trial name
- NCT06201728
- Testing
- Follow-up in a flare-up clinic
- Where
- Israel
- Volunteers
- 230 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Cystic Fibrosis
Study of Long-term Treatment With Hypertonic Saline in Patients With Cystic Fibrosis
A phase IV clinical trial, multicentric (3 Hospitals in Madrid) controlled, prospective, open and randomized of long-term treatment with hypertonic saline in cystic fibrosis patients.
- Trial name
- NCT01377792
- Testing
- Hypertonic saline
- Where
- Spain
- Volunteers
- 71 people
- Sponsor
- Adelaida Lamas Ferreiro
Chronic Obstructive Pulmonary Disease, Exacerbation Copd
15-year Mortality After Hospitalization for Exacerbation of Chronic Obstructive Pulmonary Disease
The investigators examine the 15-year mortality after an admission for an exacerbation of Chronic Obstructive Pulmonary disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease, Exacerbation Copd, Mortality
- Trial name
- MORTCOP (NCT02972775)
- Testing
- no interventions. observational study
- Where
- Netherlands
- Volunteers
- 845 people
- Sponsor
- Zuyderland Medisch Centrum
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