Clinical trials: Disease Exacerbation
Acute Coronary Syndrome
ObseRvation After Acute Coronary Syndrome for deveLopment of trEatment Options
The aim of the study is developing an individualized risk model for the unfavorable outcomes of coronary artery disease and complications from ongoing therapy, according to clinical, instrumental, biochemical and genetic…
- Trial name
- ORACLE (NCT04068909)
- Volunteers
- 1,655 people
- Sponsor
- Central State Medical Academy
Hepatitis B, Hepatocellular Carcinoma
The Risk of Exacerbation of Chronic Hepatitis B After Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma
This study aim to find out the risk of exacerbation of chronic hepatitis B after percutaneous radiofrequency ablation (RFA) or hepatectomy for HCC, and it's effect to treatment outcome.
- Trial name
- HBV-HCC (NCT00720668)
- Testing
- radiofrequency ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
COPD
EMG in COPD - Factor Analysis
Acute exacerbations of COPD contribute to significant morbidity and mortality in the United Kingdom (UK). The ability to assess response to treatment during exacerbations that require hospitalisation would allow clinicians to…
- Trial name
- EMGCOPD (NCT02721199)
- Testing
- Neural Respiratory Drive Automated EMGpara assessment
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
COPD Exacerbation, Bronchiectasis With Acute Exacerbation
Multi-omics Studies of Host-microbiome Interaction in Chronic Obstructive Pulmonary Disease and Bronchiectasis
Chronic obstructive pulmonary disease (COPD) and bronchiectasis are common chronic respiratory diseases in China. COPD is characterized by irreversible lung function decline due to airway inflammation, emphysema and alveolar…
- Trial name
- NCT05738044
- Testing
- No intervention
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
COPD Exacerbation
NIV - NAVA vs NIV - PS for COPD Exacerbation
Number of Patients: Total no. of patients = 40 patients NIV-PSV group (Group A) = 20 NIV-NAVA group (Group B) = 20 Inclusion criteria a) Patients of Chronic obstructive pulmonary disease with acute hypercapnic respiratory failure…
- Trial name
- NAVA-NICE (NCT02912689)
- Testing
- Neurally Adjusted Ventilator Assist, Pressure support ventilation
- Where
- India
- Volunteers
- 40 people
- Sponsor
- All India Institute of Medical Sciences
Lung Diseases, Obstructive
ECCO2R in the Treatment of Acute Exacerbation of COPD With Severe Hypercapnia
Patients with moderate to severe acute exacerbation of chronic obstructive pulmonary disease are often complicated with hypercapnia and respiratory failure, so they need to be admitted to ICU for monitoring and respiratory…
- Trial name
- NCT04842344
- Testing
- ECCO2R
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Li Xuyan
COPD
Appropriate Admission in COPD Exacerbation From Emergency Department. Multicenter Study
Objectives: To estimate the rate of appropriate hospital admissions , and of discharge to home episodes that would have been appropriate admissions to the hospital, on patients with exacerbations of their COPD by using…
- Trial name
- IRYSS-COPD (NCT02434536)
- Volunteers
- 2,487 people
- Sponsor
- Hospital Galdakao-Usansolo
Respiratory Distress Syndrome, Acute, Respiratory Insufficiency
Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients
This prospective, blinded observational clinical study was aimed to determine the effect of hyperhydration and muscle loss measured by Bioelectrical impedance vector analysis (BIVA) on mortality.
- Conditions
- Respiratory Distress Syndrome, Acute, Respiratory Insufficiency, Lung Ventilator, Hyperhydration
- Trial name
- NCT05991778
- Testing
- Bioelectrical impedance vector analysis (BIVA), Blood and urine analysis, cumulative water balance
- Where
- Czechia
- Volunteers
- 61 people
- Sponsor
- University Hospital Ostrava
Asthma, Vitamin D Deficiency
Vitamin D Deficiency and Asthma Exacerbation
The study aim is in two phases. First phase: to evaluate the influence of vitamin D deficiency on asthma severity, degree of airway obstruction and frequency of asthma exacerbations.
- Conditions
- Asthma, Vitamin D Deficiency, Disease Exacerbation
- Trial name
- AVD (NCT02661191)
- Testing
- oral cholecalciferol
- Volunteers
- 119 people
- Sponsor
- University of Turin, Italy
COPD (Chronic Obstructive Pulmonary Disease)
The Study of Chronic Obstructive Pulmonary Disease (COPD) Participants Treated With Dupilumab (STRIDE) Registry
The STRIDE Registry will evaluate the real-world effectiveness and safety of dupilumab in participants with COPD. The primary objective is to describe characteristics of participants newly initiated with dupilumab for COPD.
- Trial name
- STRIDE (NCT07612878)
- Testing
- Cohort 1: Dupilumab, Cohort 2: usual care only
- Where
- 7 sites in United States
- Volunteers
- 350 people
- Sponsor
- Sanofi
Heart Failure
Heart Failure Evaluation Study
Heart failure (HF) is a highly prevalent conditions that impose a significant burden to the patients, the hospital and the healthcare system. In Hong Kong, HF was one of the commonest causes of hospitalization and death.
- Trial name
- NCT05583513
- Testing
- MLHFQ (Minnesota Living with Heart Failure Questionnaire), KCCQ (the Kansas City Cardiomyopathy Questionnaire)
- Where
- Hong Kong
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
Schizophrenia
Safety and Efficacy of Cariprazine in Schizophrenia
The objective of this study is to evaluate the efficacy, safety, and tolerability of cariprazine relative to placebo for the treatment of acute exacerbation of schizophrenia.
- Trial name
- NCT01104779
- Testing
- Cariprazine
- Where
- 41 sites in United States, Colombia and 2 more
- Volunteers
- 446 people
- Sponsor
- Forest Laboratories
COPD Patients
Comparing the Efficacy of Symbicort® pMDI and Formoterol Turbuhaler in Reducing Exacerbations in Patients With Cronic Obstructive Pulmonary Disease
Comparing the efficacy of Symbicort® pMDI and Formoterol Turbuhaler in reducing exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- RISE (NCT02157935)
- Testing
- Symbicort, Formoterol turbohaler
- Where
- 371 sites in United States, Argentina and 9 more
- Volunteers
- 2,026 people
- Sponsor
- AstraZeneca
COPD Exacerbation
High-intensity Resistance Training in Post-exacerbation COPD
After a COPD exacerbation, many individuals experience severe weakness in the leg muscles, especially the quadriceps. This weakness can make daily activities difficult and slow down recovery.
- Trial name
- NCT07302425
- Testing
- HIRT, HIET
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
COPD Exacerbation Acute
The Use of Medical Devices to Monitor Chronic Obstructive Pulmonary Disease Patients Study BREATH-TRACHER 2
The proposed study will explore whether remote monitoring of a COPD patient can be undertaken using a wearable medical device.
- Trial name
- BREATH-TRACHER (NCT06419062)
- Testing
- Frontier X2
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Strathclyde
Pulmonary Cystic Fibrosis
Standardized Treatment of Pulmonary Exacerbations II
Cystic fibrosis (CF), a life-shortening genetic disease, is marked by acute episodes during which symptoms of lung infection increase and lung function decreases.
- Trial name
- STOP2 (NCT02781610)
- Testing
- Standard of care IV antibiotic(s)
- Where
- 58 sites in United States, Canada
- Volunteers
- 982 people
- Sponsor
- Chris Goss
Tracheitis, Tracheobronchitis
Evaluation of the Treatment With Klacid®SR in Patients With Lower Respiratory Tract Infection
The aim of this post-marketing observational study (PMOS) is to describe the relief of symptoms, tolerability and compliance of treatment with Klacid®SR in a dose 1000 mg once daily in patients with lower respiratory tract…
- Conditions
- Tracheitis, Tracheobronchitis, Bronchitis, Chronic Bronchitis
- Trial name
- NCT01108185
- Where
- 158 sites in Slovakia
- Volunteers
- 3,181 people
- Sponsor
- Abbott
Chronic Obstructive Pulmonary Disease
A Real-World Assessment of a COPD Disease Management Support Service (Me & My COPD)
A real world study to determine the effectiveness of a patient support service to aid COPD patients in their self management.
- Trial name
- Me&MyCOPD (NCT02300090)
- Testing
- Test Group, Control Group
- Where
- 23 sites in United Kingdom
- Volunteers
- 161 people
- Sponsor
- AstraZeneca
Cystic Fibrosis, Primary Ciliary Dyskinesia
Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia
The objective of this study is to compare the lower airways inflammatory response to infection/pulmonary exacerbation among children known to have Primary Ciliary Dyskinesia (PCD) with children known to have Cystic Fibrosis (CF)…
- Trial name
- NCT01155115
- Testing
- Sputum Collection, Pulmonary Function Testing, Exhaled Nitric Oxide
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- The Hospital for Sick Children
Acute Exacerbation of COPD
Copd Exacerbation and Pulmonary Hypertension Trial
This trial will investigate whether patiens admitted with an acute exacerbation of chronic obstructive lung disease and pulmonary hypertension will benefit from a targeted pharmacological treatment.
- Trial name
- CODEX-P (NCT04538976)
- Testing
- Sildenafil
- Where
- 5 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
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