Clinical trials: Diseases/Diagnoses
Pressure Injury
Prevention to Pressure Injury With Care Bundle
Aim: The study was conducted in order to evaluate of pressure injury prevention care bundle application in intensive care unit patients diagnosed with internal diseases.
- Trial name
- NCT05541198
- Testing
- Pressure Injury Prevention Care Bundle
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Saglik Bilimleri Universitesi
Pulmonary Tuberculosis
Evaluation of 8 Weeks of Treatment With the Combination of Moxifloxacin, PA-824 and Pyrazinamide in Patients With Drug Sensitive and Multi Drug-Resistant Pulmonary Tuberculosis (TB) (NC-002)
The purpose of this study is to assess the mycobactericidal activity of the moxifloxacin plus PA-824 plus pyrazinamide regimen after 8 weeks of treatment.
- Trial name
- NCT01498419
- Testing
- Moxifloxacin (M), Pretomid (Pa), Pyrazinamide (Z)
- Where
- 8 sites in South Africa, Tanzania
- Volunteers
- 207 people
- Sponsor
- Global Alliance for TB Drug Development
Philadelphia Positive Acute Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia, Adult
Efficacy and Safety of TKI Combined With Chemotherapy and Sequential CAR-T Cells in ND Adult Patients With Ph+ ALL
In recent years, immunotherapy (eg. blinatumomab, inotuzumab ozogamicin, CAR-T cells) has demonstrated a high safety and efficacy profile in relapsed/refractory (R/R）B-ALL.
- Trial name
- NCT06481228
- Testing
- CAR-T cells, Venetoclax, Olverembatinib
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Smoking
Carotid Plaque Screening Trial in Smokers
The purpose of this study is to determine the impact of carotid plaque screening on smoking cessation and control of other cardiovascular risk factors.
- Trial name
- CAROSS (NCT00548665)
- Testing
- Carotid ultrasound for plaque screening, Brief advice for smoking cessation
- Where
- Switzerland
- Volunteers
- 536 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
AML (Acute Myeloid Leukemia)
A Phase 1b Study of CLN-049 in Combination With Azacitidine and Venetoclax in AML Patients
A Phase 1b, open-label, multicenter, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of intravenously (IV) administered CLN-049 in combination with…
- Trial name
- NCT07722767
- Testing
- CLN-049, Azacitidine, Venetoclax
- Where
- 5 sites in United States
- Volunteers
- 90 people
- Sponsor
- Cullinan Therapeutics Inc.
Acute Myeloid Leukemia
A Study of Midostaurin Efficacy and Safety in Newly Diagnosed Patients With FLT3-mutated AML
This study evaluated the efficacy and safety of midostaurin in combination with daunorubicin/cytarabine induction, high dose cytarabine consolidation and midostaurin single agent continuation therapy in newly diagnosed patients…
- Trial name
- NCT03280030
- Testing
- Midostaurin
- Where
- 34 sites in Hong Kong, Japan and 4 more
- Volunteers
- 67 people
- Sponsor
- Novartis Pharmaceuticals
Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia
Milademetan Tosylate and Low-Dose Cytarabine With or Without Venetoclax in Treating Participants With Recurrent or Refractory Acute Myeloid Leukemia
This phase I/II trial studies the side effects and best dose of milademetan tosylate and to see how well it works with cytarabine with or without ventoclax in treating participants with acute myeloid leukemia that has come back…
- Conditions
- Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
- Trial name
- NCT03634228
- Testing
- Cytarabine, Milademetan Tosylate, Venetoclax
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer, Diagnoses Disease
Breaking Potentially Bad News in Lung Cancer Workup: Telephone Versus In-person Breaking of Final Diagnosis
Disclosure of bad news is challenging for patients, relatives and healthcare providers. Current protocols for breaking bad news assume a single, in-person meeting for breaking bad news, however cancer workup is not a single event…
- Conditions
- Lung Cancer, Diagnoses Disease, Psychosocial Stressor
- Trial name
- NCT04315207
- Testing
- Telephone call, In-person meeting
- Where
- Denmark
- Volunteers
- 225 people
- Sponsor
- Naestved Hospital
Unconscious (Psychology)
Diagnostic Value of Arterial Blood Gas Analysis in Prehospital Patients
In the anesthesiologist-manned mobile emergency car unit an analyzing device for blood gas testing is present since 2014. This study will determine if a prehospital arterial blood gas helps the doctor to make more precise…
- Trial name
- ABL (NCT03006692)
- Testing
- With arterial blood gas, parameters not being normal can be corrected
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Odense University Hospital
Epithelial Ovarian Carcinoma, Fallopian Tube Carcinoma
A Study of Maintenance DCVAC/OvCa After First-line Chemotherapy Added Standard of Care
This is a randomized, double-blind, placebo-controlled,parallel-group preliminary verifying study about safety and efficacy of maintenance DCVAC/OvCa after first-line chemotherapy added to standard of care in patients with newly…
- Conditions
- Epithelial Ovarian Carcinoma, Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma
- Trial name
- NCT04834544
- Testing
- DCVAC/OvCa
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Peking University Third Hospital
Sexual Dysfunction, Physiological
The Efficacy, Safety And Toleration Of CP-866,087 In Pre-Menopausal Women With Female Sexual Arousal Disorder.
CP-866,087 is a non-hormonal compound, acting on the central nervous system, which has been shown in animal models to restore sexual function.
- Trial name
- NCT00482664
- Testing
- CP-866,087
- Where
- 12 sites in Australia, Denmark and 3 more
- Volunteers
- 84 people
- Sponsor
- Pfizer
Ileus, Nursing Care
Abdominal Hot Water Bag Aplication Ileus Care
The role of nurses in the management of ileus is very important as they are part of the multidisciplinary approach. The study aimed to determine the effect of a hot water bag applied to the abdominal region on pain caused by…
- Conditions
- Ileus, Nursing Care, Pain
- Trial name
- Ileus (NCT07248098)
- Testing
- hot water application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Newly Diagnosed, High Risk
Treatment of High-risk Newly Diagnosed Multiple Myeloma With Minimal Residual Disease Detection
The goal of this study is to evaluate sustained MRD negativity for one year in DKRD induction \& consolidation therapy +/- ASCT in newly diagnosed high-risk multiple myeloma patients.
- Conditions
- Newly Diagnosed, High Risk, MRD, Multiple Myeloma
- Trial name
- NCT06409702
- Testing
- Carfilzomib, Daratumumab, Lenalidomide
- Where
- China
- Volunteers
- 59 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Multiple Myeloma
Exercise in Patients With Multiple Myeloma
The overall aim is to examine whether early initiated, individualized exercise training in patients newly diagnosed with multiple myeloma, irrespective of age and current performance status, will be beneficial for the…
- Trial name
- EMMY (NCT02439112)
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Zealand University Hospital
Lung Cancer, Solitary Pulmonary Nodule
4-[18F]Fluoroglutamine PET/CT in Imaging Patients With Newly Diagnosed Lung Cancer or Indeterminate Pulmonary Nodules
This clinical trial studies positron emission tomography (PET) imaging utilizing 18F-(2S,4R)4-fluoroglutamine, a glutamic acid derivative, to image patients with Newly Diagnosed Lung Cancer or Indeterminate Pulmonary Nodules.
- Conditions
- Lung Cancer, Solitary Pulmonary Nodule, Cigarette Smoking Behavior
- Trial name
- GLN (NCT03568799)
- Testing
- 18F-(2S,4R)4-fluoroglutamine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Prostate Cancer
Imaging Study to Investigate Safety and Diagnostic Performance of 18F rhPSMA 7.3 PET Ligand in Suspected Prostate Cancer Recurrence
A prospective, Phase 3, multi center, single-arm, imaging study investigating the safety and diagnostic performance of rhPSMA 7.3 (18F) Positron Emission Tomography (PET) ligand in men with suspected prostate cancer recurrence…
- Trial name
- NCT04186845
- Testing
- rhPSMA-7.3 (18F) Injection, Positron emission tomography scan
- Where
- 28 sites in United States, Finland and 1 more
- Volunteers
- 391 people
- Sponsor
- Blue Earth Diagnostics
Stage I Ovarian Cancer, Borderline Ovarian Tumors
A Prospective Multicenter Diagnostic Biomarker Study to Discriminate Borderline From Stage I Invasive Ovarian Cancer
The study aims to improve the diagnosis of ovarian cancer by distinguishing between borderline ovarian tumors (BOT) and stage I invasive ovarian cancer.
- Trial name
- BIOC (NCT06709872)
- Where
- 4 sites in Belgium, Czechia and 1 more
- Volunteers
- 400 people
- Sponsor
- KU Leuven
Hypercholesterolemia, Myopathy
DNA Diagnostic System for Statin Safety and Efficacy
Lipitor®, Zocor®, and Crestor® are statin drugs commonly taken to lower cholesterol and prevent heart disease. Statins lower cholesterol by different amounts in different patients and sometimes statins cause muscle pain, cramps…
- Trial name
- SIM (NCT00767130)
- Where
- 3 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Genomas, Inc
Breast Cancer
Evaluation of the Efficacy of Digital Breast Tomosynthesis Imaging
The primary objective of this protocol is to collect the 2-dimensional (2D) screening and diagnostic images, and 3-dimensional (3D) Digital Breast Tomosynthesis (DBT) scans from patient mammography examinations acquired on…
- Trial name
- DBT (NCT01373671)
- Testing
- SIEMENS INSPIRATION DIGITAL BREAST TOMOSYNTHESIS (DBT) SYSTEM
- Where
- United States
- Volunteers
- 764 people, healthy volunteers welcome
- Sponsor
- Siemens Medical Solutions USA - CSG
Candida Auris Infection, Candida Auris Colonization
Evaluation of Rapid Diagnostic Device for the Detection of Candida Auris
"Candida auris is an emerging fungus that can cause severe infections, particularly in hospitalized patients, and is often resistant to multiple antifungal treatments.
- Conditions
- Candida Auris Infection, Candida Auris Colonization, Nosocomial Infections
- Trial name
- DiagRaMIE Caur (NCT07253311)
- Testing
- NG-TestⓇ C.auris kit
- Where
- Greece
- Volunteers
- 554 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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