Clinical trials: Diseases of the Genitourinary System
Cervical Cancer
Clinic-based Intervention to Promote Cervical Cancer Prevention Behaviors
The project is a clinical behavioral research project based at University of Pennsylvania. The goal of this research is to design a brief clinic-based, Nurse Practitioner-guided, and theory-based health promotion intervention to…
- Trial name
- StepUp (NCT02046265)
- Testing
- Step Up to Prevention, Step Up to Prevention: knowledge, Step Up to Prevention:belief
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Peyronie Disease
French Translation and Validation of the PEYronie's Disease QUESTionnaire
This study is a prospective cohort dedicated to peyronie's disease. The aim is to validate the french translation of the peyronie's disease questionnaire. The primary endpoint is the response rate to the questionnaire.
- Trial name
- FRAPEYQUEST (NCT05768867)
- Testing
- FRAnçaise du PEYronie's Disease QUESTionnaire
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Human Papillomavirus (HPV) Infection
Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Human Papillomavirus (HPV) Vaccine (GSK580299) in Healthy Female Subjects 10-25 Years of Age.
Cervical cancer is the second most common cancer among women worldwide. Approximately 500 000 new cases are reported each year worldwide, from which 83% occur in developing countries.
- Trial name
- NCT00481767
- Testing
- Cervarix
- Where
- 2 sites in Senegal, Tanzania
- Volunteers
- 676 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Ovarian Sex Cord Stromal Tumor, Ovarian Neoplasms
TC or BEP in Treating Patients With Ovarian Malignant Sex Cord-Stromal Tumors
Investigators will conduct the trial to determine whether paclitaxel and cisplatin (PT) has the same curative effects and less adverse effects than bleomycin, etoposide and cisplatin(BEP) among newly diagnosed ovarian malignant…
- Conditions
- Ovarian Sex Cord Stromal Tumor, Ovarian Neoplasms, Ovarian Cancer
- Trial name
- SCST-01 (NCT02429700)
- Testing
- Paclitaxel, Carboplatin, Bleomycin
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Beihua Kong
Adenomyosis, Hysteroscopy
Hysteroscopic Suture Fixation of Mirena in the Treatment of Adenomyosis
The purpose of this study was to evaluate the efficacy and safety of hysteroscopic Mirena fixation in patients with adenomyosis with enlarged uterus, compared with simple Mirena placement under hysteroscopy.
- Trial name
- NCT06478992
- Testing
- A:hysteroscopic suture fixation of Mirena, A: simple Mirena placement under hysteroscopy, B: hysteroscopic suture fixation of Mirena
- Volunteers
- 144 people
- Sponsor
- First People's Hospital of Hangzhou
Urinary Tract Infections
Profiles of Urinary Tract Infections in General Practice
Urinary tract infections (UTIs) are one of the most common bacterial infections managed in general practice: they are the 2nd site of community-acquired bacterial infection after respiratory infections (4-6 million consultations…
- Trial name
- PODIUM (NCT05847036)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- CNGE Conseil
Prostate Cancer
RAD001 and Bicalutamide for Androgen Independent Prostate Cancer
In the treatment of castration-resistant prostate cancer (CRPC), therapies will long response durations remain elusive as a result of the inherent ability of prostate cancer cells to develop iterative resistance.
- Trial name
- NCT00630344
- Testing
- RAD001, Bicalutamide
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Dana-Farber Cancer Institute
Cervix Cancer
Investigation of Cervix Tumor Oxygenation and Microvasculature Using Magnetic Resonance Techniques
In cervix cancer tumor oxygen levels and fluid pressure in the tumor have been shown to be related to patient outcome. Analysis of the way tumors enhance after intravenous contrast injection using MRI and CT can be used to…
- Trial name
- NCT00242034
- Testing
- CT and MRI with contrast
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Ovarian Cancer
Screening and Identification of Ovarian Cancers
Ovarian cancer is the first mortality rate of gynecologic malignancies. The incidence of ovarian cancer increased in recent 10 years and it has become the ninth cause of malignancies in the women in Taiwan.
- Trial name
- NCT00854399
- Testing
- Staging surgery or debulking surgery
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Prostate Cancer
Post-prostatectomy Radiation Therapy--Moderate Versus Ultra-hypofractionated (Also Known as Stereotactic Body Radiation Therapy [SBRT])
The primary purpose of this study is to compare the quality of life (QOL) reported by prostate cancer patients 2 years after treatment with ultra-hypofractionated post-prostatectomy radiation therapy (also known as stereotactic…
- Trial name
- NCT05038332
- Testing
- Ultra-hypofractionated radiation therapy, Moderately Hypo-fractionated Radiation Therapy
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Michigan Rogel Cancer Center
Contraceptives, Oral
A Study of Continuous Oral Contraceptives and Doxycycline
The purpose of this study is to learn if the study drug, doxycycline, can decrease the amount of unplanned vaginal bleeding that women commonly experience when taking combined oral contraception (COC)- pills with estrogen and…
- Trial name
- NCT00480532
- Testing
- Lybrel, Doxycycline, Oracea
- Where
- 2 sites in United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors.
- Conditions
- Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck, HER2 Negative Breast Neoplasms, Esophageal Squamous Cell Carcinoma
- Trial name
- NCT04389632
- Testing
- sigvotatug vedotin, pembrolizumab, cisplatin
- Where
- 158 sites in United States, France and 5 more
- Volunteers
- 1,006 people
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
Prostatic Neoplasms
Prostate Adaptive Radiation Therapy
Prostate ART is a two phase study looking at using adaptive radiotherapy to help reduce toxicity for prostate cancer patients. Adaptive radiotherapy is a new technology that provides the ability to account for daily changes in…
- Trial name
- NCT06547398
- Testing
- Adaptive radiotherapy +/- Margin Reduction, Image guided radiotherapy
- Where
- Australia
- Volunteers
- 130 people
- Sponsor
- Royal North Shore Hospital
Polycystic Ovary Syndrome, Overweight
Stress Reduction for Overweight or Obese Women Either With Polycystic Ovary Syndrome (PCOS) or Without PCOS (Non-PCOS)
The purpose of this study is to determine the effects of stress reduction on glucose, blood pressure, quality of life and overall health and well-being in overweight or obese women, either with Polycystic Ovary Syndrome (PCOS) or…
- Conditions
- Polycystic Ovary Syndrome, Overweight, Obesity, Stress, Physiological
- Trial name
- NCT01464398
- Testing
- Stress reduction, Stress reduction with Health education
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Milton S. Hershey Medical Center
HIV Infection, HCV Coinfection
Testing and Linkage to Care for Injecting Drug Users in Kenya
Testing and Linkage to Care for Injecting Drug Users in Kenya: Interventions for people who inject drugs (PWID) in sub-Saharan African have been almost entirely absent, despite the fact that in countries like Kenya they…
- Trial name
- NCT01557998
- Testing
- POC CD4 and Peer Case Management, HCV+PWID, Control - No intervention
- Where
- Kenya
- Volunteers
- 9,449 people, healthy volunteers welcome
- Sponsor
- Yale University
AVP Deficiency, Diabetes Insipidus
Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency
The PHOENIX study aims to investigate whether oral estradiol valerate (EV) and ethinylestradiol (EE) can stimulate oxytocin (OXT) and neurophysin-1 (NP-1) release in humans.
- Trial name
- PHOENIX (NCT07361263)
- Testing
- estradiol valerate, esthinylestradiol
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
HIV Infections, Sexually Transmitted Infections
Effectiveness of Community-Level Behavioral and Biomedical Interventions for Reducing HIV/STIs in Men in Peru
This study will evaluate the effectiveness of community-level behavioral and biomedical interventions, each alone and combined, in reducing sexual risk behavior and HIV/sexually transmitted infections in Peruvian men who have sex…
- Trial name
- NCT00670163
- Testing
- Enhanced Partner Therapy (EPT), Communidades Positivas (CPOS), Standard Care
- Where
- Peru
- Volunteers
- 718 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Varicocele
The Anaesthesiological Approach to Varicocele Correction in Outpatients Setting: an Observational Analysis
The aim of this observational study was to evaluate, based on the intraoperative anesthetic that is routinely carried out at the Department of Day Surgery, the difference in timing of the patient's discharge from the hospital (ie…
- Trial name
- NCT02401087
- Testing
- Anaesthesiological procedure
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale di Circolo - Fondazione Macchi
Prostatic Neoplasms
Study of SGN-15, Antibody-Drug Conjugate, to Treat Hormone Refractory Prostate Cancer
SGN-15 is being investigated for therapy of patients with prostate cancer in combination with the cytotoxic agent, Taxotere. The study is an open label, randomized phase II study for patients with documented hormone refractory…
- Trial name
- NCT00031187
- Testing
- SGN-15 (cBR96-doxorubicin immunoconjugate), Taxotere (docetaxel)
- Where
- 11 sites in United States
- Volunteers
- 160 people
- Sponsor
- Seagen Inc.
Uterine Cervical Neoplasms
Evaluate the Effect of ReSpace™ Hydrogel on Reducing Rectal Radiation Dose in Radiotherapy for Cervical Cancer
This phase II clinical study plan to recruit 100 subjects, 1:1 divide them into experimental group and control group, and the cumulative D2cc dose for rectum during brachytherapy will be recorded and compared.
- Trial name
- NCT05690906
- Testing
- ReSpace™, gauze packing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
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