Clinical trials: Diseases, Metabolic
Dehydration
Subcutaneous vs Intravenous Hydration on Older Adults
This study will evaluate the risk of adverse effects of intravenous hydration compared to subcutaneous hydration. Half of the patients will receive hydration by the subcutaneous route the other half by the intravenous route.
- Trial name
- SCIV (NCT03710408)
- Testing
- Intravenous hydration, Subcutaneous hydration
- Where
- Denmark
- Volunteers
- 51 people
- Sponsor
- Aalborg University Hospital
Hypopituitarism, Insulin Resistance
Lipolytic Effects of GH in Hypopituitary Patients in Vivo
Growth hormone (GH) is essential for longitudinal bone growth and somatic development. These protein anabolic effects require sufficient nutritional supply.
- Conditions
- Hypopituitarism, Insulin Resistance, Endocrine System Diseases, Glucose Metabolism Disorders
- Trial name
- NCT02782208
- Testing
- Acipimox, GH substitution, GH pause
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- University of Aarhus
Mitochondrial Enzyme Deficiencies
Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access
Expanded access to DCA as continued treatment for congenital lactic acidosis.
- Trial name
- CLA (NCT01797276)
- Testing
- Dichloroacetate
- Where
- United States
- Sponsor
- University of Florida
Diabetes, Diabetes Mellitus, Type 2
The Effect of Liraglutide Compared to Sitagliptin, Both in Combination With Metformin on Glycaemic Control in Subjects With Type 2 Diabetes Mellitus
This trial is conducted in Europe and North America. The aim of this trial is to compare the effect on blood sugar control of liraglutide or sitagliptin, both in combination with metformin, in subjects with type 2 diabetes…
- Trial name
- NCT00700817
- Testing
- liraglutide, sitagliptin, metformin
- Where
- 166 sites in United States, Canada and 13 more
- Volunteers
- 665 people
- Sponsor
- Novo Nordisk A/S
Vitamin D Deficiency, Chemotherapy Effect
Vitamin D Can Increase Pathological Response of the Breast Cancer Patients Treated With Neoadjuvant Therapy
The aim of the study is to evaluate the relationship between the vitamin D replacement and pathological response in patients undergoing neoadjuvant therapy according to different molecular sub types.
- Conditions
- Vitamin D Deficiency, Chemotherapy Effect, Pathology
- Trial name
- NCT03986268
- Testing
- Vit D
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Florence Nightingale Hospital, Istanbul
Parkinson's Disease
The Effect of Rifampin on the Metabolism of Istradefylline in Healthy Volunteers.
The purpose of this study is to test whether Rifampin affects blood levels of istradefylline in humans. Rifampin could possibly decrease istradefylline levels.
- Trial name
- NCT02174250
- Testing
- Istradefylline 40 mg, Rifampin 300mg BID + istradefylline 40mg Day 8 only
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Obesity, Dyslipidemia
Dose-Ranging Study Evaluating AVE1625 in Abdominally Obese Patients With Atherogenic Dyslipidemia
Primary objective: to assess the effect of AVE1625 on weight loss over a period of 24 weeks in abdominally obese patients with atherogenic dyslipidemia.
- Trial name
- NCT00345410
- Testing
- AVE1625 B
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- Sanofi
Arthritis, Diabetes Mellitus
Use of Complementary and Alternative Medicine Among Older Mexican Americans
The purpose of this study is to examine complementary and alternative medicine use among older Mexican Americans and to determine how this use influences physical, functional, and mental health.
- Conditions
- Arthritis, Diabetes Mellitus, Fractures, Hypertension
- Trial name
- NCT00084110
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
MASLD, Type 1 Diabetes
Study of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Adults With Type 1 Diabetes
Type 1 diabetes (T1D) is a disease characterized by an absolute deficiency of insulin secondary to autoimmune destruction of pancreatic beta cells , historically individuals with T1D are not liable for metabolic complications.
- Trial name
- NCT07750210
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Sohag University
Hypercholesterolemia
Lipid-lowering Effect of Plant Stanol Drink
To determine the effect of investigational products on serum LDL cholesterol.
- Trial name
- NCT01716390
- Testing
- Drink that contains plant stanols
- Where
- Sweden
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Raisio Group
Type 2 Diabetes Mellitus, Cardiovascular Abnormalities
Curcumin for Type 2 Diabetic Patients
There are evidence that there is an association between insulin resistance and prolonged hyperinsulinemia or hyperglycemia in Type 2 diabetic patients.
- Trial name
- NCT01052597
- Testing
- curcumin
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Srinakharinwirot University
Obesity
The Effect of 5-Hydroxytryptophan (5-HTP) on Satiety
The aim of the study is to show evidence of the efficacy of 5-HTP to induce satiety and to reduce food intake (confirmatory study).
- Trial name
- NCT00328913
- Testing
- 5-hydroxytryptophan (food supplement)
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
Obesity
Effects of HMOs on the Faecal Microbiota and on Host Metabolism in Obese Children
The study is a randomised, placebo-controlled, double-blind, parallel study in obese children. A total of 75 obese children in the age 5 to 10 years, enrolled in a childhood obesity treatment program, will be included.
- Trial name
- NCT02786160
- Testing
- HMO, Dextropur
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Glycom A/S
Urinary Stone
Etiological Diagnosis of Urinary Stone in Chinese Children
The incidence of nephrolithiasis in children has been reported to increase by approximately 6-10% annually, and the incidence is currently 50 per 100,000 children with high recurrent rate.
- Trial name
- NCT02949323
- Testing
- urinary stone
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Diabetes, Gestational
Insulin Sensitivity and Secretion During Pregnancy and Post Partum in Women With Gestational Diabetes.
Aim of the study: To define insulin requirement during pregnancy and to identify the rapid changes in insulin sensitivity around parturition and the first 6 months post partum.
- Trial name
- NCT02770079
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Epilepsy, Trauma
Comparison of Oral 30 % Dextrose and iv Midazolam Sedation During MRI in Neonates
The purpose of this study is to demonstrate the effectiveness of oral glucose administration during MRI for imaging of newborns and compare with midazolam sedation.
- Conditions
- Epilepsy, Trauma, Metabolic Disease
- Trial name
- NCT02645279
- Testing
- oral 30% glucose, IV midazolam
- Volunteers
- 112 people
- Sponsor
- Baskent University
Colorectal Cancer
FITting Non-invasive Tests in Lynch Syndrome Surveillance
The purpose of this clinical study is to evaluate the accuracy of the fecal immunochemical test (FIT) in comparison to colonoscopy in patients with Lynch Syndrome (LS) who are undergoing colonoscopy surveillance.
- Trial name
- NCT06898996
- Testing
- Fecal immunochemical test
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Chicago
Hepatic Encephalopathy
Efficacy and Safety of Nifuroxazide in the Treatment of Hepatic Encephalopathy in Egyptian Patients With Liver Cirrhosis
This is a pilot study designed to evaluate the efficacy and safety of nifuroxazide in the treatment of hepatic encephalopathy in patients with grade II-III hepatic encephalopathy
- Trial name
- NCT05754996
- Testing
- Nifuroxazide, Lactulose, Rifaximin 550Mg Tab
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Type 2 Diabetes
Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of Ultra Low Doses of Dapagliflozin in Healthy Subjects
The purpose of this study is to evaluate the pharmacodynamics (PD), pharmacokinetics (PK), safety and tolerability following single oral doses of 0.001 mg to 2.5 mg dapagliflozin in healthy subjects.
- Trial name
- ULDS (NCT01135446)
- Testing
- dapagliflozin
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Overweight, Obesity
Longevity Diet and the Fasting-mimicking Diet
This retrospective clinical study examines the impact of the longevity diet and fasting-mimicking diet (FMD), either alone or combined, on body composition and health indicators.
- Conditions
- Overweight, Obesity, Metabolic Syndrome, Autoimmune Diseases
- Trial name
- NCT07065955
- Testing
- Longevity diet alone or in combination with fasting mimicking diet
- Where
- Italy
- Volunteers
- 365 people
- Sponsor
- Fondazione Valter Longo
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