Clinical trials: Diseases of the Genitourinary System
HIV Infections
Phase II/III Study of the Tolerance and Efficacy of Combined Use of Didanosine (2',3'-Dideoxyinosine; ddI) and Lentinan in HIV-Positive Patients
To determine the tolerance and side effects of a combination of lentinan and didanosine (ddI) in comparison with ddI alone. To determine whether the combination of lentinan and ddI produces a significant immunorestorative effect…
- Trial name
- NCT00002099
- Testing
- Lentinan, Didanosine
- Where
- United States
- Sponsor
- AJI Pharma USA
Human Papilloma Virus Infection
Clinical Evaluation of the APTIMA® HPV Assay Using the PANTHER™ System
The objective is to establish that APTIMA HPV Assay performance on the PANTHER System is comparable to performance on the TIGRIS System.
- Trial name
- NCT01446198
- Where
- 3 sites in United States
- Volunteers
- 11,816 people, healthy volunteers welcome
- Sponsor
- Gen-Probe, Incorporated
Metastatic Castration-Resistant Prostate Cancer
A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
The purpose of this study is to evaluate the safety, efficacy, tolerability, and pharmacokinetics (PK) of FG-3246, a cluster of differentiation 46 (CD46) targeting antibody-drug conjugate (ADC), in the treatment of participants…
- Trial name
- NCT06842498
- Testing
- FG-3246
- Where
- 23 sites in United States
- Volunteers
- 75 people
- Sponsor
- Kyntra Bio
Renal Failure
Daptomycin Study - Collection of Pharmacokinetic Samples in Patients With Renal Failure
This will be a prospective, multicenter, open-labeled, non-comparative pharmacokinetic study conducted in 10 critically ill, anuric patients receiving CVVHDF. Enrollment will take place at 3-5 clinical sites in the United States.
- Trial name
- NCT00573898
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pittsburgh
Male Infertility With Severe Oligo-terato-asteno-spermia
Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.
Some animal studies revealed that the pomegranate juice may improve sperm quality in terms of concentration, motility and morphology, as well as in fertilization rate. Minor data is available regarding the influence on male sperm.
- Trial name
- Pomegranate (NCT01918163)
- Testing
- Pomegranate pills
- Where
- Israel
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
HIV Infections, Hepatitis C
A Comparison of the Effectiveness, Safety, and Tolerability of Two Different Hepatitis C Treatments in Patients Infected With Both HIV and Hepatitis C Virus (HCV)
The purpose of this study is to see if treatment with PEG-interferon-alfa-2a (PEG-IFN) plus ribavirin is a more effective treatment for hepatitis C virus (HCV) than interferon-alfa-2a (IFN) plus ribavirin for patients infected…
- Trial name
- NCT00008463
- Testing
- Ribavirin, Interferon alfa-2a, Peginterferon alfa-2a
- Where
- 24 sites in United States
- Volunteers
- 132 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
AKI
Deep Learning Model and Risk Factors for Tacrolimus-related Acute Kidney Injury
In this study, the investigators aim to develop a risk prediction model for acute kidney injury (AKI) in hospitalized patients using the calcineurin inhibitor tacrolimus.
- Trial name
- NCT06596798
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Kidney Failure, Chronic, Hepatitis C
Safety of Sofosbuvir in People With Advanced Kidney Failure
Infection with hepatitis C virus (HCV), a hepatotropic RNA virus, is often chronic, and causes liver cirrhosis and liver cancer. The virus is transmitted through parenteral exposure.
- Trial name
- NCT03883698
- Testing
- Sofosbuvir, Daclatasvir 60 mg
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Nevirapine Induced Rash, Nevirapine Induced Hepatitis
Genotype Based Personalized Prescription of Nevirapine
Genetic tests has been suggested to reduce side effects related to Nevirapine(NVP), a commonly prescribed component of highly active antiretroviral therapy(HAART) in developing countries.
- Conditions
- Nevirapine Induced Rash, Nevirapine Induced Hepatitis, HIV, Adverse Side Effects
- Trial name
- GENPART (NCT00986063)
- Testing
- Genetic test for NVP induced rash, 3TC/D4T/NVP or 3TC/AZT/NVP
- Where
- Thailand
- Volunteers
- 1,200 people
- Sponsor
- Surakameth Mahasirimongkol
Advanced Kidney Cancer
Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Kidney Cancer
This is a phase II Randomized comparison clinical trial of activated CIK armed with anti-CD3-MUC1 bispecific antibody for advanced kidney cancer.
- Trial name
- NCT03540199
- Testing
- Activated CIK and CD3-MUC1 Bispecific Antibody in Treating Kidney Cancer, cryotherapy
- Where
- China
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Human Immunodeficiency Virus, Metabolic Syndrome
2-5 Intermittent Caloric Restriction in HIV
Background: Weight gain can lead to obesity and diabetes even in people living with human immunodeficiency virus (HIV). Researchers want to see if the technique intermittent calorie restriction can help overweight people with HIV…
- Trial name
- 2-5toWIN (NCT03489109)
- Testing
- Intermittent fasting, Standard of Care
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Retinopathy of Prematurity Both Eyes, Retinal Disease
VEGF Concentrations After Intravitreal Bevacizumab vs Ranibizumab as a Treatment for Type 1 ROP
The Retinopathy of Prematurity (ROP) is one of the leading causes of blindness on the pediatric age worldwide. This pathology is characterized for arrest of the normal vascular and neuronal retina that because of pathological…
- Conditions
- Retinopathy of Prematurity Both Eyes, Retinal Disease, Premature Birth, Eye Diseases
- Trial name
- NCT03148132
- Testing
- Bevacizumab Injection, Ranibizumab Ophthalmic
- Where
- Mexico
- Volunteers
- 16 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Cardiovascular Diseases, Nephropathy
Effect of the Aquaretic Tolvaptan on Nitric Oxide System (TORA)
The purpose of this study is to investigate the effect of tolvaptan on renal water, sodium and potassium excretion, plasma concentration of vasoactive hormones,central blood pressure, pulse wave velocity (PWV) and augmentation…
- Trial name
- NCT01638663
- Testing
- Tolvaptan
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Prostate Cancer
Predicting Cognitive Decline From Androgen Deprivation Therapy
Androgen Deprivation Therapy (ADT) is associated with cognitive impairment and dementia in men with prostate cancer. Pre-clinical data suggest that ADT-induced hypogonadism leads to accumulation of beta-amyloid plaques in the…
- Trial name
- ABC (NCT05820932)
- Testing
- Blood-based assay, Cognitive assessments, Quality of Life Surveys
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Prostate Cancer
Phase 1 Trial of PAN-301-1 (SNS-301) in Cancer Patients
This is a Phase I, open-label, parallel design study of PAN-301-1 (SNS-301), a HAAH directed nanoparticle vaccine, given intradermally in cohorts of patients with biochemically relapsed prostate cancer, using a fixed dose…
- Trial name
- NCT03120832
- Testing
- PAN-301-1
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- Sensei Biotherapeutics, Inc.
Ovarian Cancer
Development for the Peritoneal Carcinomatosis Index (PCI) in Ovarian Cancer
Primary objectives: To develop peritoneal carcinomatosis index (PCI) for ovarian cancer, tubal cancer and primary peritoneal cancer that can represent perioperative intraperitoneal tumor burden objectively Secondary objectives…
- Trial name
- NCT01538498
- Where
- South Korea
- Volunteers
- 134 people
- Sponsor
- National Cancer Center, Korea
Diabetic Kidney Disease, Chronic Kidney Disease
Long-Term Follow-up Study of Participants Exposed to Renal Autologous Cell Therapy Frozen Product
The purpose of this study is to evaluate the long-term safety, efficacy, and durability in participants with chronic kidney disease (CKD) who received up to four REACT injections, delivered percutaneously into either the same or…
- Trial name
- NCT06790498
- Testing
- Renal Autologous Cell Therapy (REACT)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Prokidney
HIV Infections
The Effects of Staggered Dosing on Interactions Between Paired Combinations of Nelfinavir, Ritonavir, and Saquinavir
The purpose of this study is to see if staggering doses of nelfinavir, ritonavir, and saquinavir has any effect on the interactions between these drugs.
- Trial name
- NCT00000898
- Testing
- Ritonavir, Nelfinavir mesylate, Saquinavir
- Where
- 4 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Premature, Thermoregulation
Delaying First Bathing and Skin Barrier Function on Infant
It is still unknown when the first bath should be done in premature newborns. Investigators think that delaying the time of the first bath compared to the time in the clinic will show some positive changes in preterm newborns.
- Trial name
- TEWL (NCT04231799)
- Testing
- Bathing
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Bladder Cancer, Urothelial Carcinoma
Feasibility of Home Instillation of UGN-102 for Treatment of Low-Grade (LG) Non-Muscle Invasive Bladder Cancer (NMIBC)
This study aims to demonstrate that home instillation of UGN-102 is a feasible alternative to instillation in a clinical setting, which might mitigate patient challenges (logistical, expense, and comfort) when receiving treatment…
- Conditions
- Bladder Cancer, Urothelial Carcinoma, Urothelial Carcinoma Bladder
- Trial name
- NCT05136898
- Testing
- UGN-102
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- UroGen Pharma Ltd.
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