Clinical trials: Disease of Bone
Paroxysmal Nocturnal Hemoglobinuria
Long-term Safety and Tolerability of HRS-5965 in Patients With Paroxysmal Nocturnal Hemoglobinuria
This is a multicenter, single-arm, open-label study. Patients with Paroxysmal Nocturnal Hemoglobinuria who had previously received and completed the HRS-5965 study well included.
- Trial name
- NCT06238544
- Testing
- HRS-5965 tablets, HRS-5965 Capsules
- Where
- 2 sites in China
- Volunteers
- 132 people
- Sponsor
- Chengdu Suncadia Medicine Co., Ltd.
Degenerative Disc Disease
P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation
The aim of this trial is to evaluate if P-15L bone graft (investigational device) is not inferior in effectiveness and safety to local autologous bone (and allograft where necessary) as an extender (control device) when applied…
- Trial name
- NCT03438747
- Testing
- P-15L Bone Graft, Local autologous bone in a TLIF with Instrumentation
- Where
- 34 sites in United States
- Volunteers
- 290 people
- Sponsor
- CeraPedics, Inc
Breast Cancer
An Observational Study in Patients With Breast Cancer and Bone Metastases Receiving Ibandronate (Bondronat)
This open non-randomized, single-arm, multicenter, observational study is designed to evaluate the correlation between bone turnover markers and the response to treatment in patients with breast cancer and bone metastases.
- Trial name
- NCT02553850
- Where
- 19 sites in Hungary
- Volunteers
- 442 people
- Sponsor
- Hoffmann-La Roche
Scoliosis, Scoliosis; Adolescence
Study Comparing the PathKeeper System for Pedicle Screw Positioning in Spine Surgery With Traditional Care
The goal of this is to evaluate performance of the Pathkeeper Surgical System. The main question[s]it aims to answer are: 1) evaluate pedicle screw position Participants will in compare Experimental arm: PathKeeper System (PKS)…
- Conditions
- Scoliosis, Scoliosis; Adolescence, Scoliosis Kyphosis, Scoliosis Lumbar Region
- Trial name
- PKSforPSP (NCT06554093)
- Testing
- Medical Device - PKS
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Deep Health Ltd.
Myelodysplastic Syndromes
A Study of ARRY-614 in Patients With Low or Intermediate-1 Risk Myelodysplastic Syndrome
This is a Phase 1 study during which patients with low or intermediate-1 risk myelodysplastic syndrome (MDS) will receive investigational study drug ARRY-614. This study has 2 parts.
- Trial name
- NCT00916227
- Testing
- ARRY-614, p38/Tie2 inhibitor; oral
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Array Biopharma, now a wholly owned subsidiary of Pfizer
X-linked Hypophosphatemia
Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH)
The primary objective of this study is to establish the effect of KRN23 treatment on improvement in XLH-associated osteomalacia as determined by osteoid volume (osteoid volume/bone volume, OV/BV).
- Trial name
- NCT02537431
- Testing
- burosumab
- Where
- 14 sites in United States, Canada and 4 more
- Volunteers
- 14 people
- Sponsor
- Kyowa Kirin, Inc.
Osteoporosis
A Comparison of PF708 and Forteo in Osteoporosis Patients
The purpose of this study is to compare the effects of two teriparatide products, PF708 and Forteo, in patients with osteoporosis.
- Trial name
- NCT03002428
- Testing
- Teriparatide (PF708), Teriparatide (Forteo)
- Where
- 26 sites in United States
- Volunteers
- 181 people
- Sponsor
- Pfenex, Inc
Arthritis, Psoriatic
Study to Evaluate the Real-World Effectiveness, Safety and Tolerability of Treatment With Apremilast in Psoriatic Arthritis Patients Followed in Canadian Routine Care (APPRAISE)
This will be a Canadian observational study utilizing a prospective cohort design. Patients with active psoriatic arthritis (PsA) for whom the treating physician has decided, prior to and independently of enrollment in the study…
- Trial name
- APPRAISE (NCT03608657)
- Testing
- Apremilast
- Where
- 19 sites in Canada
- Volunteers
- 102 people
- Sponsor
- Amgen
Ankylosing Spondylitis
Extension Study to Evaluate Safety and Efficacy of Jaktinib in Patients With Active Ankylosing Spondylitis(AS)
The purpose of this study is to determine if Jaktinib is safe and effective in participants with active ankylosing spondylitis.
- Trial name
- NCT05861128
- Testing
- Jaktinib
- Where
- China
- Volunteers
- 207 people
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Osteo Arthritis Shoulders, Osteonecrosis
Exactech Shoulder Post Market Clinical Follow-up Study
The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time.
- Conditions
- Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy
- Trial name
- NCT05603728
- Where
- 40 sites in United States, Canada and 4 more
- Volunteers
- 20,000 people
- Sponsor
- Exactech
Chronic Myeloid Leukemia - Accelerated Phase
A Pivotal Study of HQP1351 in Patients of Chronic Myeloid Leukemia in Accelerated Phase With T315I Mutation
The purpose of this study is to evaluate the efficacy of HQP1351 in patients with chronic myeloid leukemia in accelerated phase (CML-AP) harboring T315I mutation.
- Trial name
- NCT03883100
- Testing
- HQP1351
- Where
- 9 sites in China
- Volunteers
- 23 people
- Sponsor
- Ascentage Pharma Group Inc.
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Chondrofix Osteochondral Allograft Prospective Study
The overall study objective is to evaluate Chondrofix Osteochondral Allograft ("Chondrofix") for the repair of osteochondral lesions in the knee.
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01410136
- Testing
- Chondrofix Osteochondral Allograft
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Avascular Necrosis of the Femoral Head
Biologically Assisted Core Decompression of the Femoral Head Using the PerFuse Instrument and BioCUE
This study will evaluate the performance of biologically assisted core decompression with the PerFuse instrument and BioCUE in patients with bone lesions in the femoral head.
- Trial name
- REGP-44-00 (NCT02662881)
- Testing
- PerFuse Percutaneous Decompression System, BioCUE Platelet Concentration System
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Zimmer Biomet
Postmenopausal Osteoporosis
Open-label Study to Evaluate the Effect of MBP-80 on Bone Remodelling
This study will determine if daily oral intake of 200g of a marketed yogurt with fortified calcium content and a milk basic protein (MBP)80 mg benefits on bone cells activity in postmenopausal women.
- Trial name
- YogA (NCT01501344)
- Testing
- 200 g yogurt with fortified calcium content and MBP 80 mg
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Groupe De Recherche En Rhumatologie Et Maladies Osseuses Inc.
Myelofibrosis
Platform Study of Novel Ruxolitinib Combinations in Myelofibrosis Patients
The purpose of this study was to investigate the safety, pharmacokinetics and preliminary efficacy of combination treatment of ruxolitinib with 5 novel compounds: siremadlin, crizanlizumab, sabatolimab, rineterkib and NIS793 in…
- Trial name
- ADORE (NCT04097821)
- Testing
- Ruxolitinib, Siremadlin, Crizanlizumab
- Where
- 22 sites in Australia, Canada and 11 more
- Volunteers
- 45 people
- Sponsor
- Novartis Pharmaceuticals
Osteochondritis Dissecans
Use of Demineralised Bone Matrix (DBX) in Osteochondritis Dissecans (OCD)
This is a 1:1 randomised pilot study in 30 patients in 1 site in Helsinki, Finland. The investigators hypothesize that function, pain, type and quality of cartilage in adult patients with osteochondritis dissecans of the knee…
- Trial name
- NCT01283737
- Testing
- DBX Putty, Mosaicplasty
- Where
- Finland
- Sponsor
- Synthes GmbH
Cancer, Hematologic Malignancies
Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid in the treatment of bone disease from multiple myeloma.
- Conditions
- Cancer, Hematologic Malignancies, Multiple Myeloma, Oncology
- Trial name
- NCT01345019
- Testing
- Denosumab, Zoledronic acid, Denosumab (for the open-label treatment phase)
- Where
- 309 sites in United States, Australia and 27 more
- Volunteers
- 1,718 people
- Sponsor
- Amgen
Osteoarthritis, Avascular Necrosis
Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral Density
The primary purpose of this study is to measure the postoperative changes in bone mineral density, comparing the Taperloc Complete Reduced Distal Microplasty stem and the standard length Taperloc Complete Reduced Distal stem.
- Conditions
- Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Rheumatoid Arthritis
- Trial name
- taperloc (NCT02087436)
- Testing
- Taperloc Complete Microplasty, Taperloc Complete Standard
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Zimmer Biomet
Paroxysmal Nocturnal Hemoglobinuria (PNH), Paroxysmal Hemoglobinuria
A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
The purpose of this study is to evaluate the safety, effectiveness, and biological activity (how the investigational medication is processed by the body) of pegcetacoplan in 12-17 year-olds (adolescents) who have paroxysmal…
- Trial name
- NCT04901936
- Testing
- Pegcetacoplan
- Where
- 12 sites in United States, Czechia and 7 more
- Volunteers
- 12 people
- Sponsor
- Apellis Pharmaceuticals, Inc.
Osteopenia
Study to Investigate if Adding Lactulose to Vitamin D and Calcium Has an Effect on the Preservation of Bone in Postmenopausal Women
This is a randomized, double-blind, multicentre, parallel pilot clinical trial to study the efficacy of a treatment of lactulose 15 ml + vitamin D 400 U + calcium 0.5 g compared to lactulose placebo 15 ml + vitamin D 400 U +…
- Trial name
- NCT00160264
- Testing
- Lactulose, Vitamin D, Calcium
- Where
- 3 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Solvay Pharmaceuticals
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