Clinical trials: Disease Prevention
Cardiovascular Disease Prevention, Cardiometabolic Diseases
Preventative Screening and Health Coaching in a Food Insecure Population
The goal of this longitudinal study is to investigate the role of virtual health coaching on mitigation of cardiometabolic disease risk in an underserved, food insecure population.
- Conditions
- Cardiovascular Disease Prevention, Cardiometabolic Diseases, Cardiovascular Risk Factor, Cardiovascular Risk Score
- Trial name
- HEALTHCOACH (NCT06907524)
- Testing
- Longitudinal, Individualized Health Coaching
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rush University Medical Center
PARKINSON DISEASE (Disorder), Falls Prevention
Home-Based Exercise Programs for Fall Prevention in Parkinson Disease
Falls are common in patients with Parkinson disease and may lead to reduced mobility, fear of falling, loss of independence, and injury.
- Conditions
- PARKINSON DISEASE (Disorder), Falls Prevention, Exercise
- Trial name
- NCT07590700
- Testing
- Otago Home Exercise Program, Structured Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Uludag University
Autoimmune Rheumatic Diseases, Prevention
Incidence of Tuberculosis in Patients With Autoimmune Rheumatic Diseases
This is a prospective, randomized, controlled study designed to evaluate the effectiveness of annual re-screening for tuberculosis infection (TBI) (previous) in patients with autoimmune rheumatic diseases (ARDs) receiving…
- Trial name
- TB-RESCREEN (NCT07731672)
- Testing
- re-screening, No Rescreening
- Where
- Brazil
- Volunteers
- 1,660 people
- Sponsor
- University of Sao Paulo General Hospital
Hispanic Americans, Chronic Disease Prevention
Nuestro Valor: Increasing Healthier Food Access for Rural Latino Communities Through a Food Retail Intervention
The goal of this clinical trial is to adapt and implement The Value of Our Health (Our Value), a program to promote eating fruit and vegetables, for people living in rural areas.
- Conditions
- Hispanic Americans, Chronic Disease Prevention, Cancer Prevention, Fruit and Vegetable Consumption
- Trial name
- NCT07490652
- Testing
- The Value of Our Health
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Washington
Autoimmune Rheumatic Diseases, Recurrent Herpes Simplex
Prevention of Recurrence of Herpes Simplex in Autoimmune Rheumatic Diseases
The goal of this randomized, double-blind, placebo-controlled clinical trial is to evaluate the effectiveness and safety of oral suppressive therapy with acyclovir in preventing herpes simplex virus (HSV) reactivation in patients…
- Conditions
- Autoimmune Rheumatic Diseases, Recurrent Herpes Simplex, Prevention
- Trial name
- PRoHerpARD (NCT07341386)
- Testing
- Acyclovir (ACV)
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- University of Sao Paulo General Hospital
HIV, Hypertension
INTEGRATE-RX: Integrating Clinical Pharmacists in HIV Care to Mitigate Last-Mile Challenges and Reduce Cardiovascular Disease Burden
The risk of heart attacks and stroke is two times higher among people living with HIV (PLWH), as compared to the general population.
- Conditions
- HIV, Hypertension, Cardiovascular Disease Prevention
- Trial name
- INTEGRATE-RX (NCT07711366)
- Testing
- INTEGRATE-RX
- Where
- 2 sites in Kenya
- Volunteers
- 450 people
- Sponsor
- Temple University
Prevention of Venous Thromboembolism, Congenital Heart Disease
An Observational Study to Learn More About How Safe Rivaroxaban is And How Well it Works in Children With Congenital Heart Disease Who Had a Heart Surgery Called the Fontan Procedure
This is an observational study in which the data from children with congenital heart disease will be collected and studied. These children will include those who are prescribed rivaroxaban by their doctors after a heart surgery…
- Conditions
- Prevention of Venous Thromboembolism, Congenital Heart Disease, Fontan Procedure, Children
- Trial name
- NCT06193863
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- Japan
- Volunteers
- 61 people
- Sponsor
- Bayer
Musculoskeletal Disorders (MSDs), Occupational Diseases
Active Pauses for Musculoskeletal Disorder Prevention in Workers
The goal of this clinical trial is to learn if short exercise breaks at work can prevent muscle and joint pain in workers. The main questions it aims to answer are: Do strength exercises help workers move better and feel less…
- Conditions
- Musculoskeletal Disorders (MSDs), Occupational Diseases, Sedentary Behaviors, Prevention
- Trial name
- NCT07417527
- Testing
- Strength Active Pause, Mobility Active Pause
- Where
- Spain
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University of the Basque Country (UPV/EHU)
Photodamaged Skin, Skin Cancer Prevention
A Synergistic Approach to Remodeling of Photodamaegd Skin: Exploring Laser-Assisted Biostimulator Delivery
Photodamaged skin increases the risk of skin cancer, highlighting the need for preventive treatments. Laser-assisted drug delivery (LADD) using ablative fractional lasers (AFL) enhances topical drug delivery and has proven safe…
- Trial name
- SYNTROMICS (NCT07680426)
- Testing
- Ablative fractional laser, Poly-L-Lactic Acid
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- Bispebjerg Hospital
Cardiovascular Prevention
The YOU-Fish Study: Fish and Omega 3 Supplementation in Young Adults
Cardiovascular disease (CVD) is one of the major causes of mortality, however, it is estimated that approximately 75% of all cases are preventable.
- Trial name
- YOU-Fish (NCT06729229)
- Testing
- Dietary Supplement/Vitamins
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Prevention of Esophageal Varices, NASH - Nonalcoholic Steatohepatitis
Study Evaluating the Efficacy and Safety of Belapectin for the Prevention of Esophageal Varices in NASH Cirrhosis
This seamless, adaptive, two-stage, Phase 2b/3, randomized, double-blind, multicenter, parallel-groups, placebo-controlled study will assess the efficacy, safety, and tolerability of belapectin compared with placebo in patients…
- Conditions
- Prevention of Esophageal Varices, NASH - Nonalcoholic Steatohepatitis, Cirrhosis
- Trial name
- NAVIGATE (NCT04365868)
- Testing
- belapectin
- Where
- 156 sites in United States, Argentina and 13 more
- Volunteers
- 357 people
- Sponsor
- Galectin Therapeutics Inc.
Primary Prevention of Cardiovascular Disease
Polygenic Risk Score for Optimizing Primary Prevention in Intermediate-Risk Populations
The goal of this clinical trial is to determine whether incorporating a polygenic risk score (PRS) can optimize primary cardiovascular disease prevention in individuals with intermediate cardiovascular risk.
- Trial name
- PERSONAL (NCT07039123)
- Testing
- Polygenic Risk Score for Coronary Artery Disease (PRS-CAD), Standardized Risk Communication Tool (SCORE2)
- Where
- 2 sites in Switzerland
- Volunteers
- 205 people
- Sponsor
- University of Bern
Cardiovascular Disease Prevention
Effects of a Smartphone-Supported Daily Walking Intervention on Psychological Well-Being and Body Composition in Adults With Cardiometabolic Disease
This study evaluated whether a three-month smartphone-supported daily walking intervention could improve physical activity, psychological well-being, and body composition in adults with cardiometabolic disease.
- Trial name
- DAILY-WALK (NCT07674459)
- Testing
- Smartphone-Supported Daily Walking
- Where
- Lithuania
- Volunteers
- 419 people
- Sponsor
- Klaipėda University
Coronary Artery Disease, Cardiac Rehabilitation
Electronic Cardiac Rehabilitation (eCardiacRehab) Feasibility Study
In Norway, more than 11,000 patients undergo percutaneous coronary intervention (PCI) annually. However, a very recent study utilizing registry data show a national average of cardiac rehabilitation (CR) participation of only…
- Conditions
- Coronary Artery Disease, Cardiac Rehabilitation, Ethics, Continuity of Patient Care
- Trial name
- eCardiacRehab (NCT06759805)
- Testing
- eCardiacRehab
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Haukeland University Hospital
Comorbidities and Coexisting Conditions, Ethics
eCardiacRehab - a Hybrid Patient-Centered eHealth Programme
The overall aim of eCardiacRehab trial is to meet rehabilitation needs of patients with coronary artery disease (CAD) regardless of their access to traditional place-based rehabilitation by developing and evaluating the efficacy…
- Conditions
- Comorbidities and Coexisting Conditions, Ethics, Continuity of Patient Care, Older Adults (65 Years and Older)
- Trial name
- eCardiacRehab (NCT07590635)
- Testing
- eCardiacRehab
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Haukeland University Hospital
Abatacept, Acute-graft-versus-host Disease
Abatacept s.c. for aGVHD Prevention in Haplo-HCT
Acute graft-versus-host disease (aGVHD) is a potentially fatal complication after allogeneic hematopoietic cell transplantation (HCT), particularly for that with a HLA-mismatched donor.
- Conditions
- Abatacept, Acute-graft-versus-host Disease, Haplo-identical HCT, Prevention
- Trial name
- NCT04686929
- Testing
- Abatacept s.c.
- Where
- China
- Volunteers
- 29 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Non-communicable Diseases (NCD), Cardiovascular Risk
Interdisciplinary Program to Improve Lifestyle in Chronic Pathology: Alt Pirineu Aran in Fit (APA-FIT)
Interdisciplinary Program to Improve the Lifestyle of Individuals with Chronic Conditions in the Alt Pirineu and Aran Region Sedentary behavior and lack of regular physical activity have been widely recognized as urgent global…
- Conditions
- Non-communicable Diseases (NCD), Cardiovascular Risk, Obesity Prevention
- Trial name
- APA-FIT (NCT07172490)
- Testing
- APA-FIT interdisciplinary program
- Where
- Spain
- Volunteers
- 520 people
- Sponsor
- University of Barcelona
HIV, Alcohol
GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV
The goal of this clinical trial is to learn if the drug semaglutide works to reduce alcohol intake among adults living with HIV. The main questions it aims to answer are: 1.
- Conditions
- HIV, Alcohol, Smoking Cigarette, Cardiovascular Disease Prevention
- Trial name
- GL1DER HIV RCT (NCT07221214)
- Testing
- Semaglutide (Rybelsus®)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center
Pneumococcal Disease Prevention
A Study on the Immunization Schedule for the 13-Valent Pneumococcal Polysaccharide-Conjugate Vaccine in Healthy Infants
To compare the immunogenicity of the domestically produced PCV13 vaccine in healthy 2-month-old infants following administration via the 2+1 and 3+1 schedules, with the primary endpoint being the seroprevalence of specific IgG…
- Trial name
- NCT07591181
- Testing
- the domestically produced 13-valent Pneumococcal Polysaccharide Conjugate vaccine
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Beijing Center for Disease Control and Prevention
Microalbuminuria, Microalbuminuria /Creatinine Ratios ACR
New Taipei City 888 Digital Medical AI Platform for Prevention and Care of the Three Highs and Cardio-Renal-Vascular Diseases
Non-communicable diseases (NCDs), or chronic diseases, are a major public health burden globally and in Taiwan, and control of the "three highs" (hypertension, dyslipidemia, and hyperglycemia) is a national priority.
- Conditions
- Microalbuminuria, Microalbuminuria /Creatinine Ratios ACR, Cardiovascular Disease Risk Factor, Cardiovascular Disease Prevention
- Trial name
- DIGICARE-DREAM (NCT07588256)
- Testing
- Interactive digital modules, Antihypertensive Medication Management
- Where
- Taiwan
- Volunteers
- 4,162 people
- Sponsor
- New Taipei City Medical Association