Clinical trials: Disease Exacerbation
Respiratory Tract Infections
Evaluation of the Treatment With Klacid SR in Patients With Acute Tracheitis, Tracheobronchitis and Bronchitis, Acute Exacerbation of Chronic Bronchitis and Mild Community-acquired Pneumonia in Common Clinical Practice in Ukraine
To describe the relief of symptoms, tolerability, and compliance of treatment with Klacid® sustained release (SR) at a dose of 1000 mg once daily in patients with acute tracheitis, acute tracheobronchitis, acute bronchitis, or in…
- Trial name
- KLARAINE (NCT01095978)
- Testing
- Clarithromycin (Klacid SR)
- Where
- 126 sites in Ukraine
- Volunteers
- 2,822 people
- Sponsor
- Abbott
COPD Exacerbation, Chronic Obstructive Pulmonary Disease Exacerbation
Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation
Chronic obstructive pulmonary disease (COPD) is a common disorder that affects approximately 400,000 Danish citizens. About 3,000-3,500 Danes die yearly because of the disorder, and the costs associated with hospital admissions…
- Trial name
- O2flow-COPD (NCT04223050)
- Testing
- Oxygen gas
- Where
- 4 sites in Denmark
- Volunteers
- 23 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Chronic Obstructive Pulmonary Disease
Eosinophilic Cationic Protein as a Biomarker in Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease is a type of obstructive lung disease characterized by long-term breathing problems and poor airflow.
- Trial name
- NCT04008017
- Testing
- Eosinophilic Cationic Protein biomarker
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Assiut University
Acute Respiratory Disease, COPD Exacerbation Acute
Study of Hospitalised Patients With Acute Respiratory Conditions
The goal of this observational study is to learn about the short- and long-term outcomes of people admitted to hospital with an acute respiratory condition, including exacerbations of chronic lung disease, and to understand…
- Conditions
- Acute Respiratory Disease, COPD Exacerbation Acute, Asthma, Pneumonia
- Trial name
- CHESTY (NCT05095090)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Vitamin D Deficiency, Cystic Fibrosis
Efficacy of Intensive Cholecalciferol Monitoring and Supplementation on Serum vitD Levels in Pediatric Patients With CF
Cystic fibrosis (CF) is an autosomal recessive disease caused by alterations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, characterized by multisystemic alterations, mainly in the lung, intestine…
- Conditions
- Vitamin D Deficiency, Cystic Fibrosis, Bone Density, Low, Inflammation Chronic
- Trial name
- NCT05276960
- Testing
- Cholecalciferol Pill
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
COPD, Non Invasive Ventilation (NIV)
Value of Volume Oxygenation Index to Detect Early Failure of Non-invasive Ventilation in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Non-invasive ventilation (NIV) is an evidence-based treatment for patients with acute respiratory failure due to an exacerbation of Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- COPD, Non Invasive Ventilation (NIV), VOX Index
- Trial name
- NCT07074210
- Testing
- non invasive ventilation
- Volunteers
- 190 people
- Sponsor
- Assiut University
Chronic Obstructive Pulmonary Disease (COPD)
Clinical Study on Guben Kechuan Granules Promoting Disease Recovery by Regulating Immune-Inflammatory Dysregulation in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease During the Peri-Discharge Period
Chronic Obstructive Pulmonary Disease (COPD) is one of the most common chronic airway diseases in China. Western medicine treatments have good clinical efficacy, but their effectiveness is limited in patients with Acute…
- Trial name
- NCT07456813
- Testing
- Guben Kechuan Granules group
- Volunteers
- 126 people
- Sponsor
- Cuiling Feng
Asthma, Status Asthmaticus
Steroids in Children Hospitalized With Asthma
Asthma is the most common chronic disease of children. A short (3-5 day) course of a short-acting steroid such as Prednisone or Prednisolone has long been the standard of care for asthma exacerbation.
- Conditions
- Asthma, Status Asthmaticus, Wheezes
- Trial name
- NCT02780479
- Testing
- Dexamethasone, Prednisone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Chronic Rhinosinusitis (Diagnosis), Antibiotic Side Effect
Effect of Topical Sinonasal Antibiotics
In this study, patients who have had previous endoscopic sinus surgery and present with an acute exacerbation of chronic rhinosinusitis will be offered endoscopic-guided, culture-directed antibiotic therapy.
- Trial name
- NCT03935828
- Testing
- Oral versus topical antibioitics
- Sponsor
- United States Naval Medical Center, San Diego
Asthma
Retrospective Review on Patients With Recurrent Asthmatic Attacks Requiring Hospitalizations
Asthma is a common respiratory disease. around the world. Asthma exacerbation is one of the major sequelae and associated with various morbidity and mortality.
- Trial name
- NCT04479501
- Testing
- Asthma exacerbation related hospitalization
- Where
- Hong Kong
- Volunteers
- 2,280 people
- Sponsor
- Chinese University of Hong Kong
Cystitis
Study to Evaluate the Efficacy and Safety of XC243 in Patients With Exacerbation of Chronic Cystitis
Multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of XC243 in patients with exacerbation of chronic cystitis.
- Trial name
- NCT06391164
- Testing
- XC243 25 mg, XC243 50 mg, XC243 75 mg
- Where
- 8 sites in Russia
- Volunteers
- 280 people
- Sponsor
- PHARMENTERPRISES LLC
Heart Failure
Improving Drug Use for Elderly Heart Failure Patients
The aims of this randomized, clinical trial are to develop and test a multileveled pharmacy-based program to improve the care of patients with heart failure.
- Trial name
- NCT00388622
- Testing
- Pharmacist intervention
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- University of North Carolina
Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
A Comparison Study of Two Respiratory Physical Therapy Methods and Standard Medical Treatment for Treating COPD Patients During Acute Exacerbation
One of the main goals of the respiratory physical therapy is to help people who are suffering from accumulating of secretions in their airways and lungs.
- Trial name
- NCT02140892
- Testing
- respiratory physical therapy manual technique- Autogenic Drainage, respiratory physical therapy technique- IPV
- Volunteers
- 75 people
- Sponsor
- Sheba Medical Center
Crohn's Disease
The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease)
Inflammatory Bowel Disease (IBD) is an immune mediated chronic intestinal condition. It includes ulcerative colitis (UC) and Crohn's disease(CD).
- Trial name
- NCT01765998
- Testing
- Probiotic
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Myasthenia Gravis
A Pilot Trial To Assess The Feasibility And Efficacy Of SCIG In Patients With MG Exacerbation (SCIG-MG)
This is a prospective open-label, uncontrolled, single-blind, pilot clinical trial. The primary objective is to assess the efficacy, safety, feasibility and tolerability of SCIG in patients with worsening MG.
- Trial name
- SCIG-MG (NCT02774239)
- Testing
- Human normal immunoglobulin G (IgG)
- Where
- 2 sites in Canada
- Volunteers
- 26 people
- Sponsor
- University of Alberta
Schizophrenia, Mania
A Study of the Efficacy and Safety of Intramuscular Ziprasidone Followed by Oral Ziprasidone for the Treatment of Psychosis
To assess the efficacy, safety, and tolerability of intramuscular ziprasidone in the treatment of the acute exacerbation of non-organic psychosis of any etiology, including schizophrenia, acute mania, delusional disorder and…
- Conditions
- Schizophrenia, Mania, Delusional Disorder, Acute Exacerbation of Psychosis
- Trial name
- NCT00644800
- Testing
- Ziprasidone
- Where
- 8 sites in Brazil
- Volunteers
- 89 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Chronic Obstructive Airway Disease
Safety and Efficacy of Inhaled Sedation in Management of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Brief Summary (Plain Language) This study tests whether using a device called AnaConDa® to give a mild gas medicine (isoflurane) helps people with severe flare-ups of chronic obstructive pulmonary disease (COPD) breathe more…
- Trial name
- NCT07191470
- Testing
- The Anaesthetic Conserving Device (AnaConDa)
- Where
- India
- Volunteers
- 10 people
- Sponsor
- Pandit Bhagwat Dayal Sharma, PGIMS, Rohtak
Chronic Obstructive Pulmonary Disease
A Study of the Inflammatory Pathways Associated With Chronic Obstructive Pulmonary Disease Exacerbations
The purpose of this study is to observe how the inflammatory pathways differ in subjects with chronic obstructive pulmonary disease (COPD) during an acute exacerbation of COPD (AECOPD).
- Trial name
- NCT01337661
- Where
- Ireland
- Volunteers
- 26 people
- Sponsor
- MedImmune LLC
Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency
Сohort Study to Evaluate Exacerbations, Respiratory Symptoms, Physical Exercise Intolerance and Lung Functions Among Participants Who Use IQOS With Heatsticks Compared to Smokers of Conventional Cigarettes
This study evaluates frequency of exacerbations, respiratory symptoms, physical exercise intolerance and abnormal lung functions among participants who use IQOS with heatsticks compared to smokers of conventional cigarettes
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency, Physical Disability, Respiratory Disease
- Trial name
- NCT03383601
- Testing
- Heated Tobacco product IQOS/heatstick, Smoking combustible cigarettes
- Where
- Kazakhstan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Kazakhstan Academy of Preventive Medicine
Pneumonia
Physiotherapy in Patients Hospitalized Due to Pneumonia.
Acute respiratory infections are the fourth cause of hospitalization in elderly. Various studies have examined the impact of hospitalization in patients with respiratory pathology, showing the need of interventions in order to…
- Trial name
- NCT02515565
- Testing
- cephalosporin with or without erythromycin, Physiotherapy program
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Granada
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