Clinical trials: Disease Prevention
COVID-19
Safety, Tolerance and Immunogenicity of EuCorVac-19 for the Prevention of COVID-19 in Healthy Adults
Phase I/II study to determine safety, tolerance and immunogenicity of EuCorVac-19, a recombinant protein vaccine, for the prevention of COVID-19 in healthy adults
- Trial name
- NCT04783311
- Testing
- EuCorVac-19, Normal Saline
- Where
- South Korea
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- EuBiologics Co.,Ltd
Diabetic Foot Ulcers
Clinical Trials of Footwear in Patients With Diabetes-Study Arm 2,3
This is a randomized clinical trial to: (1) Determine the extent to which custom made study shoes will reduce the incidence of reulceration in diabetic individuals with prior history of foot ulcers, and (2) Estimate costs of…
- Trial name
- NCT00013299
- Testing
- Prevention of Diabetic Ulcers
- Where
- United States
- Volunteers
- 427 people
- Sponsor
- US Department of Veterans Affairs
Psychosis Associated With Alzheimer's Disease
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)
This is a Phase 3, 38-week, randomized, double-blind, placebo-controlled, multicenter, outpatient study in subjects with psychosis associated with Alzheimer's Disease.
- Trial name
- NCT05511363
- Testing
- KarXT
- Where
- 129 sites in United States, Bulgaria and 11 more
- Volunteers
- 410 people
- Sponsor
- Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Pregnancy, Malaria
Evaluation of Alternative Antimalarial Drugs for Malaria in Pregnancy
The study aims at comparing the safety, tolerability and efficacy of Mefloquine (MQ) to Sulfadoxine-Pyrimethamine (SP) as Interment Preventive Treatment in pregnancy (IPTp) for the prevention of malaria effects on the mother and…
- Conditions
- Pregnancy, Malaria, HIV Infections
- Trial name
- MiPPAD (NCT00811421)
- Testing
- Sulphadoxine-pyrimethamine, Mefloquine (full dose), Mefloquine (split dose)
- Where
- 5 sites in Benin, Gabon and 3 more
- Volunteers
- 5,820 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Concussion, Brain, Traumatic Injury
Sport Concussion Performance-Based Prevention Program
Sport-related concussions and traumatic lower body injuries (e.g., anterior cruciate ligament (ACL) tears) occur frequently in high-speed and contact/collision sports contributing to significant time loss from…
- Trial name
- NCT04992130
- Testing
- Pre-season supplementary neurologic training program
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Elopement, Autism Spectrum Disorder
A Study of the Elopement Prevention and Safety Training Program
The purpose of this study is to demonstrate the feasibility of the Elopement Prevention Safety (EPST) program in children with autism spectrum disorder (ASD) who have engaged in eloping.
- Trial name
- NCT02383732
- Testing
- Universal Safety Measures Module (All participants), Proximity Training Module (Bolting Prevention Participants), Check-In Training Module (Wandering Prevention Participants)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Emory University
Uterine Atony, Post-partum Hemorrhage
Comparison of Two Doses of Carbetocin for Prevention of Uterine Atony, During Elective Cesarean Section
The purpose of this study is to evaluate the effectiveness of two doses of carbetocin (50 mcg vs 100 mcg) in preventing uterine atony during elective cesarean section.
- Trial name
- NCT01630187
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Laval University
Atrial Fibrillation, Stroke
Systematic ECG Screening for Atrial Fibrillation Among 75 Year Old Subjects in the Region of Stockholm and Halland, Sweden
The purpose of this study is to determine whether screening for atrial fibrillation by intermittent ECG recording and initiation of anticoagulation treatment among high risk individuals is cost-effective and can lower the…
- Trial name
- NCT01593553
- Testing
- ECG screening for atrial fibrillation using intermittent ECG recorder
- Where
- Sweden
- Volunteers
- 7,173 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Premature Birth
Iron-fortified Parenteral Nutrition in the Prevention and Treatment of Anemia in Premature Infants
The purpose of this study is to determine whether iron-fortified PN is effective in the preventative and treatment of preterm infants. Preterm infants are at risk for anemia especially in preterm infants.
- Trial name
- NCT02743572
- Testing
- iron sucrose-1, iron sucrose-2, iron sucrose-3
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Atrial Fibrillation
GISSI-AF - Use of Valsartan an Angiotensin II AT1-Receptor Blocker in the Prevention of Atrial Fibrillation Recurrence
Study purpose The purpose of the study is to show that the addition of valsartan on top of established therapies can reduce the recurrence of atrial fibrillation in patients with a history of recent atrial fibrillation associated…
- Trial name
- NCT00376272
- Testing
- Valsartan
- Where
- 114 sites in Italy, Switzerland
- Volunteers
- 1,442 people
- Sponsor
- Gruppo di Ricerca GISSI
Diabetic Foot
The Effect of Thermal Evaluation in Prevention of Diabetic Foot Ulcer
The study was planned as a prospective randomized controlled clinical trial to determine the effect of thermal evaluation in preventing diabetic foot ulcers in patients with Type II Diabetes Mellitus (DM).
- Trial name
- NCT04480801
- Testing
- Thermal Evaluation and Foot Care, Foot Care
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Fatma Özkal
Cancer
Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection
RATIONALE: Heparin or M-EDTA may prevent catheter-related infections and blockages in patients at high risk for a catheter-related infection.
- Trial name
- NCT00378781
- Testing
- Heparin, Minocycline-EDTA
- Sponsor
- M.D. Anderson Cancer Center
Cirrhosis, Liver, Portal Hypertension
Carvedilol for Prevention of Esophageal Varices Progression
Carvedilol has been shown to be more potent in decreasing portal hypertension to propranolol. But the efficacy of carvedilol to delay the growth of esophageal varices in chronic hepatitis B patients was unclear.
- Trial name
- Carvedilol (NCT03736265)
- Testing
- Carvedilol
- Where
- 6 sites in China
- Volunteers
- 240 people
- Sponsor
- Beijing Friendship Hospital
Suicide Prevention, Help-Seeking Behavior
Healthcare for Men with Suicidal Thoughts: Needs Assessment
The aim of the current project is twofold, namely 1. To gain insight into needs related to help-seeking among men with (previous) suicidal thoughts (STUDY 1).
- Conditions
- Suicide Prevention, Help-Seeking Behavior, Men
- Trial name
- KUJK2NEEDS (NCT06375200)
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- University Ghent
Intracranial Aneurysms, Seizures
Seizure Prophylaxis in Aneurysm Repair
Seizures are a potential complication of surgical repair of intracranial aneurysms. In order to prevent seizures, many surgeons administer prophylactic anti-epileptic medication during the intra-operative and post-operative…
- Trial name
- NCT01974700
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Indiana University
Graft-versus-Host Disease (GVHD), Hematologic Malignancies
Allogeneic HSCT With Low-Dose Post-Transplant Cyclophosphamide for GVHD Prevention
This Phase 2, single-arm, open-label study aims to evaluate the safety and efficacy of low-dose (25 mg/kg) post-transplant cyclophosphamide (PTCy) for prophylaxis of Graft-versus-Host Disease (GVHD) in patients undergoing…
- Conditions
- Graft-versus-Host Disease (GVHD), Hematologic Malignancies, Allogeneic Stem Cell Transplantation
- Trial name
- GVHD-PTCy (NCT06926595)
- Testing
- Cyclophosphamide (primary intervention for GVHD prophylaxis)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Milton S. Hershey Medical Center
Covid19
Clinical Trial of the Immunogenicity, Safety, and Efficacy of the Gam-COVID-Vac Vaccine Against COVID-19 in Venezuela
Randomized, double-blind, placebo controlled clinical trial of immunogenicity, safety and efficacy of the Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus infection in adults.
- Trial name
- VENEZUELA (NCT04642339)
- Testing
- Gam-COVID-Vac
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Influenza
Safety, Reactogenicity and Immunogenicity of Flublok Quadrivalent (Recombinant Influenza Vaccine,Seasonal Formulation)
Flublok was studied previously in children 6 -59 months of age and demonstrated less than satisfactory immunogenicity results, especially in the 6-36 month age group.
- Trial name
- NCT01959945
- Testing
- Flublok® Quadrivalent Influenza Virus Vaccine, Fluarix Quadrivalent® Influenza Virus Vaccine
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Protein Sciences Corporation
Diarrhea
Prevention of Diarrheal Disease Due to Infection With Enterotoxigenic E. Coli (ETEC)
This is a Phase II b, double-blind, randomized, placebo-controlled study in healthy adults (age 18-65 years) to evaluate the safety, immunogenicity, different diagnostic tools and efficacy of ETVAX.
- Trial name
- NCT03729219
- Testing
- E. coli ETVAX
- Where
- Finland
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Scandinavian Biopharma AB
Diabetes Mellitus
Thickness-Varied Soft Surface on Shoe-Insoles Based on In-Shoe Pressure Measurement
The goal of this cross-sectional study is to evaluate a new shoe insole manufacturing method with the goal of further preventing foot ulceration for people with diabetes.
- Trial name
- NCT06679192
- Testing
- Milled thickness varied soft upper surface, based on plantar pressure measurement, 3mm soft upper surface, No soft upper surface
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Vastra Gotaland Region