Clinical trials: Diseases, Metabolic
Diabetes Mellitus
Use of the FreeStyle Navigator Continuous Glucose Monitoring System to Enhance Education and Glycaemic Control
To demonstrate that in patients with persistent poorly controlled diabetes, short/intermittent use of continuous glucose monitoring can driver better longer-term glycaemic control and HbA1c.
- Trial name
- NCT01214824
- Testing
- FreeStyle Navigator Continuous Glucose Monitoring System
- Where
- 5 sites in United Kingdom
- Volunteers
- 32 people
- Sponsor
- Abbott Diabetes Care
Prediabetes
Exploring Unconventional Plant-Derived Metabolites for Glycemic Control: the Case of Pomegranate
The EXPLORER study will investigate whether supplementation with a pomegranate extract rich in ellagitannins is able to improve well-being and metabolic health in individuals without diabetes.
- Trial name
- EXPLORER (NCT06659523)
- Testing
- EPS supplement intervention
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Regina Menezes
Type 2 Diabetes Mellitus
Effect of Gemigliptin on Metabolic Endotoxemia and Lipemia
This is an exploratory study on the metabolic endotoxemia associated with type 2 diabetes. The investigators will measure systemic endotoxin level and lipid level after ingestion of high fat diet to evaluate the effect of…
- Trial name
- NCT02186080
- Testing
- Gemigliptin
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Gestational Diabetes
Micronutrients in Pregnancy as a Risk Factor for Diabetes and Effects on Mother and Baby
There is a rapidly escalating epidemic of obesity and type 2 diabetes across the world, with the fastest rise occurring in low- and middle-income countries.
- Trial name
- PRiDE (NCT03008824)
- Where
- United Kingdom
- Volunteers
- 4,500 people
- Sponsor
- University of Warwick
Overweight/Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease/Steatohepatitis (MASLD/MASH)
A Single-Dose Pharmacokinetic Study of HRS-4729 Injection in Healthy Participants and Patients With Renal Impairment
This study aims to evaluate the pharmacokinetic effects of a single dose of HRS-4729 injection in participants with mild, moderate, and severe renal impairment, with 8 participants enrolled in each renal impairment group and 8…
- Conditions
- Overweight/Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease/Steatohepatitis (MASLD/MASH), Type 2 Diabetes Mellitus
- Trial name
- NCT07807059
- Testing
- HRS-4729
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
ALS (Amyotrophic Lateral Sclerosis)
Intermediate-size Patient Population Expanded Access Protocol
The purpose of this Expanded Access Program is to provide tazbentetol to ALS patients who are not eligible to enroll in an ALS clinical trial.
- Trial name
- NCT07088159
- Testing
- Tazbentetol
- Where
- 16 sites in United States
- Sponsor
- Spinogenix
Type 2 Diabetes Mellitus, Chronic Kidney Disease
Fasiglifam in Type 2 Diabetic Subjects With Chronic Kidney Disease Stage 4 or 5 on Hemodialysis
To evaluate the efficacy of fasiglifam 50 mg once daily compared to placebo on glycemic control as measured by glycosilated haemoglobin (HbA1c) over a 16-week treatment period in participants with Type 2 Diabetes Mellitus (T2DM)…
- Trial name
- NCT02015780
- Testing
- Fasiglifam, Antihyperglycemic therapy
- Where
- 30 sites in United States, Bulgaria and 5 more
- Sponsor
- Takeda
Hyperkalaemia, Chronic Kidney Disease Stage 3 and 4
Patiromer and Diet/hrQoL in Chronic Dialysis
This is a phase III, prospective, randomized, double-blind, placebo-controlled, single-center, pilot trial, aimed at assessing whether treatment with the oral potassium binder patiromer as compared to placebo allows withdrawal or…
- Conditions
- Hyperkalaemia, Chronic Kidney Disease Stage 3 and 4, Dietary Intervention
- Trial name
- PRINCE (NCT06858280)
- Testing
- Patiromer 8400 MG [Veltassa]
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Diabetes Mellitus, Type 2, Satiety Response
Metabolic Effects of a Pre-meal Protein Drink With or Without Added Amino Acids at a Subsequent Composite Meal
The purpose of the study was to investigate the efficacy of intake of whey or soy protein isolates, respectively, with or without supplementation of amino acids, on post-meal insulin secretion and glycaemic regulation.
- Trial name
- NCT01586780
- Testing
- Protein drink, Reference meal
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Lund University
Hypobetalipoproteinemia
HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism
The aim of this study is to identify new targets in cholesterol metabolism thanks to a genetically-based strategy.
- Trial name
- HYPOCHOL (NCT02354079)
- Testing
- hypobetalipoproteinemia genetic and genotypic screening
- Where
- France
- Volunteers
- 435 people
- Sponsor
- Nantes University Hospital
Postmenopausal Osteoporosis
Study to Evaluate the Pharmacokinetics (PK), Pharmacodynamics (PD), and Usability of Abaloparatide-solid Microstructured Transdermal System (sMTS) in Postmenopausal Women With Low Bone Mineral Density (BMD)
This was an open-label, single-center study to evaluate the usability of abaloparatide-sMTS by participants with low BMD.
- Trial name
- NCT04366726
- Testing
- abaloparatide-sMTS
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Radius Health, Inc.
Pregnancy Related, Anemia, Iron Deficiency
Comparison of Oral Ferrous Sulfate to Intravenous Ferumoxytol in Antepartum Iron Deficiency Anemia
Evaluate the extent to which treatment of iron deficiency anemia beyond 24-34 weeks' gestation of pregnancy with intravenous iron increases hemoglobin compared to oral iron.
- Trial name
- NCT04253626
- Testing
- Ferumoxytol Injection [Feraheme], Ferrous Sulfate
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Stanford University
Diabetes Mellitus, Type 2
Digital Diabetes Remission Trial
This is a multicentre, open-label Randomised Controlled Trial run in the United Kingdom. The main aims are to assess whether the Habitual Remission Programme (digital therapeutics + 12-week 800kcal/day low-energy diet, delivered…
- Trial name
- DIGEST (NCT05647226)
- Testing
- Digital therapeutic and intensive lifestyle programme, Standard of care
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Habitual Health Ltd
Obesity, Cardiovascular Diseases
Workplace-Sponsored Diet and Exercise Program to Reduce Obesity
This study will evaluate the effectiveness of an environmental worksite intervention to reduce obesity among hospital employees.
- Conditions
- Obesity, Cardiovascular Diseases, Heart Diseases
- Trial name
- NCT00123526
- Testing
- Diet, Physical Activity
- Where
- United States
- Volunteers
- 899 people
- Sponsor
- University of Massachusetts, Worcester
Postprandial Hypoglycemia
Canakinumab for the Treatment of Postprandial Hypoglycemia
The primary objective of this randomized trial is to test whether a treatment with canakinumab is superior to placebo in patients with postprandial hypoglycemia after bariatric surgery, that is if it improves health related…
- Trial name
- CanpHy (NCT05401578)
- Testing
- Canakinumab
- Where
- 2 sites in Switzerland
- Volunteers
- 56 people
- Sponsor
- University Hospital, Basel, Switzerland
Cardiovascular Diseases, Diabetes Mellitus
Improving Medication Safety and CVD Risk Factor Control in Kidney Transplant Recipients
There is a lack of data analyzing the influence of Cardio-vascular Diseases (CVD) risk factor control on graft survival disparities in Black transplant recipients.
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Medication Adherence
- Trial name
- NCT02763943
- Testing
- Pharmacist-led, technology enabled education intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Overweight and Obesity, Insulin Sensitivity
Does Hyperbaric Oxygen Therapy Lead to a Sustained Increase in Insulin Sensitivity?
In a recent series of studies performed by our group, we have shown that exposure to hyperbaric oxygen (HBOT) leads to an increase in insulin sensitivity in male subjects and that this improvement can be measured in all men, not…
- Trial name
- HOTAIR3 (NCT02136615)
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Diabetes Mellitus, Type 2, Inflammation
Randomized Crossover Study of Magnesium Supplementation
The investigators recent epidemiologic work in several national surveys and cohorts of men and women have shown that dietary patterns high in plant-based foods and phytochemicals are associated with lower plasma levels of…
- Trial name
- NCT00737815
- Testing
- Magnesium Citrate: a total of 500 mg elemental magnesium
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Diabetes Mellitus Progression, Diabetes Complications
Autologous Bone Marrow Transplant in Chronic Insulin Dependent Diabetic Patients
Diabetes, recently declared a pandemic by the World Health Organization, is a risk factor for increased mortality and morbidity.
- Trial name
- NCT03562208
- Testing
- Adult Bone Marrow Stem Cells
- Where
- The Bahamas
- Volunteers
- 100 people
- Sponsor
- Global Cell Med
Gastrointestinal Stromal Tumors, Small-cell Lung Cancer
A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit
This open-label clinical trial will evaluate the safety and tolerability of NN3201 in subjects with advanced and/or metastatic solid tumors known to express c-Kit.
- Conditions
- Gastrointestinal Stromal Tumors, Small-cell Lung Cancer, Adenoid Cystic Carcinoma, Uveal Melanoma
- Trial name
- NCT06805825
- Testing
- NN3201
- Where
- 5 sites in United States
- Volunteers
- 67 people
- Sponsor
- Novelty Nobility, Inc.
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