Clinical trials: Diseases/Diagnoses
Autoimmune Hepatitis
Budesonide 3x3mg/d Versus Prednisone in Active Autoimmune Hepatitis
This is a multicentre, multinational clinical study. It comprised two consecutive segments (A and B). Segment A was designed as a randomized, double-blind, double-dummy, active-controlled, two-arm parallel-group study.
- Trial name
- NCT00838214
- Testing
- budesonide, prednisone
- Where
- Germany
- Volunteers
- 208 people
- Sponsor
- Dr. Falk Pharma GmbH
Branch Atheromatous Disease, Acute Ischemic Stroke
Early Identification and Diagnosis of BAD-related Stroke
Branch atheromatous disease (BAD)-related stroke is an important subtype of acute ischemic stroke involving penetrating arteries and is associated with early neurological deterioration.
- Conditions
- Branch Atheromatous Disease, Acute Ischemic Stroke, Cerebral Infarction
- Trial name
- SMART-BAD (NCT07693816)
- Testing
- Multisource clinical-imaging artificial intelligence diagnostic assessment
- Where
- 11 sites in China
- Volunteers
- 1,602 people
- Sponsor
- Peking Union Medical College Hospital
Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1
Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
This phase II/III trial is studying the side effects and how well giving dasatinib together with combination chemotherapy works in treating young patients with newly diagnosed acute lymphoblastic leukemia (ALL).
- Conditions
- Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1, Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1
- Trial name
- NCT00720109
- Testing
- Asparaginase, Cyclophosphamide, Cytarabine
- Where
- 134 sites in United States, Australia and 3 more
- Volunteers
- 63 people
- Sponsor
- National Cancer Institute (NCI)
Ankle Injuries, Instability; Ankle (Ligaments) (Old Injury)
A Morphological Study in Volleyball Athletes With Cronic Ankle Instability
The former purpose of this study to investigate the effect of transverse abdominis, lumbar multifidus, vastus lateralis, lateral gastrocnemius, anterior talofibular ligament of morphology on explosive power and balance…
- Conditions
- Ankle Injuries, Instability; Ankle (Ligaments) (Old Injury), Radiological Devices Associated With Adverse Incidents, Diagnostic and Monitoring Devices, Athlete Foot
- Trial name
- NCT05746663
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Atrial Fibrillation, Atrial Fibrillation New Onset
Diagnostic Approach of Early Atrial Fibrillation, Silent Stroke and Cognitive Disorder in Patients With High-risk
The goal of this observational study is to determine the impact of the combined use of cardiac rhythm recording devices, biomarkers, echocardiogram, and Magnetic Resonance Imaging (MRI) on the early detection of AF, silent…
- Conditions
- Atrial Fibrillation, Atrial Fibrillation New Onset, Dementia, Stroke
- Trial name
- PREFA-TE (NCT05772806)
- Testing
- Electrocardiogram
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Pulmonary Embolus/Emboli, Thromboembolism, Pulmonary
Venous Phase Dual Energy CT in Patients Suspected for Pulmonary Embolism.
Venous phase spectral or dual energy (DE) chest computed tomography (CT) in patients with suspected pulmonary embolism (PE) compared to standard computed tomography pulmonary angiography (CTPA): sensitivity, evaluation of iodine…
- Trial name
- NCT04859478
- Testing
- Dual energy / spectral portal venous chest computed tomography
- Where
- 2 sites in Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital at Herlev
Type 1 Diabetes, Diabetes Mellitus, Type 1
Insulin and Abatacept in Recently-diagnosed Type 1 Diabetes
The goal of this clinical trial is to test whether the combination of two safe immune therapies called abatacept and nasal insulin can preserve pancreas function in recently-diagnosed type 1 diabetes.
- Trial name
- IAA (NCT05742243)
- Testing
- Abatacept (CTLA4-Ig) and nasal insulin (Humulin R®)
- Where
- 6 sites in Australia
- Volunteers
- 68 people
- Sponsor
- Melbourne Health
Injection Site Reaction
Prospective Study to Assess Tissue Responses After Injection With Biostimulatory Products
The objective of this study is to identify and assess in vivo tissue responses after injection with various biostimulatory products at various timepoints.
- Trial name
- NCT06093815
- Testing
- Injection
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Acute Myeloid Leukemia (AML)
Randomized Phase III Study of Intensive Chemotherapy With or Without Dasatinib (Sprycel™)
This is a randomized phase III open-label, multicenter trial evaluating standard induction therapy (daunorubicin [DNR] and cytarabine [Ara-C]) and consolidation therapy (high-dose cytarabine [HDAC]) with or without dasatinib in…
- Trial name
- NCT02013648
- Testing
- Dasatinib, Cytarabine, Daunorubicin
- Where
- 54 sites in Austria, Germany
- Volunteers
- 204 people
- Sponsor
- University of Ulm
Breast Cancer
Nipple Secretion Samples in Detecting Breast Cancer in Patients and Healthy Participants Undergoing Breast Cancer Screening, Breast Diagnostic Studies, or Treatment for Benign Breast Disease
RATIONALE: Diagnostic procedures that measure biomarker levels in nipple section and blood samples, may help in the early detection of breast cancer.
- Trial name
- NCT00813878
- Testing
- protein analysis, protein expression analysis, proteomic profiling
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- City of Hope Medical Center
Glioblastoma
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma
Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/III response adaptive randomization platform trial designed to evaluate multiple therapies in newly diagnosed…
- Trial name
- GBM AGILE (NCT03970447)
- Testing
- Temozolomide, Lomustine, Regorafenib
- Where
- 63 sites in United States, Australia and 4 more
- Volunteers
- 2,250 people
- Sponsor
- Global Coalition for Adaptive Research
Immune Deficiency, HIV-related Gut Disease - Cause Unknown
Immune Activation in HIV-1 Infected Patients Under AntiRetroviral Treatment
Immune Activation persists in HIV-1 infected patients despite efficient antiretroviral treatment. This immune activation is responsible for immune deficiency as well as for non-AIDS related comorbidities, such as non-alcoholic…
- Conditions
- Immune Deficiency, HIV-related Gut Disease - Cause Unknown, Activation of Latent Virus, Other Diagnoses, Comorbidities, and Complications
- Trial name
- ACTIVIH (NCT02334943)
- Testing
- Blood test
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Aortic Valve Stenosis
Aortic Stenosis Pre-Transcatheter Aortic Valve Replacement (TAVR) Procedure CT Scan
The purpose of this study is to evaluate contrast media volume, safety and 30-day outcome of patients after a computed tomography (CT) scan.
- Trial name
- NCT01843426
- Testing
- Low-volume, low-concentration contrast (iodixanol - Visipaque 270) CT scan
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Respiratory Infections, Antibiotic
Study Evaluating the Impact of Using Triplex Rapid Diagnostic Tests (SARS-CoV-2/Influenza/RSV) on Antibiotic Prescribing
Respiratory infections are very common, especially during winter, and are often caused by viruses such as influenza, SARS-CoV-2 or respiratory syncytial virus (RSV).
- Trial name
- TROD-VILLE (NCT07243249)
- Testing
- TROD
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrhythmia, Diagnostic/Monitoring Devices Related to Adverse Incidents
Cardiac Arrhythmia Telemetry; Conventional vs HeartWatch
Heart rhythm disorders are common and significantly impact the lives of those affected and their families. The main problems can be categorized as: a) atrial fibrillation or AF and atrial flutter, b) supra-ventricular tachycardia…
- Conditions
- Cardiac Arrhythmia, Diagnostic/Monitoring Devices Related to Adverse Incidents, Atrial Fibrillation (AF)
- Trial name
- CATCH (NCT06164808)
- Testing
- HeartWatch
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- HelpWear Inc.
Tennis Elbow
Non-Surgical Treatment Approaches in Patients With Newly Diagnosed Lateral Epicondylitis: A Randomized Clinical Trial
Lateral epicondylitis (tennis elbow) is a painful musculoskeletal condition, which is considered to be due to overuse, over-stress or over-exertion of the wrist extensors of the forearm, especially extensor carpi radialis brevi.
- Trial name
- NCT02930304
- Testing
- first physiotherapy, second physiotherapy, third physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Hacettepe University
Marginal Zone Lymphoma
Optimize Study - Orelabrutinib Combined With BR/G in Untreated Marginal Zone Lymphoma (MZL)
This is a multi-center, prospective cohort study. The main purpose of Cohort A is to evaluate the efficacy and safety of Orelabrutinib combined with BR (bendamustine and rituximab) for previously untreated young patients with…
- Trial name
- NCT06504940
- Testing
- Orelabrutinib combined with bendamustine and rituximab, Orelabrutinib combined with obinutuzumab
- Where
- China
- Volunteers
- 69 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Peripheral Arterial Disease (PAD), Ankle Brachial Index
Automated ABPI in Peripheral Arterial Disease a Pilot Study
The aim of this pilot study is to investigate the diagnostic accuracy of two automated ABPI devices across the spectrum of PAD (asymptomatic PAD, suspected symptomatic PAD [IC; including mild moderate and severe IC based on the…
- Conditions
- Peripheral Arterial Disease (PAD), Ankle Brachial Index, Diagnostic Accuracy, Feasibility Studies
- Trial name
- AUTO-PAD (NCT07850349)
- Testing
- MESI mTablet, BlueDop vascular Expert (BlueDopVE)
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Wound Heal, Oral Dryness
Assessing the Efficacy of a Carbamide Peroxide Mouthwash for Oral Wound Healing, Oral Hygiene and Xerostomia Relief
The aim of this study is to evaluate the efficacy and safety of a carbamide peroxide mouthwash regarding oral wound healing, postoperative symptoms, xerostomia (dry mouth) and oral hygiene improvement.
- Conditions
- Wound Heal, Oral Dryness, Postoperative Pain, Sjogren's Syndrome
- Trial name
- NCT06363955
- Testing
- Carbamide Peroxide Mouthwash
- Where
- Greece
- Volunteers
- 54 people
- Sponsor
- National and Kapodistrian University of Athens
Alzheimer Disease (AD)
Generation of Synthetic [18F]FDG PET From Early-Phase Amyloid PET in Alzheimer's Disease
This study aims to test a new artificial intelligence (AI) method to create brain scan images without needing an extra scan. Currently, patients with memory problems often undergo two types of PET scans (Amyloid PET and FDG PET)…
- Trial name
- NCT07431255
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- IRCCS San Raffaele
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