Clinical trials: Diseases/Diagnoses
Acute Myeloid Leukemia
Phase II Clofarabine and Cytarabine for Newly Diagnosed Acute Myeloid Leukemia
The combination of clofarabine and cytarabine is an effective and reasonably well-tolerated treatment regimen in patients with either relapsed/refractory or newly diagnosed AML.
- Trial name
- UPCI 13-066 (NCT01960387)
- Testing
- Clofarabine, Cytarabine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Pittsburgh
Primary Aldosteronism
New Screening and Diagnostic Cut-off Points of PA Patients
This study aims to establish the screening and diagnostic cut-off points for primary aldosteronism patients by a novel small molecule "sandwich method" aldosterone and renin chemiluminescent immunoassay.
- Trial name
- NCT06571084
- Where
- China
- Volunteers
- 770 people
- Sponsor
- China National Center for Cardiovascular Diseases
Pancreatic Cancer
Diagnostic Laparoscopy in the Preoperative Staging of Pancreatobiliary Cancer
The purpose of this study is to evaluate the role of routine Staging Laparoscopy in patients with potentially resectable pancreatobiliary cancer.
- Trial name
- NCT02479984
- Testing
- Staging Laparoscopy, Laparoscopic ultrasound
- Where
- South Korea
- Volunteers
- 193 people
- Sponsor
- National Cancer Center, Korea
Diagnosis
Diagnostic Performance of Ai vs Junior Dentists
OBJECTIVES Compare diagnosis of Periapical lesions \& Proximal caries by AI and junior dentists Evaluate Validity of a deep learning based convolutional neural network (CNN) for detecting proximal caries lesions, periapical…
- Trial name
- NCT07908017
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Jordan
HIV Infections, Sexual Health
Sexual Health of Sub-Saharan African Migrant Women Recently Diagnosed With HIV in Île-de-France: Missed Opportunities for Prevention
This study looks at the sexual health of women from Sub-Saharan Africa who recently found out they have HIV after arriving in Île-de-France.
- Conditions
- HIV Infections, Sexual Health, Migrants, Women's Health
- Trial name
- NCT07011017
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Lymphoma, Lymphoblastic
German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults
This study evaluates the efficacy and tolerability of treatment for T-lymphoblastic lymphoma (T-LBL) according to a protocol for acute lymphoblastic leukemia.
- Trial name
- NCT00199017
- Testing
- Dexamethasone/Prednisolone, Cyclophosphamide, Vincristine
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Non-Small Cell Lung Cancer
Time Trends in Waiting Times of NSCLC Patients.
A large group of non-small cell lung cancer patients is treated with radiotherapy. Delivery of very high radiation doses is needed to obtain local control, but due to the large tumor and nodal volume this is often impossible…
- Trial name
- NCT01946490
- Where
- Netherlands
- Sponsor
- Maastricht Radiation Oncology
Neurodegenerative Diseases, Dementia
Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis
This cohort study aims to determine if a blood test can aid with diagnosing dementia in anyone presenting with cognitive complaints to a single healthcare network.
- Trial name
- NAVAIDD (NCT06339190)
- Testing
- Venepuncture
- Where
- 2 sites in Australia
- Volunteers
- 1,000 people
- Sponsor
- Monash University
Osteoarthritis, Knee, Pain
Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain
Chronic painful knee OA is a major cause of disability in older adults. In patients whose symptoms are refractory to conservative management but who do not wish to undergo TKA or, alternatively, are not operative candidates…
- Conditions
- Osteoarthritis, Knee, Pain, Nerve; Lesion
- Trial name
- NCT02578108
- Testing
- genicular nerve diagnostic block with lidocaine (local anesthetic), genicular nerve radiofrequency ablation
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Northwestern University
Brain Lesion (General), Mrs
Role of MRS in Brain Lesions
Aim of the study is evaluation of accuracy of magnetic resonance spectroscopy in differentiation between neoplastic and non neoplastic lesions and determination the type of neoplasm
- Trial name
- NCT05565690
- Testing
- MRS
- Volunteers
- 64 people
- Sponsor
- Assiut University
Steatosis, Obesity
Evaluation of the Diagnostic of Hepatic Fibrosis With the in Severe Obese Patients Candidates to Bariatric Surgery
Background: The XL probe of FibroScan was recently developed to realize liver stiffness measurements (LSM) in overweight patients.
- Conditions
- Steatosis, Obesity, Fibrosis, Liver
- Trial name
- NCT03548597
- Testing
- Evaluation of the Diagnostic of Hepatic Fibrosis With the XL Probe of the Fibroscan Versus Biopsies in Severe Obese Patients Candidates to Bariatric Surgery
- Volunteers
- 132 people
- Sponsor
- European Georges Pompidou Hospital
Multiple Myeloma
Study of Daratumumab Combined With Carfilzomib, Lenalidomide and Dexamethasone for Newly Diagnosed Multiple Myeloma
This study is being done because, despite major advances in therapy, MM is still considered an incurable disease. The purpose of this study is to determine the efficacy (how well it works) of the study treatment that combines the…
- Trial name
- NCT04113018
- Testing
- Carfilzomib, lenalidomide, dexamethasone (KRd) + Daratumumab
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Wake Forest University Health Sciences
Acute Myeloid Leukemia
Tipifarnib Versus Best Supportive Care in the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML)
The purpose of this study is to determine the effectiveness of tipifarnib in patients aged 70 or more with acute myeloid leukemia. Tipifarnib belongs to a class of drugs called Farnesyl Transferase Inhibitors (FTI).
- Trial name
- NCT00093990
- Testing
- Tipifarnib;Zarnestra; R115777
- Volunteers
- 457 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Breast Cancer, Benign Breast Condition
ATUSA Ultrasound Diagnostic Imaging for Breast Lesions Evaluation (AUDIBLE) - iSono Health
AUDIBLE is a multi-site, clinical study conducted in the United States aimed at gathering data on 3D Automated Breast Ultrasound imaging using the iSono Health ATUSA system.
- Conditions
- Breast Cancer, Benign Breast Condition, Breast Fibroadenoma, Breast Neoplasms
- Trial name
- AUDIBLE (NCT07505797)
- Testing
- ATUSA 3D Automated Breast Ultrasound System
- Where
- 2 sites in United States
- Volunteers
- 800 people
- Sponsor
- iSono Health, Inc.
Glioblastoma Multiforme
Trial of AEO in New Glioblastoma (GBM)
This is a multicenter, Phase 2, Proof-of-concept study in subjects with newly diagnosed glioblastoma multiforme (GBM). All subjects will receive standard of care therapy for the treatment of their GBM and any Anti-Epileptic Drug…
- Trial name
- AEO (NCT04450160)
- Testing
- Anhydrous Enol-Oxaloacetate (AEO), Standard of Care
- Volunteers
- 80 people
- Sponsor
- MetVital, Inc.
Periodontitis
AI-Based Radiographic Detection of Periodontal Defects
The primary objective of the study is to develop and validate a machine learning model for the automatic identification of periodontal vertical bone defects, improving diagnostic accuracy and efficiency.
- Trial name
- NCT07086625
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Cagliari
Type 1 Diabetes
Atorvastatin in New Onset Type 1 Diabetes Mellitus (T1DM)
The goal of this application is to evaluate the safety and efficacy of atorvastatin as a potential treatment to preserve beta cell function in children and young adults with newly diagnosed type 1 diabetes (T1DM).
- Trial name
- TIDM (NCT00529191)
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital of Philadelphia
Acute Promyelocytic Leukemia (APL)
Oral Arsenic With ATRA for Newly Diagnosed Patients With Acute Promyelocytic Leukemia
It is a non-randomized, multicenter, prospective study, aiming to treat patients with newly diagnosed acute promyelocytic leukemia with a combination of oral arsenic and atra, with low dose chemotherapy for those with high-risk…
- Trial name
- IC-APL2020 (NCT06982274)
- Testing
- Realgar-Indigo Naturalis Formulation
- Where
- Brazil
- Volunteers
- 115 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Chronic Kidney Diseases, Obesity
The Impact of Misclassification of Obesity by Body Mass Index on Mortality in Patients With Chronic Kidney Disease
Unlike the general population, a higher body mass index (BMI) is associated with greater survival among patients with chronic kidney disease (CKD).
- Trial name
- NCT03285074
- Testing
- No intervention
- Volunteers
- 326 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Pancreatic Cancer
Chyle Leak After Pancreatic Operation
With the development of pancreatic surgery, the surgeon has put more emphasis on chylous fistula as the postoperative complications in recent years.
- Trial name
- NCT03127150
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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