Clinical trials: Diseases/Diagnoses
Diabetes Mellitus, Type 2
Effect of Liraglutide Combined With Short-term CSII on Long-term Glycemic Remission and β Cell Function
The purpose of this study is to investigate and evaluate the effects of liraglutide combined with short-term continuous subcutaneous insulin infusion(CSII) on long-term glycemic control and β-cell function in newly diagnosed type…
- Trial name
- NCT01790308
- Testing
- CSII, Liraglutide
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Prostate Carcinoma
Multiparametric MRI in Evaluating Cancer Stage and Helping Treatment Planning in Patients With Prostate Cancer
This phase II trial studies how well multiparametric magnetic resonance imaging (MRI) works in evaluating cancer stage and helping treatment planning in patients with prostate cancer.
- Trial name
- NCT03697148
- Testing
- Multiparametric Magnetic Resonance Imaging
- Where
- 44 sites in United States
- Volunteers
- 852 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Cardiac Arrest
Coronariography in OUt of hosPital Cardiac arrEst
Prospective, multicenter, randomized clinical trial. Survivors from an out-of-hospital cardiac arrest (OHCA) without ST segment elevation in their EKG will be recruited.
- Trial name
- COUPE (NCT02641626)
- Testing
- Urgent Coronary Angiography, Deferred Coronary Angiography
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- Hospital San Carlos, Madrid
T Acute Lymphoblastic Leukemia, T Lymphoblastic Lymphoma
Adding Targeted Drugs to Usual Chemotherapy for Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LBL)
This phase II trial tests the safety and effectiveness of giving chemotherapy with or without venetoclax and/or navitoclax for the treatment of patients with newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL) or T-cell…
- Trial name
- NCT06210750
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Sponsor
- National Cancer Institute (NCI)
Diffuse Intrinsic Pontine Glioma, Brain Tumor, Recurrent
Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors
This is a Phase I clinical trial evaluating abemaciclib (LY2835219), an inhibitor of cyclin dependent-kinases 4 and 6 (Cdk 4/6) in children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) (Stratum A)…
- Conditions
- Diffuse Intrinsic Pontine Glioma, Brain Tumor, Recurrent, Solid Tumor, Recurrent, Neuroblastoma, Recurrent, Refractory
- Trial name
- AflacST1501 (NCT02644460)
- Testing
- Abemaciclib
- Where
- 4 sites in United States
- Volunteers
- 53 people
- Sponsor
- Emory University
Tele-nursing
The Effect of Nursing Follow-Up by Phone on The Self-Efficacy,Pain,Disease Activity in Rheumatoid Arthritis Patients
The aim of this study was to determine the effect of nursing follow-up by phone on the self-efficacy status, pain, and disease activity of individuals with RA using biological agents.
- Trial name
- NCT05863338
- Testing
- NURSING FOLLOW-UP BY PHONE
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Cumhuriyet University
Multiple Myeloma
Iberdomide-dexamethasone Alone or in Combination With Standard MM Treatment Regimens in Transplant Ineligible Newly Diagnosed Patients.
This is a multicenter, phase II, national, and open-label study to evaluate the efficacy and safety of two different combinations, iberdomide-dexamethasone (IBERDEX) and iberdomide-dexamethasone in combination with daratumumab…
- Trial name
- NCT05527340
- Testing
- Iberdomide, Dexamethasone, Daratumumab
- Where
- 9 sites in Spain
- Volunteers
- 140 people
- Sponsor
- PETHEMA Foundation
Multiple Myeloma
Linvoseltamab in Addition to Lenalidomide (L2) During Maintenance Therapy of NDMM to Deepen Responses or Redrive MRD Negativity After Relapse
The purpose of this study is to determine whether giving linvoseltamab with lenalidomide during maintenance treatment to participants with multiple myeloma will: 1.
- Trial name
- NCT06910124
- Testing
- Linvoseltamab, Lenalidomide
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Dickran Kazandjian, MD
Prostate Carcinoma
A Point of Prostate Cancer Diagnosis Virtual Reality Assistant Intervention in Supporting Newly Diagnosed Black Men
This clinical trial tests how well a point of prostate cancer diagnosis (PPCD) virtual reality assistant (ViRA) intervention works in supporting Black men with newly diagnosed prostate cancer.
- Trial name
- NCT07126548
- Testing
- Best Practice, Discussion, Survey Administration
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Alcohol Use, Drug Use
Trial of an Adapted STD Screening and Risk Reduction Intervention
The goal of this research study is to evaluate the impact of a paraprofessional-delivered, culturally adapted, evidence-based intervention (EBI) on sexually transmitted disease (STD), substance use and poor mental/emotional…
- Conditions
- Alcohol Use, Drug Use, Diagnostic Self Evaluation, Gonorrhea
- Trial name
- NCT02513225
- Testing
- Project EMPWR, Optimized Standard Care (OSC)
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Seizures, Development Delay
Review of Diagnostic Yield of MRI Brain Results in Children Under Age 3 Years
The investigators aim to identify the frequency with which an elective brain MRI yields and etiologic diagnosis to explain its indication.
- Conditions
- Seizures, Development Delay, Anesthetic Neurotoxicity
- Trial name
- NCT03561168
- Testing
- Change in plan of care based on MRI results
- Where
- United States
- Volunteers
- 561 people
- Sponsor
- Baylor College of Medicine
Acute Kidney Injury
Sonographic Venous Doppler Imaging in Acute Kidney Injury
The first presentations of patients with acute kidney injury (AKI) are usually to the emergency departments. While the mortality rate is 5-10% in uncomplicated AKI, it is between 40-90% in patients hospitalized in the intensive…
- Trial name
- NCT04948710
- Testing
- Sonography
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Gazi University
Light Chain (AL) Amyloidosis
A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of NXC-201 Compared With Daratumumab With Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) in Newly Diagnosed Systemic AL Amyloidosis
The purpose of this study is to evaluate the efficacy and safety of NXC-201 compared with Dara-CyBorD (daratumumab-cyclophosphamide-bortezomib-dexamethasone) in the treatment of newly diagnosed amyloid light chain (AL)…
- Trial name
- NEXICART-3 (NCT07709715)
- Testing
- NXC-201, Dara-CyBorD
- Volunteers
- 260 people
- Sponsor
- Nexcella Inc.
Central Nervous System Neoplasms
Diagnostic Efficiency of Artificial Intelligence for Surgical Neuropathology
This is a multi-center, prospective, self-controlled, diagnostic accuracy comparative study of Artificial Intelligence Diagnostic System for Surgical Neuropathology.
- Trial name
- NCT04671368
- Testing
- Artificial Intelligence, Practicing Pathologists, Gold Standard
- Volunteers
- 141 people
- Sponsor
- Jinsong Wu
Sepsis, Diagnosis
The RightCall: Implementing a Sepsis Diagnostic Toolkit to Improve Pediatric Diagnosis in ED Transfer Calls
Sepsis is a leading cause of death in children, and an early diagnosis that improves outcomes is less likely in children who are treated in general Emergency Departments (EDs), that treat adults and children, compared to…
- Conditions
- Sepsis, Diagnosis, Emergencies
- Trial name
- RightCall (NCT07051668)
- Testing
- Pediatric Sepsis Diagnostic Toolkit
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Colorado, Denver
Eye Cancer
MRI in Diagnosing Solid Tumors of the Eye and Orbit
This study is being done due to a new imaging method that may help others in the future to improve evaluation of diseases in the eye and eye socket and to help make a decision concerning best treatment of the disease.
- Trial name
- NCT01653080
- Testing
- dynamic contrast-enhanced MRI
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Cincinnati
Tuberculosis
Evaluation and Demonstration of New Tuberculosis Diagnostics for Indonesia
The goal of this cluster-randomised controlled trial (CRCT) is to learn whether the use of new non-sputum-based diagnostic tests and other intervention components for tuberculosis (TB) diagnosis in healthcare facilities (HCF) can…
- Trial name
- EVIDENT (NCT07293455)
- Testing
- nPOC Testing Intervention Package
- Where
- Indonesia
- Volunteers
- 40,000 people
- Sponsor
- Universitas Padjadjaran
Gallbladder Cancer
Predicting Incidental Gallbladder Cancer
The goal of this observational study is to identify risks factors for incidental (unexpected) gallbladder cancer in adult patients undergoing routine gallbladder surgery (cholecystectomy) for conditions such as gallstones or…
- Trial name
- P-iGBC (NCT06531408)
- Where
- United Kingdom
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Acute Lymphoblastic Leukemia, Child
Treatment of Newly Diagnosed High Risk Acute Lymphoblastic Leukemia in Children
Treatment of pediatric acute lymphoblastic leukemia (ALL) has advanced and the overall survival exceeds 80% nowadays. However the overall survival of high risk ALL remains 75-90%, thus recent studies focus on treatment…
- Trial name
- NCT02339350
- Testing
- high dose methotrexate, Intrathecal triple chemotherapy
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- The Korean Society of Pediatric Hematology Oncology
Health Services Misuse, Physician's Practice Patterns
Primary Care Clinician Commitments to Choosing Wisely®
This pragmatic trial examines the uptake and effects of primary care clinician commitments to follow 3 Choosing Wisely® recommendations.
- Conditions
- Health Services Misuse, Physician's Practice Patterns, Guideline Adherence, Unnecessary Procedures
- Trial name
- NCT02247050
- Testing
- Commitment invitation
- Where
- 6 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Michigan
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