Clinical trials: Diseases of the Genitourinary System
Human Immunodeficiency Virus
Single Ascending Dose (SAD)/Multiple Ascending Dose(MAD) Safety/Pharmacokinetic (PK) Study of KM-023
The purpose of this study is to investigate the safety and pharmacokinetics of KM-023 after single/multiple dosing.
- Trial name
- NCT01348516
- Testing
- KM-023
- Where
- South Korea
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Kainos Medicine Inc.
Carcinoma Cervix,Stage III
Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Cervix
The primary aim of the trial is to study the impact of nelfinavir on 3 year disease free survival in patients with advanced carcinoma of cervix receiving standard chemoradiation (Cisplatin and Radiotherapy).
- Trial name
- NELCER (NCT03256916)
- Testing
- Nelfinavir, Cisplatin, Pelvic EBRT and Brachytherapy
- Where
- India
- Volunteers
- 348 people
- Sponsor
- Tata Memorial Hospital
Cervical Carcinoma, Adenocarcinoma
PARa-aOrtic LymphAdenectomy in Locally Advanced Cervical Cancer
This is an international, multicenter and randomized open-label phase III study designed to demonstrate, in patients with stage IIIC1 cervical cancer, whether para-aortic lymphadenectomy followed by tailored chemoradiation is…
- Conditions
- Cervical Carcinoma, Adenocarcinoma, Adenosquamous Carcinoma
- Trial name
- PAROLA (NCT05581121)
- Testing
- Standard treatment: Control arm, Experimental arm
- Where
- 37 sites in Czechia, France and 2 more
- Volunteers
- 510 people
- Sponsor
- Institut Claudius Regaud
Acute Myelogenous Leukemia, Ovarian Cancer
Galinpepimut-S in Combination With Pembrolizumab in Patients With Selected Advanced Cancers
To evaluate the safety, tolerability, and anti-tumor activity of galinpepimut-S in combination with pembrolizumab in patients with selected advanced cancers.
- Conditions
- Acute Myelogenous Leukemia, Ovarian Cancer, Colorectal Cancer, Triple-negative Breast Cancer
- Trial name
- NCT03761914
- Testing
- galinpepimut-S, pembrolizumab, Montanide
- Where
- 12 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Sellas Life Sciences Group
Kidney Diseases
Patients With Renal Impairment and Diabetes Undergoing Computed Tomography (CT)
The main purpose of this study is to compare the incidence of contrast induced nephrotoxicity following the administration of Isovue (iopamidol) or Visipaque in diabetic patients with moderate to severe chronic renal impairment…
- Trial name
- NCT00289614
- Testing
- Iopamidol 370 mgI/dL
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Bracco Diagnostics, Inc
Renal Artery Stenosis
Formula PTX Renal Stent Clinical Study
The purpose of the study is to evaluate the safety and effectiveness of the PTX-coating on the Formula PTX Balloon-Expandable Stent in treatment of renal artery stenosis.
- Trial name
- NCT01057316
- Testing
- Formula PTX Stent - Dose 1, Formula PTX Stent - Dose 2, Formula PTX Stent - Dose 3
- Where
- 12 sites in Czechia, France and 2 more
- Volunteers
- 120 people
- Sponsor
- Cook Group Incorporated
HIV, Cervical Cancer
ACCESS: Accelerating Cervical Cancer Elimination Through the Integration of Screen-and-treat Services
While there has been a significant increase in the uptake of antiretroviral therapy among women living with HIV (WLHIV) in many low- and-middle income countries (LMICs), the coverage of cervical cancer screening and treatment…
- Trial name
- ACCESS (NCT06128304)
- Testing
- Core Implementation strategies, Core+ Enhanced Implementation Strategies
- Where
- 2 sites in United States, Nigeria
- Volunteers
- 2,436 people
- Sponsor
- University of California, San Diego
Renal Disease
Ides in Highly Sensitized (HS) Patients Awaiting Kidney Transplantation
This is a single center phase I/II open label, exploratory study assessing safety and efficacy of IdeS® (Hansa Medical, Lund, Sweden) given immediately prior to kidney transplantation.
- Trial name
- NCT02426684
- Testing
- IdeS® (Imlifidase)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Cedars-Sinai Medical Center
Prostatectomy, Prostate Cancer
Physical Activity Intervention in African American Men After Radical Prostatectomy
The purpose of this pilot study is to evaluate the feasibility of recruiting African American prostate cancer survivors to a 12 week physical activity intervention study of three arms (aerobics, resistance training, and usual…
- Trial name
- NCT02621684
- Testing
- Community Health Activities Model Program for Seniors (CHAMPS), Lifetime Total Physical Activity Questionnaire, Expanded Prostate Cancer Index Composite (EPIC)
- Sponsor
- Washington University School of Medicine
Prostate Cancer
AGS-1C4D4 in Patients With Advanced Hormone Refractory Prostate Cancer
The present study will investigate the safety, tolerability and spectrum of side effects of AGS-1C4D4. As such, this study will characterize the dose limiting toxicities (DLT) and potentially the maximum tolerated dose (MTD) of…
- Trial name
- NCT00519233
- Testing
- AGS-1C4D4
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Astellas Pharma Inc
End-Stage Renal Disease
Intelligent Control Approach to Anemia Management
First clinical evaluation of "Smart Anemia Manager" algorithm.
- Trial name
- NCT00572533
- Testing
- ESA Dose Adjustment per standard Anemia Management Protocol, ESA Dose Adjustment per "Smart Anemia Manager" Algorithm
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Louisville
Urinary Incontinence
Implementing a Mobile Health Application for Women Veterans With Urinary Incontinence (MyHealtheBladder): Function QUERI 3.0
Implementing a Mobile Health Application for Women Veterans with Urinary Incontinence (MyHealtheBladder): Function QUERI 3.0 aims to compare implementation approaches while also gathering information on clinical effects of the…
- Trial name
- MHB (NCT07219433)
- Testing
- Implementation Strategy: Foundational Arm, Implementation Strategy: REACH Arm
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Breast Cancer, Lung Cancer
Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning
The goal of this clinical trial is to explore feasibility, acceptability, and effectiveness of end-of-life conversation game "Hello" as a tool to help individuals with breast, lung, and/or genito-urinary cancers treated at Penn…
- Conditions
- Breast Cancer, Lung Cancer, Genito Urinary Cancer
- Trial name
- NCT06028152
- Testing
- End-of-life conversation game called "Hello"
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Milton S. Hershey Medical Center
Post Partum Depression
Adaptation and Pilot Testing of Web and Mobile Interface for the VID-KIDS Intervention
COVID-19 has placed unprecedented strains on parents impacted by toxic stress (depression, addiction, intimate partner violence, and poverty) and reluctant to see mental health-service providers in home/clinic due to fears of…
- Trial name
- VID-KIDS (NCT04818047)
- Testing
- VID-KIDS Intervention Program
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Uterine Fibroid, Heavy Menstrual Bleeding
Ulipristal Acetate in Symptomatic Uterine Fibroid
This study evaluates the effectiveness and safety of ulipristal acetae (UPA) in women with symptomatic uterine fibroids. Those who fulfilled inclusion/exclusion criteria will be treated UPA at daily dose of 5mg.
- Trial name
- NCT04132349
- Testing
- Ulipristal Acetate 5 mg
- Where
- Vietnam
- Volunteers
- 25 people
- Sponsor
- Mỹ Đức Hospital
Smoking, HIV Infections
A Trial to Test the Efficacy of a Tailored Intensive Smoking Cessation Intervention in Persons With HIV (PWHs)
The purpose of this study is to determine whether an intensive, eight session behavioral intervention is superior to standard care in achieving abstinence from cigarettes in smokers living with HIV/AIDS.
- Conditions
- Smoking, HIV Infections, AIDS
- Trial name
- NCT01106638
- Testing
- Positively Smoke Free, Standard care
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Montefiore Medical Center
Bladder Cancer, TURBT
Sequential Chemotherapy Followed by Ultrahypofractionated Radiotherapy for Muscle-Invasive Bladder Cancer
Muscle-invasive bladder cancer (MIBC) is a potentially lethal disease for which radical cystectomy with appropriate systemic therapy remains a standard curative approach in medically fit patients. .
- Conditions
- Bladder Cancer, TURBT, Radiotherapy
- Trial name
- NCT07914101
- Testing
- Transurethral Resection of Bladder Tumor, Sequential Systemic Chemotherapy, radiotherapy
- Volunteers
- 71 people
- Sponsor
- Assiut University
HIV Infections, Tuberculosis
Prevalence of HIV and Tuberculosis in Masiphumelele Township, Cape Town, South Africa
The purpose of this study is to estimate the amount of HIV and tuberculosis (TB) infection in individuals 15 years and older in the Masiphumelele township of Cape Town, South Africa.
- Trial name
- NCT00096681
- Volunteers
- 762 people, healthy volunteers welcome
- Sponsor
- CIPRA SA
Miscarriage in First Trimester
Comprehensive Assessment of First Trimester Pregnancy Loss
The FIRST-CARE Study is a prospective research project conducted at Hospital de la Santa Creu i Sant Pau (Barcelona, Spain), aimed at better understanding the causes and consequences of first-trimester pregnancy loss…
- Trial name
- FIRST-CARE (NCT07293819)
- Where
- 2 sites in Spain
- Volunteers
- 225 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
HIV Infection, Cardiovascular Disease
Effect of Maraviroc on Endothelial Function in HIV-Infected Patients
The purpose of this study is to determine the potentially beneficial aspects of CCR5 inhibition on inflammation and endothelial function as measured by brachial artery reactivity in antiretroviral treated HIV patients with an…
- Conditions
- HIV Infection, Cardiovascular Disease, Inflammation, HIV Infections
- Trial name
- NCT00844519
- Testing
- Maraviroc
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, San Francisco
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