Clinical trials: Disease Susceptibility
Pseudotumor Cerebri, Cystinosis
The Role of Susceptibility to Thrombosis in the Pseudotumor Cerebri of Nephropathic Cystinosis: A Case-Control Study
This study will examine whether the tendency to have thrombosis, or the formation of blood clots inside blood vessels, has a role in the development of pseudotumor cerebri (PTC).
- Trial name
- NCT00071903
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Parkinson's Disease, Multiple System Atrophy
Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes
Parkinsonian syndrome is clinically characterized by the presence of resting tremor, rigidity, bradykinesia and postural instability.
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy, Vascular Parkinsonism
- Trial name
- PARKIMAGE (NCT02445469)
- Testing
- MRI exam of the brain
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
End Stage Renal Disease (ESRD)
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium
This study will identify which regions on the genes, and genes themselves, may account for an increased risk of end stage renal disease (ESRD), that is, near-total loss of kidney function, for people of African American descent.
- Trial name
- NCT00559767
- Where
- United States
- Volunteers
- 2,860 people
- Sponsor
- National Cancer Institute (NCI)
Drug Resistant Malaria Due to Plasmodium Falciparum
Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa
The antimalarial drugs efficacy and safety study will be conducted in the Clinics and hospital of the Cameroon Development Corporation (CDC) Estates, Tiko Health District, located in a typical forest and rainfall area in the…
- Trial name
- NCT02974348
- Testing
- Arthemeter-lumefantrine, Artesunate mefloquine, Dihydroartemisinin piperaquine
- Where
- Cameroon
- Volunteers
- 300 people
- Sponsor
- University of Bamenda
Disorder; Trance, Anxiety
Hypnosis-Based Machine Learning Biomarker Study
This study seeks to contribute to the growing body of literature on hypnosis by providing robust, data-driven insights into the physiological mechanisms underlying trance states.
- Trial name
- NCT07102810
- Testing
- Standardized Hypnotic Susceptibility Testing
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Bacterial Vaginosis, Vaginal Discharge
Study of How Bacterial Vaginosis and Its Treatment Affects Cervical and Vaginal Tissue
This is a research study to determine whether bacterial vaginosis (BV) changes the cervico-vaginal tissue (skin covering the cervix and vagina) and makes women at higher risk for getting HIV (Human Immunodeficiency Virus).
- Trial name
- CONRADBV (NCT01347632)
- Testing
- Metronidazole
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- CONRAD
Breast Cancer Surgery
Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer
Patients with a germline pathogenic variant (GPV) in high-penetrance breast cancer susceptibility genes who are considering risk reducing mastectomy (RRM) often strongly desire to keep their nipple areola complex but inquire as…
- Trial name
- NSM (NCT06888388)
- Testing
- Nipple Sparing Mastectomy (NSM), Skin-Sparing Mastectomy (SSM), Total (Simple) Mastectomy
- Where
- 16 sites in United States, Australia and 6 more
- Volunteers
- 4,700 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Isolates of Dermatophytes
Epidemiological and Molecular Analysis of Scalp Ringworm in France
Ringworm of the scalp or tinea capitis (TC) is the most common fungal infection in children. Few data are currently available in France concerning these infections, either on the distribution of the causative dermatophytes…
- Trial name
- TCC-France (NCT07631351)
- Where
- France
- Volunteers
- 701 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Ischemic Stroke
Susceptibility Weighted Imaging for Detection of Thrombus in Acute Ischemic Stroke.
It is a retrospective cross-sectional study, where consecutive stroke patients with vessel occlusion on magnetic resonance angiography (MRA) will be included for the study for one year.
- Trial name
- NCT05738070
- Testing
- Magnetic resonance imaging
- Where
- Nepal
- Volunteers
- 105 people
- Sponsor
- Upendra Devokta Memorial National Institute of Neurology and Allied Scicences
Bladder Cancer
Interdisciplinary Case-Control Study of Bladder Cancer in Spain
The incidence rate of bladder cancer in the Barcelona area of Spain is almost identical to that of the U.S. Cigarette smoking has been identified as the most significant risk factor for bladder cancer, followed by occupational…
- Trial name
- NCT00341861
- Where
- Spain
- Volunteers
- 2,925 people
- Sponsor
- National Cancer Institute (NCI)
Helicobacter Infections
Levofloxacin Versus Clarithromycin Triple Therapy in First-Line Treatment for Helicobacter Pylori Eradication
Clarithromycin-based triple therapy containing a proton-pump inhibitor (PPI) twice daily, amoxicillin 1g twice daily, and clarithromycin 500 mg twice daily for 7 days is one of the standard firs-line therapy for Helicobacter…
- Trial name
- NCT00816140
- Testing
- Cravit based triple therapy, Klaricid based triple therapy
- Where
- Taiwan
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
HIV Infections
Understanding HIV Susceptibility in the Female Genital Tract
There is great variability in susceptibility from one person to another, and less than one in a hundred sexual exposures to HIV results in infection.
- Trial name
- NCT03064425
- Testing
- Vaginal and blood sample collection
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Tuberculosis
Paradoxical Tuberculosis Reactions in Patients Without HIV Infection
Background: Most people with tuberculosis (TB) feel better after starting treatment. But for some people, the opposite happens. They may feel better at first, but then suddenly get worse. This is a paradoxical reaction.
- Trial name
- NCT04052022
- Where
- 3 sites in United States, Mexico
- Volunteers
- 140 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Fitness Trackers, Sedentary Time
Fullscale_Intervention Study: Genetic Risk Communication in Coronary Heart Disease and Wearables
Background: This study aims to determine the effects of communicating genetic risk for Coronary Heart Disease (CHD) alone or in combination with goal setting and prompts from a wearable device on objectively measured sedentary…
- Conditions
- Fitness Trackers, Sedentary Time, Genetic Predisposition to Disease, Coronary Heart Disease
- Trial name
- NCT05789966
- Testing
- Genetic Risk Estimate+Health Coaching, Genetic Risk Estimate + Fitbit Functions+Health Coaching
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Asthma
Genetic Susceptibility to Childhood Respiratory IIlness in Mexico City
We propose to add a collection of genetic material to a clinical trial of anti-oxidant supplementation for the amelioration of asthma in 7-12 year olds being conducted at a public pediatric hospital in Mexico City.
- Trial name
- NCT00339521
- Where
- Mexico
- Volunteers
- 2,362 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Rare Diseases, Genetic Predisposition
Whole Genome Trio Sequencing as a Standard Routine Test in Patients With Rare Diseases - "GENOME FIRST APPROACH"
The GENOME FIRST APPROACH project will enroll patients (n = 450) and their healthy parents with unclear molecular cause of the disease, suspected genetic cause of the disease and the healthy parents of those affected for trio…
- Trial name
- NCT03954652
- Testing
- WGS-Diagnostic
- Where
- Germany
- Volunteers
- 1,350 people
- Sponsor
- University Hospital Tuebingen
Uveal Melanoma, Cutaneous Melanoma
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome
This research will have a significant impact on the overall management of those cancer patients and their family members who are at risk for hereditary cancer due to germline inactivation of BAP1.
- Conditions
- Uveal Melanoma, Cutaneous Melanoma, BAP1 Gene Mutation, Renal Cell Carcinoma
- Trial name
- NCT04792463
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Mohamed Abdel-Rahman
Brain Diseases
Evaluation of a New MRI Technique to Reduce Breathing-Related Artifacts in Brain Imaging
This study aims to improve the quality of brain magnetic resonance imaging (MRI) scans by testing a new imaging method that reduces distortions caused by breathing.
- Trial name
- DORK (NCT07305948)
- Testing
- Dual Free Induction Decay (FID) Navigator Off-Resonance Corrected (DORK) 3D Susceptibility Weighted (SWI) Echo Planar Imaging (EPI)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Region Stockholm
Healthy, Hypertrophic Cardiomyopathy
Investigation Into the Use of Ultrasound Technique in the Evaluation of Heart Disease
The human heart is divided into four chambers. One of the four chambers, the left ventricle, is the chamber mainly responsible for pumping blood out of the heart into the circulation.
- Conditions
- Healthy, Hypertrophic Cardiomyopathy, Left Ventricular Hypertrophy
- Trial name
- NCT00001632
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Prostate Cancer
The i4i PRODICT® Study: Evaluation of the i4i PRODICT® Test in Different Ethnic Groups (The i4i PRODICT® Study).
The i4i PRODICT® study has been developed to investigate the uptake and acceptability of the i4i PRODICT® test which combines both common and rare genetic changes (genetic variants) into one saliva-based DNA test to estimate a…
- Trial name
- NCT06636526
- Testing
- The i4i PRODICT® test., Prostate cancer screening, MRI Scan
- Where
- 3 sites in United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom