Clinical trials: Diseases/Diagnoses
Prostate Carcinoma
Ultrasound-Based Imaging Using the Aixplorer System in Diagnosing Prostate Cancer in Patients Undergoing Biopsy
This clinical trial studies an ultrasound-based imaging procedure called elastography using the Aixplorer system in diagnosing prostate cancer in patients undergoing biopsy.
- Trial name
- NCT03013413
- Testing
- Shear Wave Elastography, Ultrasound Elasticity Imaging, Ultrasound-Guided Prostate Biopsy
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Chronic Graft-versus-Host-Disease, Allogeneic Hematopoietic Stem Cell Transplantation
Polyomic Biomarker Verification in Adult Chronic Graft-Versus-Host Disease (ABLE3.0/CTTC2201)
Chronic graft-versus-host disease (cGvHD) is one of the most serious complications following BMT (Bone Marrow Transplantation). cGvHD occurs when donor immune cells "attack" the tissues and organs of the person receiving the BMT.
- Conditions
- Chronic Graft-versus-Host-Disease, Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Blood Cancer
- Trial name
- NCT05692713
- Where
- 10 sites in United States, Canada
- Volunteers
- 320 people
- Sponsor
- University of British Columbia
Type 2 Diabetic Patients, T2DM (Type 2 Diabetes Mellitus)
Comparing the Efficacy and Safety Between Continuous Subcutaneous Beinaglutide and CSII for Newly Diagnosed T2DM Patients
The efficacy, safety and post-treatment disease control will be compared between groups of continuous subcutaneous Beinaglutide infusion and continuous subcutaneous insulin infusion (CSII) in adult patients with newly diagnosed…
- Conditions
- Type 2 Diabetic Patients, T2DM (Type 2 Diabetes Mellitus), T2DM
- Trial name
- NCT03987308
- Testing
- Beinaglutide, Insulin aspart
- Where
- 16 sites in China
- Volunteers
- 115 people
- Sponsor
- Beijing Hospital
Breast Cancer, Transcriptomes
Transcriptomes Breast, Ovarian and Leukocyte Hereditary Genes Predisposing to Breast and / or Ovarian Cancer
This is a case-control study of molecular diagnostics. This study requires two steps: The first part of the study will be conducted on a population of 20 women without breast cancer and, or ovarian family (Healthy Volunteers…
- Conditions
- Breast Cancer, Transcriptomes, Molecular Diagnostic, Ovarian Cancer
- Trial name
- CASOHAR (NCT02560818)
- Testing
- collection of a blood sample and breast and ovarian tissue, use of a previous blood collection for patients
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Francois Baclesse
Thyroid Nodule, Thyroid Carcinoma
CEUS Improves the Diagnostic Performance of SRSS of Thyroid Carcinoma
Contrast-enhanced ultrasound (CEUS) can sensitively show the blood perfusion characteristics of thyroid nodules, which is a useful supplement to gray-scale ultrasound.
- Trial name
- NCT06146764
- Testing
- Contrast-enhanced Ultrasound
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Bone Cancer, Ewing's Sarcoma
Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma
The outcome of patients with metastatic Ewings Sarcoma is poor with current standard of care chemotherapy, with less than 30% survival.
- Trial name
- NCT01313884
- Testing
- Irinotecan, Vincristine, Temozolomide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Stanford University
Age-Related Macular Degeneration (AMD), Neovascular Age-Related Macular Degeneration (nAMD) Wet AMD
The Efficacy of Home OCT Supported Management in Patients Diagnosed With Neovascular-AMD and Undergoing a Drug Switch to Faricimab
Age-related macular degeneration (AMD) is a common eye disease that can lead to vision loss. The neovascular ("wet") form of AMD is usually treated with repeated injections into the eye.
- Trial name
- NCT07744984
- Testing
- Home Optical Coherence Tomography (Home OCT)
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Rabin Medical Center
Epilepsy
A Prospective Cohort Study on the Comorbid Depression in Patients With Newly-diagnosed Epilepsy
Epilepsy is a chronic brain disease with recurrent seizures and the comorbidity of psychiatric diseases are very common. The prevalence of depression in patients with refractory epilepsy is about 60%.
- Trial name
- NCT04517058
- Testing
- psychology therapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Kidney Neoplasms
Evaluation of Diagnostic Value of Molecular Markers in Renal Cancer
Renal cancer is frequent and its diagnosis mainly dependant on imaging. More than 50% of renal tumors are currently diagnosed without symptoms.
- Trial name
- CMM (NCT00491621)
- Testing
- surgery or biopsy of the kidney tumor
- Where
- 7 sites in France
- Volunteers
- 74 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Vision Disorders
Optical Coherence Tomography Measurements in Eyes With Band Atrophy
The study is designed to evaluate the ability of optical coherence tomography and VCC scanning laser polarimetry to measure and identify the pattern of band atrophy of the optic nerve in patients with long standing chiasmal…
- Trial name
- NCT00395122
- Testing
- Retinal nerve fiber layer and macular thickness measurements
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Multiple Myeloma
A Phase III Trial on the Effect of Elotuzumab in VRD Induction /Consolidation and Lenalidomide Maintenance in Patients With Newly Diagnosed Myeloma
Trial in patients with newly diagnosed myeloma to evaluate the effect of elotuzumab in induction and consolidation therapy with bortezomib/lenalidomide/dexamethasone and in lenalidomide maintenance treatment
- Trial name
- GMMG-HD6 (NCT02495922)
- Testing
- elotuzumab, Lenalidomide, Bortezomib
- Where
- 68 sites in Germany
- Volunteers
- 564 people
- Sponsor
- University of Heidelberg Medical Center
Radiculopathy, Hoffman's Reflex
The Diagnostic Role of Adding the Hoffman Reflex Study for L5 Radiculopathy in the Electrodiagnostic Laboratory
The H-reflex is one of the most popular topics in reflexology and one of the late responses involved in routine nerve conduction studies in the electromyography (EMG) laboratory.
- Trial name
- NCT05269602
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- TC Erciyes University
Thoracoscopy, Pleural Effusion Disorder
Visual Assessment vs ROSE in Diagnosing Pleural Effusion Using Medical Thoracoscopy
The goal of this observational diagnostic study is to find how well two evaluation methods used during medical thoracoscopy can help identify whether pleural disease is malignant or benign.
- Trial name
- NCT07286045
- Testing
- Medical thoracoscopy
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Ain Shams University
Coronary Artery Disease, Myocardial Ischemia
Comprehensive Functional Assessments for NOCAD
To validate and investigate the efficacy of comprehensive functional assessments for the diagnostic and prognostic value in NOCAD.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Microvascular Dysfunction
- Trial name
- NCT06175572
- Testing
- coronary physiological indices
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Oral Leukoplakia (OL), Oral Squamous Cell Carcinoma (OSCC)
FENDRR and CRNDE With DUSP1 and DMBT1 in Oral Leukoplakia and Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is the most common cancer of the mouth and is often preceded by oral leukoplakia (OL), a white patch of the oral lining that can turn into cancer.
- Trial name
- NCT07906795
- Where
- Egypt
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Amina Fouad Farag
Lower Gastrointestinal Bleeding, Small Bowel Bleeding
Urgent Panendoscopy in Patients Presenting With Hematochezia
Gastrointestinal bleeding is a significant emergency condition requiring prompt diagnosis. Current evidence presents a clinical paradox: urgent colonoscopy (within 24 hours) shows no clear benefit in several studies, while urgent…
- Trial name
- NCT06985277
- Testing
- Urgent endoscopy strategy, Standard colonoscopy with standard VCE group
- Where
- Thailand
- Volunteers
- 188 people
- Sponsor
- Mahidol University
Antimicrobial Resistance
Algorithm Using a Rapid Diagnostic Test for the Management of Childhood Febrile Diseases.
In Sub-Saharan Africa (SSA), fever remains a major public health problem in children. The introduction of malaria rapid diagnostic tests (RDTs) in routine healthcare has greatly improved the management of malaria.
- Trial name
- e-MANIC (NCT05285657)
- Testing
- Two-step malaria RDT detecting PfHRP2/pLDH (SD Ag Bioline Malaria Ag P.f/Pan: Standard Diagnostics, Hagal-Dong, Korea)
- Where
- 2 sites in Burkina Faso
- Volunteers
- 1,176 people
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Colorectal Cancer
Assessment of the Diagnostic Role of Serum Insulin-like Growth Factor Binding Protein-3 as a Potential Biomarker for Colorectal Cancer (CRC) in Egypt
1. evaluation of diagnostic importance of insulin like growth factor binding protein3 in patient with recently diagnosed as Colorectal cancer 2.
- Trial name
- NCT05850559
- Testing
- evaluation of diagnostic importance of insulin like growth factor binding protein3 in patient with recently diagnosed as Colorectal cancer
- Volunteers
- 50 people
- Sponsor
- Assiut University
Disseminated Intravascular Coagulation (DIC)
A Clinical Study of KW-3357 in Patients With DIC
To evaluate the efficacy and safety of KW-3357 with concomitant use of heparin using multi-center, non-comparative, open-label method in patients diagnosed as disseminated intravascular coagulation (DIC) by the diagnostic…
- Trial name
- 3357-005 (NCT01384396)
- Testing
- KW-3357
- Where
- Japan
- Volunteers
- 15 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Gestational Diabetes Mellitus (GDM)
Screening for Dysglycemia During Postpartum Period in Women With GDM
Gestational diabetes mellitus (GDM) is one of the most common clinical conditions in pregnancy, with an increasing incidence due to the rise in overweight women and the postponement of motherhood.
- Trial name
- NCT07489456
- Testing
- Whatsapp message
- Where
- Brazil
- Volunteers
- 182 people
- Sponsor
- University of Sao Paulo General Hospital
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