Clinical trials: Diseases, Metabolic
Pregnancy, Gestational Diabetes Mellitus
Investigation of Mechanisms for Transmission of Impaired Glucose Metabolism in Infants Exposed to Diabetes in Utero
This proposed study; Investigation of mechanisms for transmission of impaired glucose metabolism in infants exposed to diabetes in utero, will test the overarching hypothesis that impaired maternal substrate oxidation (metabolic…
- Trial name
- IMAGINE (NCT02926079)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Type 2 Diabetes Mellitus
Preferred Treatment of Type 1.5 Diabetes
The purpose of this research was to test whether one treatment was superior over another in the management of type 1.5 diabetes.
- Trial name
- NCT00194896
- Testing
- rosiglitazone, glyburide
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Washington
Obesity & Overweight, Healthy Adult
Vitis Intervention Trial in Substrate Metabolism
Obesity is associated with reduced metabolic flexibility (MetFlex), the capacity to shift between carbohydrate and lipid oxidation in response to nutrient availability.
- Trial name
- VITIS (NCT07800988)
- Testing
- Freeze-Dried Whole Grape Powder
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obesity, Diabetes
Crossover Trials Which Assessed Consumption of Slowly Digestible Carbohydrates for 21 Days on Gastric Emptying Rates
To gain a better understanding about the conditioning effect of consumption of slowly digestible carbohydrate on gastric emptying rate, respiratory quotient and metabolic flexibility, this study will focus on monitoring change in…
- Trial name
- INT (NCT05430061)
- Testing
- slowly digestible carbohydrate
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Purdue University
Osteoporosis
AI Model for Bone Mineral Density Prediction From X-Ray Images
Osteoporosis, a pervasive skeletal disorder characterized by diminished bone strength predisposing individuals to an increased risk of fractures, presents a substantial public health challenge globally.
- Trial name
- NCT06652061
- Testing
- Dual Energy X-Ray Absorptiometry Scan (DEXA Scan), X-Ray (Hip and Spine)
- Where
- Bangladesh
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Bangladesh University of Engineering and Technology
Hypercholesterolemia, Atherosclerotic Cardiovascular Disease
Evaluation of Long-Term Efficacy of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia at High Cardiovascular Risk
The purpose of this study is to see if bemedoic acid (ETC-1002) is effective versus placebo in patients with high cardiovascular risk and elevated LDL cholesterol not adequately controlled by their current therapy.
- Trial name
- CLEAR Wisdom (NCT02991118)
- Testing
- bempedoic acid
- Where
- 2 sites in United States
- Volunteers
- 779 people
- Sponsor
- Esperion Therapeutics, Inc.
Osteopenia, Osteoporosis
The Effects of Bovine Colostrum in Bone Metabolism in Humans
Osteoporosis constitutes a major public health concern. For instance, in European Union 1 in 3 women and at least 1 in 6 men will suffer an osteoporotic fracture during their lifespan.
- Trial name
- NCT04040010
- Testing
- Colostrum supplementation for bone loss
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Morbid Obesity, Opioid-Related Disorders
Recovery of Ventilation After General Anesthesia in Morbidly Obese Patients
This is an observational study of morbidly obese patients recovering from general anesthesia after weight-loss surgery. The investigators aim to assess ventilatory function and how this is influenced by the diagnosis of…
- Conditions
- Morbid Obesity, Opioid-Related Disorders, Surgery--Complications, Sleep Apnea Syndromes
- Trial name
- NCT03925610
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Stanford University
Forensic Psychiatric Patients, Cardio Vascular Disease
Improving Lifestyle Habits and Metabolic Health in Forensic Psychiatric Patients
Background:People in compulsory forensic psychiatric care experience high rates of metabolic syndrome, cardiovascular disease, and related lifestyle risk factors, yet structured preventive health interventions are uncommon in…
- Conditions
- Forensic Psychiatric Patients, Cardio Vascular Disease, Health Promotion, Forensic Mental Health
- Trial name
- FOR-HEALTH (NCT07157813)
- Testing
- Structured Health Dialogue
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kronoberg County Council
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Effects of Long-lasting Bicarbonate-Sulfate-Calcium-Magnesium Water Intake on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Outcome
Background: Fonte Essenziale®, a mineral water rich in bicarbonate, sulphate, calcium, and magnesium, has shown potential in modulating the gut-liver axis and microbiota in hepatic steatosis.
- Trial name
- FonteESSEMASLD (NCT07211113)
- Testing
- Fonte Essenziale® mineral water
- Where
- Italy
- Volunteers
- 87 people
- Sponsor
- University of Campania Luigi Vanvitelli
Elevated Triglycerides, Diabetes
Change of Fructose to Fat in South Asians
The purpose of this study is to determine whether hepatic de novo lipogenesis (DNL) in response to the ingestion of a mixture of glucose and fructose is greater in South Asians compared to controls (Caucasians).
- Conditions
- Elevated Triglycerides, Diabetes, Cardiovascular Disease, Dyslipidemia
- Trial name
- NCT01562782
- Testing
- Fructose + Glucose Beverage
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- The Rogosin Institute
Type 2 Diabetes
Cardiometabolic Impact of a Produce Prescription Program in Patients With Type 2 Diabetes and Food Insecurity
This study is testing whether providing monthly vouchers to buy fruits and vegetables can help improve blood sugar control in adults with type 2 diabetes.
- Trial name
- GARDEN-CARDIO (NCT07674979)
- Testing
- Produce Gift Card and Dietary Education, Usual Care
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- West Virginia University
Diabete Type 2, Aerobic Exercise
Type 2 Diabetes Mellitus and Downhill Aerobic Exercise Training
The purpose of this study is to compare the effects of an 8-week supervised downhill walking training program, prescribed based on the 6-minute walk test, on functional capacity, peripheral muscle strength, and cardiovascular…
- Conditions
- Diabete Type 2, Aerobic Exercise, Walking
- Trial name
- NCT07693296
- Testing
- Downhill Aerobic Walking Training, Level Aerobic Walking Training, Home exercise session
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Acibadem University
Obesity
To Study Different Levels of MK0493 for Safety, Efficacy, and Tolerability in Obese Patients (0493-017)(COMPLETED)
To study different doses of MK0493 for safety, efficacy and tolerability in obese patients.
- Trial name
- NCT00482196
- Testing
- MK0493
- Volunteers
- 173 people
- Sponsor
- Merck Sharp & Dohme LLC
Impaired Glucose Tolerance
Effects of Artificial Sweeteners on Gut Microbiota and Glucose Metabolism
The Objectives of this study is to determine the effect(s) of daily non-caloric artificial sweetener (NAS) consumption (sucralose or aspartame) on the composition of the bacteria and also to determine the changes in glucose…
- Trial name
- NCT02569762
- Testing
- Sucralose-Aspartame, Aspartame-Sucralose
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Type 2 Diabetes
Pilot Study of the Effect of MN-504 Cobiotic Formulation on the Efficacy and Tolerability of Metformin
The purpose of the study is to determine if NM504 will prevent GI side effects that are associated with using metformin for the treatment of diabetes.
- Trial name
- NCT01866462
- Testing
- NM504
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NuMe Health
Cardiovascular Diseases, Heart Diseases
Genomic Dissection of a QTL Affecting the Lipid Profile
To search for the genetic cause of the metabolic syndrome, a lipid disorder that poses a major risk for coronary heart disease.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Hyperlipidemia, Familial Combined
- Trial name
- NCT00064688
- Sponsor
- Medical College of Wisconsin
Obesity, Insulin Resistance
Neural Functioning of Feeding Centers in Obese Youth
To explore whether obese adolescents with insulin resistance and relative low leptin levels exhibit functional alterations of the neuronal circuits involved in the regulation of energy metabolism and food seeking behaviors.
- Trial name
- NCT01808846
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Yale University
Osteoporosis, Turner's Syndrome
Hormone Replacement Therapy to Treat Turner Syndrome
This study will evaluate the effects of hormone replacement therapy on patients with Turner syndrome (TS)-a genetic disorder in females in which part or all of one X chromosome is missing.
- Trial name
- NCT00013546
- Testing
- TMTDS
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Gestational Diabetes
Serum Biomarkers Associated With Postpartum T2DM in Women With GDM
Gestational diabetes mellitus (GDM) is commonly linked to the development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with GDM in order to find novel biomarkers for T2DM.
- Trial name
- NCT04539288
- Where
- China
- Volunteers
- 3,099 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
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