Clinical trials: Diseases, Metabolic
Hypocalcemia, Thyroid
Is There Benefit From Early Postoperative PTH Monitoring?
This study is designed as a prospective non-randomized longitudinal single-center cohort study. It will enroll around 120 patients undergoing total thyroidectomy with data being collected from September 2019 up to December 2019.
- Conditions
- Hypocalcemia, Thyroid, Postoperative Complications, Parathyroid Dysfunction
- Trial name
- NCT04160637
- Testing
- Immediate postoperative PTH serum sampling and cut-off value identification
- Where
- Croatia
- Volunteers
- 120 people
- Sponsor
- University Hospital Sestre Milosrdnice
Hyperphosphatemia
Phosphate Binder-combination Study of KHK7791 in Hyperphosphatemia Patients
To evaluate the effect and safety of KHK7791 in combination with phosphate binders to treat Hyperphosphatemia in ptatients on HD.
- Trial name
- NCT03864445
- Testing
- KHK7791, Placebp
- Where
- Japan
- Volunteers
- 47 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Diabetes Mellitus, Type 2, Obesity
Microbiome and Health Indicators in People With Obesity, Prediabetes and Type 2 Diabetes Undergoing a Lifestyle Intervention
The incidence of type 2 diabetes worldwide is growing rapidly, being one of the fastest growing global health emergencies of the 21st century according to the International Diabetes Federation.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, PreDiabetes
- Trial name
- MicrobiAr (NCT05372445)
- Testing
- Non-intensive intervention, Intensive intervention
- Where
- Argentina
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Genetic Disorder, Prader-Willi Syndrome
Retrospective Observational Study on Efficacy and Safety of Norditropin® in Children With Prader-Willi Syndrome
This study is conducted in Europe. The aim of this observational study is to collect data from children with Prader-Willi Syndrome, who have been treated off-label with Norditropin® for more than 12 months to seek approval for…
- Trial name
- NCT00705172
- Testing
- somatropin
- Where
- 3 sites in Denmark, Germany and 1 more
- Volunteers
- 41 people
- Sponsor
- Novo Nordisk A/S
Body Mass Index Quantitative Trait Locus 5 Disorder, Tangier Disease
Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children
The investigators aimed to determine the effects of HP diet on adiponectin and inflammatory factors among overweight and obese children.
- Trial name
- NCT01886495
- Testing
- nutrition intervention
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Kidney Failure
Vitamin Metabolism in Kidney Disease
The purpose of this study is to evaluate the urinary excretion and renal metabolism of vitamins, in particular vitamin B12 and folate, in relation to various renal conditions involving loss of renal function and/or proteinuria.
- Trial name
- NCT00257439
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Obesity, Insulin Resistance
Regional Fat Depots and Insulin Resistance
The biological basis for insulin resistance associated with obesity is unknown. By studying equally-overweight/obese individuals who are either insulin resistant or insulin sensitive, the investigators will compare…
- Conditions
- Obesity, Insulin Resistance, Diabetes Mellitus Type 2
- Trial name
- NCT01336777
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Stanford University
Diabetes Mellitus, Type 2
Comparative Metabolomics in Diabetes Patients From Sri Lanka and Switzerland
This study is a case-control study, where the assumed different subtypes of type 2 diabetes in people of Tamil ethnicity and Swiss origin living in Bern, Switzerland will be examined by measuring the metabolite profiles and the…
- Trial name
- NCT05787457
- Testing
- Clinical examination, Blood testing, MRI
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Asthma, Obesity
Effects of Weight Loss in Obese Difficult-to-treat Asthmatics
Sixty percent of patients with difficult to control asthma seen in our outpatient clinic are obese. The impact of weight reduction in this subpopulation of asthmatics has not been studied.
- Conditions
- Asthma, Obesity, Weight Loss
- Trial name
- NCT01047657
- Testing
- Low caloric diet plus orlistat and sibutramine
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- University of Sao Paulo General Hospital
Diabetes Mellitus, Type 1
Reversing Type 1 Diabetes After it is Established
The primary purpose of this study is to determine if giving the combination therapy consisting of Thymoglobulin® (ATG) and Neulasta® (GCSF) to patients with established Type 1 Diabetes (T1D) is safe and secondarily, if the ATG…
- Trial name
- NCT01106157
- Testing
- Anti-Thymocyte Globin (ATG), Pegylated GCSF
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Wilson Disease
Study of ALXN1840 Versus Standard of Care in Pediatric Participants With Wilson Disease
This study is being conducted to evaluate the efficacy, safety, pharmacokinetics (PK), and pharmacodynamics of ALXN1840 versus standard of care in pediatric participants with Wilson disease (WD).
- Trial name
- NCT05047523
- Testing
- ALXN1840, Standard of Care
- Where
- 20 sites in Australia, France and 5 more
- Volunteers
- 40 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Type 2 Diabetes
Impact on Glycemic Variability in Newly Onset T2DM Patients Initiating Dapagliflozin Plus Metformin Versus Metformin Alone
This study will compare the effect of Dapagliflozin added to Metformin vs Metformin alone on blood sugar fluctuations of adults with a recent diagnosis of Type 2 Diabetes (T2D). The duration of the protocol will be 12 weeks.
- Trial name
- MAGNNIFY (NCT04090580)
- Testing
- Continuous glucose monitoring
- Where
- Mexico
- Volunteers
- 88 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Metabolic Health, Cardio Respiratory Fitness
HIIT, Cardiorespiratory Fitness, and Metabolic Health in Healthy Young Adults
The purpose of this study was to investigate the effects of a high-intensity interval training (HIIT) intervention on cardiorespiratory fitness (CRF) and cardiometabolic health in active male university students.
- Trial name
- NCT07719296
- Testing
- High-intensity interval training (HIIT) program
- Where
- Tunisia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- High Institute of Sports and Physical Education of Kef
Crohn's Disease
A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease
Background VSL#3 has been reported as an effective adjuvant therapy both in inducing and maintaining remission in pediatric patients affected by Ulcerative Colitis.
- Trial name
- NCT01632462
- Testing
- VSL#3
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federico II University
Obesity, ESRD
Bariatric Surgery for ESRD Patients vs Control
This study will address a true clinical problem by developing a risk/benefit analysis for rapid surgical weight loss in the ESRD population.
- Trial name
- NCT00580762
- Testing
- Roux-en-y gastric bypass (RYGB)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Sickle Cell Disease, Vitamin D Deficiency
High Dose Vitamin D Supplementation in Children With Sickle Cell Disease
Suboptimal vitamin D status is well reported in sickle cell disease (SCD) patients and associated with a negative impact on health-related quality of life (HRQL).
- Conditions
- Sickle Cell Disease, Vitamin D Deficiency, Health Related Quality of Life, Hand Grip Strength
- Trial name
- NCT06274203
- Testing
- Vitamin D3
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Dilated Cardiomyopathy
Pathophysiology of Dilated Cardiomyopathy
This will be a cross-sectional, observational study. Null hypothesis: There is no difference in the amount of extracellular volume (ECV or scarring) in the hearts of patients with heart failure as compared to control subjects.
- Trial name
- NCT02001961
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Obesity, Bariatric Surgery Candidate
Brain Gut Axis Changes After Bariatric Surgery and Their Relationship to Weight Loss
Assessing the changes in the brain-gut axis after weight loss surgery and their relationship with weight loss and changes in eating behaviors.
- Trial name
- NCT04429386
- Testing
- Bariatric surgery
- Volunteers
- 22 people
- Sponsor
- University of California, Los Angeles
Arthritis
Pharmacokinetics and Metabolism Study of Radiolabeled BMS-986142 in Healthy Male Subjects
This is an open-label, single-dose, study in healthy males. The primary objective is to assess the pharmacokinetics (PK), metabolism, and routes of elimination of a single oral dose of radiolabeled BMS-986142 in healthy male…
- Trial name
- NCT02880670
- Testing
- BMS-986142
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Diabetes Mellitus, Type 1
Participant-Reported Outcomes With the Accu-Chek® Solo Micropump System
This interventional device study aims to compare mainly standard Multiple Daily Injection (MDI) therapy vs. Accu-Chek® Solo Micropump System and investigates participant satisfaction.
- Trial name
- PRO Solo (NCT03478969)
- Testing
- Accu-Chek® Solo micropump system, mylife™ OmniPod® Insulin Management System, Multiple Daily Injections (MDI) therapy
- Where
- 21 sites in Austria, Germany and 2 more
- Volunteers
- 181 people
- Sponsor
- Hoffmann-La Roche
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