Clinical trials: Diseases, Metabolic
Vitamin D Deficiency, HIV
Vitamin D in HIV-Infected Patients on HAART
This is a research study to look at vitamin D deficiency (low levels) in men and women with HIV. As part of your regular medical care, you will be screened for vitamin D deficiency.
- Trial name
- NCT01250899
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of California, Los Angeles
Overweight, Autism Spectrum Disorder
Treatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorders (ASD)
The purpose of this study is to determine whether metformin is safe and effective in the treatment of weight or weight gain in young people with Autism Spectrum Disorders (ASD) who are currently taking atypical antipsychotic…
- Trial name
- MET (NCT01825798)
- Testing
- Metformin
- Where
- 4 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
HIV Infections
Endothelial Dysfunction as a Risk Factor in HIV Study
Highly active antiretroviral therapy (HAART) has proven effective in altering the natural history of HIV infection in many patients. However, this therapy may not be sustainable because of the toxicities of the medications.
- Trial name
- NCT00039663
- Testing
- Pravastatin, Gemfibrozil, Rosiglitazone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Preventive Health Services, Health Communication
Patients Engaged in Prevention: Enhancing Outreach to Increase Patient Engagement in Diabetes Prevention
This study examines whether a health message that includes a self-affirmation intervention (where people reflect on values that are important to them) increases acceptance of the message and encourages people to take steps to…
- Trial name
- PEP (NCT03550066)
- Testing
- Values affirmation, No affirmation
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Hypocalcemia
Clinical Assessment of Low Calcium In traUMa (CALCIUM)
Major trauma frequently occurs in the deployed, combat setting and is especially applicable in the recent conflicts with explosives dominating the combat wounded.
- Trial name
- CALCIUM (NCT05885256)
- Testing
- Amending current standard trauma order set
- Where
- United States
- Volunteers
- 391 people
- Sponsor
- Brooke Army Medical Center
Liver Cirrhosis
Branched Chain Aminoacid Supplementation in Patients With Liver Cirrhosis
Malnutrition is a frequent complication in patients with liver cirrhosis. Most patients have decreased dietary intake due to ascites, hepatic encephalopathy and pro-inflammatory cytokines.
- Trial name
- NCT02023229
- Testing
- Branched-chain aminoacids, High-fiber high protein diet
- Where
- Mexico
- Volunteers
- 68 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Diabete Type 2, Pharmacogenomic Drug Interaction
PATHS-T2D: A Recall-by-Genotype Study of Physiologic and Pharmacologic Responses
This research study aims to learn about how the body responds to food through different genetic pathways and how these responses may change during a short course of orforglipron.
- Trial name
- PATHS-T2D (NCT07739537)
- Testing
- Orforglipron
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Hyperandrogenism, Metabolic Cardiovascular Syndrome
Phlebotomy and Polycystic Ovary Syndrome
AIMS To study the effects of the decrease in iron tissue depots after scheduled bloodletting on insulin sensitivity, carbohydrate metabolism, classic and non-classic cardiovascular risk factors in patients with functional…
- Trial name
- NCT02460445
- Testing
- Phlebotomy, ethinylestradiol, Cyproterone Acetate
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Manuel Luque Ramírez
Glucocorticoids, Overweight and Obesity
Acute Consequences of Glucocorticoid Secretion in Overweight and Obese Individuals During Maximum Calorie Intake
The investigator aim to understand whether food-induced glucocorticoids influence fat mass in overweight and obese people. In a randomized, cross-over study, 23 overweight and obese volunteers will receive a block and replace…
- Conditions
- Glucocorticoids, Overweight and Obesity, Overeating
- Trial name
- Gluco-Max (NCT06556277)
- Testing
- Metyrapone And Hydrocortisone
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Type 2 Diabetes
Perceptions of Passive Heating in Individuals With T2DM
Current treatments for type 2 diabetes (e.g., lifestyle changes and clinical interventions such as medication), have been shown to be unsustainable due to low levels of physical activity and increasing clinical costs.
- Trial name
- NCT05016375
- Testing
- Interview
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Portsmouth
Cirrhosis, Hepatic Encephalopathy
Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System
The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.
- Trial name
- NCT00424957
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Osteoporosis
The Relationship Between Osteoporosis and Sarcopenia Parameters in Postmenopausal Women Under 60
This cross-sectional study will include postmenopausal women under the age of 60 who visited the Physical Medicine and Rehabilitation outpatient clinic at Beylikdüzü State Hospital between June 25 and July 25, 2025.
- Trial name
- NCT07045012
- Volunteers
- 52 people
- Sponsor
- Beylikduzu State Hospital
Type 1 Diabetes
Initial Testing of the Diabeloop Algorithm in T1D Patients on Pump Therapy Over the Prandial Period and Physical Activity.
The main objective is to assess if the Diabeloop algorithm provides better glycemic control than a "manual" usual algorithm of patients with type 1 diabetes treated by insulin pump during meals, and during activity qualified…
- Trial name
- DiabeloopWP6-0 (NCT01754181)
- Testing
- Insulin
- Where
- 3 sites in France
- Volunteers
- 18 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Diabetes Mellitus, Coronary Disease
Empagliflozin Versus Sitagliptin Therapy for Improvement of Myocardial Perfusion Reserve in Diabetic Patients With Coronary Artery Disease
This trial evaluates the effects of Empagliflozin versus Sitagliptin, in addition to standard of care, on global myocardial perfusion reserve using dynamic single-photon emission computed tomography (SPECT) images.
- Trial name
- ELITE (NCT03208465)
- Testing
- Empagliflozin, Sitagliptin
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- CHEOL WHAN LEE, M.D., Ph.D
Weight Loss, Starvation
Resistance Exercise and Protein During Weight Loss
The purpose of this study is to determine if post-exercise protein supplementation can rescue the anabolic response of muscle and bone to resistance exercise during caloric restriction.
- Trial name
- RIDE (NCT03600311)
- Testing
- Caloric Restriction, Post-Exercise Protein, Energy Balance
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Hypercholesterolemia
Nutraceutical in Cardiovascular Primary Prevention
Nutraceuticals have attracted interest as possible approach to be associated with lifestyle changes for lowering plasma cholesterol levels in patients with moderate hypercholesterolemia.
- Trial name
- NIRVANA (NCT03216811)
- Testing
- nutraceutical
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- University Hospital of Ferrara
Obesity, Abdominal
Efficacy of Electro-acupuncture for Abdominal Obesity: Study for a Randomized Controlled Trial
Electro-acupuncture provides stimulation to acupoints, and has been widely used to treat abdominal obesity in China despite of lack of high-level evidence for treatment efficacy.
- Trial name
- NCT04957134
- Testing
- Electro-acupuncture
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Hubei Hospital of Traditional Chinese Medicine
Allergic Rhinitis
Validation of Laser Doppler Flowmetry to Identify Allergic Rhinitis Patients With Pharmacogenetic Alterations in Histamine Metabolism
The hypothesis to be proven is that histamine iontophoresis with measurement of microvascular blood flow by laser Doppler flowmetry can be used as a reliable marker to characterize the normal microvascular cutaneous response to…
- Trial name
- NCT00362999
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Children's Mercy Hospital Kansas City
Ischemic Stroke
hsCRP in Japan Statin Treatment Against Recurrent Stroke (J-STARS hsCRP)
Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A(HMG-CoA) reductase can play a role in preventing recurrent vascular events from ischemic heart disease patients, whose mechanism consists in not only the reduction of serum…
- Trial name
- NCT00361699
- Testing
- Statin
- Where
- 2 sites in Japan
- Volunteers
- 1,095 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Obesity, Abdominal
Impact of Preoperative Hypocaloric Hyperproteinic Lipid Restricting Diet on Bariatric Surgery
Obesity is one of the greatest pandemics of the 21st century with 30 million new cases each year. In France each year, 60,000 bariatric surgery procedures are performed.
- Trial name
- LipiDiet (NCT05529199)
- Where
- France
- Volunteers
- 776 people
- Sponsor
- University Hospital, Strasbourg, France
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