Clinical trials: Disease Prevention
Cancer and Chronic Disease Prevention
BETTER HEALTH: Durham
The BETTER intervention consists of supportive meetings between a specially trained prevention practitioner nurse and individuals aged 40-64 years to review recommended chronic disease prevention and screening activities (CDPS).
- Trial name
- NCT03052959
- Testing
- Immediate Intervention, Wait List Intervention
- Where
- Canada
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Prevention of Chikungunya Virus Infection
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-1944 in Healthy Adults
This is a Phase 1, FIH, single-center, randomized, placebo controlled, dose escalation study to evaluate the safety, tolerability, PK, and PD of mRNA-1944 in healthy adult subjects.
- Trial name
- NCT03829384
- Testing
- mRNA-1944
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
HIV Prevention, Sexually Transmitted Diseases
HOME Study: a Combination Support Package to Increase Uptake of PrEP and HIV/STI Testing
Home HIV self-testing has been FDA approved and allows users to read their own HIV test results at home, while home sexually transmitted infection (STI) test self-collection allows men to use a swab at home and mail it in for…
- Conditions
- HIV Prevention, Sexually Transmitted Diseases, Pre-Exposure Prophylaxis
- Trial name
- NCT03138135
- Testing
- HOME Study intervention, Control
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
Prevention of COVID19
Immunogenecity and Safety of VaccinemRNA-1273 in Elderly Volunteers (Over 65 y) Compared to Younger Ones (18-45y)
This study aims to evaluate the immunogenicity of Moderna mRNA-1273 vaccine in volunteers aged 65 years or more compared to volunteers aged 18-45 years, over 24 months duration.
- Trial name
- CoviCompareM (NCT04748471)
- Testing
- mRNA-1273
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congenital Heart Disease, Health Related Physical Fitness
Web-based Motor Intervention to Increase Health Related Physical Fitness in Children With Congenital Heart Disease
Children with congenital heart diseases (CHD) often show reduced health related physical fitness as well as limitations in gross and fine motor skills/development.
- Conditions
- Congenital Heart Disease, Health Related Physical Fitness, Motor Skills, Cardiovascular Prevention
- Trial name
- NCT03488797
- Testing
- Supervised web- and home-based exercise intervention
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Cardiovascular Diseases, Secondary Prevention
ICF in Secondary Prevention of Cardiovascular Disease
The aim of this study was to develop a practical protocol based on the ICF(The International Classification of Functioning, Disability, and Health) the risk factors of cardiovascular disease (CVD) in secondary prevention.
- Conditions
- Cardiovascular Diseases, Secondary Prevention, Risk Factor, Cardiovascular
- Trial name
- NCT04590287
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Poznan University of Medical Sciences
Prevention of Diseases of the Musculoskeletal System
Testing the Effectiveness and Safety of a Passive Industrial Exoskeleton for Back Support
This research will provide data on evaluation of the effectiveness and safety of using a passive exoskeleton designed to reduce the negative impact of static and dynamic loads associated with body tilts, lifting and holding…
- Trial name
- NCT04514172
- Testing
- Passive industrial exoskeleton for back support, The protocol will be performed without exoskeleton
- Where
- Russia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution "Izmerov Research Institute of Occupational Health"
Prevention of Diseases of the Musculoskeletal System
Testing the Effectiveness and Safety of a Passive Industrial Exoskeleton for the Upper Limb
This research will provide data on evaluation of the effectiveness and safety of using a passive exoskeleton designed to reduce the negative impact of static and dynamic loads associated with lifting and holding weights and…
- Trial name
- NCT04514185
- Testing
- Passive industrial exoskeleton for the upper limb, The protocol will be performed without exoskeleton
- Where
- Russia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution "Izmerov Research Institute of Occupational Health"
Ebola Virus Disease, Prevention
International Multicenter Study of the Immunogenicity of Medicinal Product GamEvac-Combi
The purpose of this study is to evaluate immunogenicity, epidemiological efficacy and safety of medicinal product GamEvac-Combi - Combined Vector-Based Vaccine against Ebola Virus Disease, 0.5 ml+0.5 ml/dose
- Trial name
- NCT03072030
- Testing
- GamEvac-Combi (vaccine)
- Where
- 2 sites in Guinea, Russia
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Prevention of Diseases of the Musculoskeletal System
Testing the Effectiveness and Safety of a New Prototype of a Passive Industrial Exoskeleton for Back Support
This research will provide data on evaluation of the effectiveness and safety of using a passive exoskeleton designed to reduce the negative impact of static and dynamic loads associated with body tilts, lifting and holding…
- Trial name
- NCT04263220
- Testing
- Industrial passive exoskeleton with a specific value of the torque of the spring for supporting the back, protocol will be performed without exoskeleton
- Where
- Russia
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution "Izmerov Research Institute of Occupational Health"
Diet Prevention of Metabolic Diseases
Prebiotic Effects on Glucose Tolerance
The primary purpose of this project is to evaluate effects in healthy humans on glucose tolerance of cereal products with high amounts of fermentable dietary fibre.
- Trial name
- NCT03944343
- Testing
- Cereal based products
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Lund University
Prevention
Management of Dementia With Olive Oil Leaves - GOLDEN
Mild Dementia (Mild Dementia) is a state of mind disorder (memory, reason, attention, concentration, time orientation) with difficulty in the complex activities of everyday life (bank accounts, shopping, transportation, etc).The…
- Trial name
- GOLDEN (NCT04440020)
- Testing
- Beverage of Olive Oil Leaves, Mediterranean Diet
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
HIV/AIDS, Sexually Transmitted Diseases
MHealth Intervention of HIV and STDs Partner Notification for MSM
Men who have sex with men (MSM) have become a focus of HIV and other sexually transmitted diseases (STD) control in China. Most of MSM who seek causal partners through online dating platforms do not know their sexual partners'…
- Conditions
- HIV/AIDS, Sexually Transmitted Diseases, Prevention
- Trial name
- NCT04349748
- Testing
- Health education, and regular HIV and STDs testing prompting service, Health status inquiry through app (partner notification)
- Volunteers
- 6,172 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Dependence, China
Cardiovascular Diseases, Prevention
Acute Effects of Beet Extract on Autonomic and Cardiovascular Recovery After Exercise
Dietary NO3 is found in high concentrations in green leafy vegetables and beets. Studies weighing the action of NO3 for ergogenic purposes have found metabolic improvement in skeletal muscle during exercise in hypoxia, lowering…
- Trial name
- NCT04094233
- Testing
- Beetroot extract
- Where
- Brazil
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Graft-versus-host Disease Prevention
Fecal Transplant +/- Gut Decontamination in Preventing Acute Graft Versus Host Disease in Patients Given Broad-Spectrum Antibiotics
This phase II trial studies how well a fecal microbiota transplant with or without total gut decontamination works in preventing graft versus host disease in patients exposed to broad-spectrum antibiotics.
- Trial name
- NCT03862079
- Testing
- Best Practice, Fecal Microbiota Transplantation, Nystatin
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Cardiovascular Diseases, Primary Prevention
Proactive Cardiovascular Prevention Strategy in Subjects With High Genetic Risk
A polygenic risk score (PRS) will be developed and implemented into the primary care digital work-flow. 1000 study subjects with no known cardiovascular disease, diabetes or statin treatment and with high PRS (men of 30-65, women…
- Trial name
- EstPerMedCV (NCT04291157)
- Testing
- CVD risk estimation incorporating the PRS and guideline based preventive interventions., Standard GP care
- Where
- 2 sites in Estonia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Alar Irs
Socioeconomic Status, Secondary Prevention
Socioeconomic Status, Secondary Prevention Activities and Recurrence After a Myocardial Infarction
This is a nationwide cohort study on real-world patients (n≈30,000) surviving a first myocardial infarction (MI) 2006-2013 and alive to attend a routine 1-year follow-up.
- Conditions
- Socioeconomic Status, Secondary Prevention, Myocardial Infarction, Cardiovascular Disease
- Trial name
- NCT04199663
- Volunteers
- 30,191 people
- Sponsor
- Karolinska Institutet
HIV/AIDS and Infections, Sexually Transmitted Diseases
Puerto Rico Cuidalos Parent-adolescent Program
Latino adolescents are at high risk for HIV/AIDS, other sexually transmitted infections (STIs), and unintended pregnancies. Puerto Rican adolescents, in particular, experience disparities in these areas, yet few adolescent and…
- Conditions
- HIV/AIDS and Infections, Sexually Transmitted Diseases, Pregnancy Prevention
- Trial name
- NCT03063385
- Testing
- Parental Communication intervention, Health promotion control condition
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Prevention of CMV Infection or Disease
Letermovir (MK-8228) Versus Placebo in the Prevention of Clinically-Significant Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients (MK-8228-001)
The study evaluated the efficacy and safety of letermovir (MK-8228) for the prevention of clinically-significant CMV infection in adult, CMV-seropositive recipients of allogeneic hematopoietic stem cell transplant (HSCT).
- Trial name
- NCT02137772
- Testing
- Letermovir
- Volunteers
- 570 people
- Sponsor
- Merck Sharp & Dohme LLC
Primary Prevention of Cardiovascular Disease
Primary Prevention Program
A systematic collection of retrospective and prospective data based on non-intervention patient observation, aimed to assess the risks, course and outcomes of a disease or a group of diseases: the retrospective part: database of…
- Trial name
- 3P (NCT03927196)
- Testing
- extended counseling
- Where
- 5 sites in Russia
- Volunteers
- 2,912 people
- Sponsor
- National Research Center for Preventive Medicine