Clinical trials: Diseases/Diagnoses
Ovarian Cancer, Endometrial Cancer
Exploring the Potential of Novel Biomarkers Based on Plasma microRNAs for a Better Management of Pelvic Gynecologic Tumors
This trial is a non-randomized, open label and multicenter study. It aims to : for endometrial cancer.:validate the 5-miR index assessed in plasma samples as a diagnostic marker to assess the risk of lymph node metastases for…
- Trial name
- GYNO-MIR (NCT03776630)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 363 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prostate Cancer
Telomere Associated Variables (TAVs) in Prostate Cancer
This research project results from the interest in continuing the collaboration with the previous LL-HURS-ONC001 clinical validation study, which gives cause to the present study.
- Trial name
- NCT04124900
- Where
- 10 sites in United States, Spain
- Volunteers
- 509 people
- Sponsor
- Life Length SL
Leukemia, Acute Myeloid Leukemia
Study Evaluating the Addition of Amifostine (Ethyol®) to Idarubicin and Cytosine Arabinoside in Older Patients With Acute Myeloid Leukemia
The primary objectives of this study are: 1. To evaluate whether the addition of amifostine will allow for the safe administration of idarubicin at a dose of 21 mg/m² in combination with standard-dose ara-C in older patients with…
- Trial name
- NCT00086099
- Testing
- Idarubincin and Amufostine (Ethyol), Idarubincin
- Where
- 19 sites in United States, Israel
- Volunteers
- 54 people
- Sponsor
- MedImmune LLC
Bronchiolitis Acute
Use of Lung Ultrasound in Children With Acute Bronchiolitis
Bronchiolitis is the leading cause of hospitalization in infants. The diagnosis is clinical and chest x-ray (CXR) should be reserved for severe cases in which signs of pulmonary complications are present.
- Trial name
- NCT03280732
- Testing
- Lung Ultrasound
- Where
- Italy
- Volunteers
- 87 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Amyloidosis
Diagnostic Utility of F-18 Florbetapir PET/MR in Peripheral Nerve Amyloidosis
The primary aim of this study will be to examine the diagnostic utility of 18-F Florbetapir PET/MR (Positron Emission Tomography/Magnetic Resonance) in imaging patients with pathologically-confirmed systemic amyloidosis involving…
- Trial name
- NCT03019029
- Testing
- 18-F Florbetapir PET/MR scan
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Myopathy, Neuropathy
Identification of Tongue Involvement in Late-Onset Pompe Disease
This purpose of this study is to determine if tongue strength and tongue ultrasound measurements differentiates patients with untreated late-onset Pompe Disease (LOPD) from patients with acquires/hereditary myopathies or…
- Conditions
- Myopathy, Neuropathy, Glycogen Storage Disease Type II (Late-onset Pompe Disease)
- Trial name
- NCT02765828
- Testing
- Observational study
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Duke University
Checkpoint Inhibitor-related Pneumonitis
Diagnostic Biomarkers for Checkpoint Inhibitor-related Pneumonitis
Checkpoint inhibitor-related pneumonitis (CIP) is a common fatal immune-related adverse events of PD-1/PD-L1 inhibitors. Early diagnosis of CIP is crucial for timely intervention and improved prognosis; however, the absence of…
- Trial name
- NCT07340892
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhou Chengzhi
Type1 Diabetes Mellitus
PET-CT Scan Method to Monitor Pancreatic B-Cell Loss in Diabetes Mellitus
The pancreas is an organ that plays major roles in the digestion of food. A part of the pancreas called islet beta-cells produces insulin, which regulates the amount of glucose (a sugar) present in the blood at all times.
- Trial name
- NCT00633763
- Testing
- 18F-fallypride
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Traumatic Brain Injury
The Research for New Clinical Diagnostic Strategy of Specific Biomarkers for Traumatic Brain Injury
Traumatic brain injury (TBI) is the most common type of nerve injury and it severely endangers the public health. It is necessary to accurately measure the early neurological function of brain injury for monitoring its prognosis…
- Trial name
- NCT03976492
- Testing
- diagnostic of specific biomarkers
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Baiyun Liu
Pediatric Acute Lymphoblastic Leukemia
Treatment of Newly Diagnosed High Risk Pediatric Acute Lymphoblastic Leukemia
Clinical and genetic factors consistent with High risk : Induction → Consolidation 1. BM MRD \< 0.01% : IM #1 → DI #1 → IM #2 → Maintenance 2. BM MRD ≥ 0.01% : IM #1 → DI #1 → IM #2 → DI #2 → Maintenance 3.
- Trial name
- HR ALL (NCT06184009)
- Testing
- ALL, High risk
- Where
- 9 sites in South Korea
- Volunteers
- 370 people
- Sponsor
- Jae Wook Lee
Metastatic Prostate Cancer
The Effect of Metformin in Patients With Newly Diagnosed mHSPC
The purpose of this study is to assess the effect of the addition of metformin to abiraterone on survival in patients with newly diagnosed metastatic hormone-sensitive prostate cancer.
- Trial name
- NCT04925063
- Testing
- Metformin
- Where
- China
- Volunteers
- 266 people
- Sponsor
- Sun Yat-sen University
Secondary Progressive Multiple Sclerosis (SPMS)
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
The purpose of this study is to provide efficacy and safety data for remibrutinib in patients with secondary progressive multiple sclerosis (SPMS)
- Trial name
- REMASTER (NCT07225504)
- Testing
- Remibrutinib (blinded), Remibrutinib (Open label)
- Where
- 296 sites in United States, Argentina and 34 more
- Volunteers
- 1,275 people
- Sponsor
- Novartis Pharmaceuticals
Pancreatic Cancer
BIOmarkers in Patients With Pancreatic Cancer ("BIOPAC")
No validated biomarkers to identify PC at an early stage and to predict treatment outcomes in the individual patient exist. The objective of the present study is to find diagnostic, prognostic and predictive biomarkers.
- Trial name
- BIOPAC (NCT03311776)
- Where
- Denmark
- Volunteers
- 5,000 people
- Sponsor
- Inna Chen, MD
Stress Incontinence, Female
Evaluation of Transperineal US in Stress Incontinence
Stress urinary incontinence (SUI) has an observed prevalence of between 4%and 35%.Identified risk factors are aging, obesity and repeated pregnancies and deliveries.
- Trial name
- NCT03397368
- Testing
- Transperineal Ultrasound -
- Where
- 2 sites in Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Prostate Cancer
68Ga-NOTA-BBN-RGD PET/CT in Prostate Cancer Patients
This is an open-label positron emission tomography/computed tomography (PET/CT) study to investigate the diagnostic performance and evaluation efficacy of 68Ga-NOTA-BBN-RGD in prostate cancer patients.
- Trial name
- NCT02747290
- Testing
- 68Ga-NOTA-BBN-RGD
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Parathyroid Adenoma, Hyperparathyroidism
Trial Comparing 2 Diagnostic Strategies for Preoperative Localization of Parathyroid Adenoma in Primary Hyperparathyroidism:TEMP / CT With Tc99m-sestaMIBI or PET / CT With F18-choline in First Intention
The investigators hypothesize that positron emission tomography with fluorocholline (F18-choline PET) will reduce the proportion of unnecessary invasive surgery decisions and that the higher cost of positron emission tomography…
- Conditions
- Parathyroid Adenoma, Hyperparathyroidism, F18-choline
- Trial name
- APACH2 (NCT04040946)
- Testing
- MIBI scintigraphy, F18-choline PET
- Where
- 4 sites in France
- Volunteers
- 59 people
- Sponsor
- Centre Francois Baclesse
Coronary Microvascular Disease, Ischemic Heart Disease
A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction
Among patients with stable ischemic heart disease who are referred for coronary angiography, a substantial proportion have non-obstructive coronary artery disease (CAD).
- Conditions
- Coronary Microvascular Disease, Ischemic Heart Disease, Myocardial Ischemia
- Trial name
- NCT03537586
- Testing
- Bivalirudin, Adenosine, Heparin
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- NYU Langone Health
Ulcerative Colitis (UC), Fecal Calprotetin
DYNAMIC-UC: Early qFIT and Calprotectin Change Predicting Relapse in Biologic-Naive Ulcerative Colitis
This multicenter prospective cohort study aims to evaluate whether a >50% decrease or normalization of both quantitative fecal immunochemical test (qFIT) and fecal calprotectin (FC) levels at 2 weeks after starting conventional…
- Conditions
- Ulcerative Colitis (UC), Fecal Calprotetin, FIT, Biomarker
- Trial name
- DYNAMIC-UC (NCT07111273)
- Testing
- FC and FIT TEST at WEEK0 2 4
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Brain Injuries, Pulmonary Embolism
Improving the Stewardship of Diagnostic Imaging Resources in Alberta Emergency Departments
Utilization of diagnostic imaging in the Emergency Department has increased dramatically over the past two decades, driven by an increased availability of advanced imaging, legal pressures to exclude serious diagnoses in low-risk…
- Trial name
- NCT02410941
- Testing
- Clinical decision support
- Where
- 16 sites in Canada
- Volunteers
- 52,058 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Groin Pain
Anatomical, Radiological and Biomechanical Examination of Athletic Groin Pain Patients and Physical Therapy Intervention
Athletic groin pain (AGP) is a chronic condition common in multi-directional sports (Walden et al. 2007, Robinson et al. 2004, Murphy et al. 2012). It is a complex injury with a challenging diagnosis.
- Trial name
- NCT02437942
- Testing
- Biomechanics led physical therapy rehabilitation
- Where
- Ireland
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Sports Surgery Clinic, Santry, Dublin
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