Clinical trials: Disease Exacerbation
Lung Diseases, Obstructive
Prospective Randomized Study of Nasal High Flow in Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The main oxygen therapy to the patients with acute exacerbation of Chronic obstructive pulmonary disease, who are mild to moderate respiratory insufficiency (arterial blood gas analysis showed pH = 7.35, PO2 <…
- Trial name
- NCT02439333
- Testing
- Nasal high flow cannula (Fisher & Paykel Healthcare, Auckland, New Zealand), nasal catheter or Venturi mask
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Li Xuyan
Pulmonary Disease, Chronic Obstructive
Prevalence of Different Haptoglobin Phenotypes in Patients With COPD- Frequent Exacerbators Versus Non Exacerbators
Chronic obstructive pulmonary disease (COPD) is a common disease in smokers. COPD has a slowly deteriorating course, punctuated by exacerbations- acute events characterized by increasing shortness of breath and putrid sputum.
- Trial name
- NCT01745419
- Where
- Israel
- Volunteers
- 105 people
- Sponsor
- Carmel Medical Center
COPD, COPD Exacerbation
Evaluation of Eosinophil Phenotype in COPD Patients
This is a pilot non pharmacological observational study. Aim of the study is to analyze the immunophenotype of circulating eosinophils in chronic obstructive pulmonary disease (COPD) patients, and to correlate results with…
- Trial name
- V-FEO (NCT04494308)
- Testing
- biomarker identification
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele Roma
Asthma
Predictors of Asthma Exacerbations in Children
The purpose of this study is to determine whether parameters of the pulmonary function tests and the bronchial hyperresponsiveness to methacholine are predictors of asthma exacerbations.
- Trial name
- NCT01449435
- Testing
- Methacholine challenge testing
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Pulmonary Disease, Chronic Obstructive
Investigate the Impact of Early Treatment Initiation With Tiotropium in Patients Recovering From Hospitalization for an Acute COPD Exacerbation 1
A randomized, placebo-controlled, double-blind, parallel group, multi center study to assess the safety and efficacy of tiotropium bromide (18 µg) delivered via the HandiHaler® in Chronic Obstructive Pulmonary Disease (COPD)…
- Trial name
- NCT01663987
- Testing
- tiotropium bromide
- Where
- 50 sites in United States, Puerto Rico
- Volunteers
- 79 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease, Exacerbation Copd
15-year Mortality After Hospitalization for Exacerbation of Chronic Obstructive Pulmonary Disease
The investigators examine the 15-year mortality after an admission for an exacerbation of Chronic Obstructive Pulmonary disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease, Exacerbation Copd, Mortality
- Trial name
- MORTCOP (NCT02972775)
- Testing
- no interventions. observational study
- Where
- Netherlands
- Volunteers
- 845 people
- Sponsor
- Zuyderland Medisch Centrum
Chronic Obstructive Pulmonary Disease
Education With Inhalers in Patients With COPD Exacerbation
Chronic obstructive pulmonary disease (COPD) is a public health problem with great morbidity. The main therapeutic strategy is inhalers.
- Trial name
- NCT03337958
- Testing
- Ventilatory re-education
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Universidad de Granada
Asthma
Mechanism(s) of Airflow Limitation During Exacerbation of Asthma
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction.
- Trial name
- NCT01225913
- Testing
- fluticasone/salmeterol in all asthmatics, budesonide/formoterol or fluticasone/salmeterol in all asthmatics
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Gelb, Arthur F., M.D.
Schizophrenia
Study Evaluating RGH-188 in the Treatment of Patients With Schizophrenia
This is a study designed to evalute the safety and efficacy of RGH-188 in the treatment of acute schizophrenia. This study will be 10 weeks in duration; 6 weeks double-blind treatment, and 4 weeks safety follow-up.
- Trial name
- NCT00404573
- Testing
- RGH-188
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Forest Laboratories
Allergic Asthma, Uncontrolled Moderate to Severe
Efficacy and Safety of Zerafil® (Omalizumab) in Participants With Uncontrolled Moderate to Severe Allergic Asthma
The purpose of this study is to evaluate the efficacy and safety of Omalizumab produced by CinnaGen compared with Xolair® (Genentech, Inc., USA And Novartis Pharmaceuticals Corp, Switzerland) in subjects with uncontrolled…
- Trial name
- NCT05813470
- Testing
- Omalizumab (CinnaGen), Omalizumab (Genentech, Inc., USA and Novartis Pharmaceuticals Corp, Switzerland)
- Where
- 22 sites in Iran
- Volunteers
- 256 people
- Sponsor
- Cinnagen
Chronic Obstructive Pulmonary Disease With Exacerbation
Comparative Effectiveness of Roflumilast and Azithromycin in Reducing Exacerbations in Severe Chronic Obstructive Pulmonary Disease ( COPD ) Patients With Chronic Bronchitis Phenotype
"The study is a randomized controlled trial comparing roflumilast and azithromycin as add-on therapies in 70 patients with severe chronic obstructive pulmonary disease (COPD ) and frequent exacerbations.
- Trial name
- COPD (NCT07795086)
- Testing
- Roflumilast Oral Tablet, Azithromycin 250 mg
- Volunteers
- 70 people
- Sponsor
- Sidra Aziz
COPD
Effect of Education and Respiratory Rehabilitation on Quality of Life in COPD Patients
In patients with COPD and a history of recent exacerbation, to compare the quality of life after completing a joint program of health education and respiratory rehabilitation with those patients who only receive respiratory…
- Trial name
- EDUEPOC (NCT03889054)
- Testing
- Education program
- Volunteers
- 66 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Breast Cancer, Palliative Care
The Impact of SPC on Advanced Breast Cancer Patients
The aim of this prospective, observational study is the evaluation of the effectiveness of a 14-day Specialist Palliative Care therapy in participants with advanced breast cancer carried out in a stationary palliative care unit…
- Conditions
- Breast Cancer, Palliative Care, Quality of Life, Cancer, Breast
- Trial name
- NCT03612934
- Testing
- Specialist Palliative Care
- Volunteers
- 144 people
- Sponsor
- Silesian University of Medicine
Chronic Obstructive Pulmonary Disease (COPD)
129-Xe MRI Study of Single Triple Therapy Inhaler Effects in COPD Patients With Moderate-severe Dyspnea and/or Poor Health Status With High or Low Risk of Exacerbation
The goal of this study is to study how 12-weeks daily (and optional 48-weeks) single inhaler triple therapy (fluticasone furoate (FF)-an inhaled corticosteroid; umeclidinium (UMEC)-a long-acting muscarinic antagonist; vilanterol…
- Trial name
- MUST (NCT07192016)
- Testing
- fluticasone furoate(FF)/umeclidinium (UMEC)/vilanterol(VI) (100/62.5/25) mcg
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
COPD Exacerbation Acute, COPD Exacerbation
PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPD
Acute exacerbation of chronic obstructive pulmonary disease (COPD) is defined acute worsening of respiratory symptoms requiring additional therapy.
- Trial name
- PAINT-COPD (NCT06160687)
- Testing
- PSV mode during NIV, ASV intellisync
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Bronchitis, Bronchitis, Chronic
A Study of the Safety and Effectiveness of Levofloxacin Compared With Cefaclor in the Treatment of Adults With Chronic Bronchitis Experiencing Rapid Onset of Worsening of Symptoms Caused by Bacteria
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with cefaclor, another antibiotic, in the treatment of adults with chronic bronchitis experiencing rapid onset of…
- Trial name
- NCT00257140
- Testing
- levofloxacin
- Volunteers
- 367 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Cystic Fibrosis
Cystic Fibrosis Foundation (CFF) Biomarkers of Exacerbation
Clinical and translational research in cystic fibrosis (CF) is hampered by a lack of biomarkers that can be used to identify promising new therapies.
- Trial name
- NCT00788359
- Where
- 5 sites in United States
- Volunteers
- 123 people
- Sponsor
- University of Colorado, Denver
Chronic Obstructive Pulmonary Disease
The Influence of an Acute Exacerbation During Pulmonary Rehabilitation in COPD Patients Awaiting Lung Transplantation
Data from chronic obstructive pulmonary disease patients awaiting lung transplantation which performed a pulmonary rehabilitation program will be analyzed retrospectively.
- Trial name
- NCT04363723
- Testing
- Pulmonary Rehabilitation
- Where
- Germany
- Volunteers
- 559 people
- Sponsor
- Klaus Kenn
Chronic Obstructive Pulmonary Disease
Treatment in Patients Hospitalized With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease has become a serious global health care and public health problems due to its high prevalence, high morbidity and heavy economic burden.
- Trial name
- TripAE (NCT02219360)
- Volunteers
- 400 people
- Sponsor
- Beijing Chao Yang Hospital
Chronic Unexplained Nausea and Vomiting, Gastroparesis
Non-invasive Vagal Nerve Stimulation (nVNS) for Symptomatic Exacerbation of Nausea in Patients With Gastroparesis and Related Disorders
The hypothesis of this pilot study is that nVNS will result in relief of nausea by modulation of vagal nerve activity. nVNS is the first non-invasive, handheld medical device applied on the side of the neck and sends gentle…
- Trial name
- nVNS (NCT04857281)
- Testing
- nVNS (gammaCore)
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Johns Hopkins University
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