Clinical trials: Diseases, Metabolic
Osteoporosis, Osteopenia
Effects of Hesperidin on Bone Mineral Density and Bone Metabolism of Postmenopausal Women
Fruits and vegetables are rich in a variety of flavonoids with antioxidant properties. These compounds may be partially responsible for some of the positive links found between fruits and vegetables intake and higher bone mineral…
- Trial name
- NCT00330096
- Testing
- Hesperidin
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Obesity, Overweight
Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese Individuals
This study evaluates the impact of increased intake of fruits and vegetables and whole grains on markers of inflammation and gut microbial composition.
- Trial name
- NCT02602496
- Testing
- Fruits and Vegetables, Whole Grain, Control
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Benign Multinodular Goiter, Thyroidectomy
Intraoperative Methylene Blue Spray for the Identification and Preservation of Vital Structures in Thyroidectomy
This randomized controlled trial aims to evaluate the efficacy of intraoperative methylene blue (MB) spray in improving the identification and preservation of the recurrent laryngeal nerve (RLN) and parathyroid glands (PGs)…
- Conditions
- Benign Multinodular Goiter, Thyroidectomy, Recurrent Laryngeal Nerve Injury, Hypoparathyroidism
- Trial name
- NCT07395388
- Testing
- Intraoperative topical methylene blue spray, Conventional Dissection
- Where
- Pakistan
- Volunteers
- 136 people
- Sponsor
- Services Hospital, Lahore
Dyslipidemia, Hyperlipidemia
Rosuvastatin Adherence App Study in China
This is a randomized, two-arm, open label, Phase IV clinical trial to evaluate if the provision of a smart phone-based patient support tool prolongs the patient's rosuvastatin treatment duration.
- Trial name
- eHELP China (NCT02433288)
- Testing
- Smart phone based patient support tool, Control application: only for data collection
- Where
- 25 sites in China
- Volunteers
- 885 people
- Sponsor
- AstraZeneca
Obesity, Childhood Obesity
The Effects of Integrative Neuromuscular Training on Physical Function in Overweight Children
Childhood obesity is an ongoing and increasing issue, resulting in changes in body mass which cause biomechanical alterations in the lower limbs.
- Trial name
- NCT05724303
- Testing
- 8-week neuromuscular training program
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- St. Mary's University, Twickenham
Accidental Falls, Osteoporosis
Prevention of Falls and Its Consequences in Elderly People
Falls are an important risk factor for fragility fractures. Both are associated with the ageing process and as they rise also increase the risk of mortality, disability and dependency.
- Trial name
- PRECIOSA (NCT02617303)
- Testing
- OTAGO's exercises, COMMON PRACTICE
- Where
- 11 sites in Spain
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Type 2 Diabetes
Comparing the Effects of Insulin Glargine on Blood Glucose Between Needle-free Jet Injection and Insulin Pen
To comparing the blood sugar improvement and patient sensibility of insulin glargine injected with needle-free jet injector and conventional insulin pen
- Trial name
- NCT04074603
- Testing
- The needle-free jet injector, Conventional insulin pen
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Jian-hua Ma
Type 2 Diabetes Mellitus
Comparison of Exenatide vs. Biphasic Insulin Aspart 30 on Glucose Variability in Type 2 Diabetes
This is a multi-centre, open-label, randomized, parallel trial to compare the effect of Exenatide versus Biphasic insulin Aspart 30 on glucose variability and inflammatory markers in type 2 diabetes mellitus (T2DM) patients…
- Trial name
- NCT02449603
- Testing
- Exenatide, Biphasic insulin Aspart 30
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xijing Hospital
Hypoglycemia
Hypoglycemia and the Mineralocorticoid Receptor
The purpose of this study is to look at whether blockade of the mineralocorticoid receptor will result in changes in the cardiovascular and inflammatory response to hypoglycemia.
- Trial name
- HypoMR (NCT01394627)
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Disease, Type II Diabetes
Heart-Kidney-Diabetes Multidisciplinary Care MOdels for CardiovascuLar Health In Patients With Chronic Kidney DiSease and Diabetes: A PragmaTIC Cluster Randomized Controlled Trial (HOLISTIC)
Our overarching goal of this study is to provide rigorous evidence for using an accelerated risk-based approach to implementing guideline directed medical therapies (GDMT) using a multidisciplinary care model (MCM) versus a usual…
- Trial name
- HOLISTIC (NCT07811427)
- Testing
- The intervention with the MCM is Kidney-Heart GDMT initiation and titration for dose optimization (as clinically tolerated), within 4 months of enrollment in the study.
- Volunteers
- 570 people
- Sponsor
- Baim Institute for Clinical Research
Malnutrition
Malnutrition Clinical Characteristics Validation Study
Malnutrition (under-nutrition) occurs in approximately 30% of hospitalized adults worldwide and results in poor outcomes. However there is no universal method for diagnosing malnutrition.
- Trial name
- MCC (NCT02182427)
- Where
- 4 sites in United States, Australia
- Volunteers
- 54 people
- Sponsor
- Academy of Nutrition and Dietetics
Type 2 Diabetes Mellitus
Safety and Efficacy of Exenatide as Monotherapy
This Phase 3 trial is designed to compare the effects of twice-daily exenatide and twice-daily placebo with respect to glycemic control in drug-naive patients with type 2 diabetes treated with diet and exercise.
- Trial name
- NCT00381342
- Testing
- exenatide
- Where
- 19 sites in United States, India and 3 more
- Volunteers
- 233 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Rising Doses of BI 187004 in Patients With Type 2 Diabetes Mellitus
To investigate safety, tolerability, pharmacokinetics and pharmacodynamics of BI 187004 following multiple dose administration over 14 days.
- Trial name
- NCT01874483
- Testing
- BI 187004
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- Boehringer Ingelheim
Diabetes
Study on Improvement of Blood Glucose Control in Patients With Diabetes Type 2 Using SMBG
This clinical study is to determine if the use of structured testing, which is a blood glucose monitoring, via the Accu-Chek 360° View blood glucose analysis tool has a positive effect on the subjects overall glycemic control.
- Trial name
- NCT01820169
- Testing
- ;Accu-Chek Compact Plus LCM bulk Japan
- Where
- Japan
- Volunteers
- 2 people
- Sponsor
- Hoffmann-La Roche
Diabetes Mellitus, Type 2
Effect of Exercise on Cardiometabolic Risk Factors in Type II Diabetic Patients
Background: Physical activity is known to modify some of the diabetes risk factors; however, solid evidence is still needed to precisely know the optimum form of training best fits the individual needs of type II diabetic (T2D)…
- Trial name
- NCT04759469
- Testing
- High-intensity interval training, Moderate intensity interval training
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Peripheral Artery Disease, Diabetes Mellitus
Cocoa Flavanols and Painfree Walking Distance
To characterize potential vascular long-term effects of flavanols in patients with peripheral artery occlusive disease (PAOD), a placebo-controlled double-blinded randomized control study will be performed in 62 patients…
- Trial name
- NCT01064583
- Testing
- cocoa
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
NAFLD, Obesity
Biomarkers in the Diagnosis and Prognosis of NAFLD
Fibrosis is considered the leading cause of liver diseases and related mortality. Specifically, hepatic fibrosis is regarded as the consequence of reparative mechanisms initiated by hepatocytes in response to chronic damage.
- Conditions
- NAFLD, Obesity, Liver Fibrosis, Diabetes Mellitus, Type 2
- Trial name
- NCT06098417
- Testing
- Plasma Test, Liver biopsy, Visceral adipose tissue biopsy
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Trieste
Atypical Femoral Fractures, Osteoporosis
Exome Sequencing for Atypical Femoral Fractures
The purpose of this study is to determine whether women who have atypical subtrochanteric and diaphyseal femoral fractures after treatment with bisphosphonates for osteoporosis, have a genetic predisposition to these unusual…
- Conditions
- Atypical Femoral Fractures, Osteoporosis, Bisphosphonate Therapy
- Trial name
- NCT02731040
- Testing
- Bisphosphonate
- Volunteers
- 38 people
- Sponsor
- Washington University School of Medicine
LDL Cholesterol, Triglycerides
Safety and Efficacy of a Natural Health Product in Reducing Cholesterol and Triglyceride Levels.
The purpose of this study is to assess the safety and efficacy of a natural health product among participants with elevated LDL cholesterol and triglyceride levels.
- Trial name
- NCT01028274
- Testing
- Investigational Product 1, Investigational Product 2
- Where
- Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Nordic Pharma, USA
Osteoporosis, Postmenopausal
Menopause Osteoporosis and Bone Intervention Using Lifestyle Exercise.
Aim: to examine the effect of an exercise intervention for preventing osteoporosis among postmenopausal women. Objectives: To examine whether mean values for Broadband Ultrasound Attenuation (BUA) using Quantitative Ultrasound…
- Trial name
- MOBILE (NCT04469374)
- Testing
- Jumping exercise
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Staffordshire University
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