Clinical trials: Diseases/Diagnoses
Atrial Fibrillation, Tachycardia
Electrocardiographic Diagnostic Performance of the Apple Watch Augmented With an Artificial Intelligence Algorithm
The SWAF study will compare the performance of a smartwatch combined with Cardiologs Platform algorithm in the detection of Atrial Fibrillation and other arrhythmias with that measured on a manually read 12-lead ECG in subjects…
- Conditions
- Atrial Fibrillation, Tachycardia, Bradycardia, Premature Supraventricular Beat
- Trial name
- NCT05167058
- Testing
- Cardiologs Platform
- Where
- 3 sites in United States
- Volunteers
- 220 people
- Sponsor
- Cardiologs Technologies
Lactose Intolerance
Lactobreath: A Study to Diagnose Lactose Intolerance Using Breath Markers
Food intolerances affect many people and can cause discomfort and dietary challenges. One common cause is difficulty digesting certain carbohydrates called FODMAPs.
- Trial name
- Lactobreath (NCT06177938)
- Testing
- Lactose solution/Glucose solution
- Where
- Switzerland
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- ETH Zurich
Dyspnea
Evaluation of the Impact of Pleuropulmonary Ultrasound on the Diagnosis of Dyspnea
Dyspnea is a subjective symptom perceived by the patient as a sensation of "breathing discomfort", "suffocation", "lack of air" or "difficulty inhaling or exhaling". It is a frequent reason for calling for help (8% of calls).
- Trial name
- LU-SMUR (NCT07104578)
- Testing
- Pleuropulmonary ultra sound
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Toulouse
Glioblastoma, MGMT-Unmethylated Glioblastoma
Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma
This Phase I study investigated the side-effects and best dose of microtubule-targeted agent BAL101553 when given together with radiation therapy in treating patients with newly-diagnosed O6-methylguanine-DNA methyltransferase…
- Trial name
- NCT03250299
- Testing
- Microtubule-Targeted Agent BAL101553, Radiation Therapy
- Where
- 8 sites in United States
- Volunteers
- 26 people
- Sponsor
- Basilea Pharmaceutica
Vulvodynia, Mycoses
Prospective Data Bank Creation to Study Vaginal Conditions
The purpose of this study is to identify and elucidate the pattern and perhaps role of atypical proteins, cytokines and vaginal microbial flora in the pathogenic mechanisms involved in the development of vulvodynia, recurrent…
- Conditions
- Vulvodynia, Mycoses, Bacterial Vaginosis, Preterm Labor
- Trial name
- CRIPB-13-002 (NCT01829204)
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Diabetes Mellitus, Type 1
EDCR Study - Etanercept Diamyd Combination Regimen -Open Trial to Evaluate Safety in Children With Type 1 Diabetes
The objectives of this study is to: Evaluate the tolerability of a combination therapy with Diamyd, vitamin D and etanercept Evaluate how the above mentioned treatments influence the immune system and endogenous insulin secretion
- Trial name
- NCT02464033
- Testing
- GAD-Alum, Vitamin D, Etanercept
- Where
- 8 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Johnny Ludvigsson
Crohn's Disease, Ulcerative Colitis
Protein Metabolism in Newly Diagnosed Pediatric Inflammatory Bowel Disease
Inflammatory bowel disease, which includes both Crohn's disease and ulcerative colitis, is a disease of the gastrointestinal tract leading to symptoms of abdominal pain, diarrhea, and growth disturbance.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Protein Metabolism
- Trial name
- NCT00586352
- Testing
- stable isotope infusions
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Indiana University
Breast Cancer
MammoVerse: Breast Cancer Sexual Health Focus Groups
The purpose of this study is to explore the lived experiences, emotional challenges, and coping processes related to changes in sexual health and intimacy among women diagnosed with breast cancer.
- Trial name
- NCT07644858
- Testing
- Questionnaires and Focus Group
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Central Florida
Chronic Diarrhoea, Lymphocytic Colitis
Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis
The purpose of this study is to determine whether chromoendoscopy using Indigo-Carmine dye spray is useful in diagnosing microscopic colitis among patients undergoing colonoscopy due to chronic watery diarrhea.
- Conditions
- Chronic Diarrhoea, Lymphocytic Colitis, Collagenous Colitis
- Trial name
- NCT01504048
- Testing
- Colonoscopy with Indigo-Carmine Chromoendoscopy
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Karolinska University Hospital
Multiple Myeloma, Hematopoietic Stem Cell Mobilization
Comparison Study of EAP and CG Regimens for Mobilizing Hematopoietic Stem Cells in Multiple Myeloma Patients
This is a prospective, randomized, two-arm, multicenter, exploratory study aimed at evaluating the efficacy and safety of the combination of etoposide, cytarabine and Pegfilgrastim (EAP regimen) for mobilizing hematopoietic stem…
- Trial name
- NCT06520176
- Testing
- Etoposide, Cytarabine, Pegfilgrastim
- Where
- 16 sites in China
- Volunteers
- 99 people
- Sponsor
- The Affiliated People's Hospital of Ningbo University
Coronary Artery Disease
Diagnostic Performance of Noninvasive Fractional Flow Reserve From Computed Tomography
Fractional Flow Reserve derived from computed tomography(FFRCT) is a novel method for determining the physiologic significance of coronary artery disease (CAD), which will help physicians in clinical decision-making and decrease…
- Trial name
- PERFECT (NCT01747317)
- Testing
- FFR (PressureWire)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Myeloproliferative Neoplasm
Diagnostic Characterization and Evolution of "Triple Negative" Thrombocytosis (CASTETTE)
Evaluation of Event free survival in patients with triple-negative thrombocytosis
- Trial name
- CASTETTE (NCT06481332)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Liver Cirrhosis, Hepatic Encephalopathy (HE)
Equivalence of Electronic vs Paper-based PHES in Diagnosing Hepatic Encephalopathy
The goal of this clinical trial is to learn if an electronic version of the Psychometric Hepatic Encephalopathy Score (PHES) works as well as the standard paper version to diagnose minimal hepatic encephalopathy (MHE) in adults…
- Conditions
- Liver Cirrhosis, Hepatic Encephalopathy (HE), Minimal Hepatic Encephalopathy
- Trial name
- NCT07874204
- Testing
- Paper-based PHES, Electronic PHES
- Volunteers
- 80 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Arrhythmia, Cardiovascular Diseases
Diagnostic Investigation of Sudden Cardiac Event Risk
The overall objective of the DISCERN study is to develop and validate a genomic diagnostic assay to identify patients at increased risk for lethal ventricular arrhythmias and sudden cardiac death (SCD).
- Conditions
- Arrhythmia, Cardiovascular Diseases, Heart Failure, CVD
- Trial name
- DISCERN (NCT00500708)
- Where
- 8 sites in United States
- Volunteers
- 1,564 people
- Sponsor
- CardioDx
Systemic Inflammatory Response Syndrome, Sepsis
Alpha-1-acid Glycoprotein as a Biomarker of Developmental Diagnosing and Monitoring Effectiveness in Sepsis
To assess the potential value of alpha-1-acid glycoprotein (AGP) for early diagnosis and prognosis of patients with sepsis, and then compared with C-reactive protein (CRP), procalcitonin (PCT), white blood cell (WBC) counts…
- Trial name
- NCT01838525
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Multiple Myeloma
A Safety Study of Carfilzomib, Cyclophosphamide & Dexamethasone Prior to ASCT in Patients With Newly Diagnosed Myeloma
This is a dose finding pilot study to evaluate the safety and determine the maximum tolerated dose of the combination of carfilzomib and cyclophosphamide with dexamethasone (Car-Cy-Dex) prior to autologous stem cell transplant…
- Trial name
- 11-MM-01 (NCT01660750)
- Testing
- Carfilzomib, Cyclophosphamide, Dexamethasone
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Criterium, Inc.
Gestational Diabetes
Efficacy of Treatment for Gestational Diabetes Diagnosed by the IADPSG Criteria.
There is a lack of international uniformity in the approach to the screening and diagnosis of gestational diabetes mellitus (GDM).
- Trial name
- NCT02708758
- Testing
- Medical Nutrition Therapy
- Where
- Mexico
- Volunteers
- 400 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Myelodysplastic Syndrome (MDS)
Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome
Myelodysplastic Syndrome (MDS) is a group of disorders that gradually affect the ability of a person's bone marrow (semi-liquid tissue present in many bones like backbones) to produce normal blood cells.
- Trial name
- Verona (NCT04401748)
- Testing
- Venetoclax, Azacitidine
- Where
- 220 sites in United States, Australia and 21 more
- Volunteers
- 531 people
- Sponsor
- AbbVie
Lymphoma, B-Cell, Neoplasms
Omic Technologies Applied to the Study of B-cell Lymphoma for the Discovery of Diagnostic and Prognosis Biomarkers
The goal of this observational study is to determine the plasma metabolomic profile in diffuse large B-cell lymphoma and high-grade B lymphomas patients before, during and after treatment by ultra-high performance liquid…
- Conditions
- Lymphoma, B-Cell, Neoplasms, Cancer, High-grade B-cell Lymphoma
- Trial name
- NCT05834426
- Testing
- Plasma metabolomic profile by Ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-QTOFMS)
- Where
- Ecuador
- Volunteers
- 50 people
- Sponsor
- Sociedad de Lucha Contra el Cáncer del Ecuador
Syphilis
Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Diagnose Infectious Syphilis
The goal of this observational study is to evaluate the sensitivity, specificity, and utility of the DPP® Syphilis Screen \& Confirm antibody point-of-care test (POCT) to diagnose infectious syphilis in participants attending the…
- Trial name
- NCT06927843
- Testing
- point of care test
- Where
- Canada
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
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