Clinical trials: Diseases/Diagnoses
Intrauterine Adhesion
Investigating the Association Between Diagnostic and Therapeutic Management Models and Prognosis of Intrauterine Adhesions Based on a Large-Scale Prospective Cohort Study
This research plan aims to explore a new diagnosis and treatment management model for intrauterine adhesions and verify its efficacy and feasibility through a multicenter real-world study.
- Trial name
- NCT07421908
- Testing
- Transcervical resection of adhesion, Uterine cavity stent, Traditional Chinese medicine for tonifying the kidney
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Myeloproliferative Disorder, Essential Thrombocythemia
Pilot Study for the Development of a Diagnostic Score to Differentiate Myeloproliferative Neoplasms.
Prospective study for the development of a non-invasive score for differentiating prefibrotic myelofibrosis from essential thrombocytosis and overt myelofibrosis.
- Conditions
- Myeloproliferative Disorder, Essential Thrombocythemia, Primary Myelofibrosis, Prefibrotic Stage, Primary Myelofibrosis, Fibrotic Stage
- Trial name
- BioScoreSMP (NCT03869476)
- Testing
- Non-invasive diagnosis score
- Where
- 2 sites in France
- Volunteers
- 133 people
- Sponsor
- University Hospital, Angers
COVID-19
A Single-center, Interventional Diagnostic Study With Minimal Risks and Constraints, Aimed at Longitudinally Evaluating Serum Antibody Levels in Patients With COVID-19 According to the Severity of Their Symptoms.
The COVERT protocol was designed to assess, through a longitudinal analysis, the level of antibodies present in the serum of patients with COVID-19, the duration and the persistence of the humoral response in correlation with the…
- Trial name
- COVERT (NCT06862531)
- Testing
- blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Bioaster
Cystitis, Interstitial
Smartphone-based Self-care Education Program for Women With Interstitial Cystitis: Educational Remote IC Aide
To implement and assess clinical efficacy of a text message and multimedia-based program that (i) remotely delivers first- and second-line American Urological Association (AUA) treatments of IC/BPS; (ii) integrates treatment of…
- Trial name
- ERICA (NCT05260112)
- Testing
- ERICA
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Pennsylvania
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Megakaryoblastic Leukemia (M7)
Tipifarnib and Etoposide in Treating Older Patients With Newly Diagnosed, Previously Untreated Acute Myeloid Leukemia
This randomized phase II trial is studying the side effects and how well giving tipifarnib together with etoposide works in treating older patients with newly diagnosed, previously untreated acute myeloid leukemia.
- Conditions
- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a)
- Trial name
- NCT00602771
- Testing
- tipifarnib, etoposide
- Where
- 5 sites in United States
- Volunteers
- 84 people
- Sponsor
- National Cancer Institute (NCI)
Severe Mental Illness
Physical Activity for People With Behavioral Diagnoses
Our aims are to 1) test that our intervention that can be measured with high fidelity. 2) determine the feasibility of the intervention including recruitment, procedures, measures, intervention acceptability and resources .
- Trial name
- NCT05041634
- Testing
- IHOPE
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Oklahoma
Dental Caries
AI-Based Detection of Dental Caries in Children
This study aims to evaluate the effects of an artificial intelligence (AI)-based caries detection system on the diagnosis and categorization of dental caries in pediatric patients.
- Trial name
- NCT06984029
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Noura Nageh Ramadan Ahmed
Heart, Heart Failure
Kosmos PLAX EF Pivotal Study
The purpose of this study is to validate the efficacy of Kosmos PLAX EF, an AI-assisted workflow that uses a cardiac ultrasound clip in Parasternal Long Axis (PLAX) cardiac view to calculate Left Ventricular Ejection Fraction…
- Conditions
- Heart, Heart Failure, Ejection Fraction, Left Ventricular Ejection Fraction
- Trial name
- NCT07771231
- Testing
- PLAX EF Manual vs. Automatic Measurement
- Where
- United States
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- EchoNous Inc.
Cerebral Vasospasm
Non-Significant Risk Study Comparing the Nautilus NeuroWaveTM to Transcranial Doppler as an Aid to Diagnosing Vasospasm
The purpose of the study is to determine the sensitivity, specificity and predictive values of the Jan Medical NeuroWave System in detecting moderate and severe vasospasm in comparison to Trans Cranial Doppler(TCD).
- Trial name
- NCT01595802
- Testing
- Nautilus NeuroWave, Transcranial Doppler (TCD)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Jan Medical, Inc.
Arrhythmias, Cardiac
Automated Diagnostic Performance of Smartwatch ECG for Arrhythmia Detection Using the PulseAI Neural Network.
The study is to evaluate the performance of the PulseAI neural network technology at interpreting ECG data recorded using a single-lead Smartwatch (Apple Watch).
- Trial name
- NCT05668377
- Testing
- PulseAI ECG Platform
- Where
- Ireland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- PulseAI Ltd
Caries,Dental
Caries Detection With Two Different Caries Detecting Devices
The primary aim of this study will be to compare the effectiveness of the novel LumiCare™ rinse and with QLF in determining caries progression.
- Trial name
- NCT06152081
- Testing
- LumiCare rinse, QLF Inspektor Pro Imaging
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tufts University
Brain and Central Nervous System Tumors
Temozolomide in Treating Patients With Anaplastic Oligodendroglioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of temozolomide in treating patients with anaplastic…
- Trial name
- NCT00003465
- Testing
- temozolomide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
COVID-19, Corona Virus Infection
Hydroxychloroquine in Patients With Newly Diagnosed COVID-19 Compared to Standard of Care
This study will assess the efficacy of hydroxychloroquine in reducing the severity of symptoms in patients with COVID-19
- Conditions
- COVID-19, Corona Virus Infection, SARS-CoV-2, 2019-nCoV
- Trial name
- NCT04334967
- Testing
- Hydroxychloroquine, Vitamin C
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Providence Health & Services
Low Back Pain, Muscle Atrophy
Effect of a Supervised Exercise Program in Patients With Chronic Low Back Pain
This study evaluates the effect of a supervised exercise program on paraspinal muscle morphology and function, as well as disability/function in patients with non-specific chronic low back pain.
- Conditions
- Low Back Pain, Muscle Atrophy, Diagnostic Imaging, Exercise Therapy
- Trial name
- NCT04257253
- Testing
- Targeted exercise program, General exercise program
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Concordia University, Montreal
Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders
Telepsychiatry in Children: Diagnostic Evaluation of Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder recognized as a major national cause in 2012. The French Autism Plan 2018-2022 emphasizes early diagnosis and intervention for better cognitive and behavioral…
- Trial name
- TELE-TSA (NCT06622395)
- Testing
- Remote diagnosys
- Where
- France
- Volunteers
- 137 people
- Sponsor
- Centre Hospitalier St Anne
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, NAFLD - Non-Alcoholic Fatty Liver Disease
Development of a Quantifiable Ultrasound Biomarker for Hepatic Steatosis
The research study is considering a non-invasive way to measure the percentage of fat in the liver using ultrasound. This could help detect early signs of a very common condition called metabolic dysfunction-associated steatotic…
- Trial name
- LYNX (NCT07270601)
- Testing
- Verasonics NXT Data Acquisition System, Philips EPIQ Elite, EchoSense FibroScan
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- ContextVision AB
Pelvic Floor Disorders, Pelvic Organ Prolapse
Pelvic Floor Rehabilitation of Female Pelvic Floor Dysfunction
The goal of this observational study is to learn about the therapeutic effects of different pelvic floor rehabilitation treatments, including pelvic floor muscle training , pelvic floor biofeedback electrical stimulation, and…
- Trial name
- NCT06461234
- Testing
- Pelvic floor muscle training, Biofeedback electrical stimulation, Magnetic Stimulation
- Where
- China
- Volunteers
- 1,360 people
- Sponsor
- Mingfu Wu
Community-acquired Pneumonia
Accuracy of Lung Injury Biomarkers in the Initial Investigation of Patients With Suspected Pneumonia
The aim of this study is to investigate the diagnostic and prognostic value of surfactant protein D, Krebs von den Lungen (KL-6), and Chitinase-3-like protein 1 (YKL-40) in the initial investigation of patients hospitalized with…
- Trial name
- NCT04686331
- Testing
- Biomarkers for pneumonia
- Where
- Denmark
- Volunteers
- 411 people
- Sponsor
- University of Southern Denmark
Pulmonary Tuberculosis Suspected, Other Specified Chronic Obstructive Pulmonary Disease
ENOSE in Pulmonary Tuberculosis in Yogyakarta
Electronic noses detecting patterns of volatile molecules have recently been introduced for different diagnostic purposes. The diagnostic accuracy of a prototype e-nose device (Bruins et al (2013) in Bangladesh showed sensitivity…
- Conditions
- Pulmonary Tuberculosis Suspected, Other Specified Chronic Obstructive Pulmonary Disease, Pulmonary Tuberculosis TB (+) Histology, (-) Bacteriology
- Trial name
- YOGYATBNOSE (NCT02219945)
- Testing
- 5 min exhaled breath sampling with soft nose clamp
- Where
- Indonesia
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Tjip van der Werf
Total Hip Arthroplasty (THA)
Observational Study on AI Accuracy in Diagnosing and Treating Failed or Painful Hip Arthroplasty
Primary Goal: This study aims to evaluate the diagnostic and therapeutic accuracy of GPT-4 (an advanced AI language model) compared to three orthopedic surgeons with varying experience levels in cases of failed or painful total…
- Trial name
- PAINGPT (NCT07012577)
- Testing
- GPT-4 Assessment, Arthroplasty Fellow Assessment, Specializing Resident (4th year) Assessment
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
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