Clinical trials: Diseases of the Genitourinary System
Spermatogenesis and Semen Disorders, Infertility, Male
Power Prenatal Supplements for Sperm Quality
Male factor infertility is a leading cause of primary and secondary infertility. Poor sperm quality is defined as having an abnormal semen analysis [WHO 2020 - https://www.who.int/publications/i/item/9789240030787].
- Trial name
- NCT05410782
- Testing
- Power Prenatal for Sperm
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Bird and Be Co Inc
Diabetic Kidney Disease
Study to Evaluate the Pharmacokinetics of Selonsertib in Participants With Normal and Impaired Hepatic Function
The primary objective of this study is to evaluate the pharmacokinetics (PK) of selonsertib in participants with impaired hepatic function relative to matched, healthy controls.
- Trial name
- NCT02509624
- Testing
- Selonsertib
- Where
- 5 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Atherosclerosis, HIV Infections
Rosiglitazone (Avandia®) Treatment in HIV: Its Effect on Blood Vessels
This trial will study the effect of rosiglitazone on the progression of atherosclerosis (hardening of blood vessels) through improvements of the sugar and fat metabolism (body buildup, breakdown and excretion of sugar and fat).
- Trial name
- NCT00143624
- Testing
- Rosiglitazone maleate
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Cervical Intraepithelial Neoplasia
Topical Imiquimod vs. LEEP for Women With Carcinoma In-situ of the Cervix
OBJECTIVE: The standard of care for high grade cervical intraepithelial neoplasia grade 2 to 3 (CIN 2-3) has been the excision of the cervical transformation zone by way of a loop electrosurgical excision procedure (LEEP) or cold…
- Trial name
- NCT02130323
- Testing
- Imiquimod, Loop Electrosurgical Excision Procedure
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Stone, Kidney
Endoscopic Combined Intrarenal Surgery Versus Multi-Tract Percutaneous Nephrolithotomy for Complex Renal Stones:
The aim of this study is to compare outcomes of endoscopic combined intrarenal surgery (ECIRS) with the multi-tract percutaneous nephrolithotomy for management of complex renal stones.
- Trial name
- NCT05460559
- Testing
- Group A (p-PCNL) procedure, Group B (s-ECIRS) procedure
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Mansoura University
Chronic Kidney Disease
The Effect of Citrasate Dialysate on Heparin Dose in Hemodialysis
An alternative to systemic heparin anticoagulation for HD is citrate dialysate (CD). CD contains a small amount of citric acid rather than acetic acid as the acidifying agent.
- Trial name
- NCT01466959
- Testing
- citrate dialysate (CD), acetic-acid based dialysate (AD)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Stress Urinary Incontinence
Effects of Therapies in Women With Stress Urinary Incontinence
Purpose: This study aims to evaluate how surgical and medical treatments affect quality of life, depression status, and social participation in women with stress urinary incontinence (SUI).
- Trial name
- NCT06912880
- Testing
- trans obturator tape surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Eastern Mediterranean University
Uterine Cervical Neoplasms
Nimotuzumab High-risk, Locally Advanced Squamous Cell Carcinoma of the Cervix
The efficacy and safety of nimotuzumab in the treatment of high-risk, locally advanced squamous cell carcinoma of the cervix.
- Trial name
- CC11 (NCT06771596)
- Testing
- Nimotuzumab Injection
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
GYN Disorders
GENERATE - Next GENERATion of GynEcological Surgery - Robotic Assisted Surgery in Gynecological Indications
GENERATE - Next GENERATion of GynEcological Surgery - Robotic Assisted Surgery in Gynecological Indications Generate real-world evidence in the use of the da Vinci Surgical Systems for gynecological indications within the German…
- Trial name
- GENERATE (NCT05867927)
- Testing
- Robotic-assisted surgery (da Vinci), Non-da Vinci Surgery
- Where
- 15 sites in Germany
- Volunteers
- 1,250 people
- Sponsor
- Intuitive Surgical
PCOS (Polycystic Ovary Syndrome)
Can Drospirenone be Used to Prevent LH Surge in Controlled Ovarian Stimulation in PCOS?!
The goal of this clinical trial is to learn if drospirenone can work to prevent LH surge in controlled ovarian stimulation in PCOS cases undergoing ART cycles.
- Trial name
- PPOS (NCT06608186)
- Testing
- Cetrorelix drug, Drospirenone drug
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ahmed Saad
Oligospermia
Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men
This study will analyse the sperm global methylation status of 62 infertile men before assisted reproductive techniques. Some of these patients (20%) present hypomethylation of H19 locus.
- Trial name
- METHYLHOMME (NCT01239186)
- Testing
- methylation analyses on spermatozoa from infertile men
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ovarian Cancer, Malnutrition
Exercise and Nutrition Intervention in Ovarian Cancer
The objective of this multicenter randomized controlled trial is to compare a 6-month exercise and nutrition intervention (intervention group, IG) aimed at maintaining or improving physical functioning and quality of life with…
- Conditions
- Ovarian Cancer, Malnutrition, Muscle Wasting, Fatigue
- Trial name
- BENITA (NCT06250686)
- Testing
- combined exercise and nutrition intervention
- Where
- 7 sites in Germany
- Volunteers
- 185 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Stone Ureter
Outcome of URS in Fresh Versus Recurrent Cases of Stone Ureter
Comparison of Ureteroscopy in fresh versus recurrent cases of stone ureter
- Trial name
- NCT06592469
- Testing
- Ureteroscopy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
HIV Infection
Comparing the Effectiveness Between Ritonavir Boosted Atazanavir and Efavirenz for the First HIV Treatment
A selection study in treatment naive HIV patients to compare the virologic success rate of once daily antiretroviral treatment regimens at the 48th week with Epzicom(lamivudine and abacavir) plus efavirenz and Epzicom plus…
- Trial name
- NCT00280969
- Testing
- atazanavir arm, efavirenz
- Where
- Japan
- Volunteers
- 71 people
- Sponsor
- International Medical Center of Japan
Chronic Prostatitis, Pelvic Pain
Open-Label Study of Thalidomide for Chronic Prostatitis/Chronic Pelvic Pain
To determine the efficacy of thalidomide for treatment of the Chronic Pelvic Pain Syndrome (CPPS).
- Trial name
- NCT00301405
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Kenneth Peters, MD
Interstitial Cystitis, Bladder Pain Syndrome
The Female Microbiome in Patients Undergoing Bladder Instillation Therapy
The underlying pathophysiology for BPS/IC is currently an active area of research. There is speculation that there may be alteration in the bladder and vaginal microbiome that contributes to the symptomatology of BPS/IC, however…
- Conditions
- Interstitial Cystitis, Bladder Pain Syndrome, Microbial Colonization
- Trial name
- NCT05414305
- Testing
- Heparin & Alkalinized Lidocaine Bladder Instillation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Walter Reed National Military Medical Center
HIV Infections
NNRTI vs PI Regimens for HIV Infected Women After They Have Taken Nevirapine to Prevent Mother-To-Child HIV Transmission
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are commonly included in anti-HIV drug regimens. However, HIV infected women who have previously taken the single dose NNRTI nevirapine (SD NVP) for the prevention of…
- Trial name
- OCTANE (NCT00089505)
- Testing
- Emtricitabine, Emtricitabine/Tenofovir disoproxil fumarate, Lopinavir/Ritonavir
- Where
- 11 sites in Botswana, Kenya and 5 more
- Volunteers
- 745 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
HIV Infections
A Study of Amprenavir in HIV-Infected Patients
The purpose of this study is to see if it is safe to give amprenavir (APV) to HIV-infected patients. This study also examines the effect APV has on the level of HIV in the blood.
- Trial name
- NCT00002405
- Testing
- Amprenavir
- Where
- United States
- Sponsor
- Glaxo Wellcome
HIV Infections
Promoting Adherence to Anti-HIV Drug Regimens
One of the main causes of treatment failure in HIV infected individuals is lack of adherence to complicated drug regimens. The purpose of this study is to evaluate the effectiveness of a behavioral intervention program designed…
- Trial name
- NCT00051805
- Testing
- Promotion of adherence to ARV medications
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chorioamnionitis
Treatment of Chorioamnionitis After Delivery
Chorioamnionitis occurs in 1% to 5% of term pregnancies and may complicate up to 25% of cases of preterm labor. The traditional regimen used to treat intra-amniotic infection is intravenous ampicillin 2g every 6 hours and…
- Trial name
- NCT00814905
- Testing
- saline, ampicillin gentamicin, Ampicillin gentamicin clindamycin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, Portsmouth
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