Clinical trials: Diseases of the Nervous System
Optic Neuropathy, Glaucoma
Hyperbaric Oxygen Therapy for Optic Neuropathies
The purpose of the study is to evaluate the neuroprotective efficacy of hyperbaric oxygen for the treatment in patients with optic neuropathy.
- Trial name
- HBOT (NCT06128720)
- Testing
- Hyperbaric Oxygen
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Stroke, Quality of Life
Effects of Two Home Ergonomics Programmes in Post-stroke Patients
The main objective of the clinical trial is to evaluate the effectiveness of two home ergonomics programmes, by reference to a control group, on functional capacity and quality of life in post-stroke patients.
- Trial name
- NCT03665220
- Testing
- Ergonomic adjustments, Kinesiotherapy plus ergonomic adjustments, Healthcare education
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Universidad de Granada
Spastic Cerebral Palsy
Circuit Training in Children With Cerebral Palsy
The aim of our study is to reveal the results of circuit training to be applied to the children with Cerebral Palsy (CP) for improving their muscular strength and trunk control and also to determine their effects in terms of…
- Trial name
- NCT03529682
- Testing
- exercise, control group
- Where
- Cyprus
- Volunteers
- 62 people
- Sponsor
- Eastern Mediterranean University
Orthostatic Hypotension
Vitamin K Status and Markers of Vascular Function in Patients With and Without Postural Hypotension
Postural hypotension is common in older people, leading to falls, decline in function, and dependence. Available treatments have limited efficacy and tolerability; novel approaches to treatment are therefore needed.
- Trial name
- VITKOH (NCT02505282)
- Testing
- Vitamin K status
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Epilepsy, Epilepsy, Focal
A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures.
The purpose of this study is to demonstrate that RWJ-333369 is safe and effective as add-on treatment of partial onset seizures.
- Conditions
- Epilepsy, Epilepsy, Focal, Seizure Disorder, Complex Partial Seizures
- Trial name
- NCT00425282
- Testing
- RWJ-333369
- Volunteers
- 566 people
- Sponsor
- SK Life Science, Inc.
Fibromyalgia Syndrome
The Effect of Positive Psychotherapy Based Psychoeducation on Pain Perception With Fibromyalgia Syndrome
Fibromyalgia (FM) is characterized by symptoms such as chronic widespread pain, severe fatigue, sleep disturbances, extremity paresthesia, stiffness, mood disturbances, and cognitive impairment lasting more than 3 months without…
- Trial name
- NCT06147882
- Testing
- The group will include patients with fibromyalgia syndrome who will receive positive psychotherapy.
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Duzce University
Sarcopenia, Sarcopenia in Elderly
Acute Sarcopenia in Hospitalized Older Adults
Acute sarcopenia is a rapid decline in muscle mass and function occurring within 28 days of a major stressor, such as hospitalization, infection, or surgery. It is frequent but often underdiagnosed in older adult.
- Trial name
- BASIS (NCT07454759)
- Testing
- Acute sarcopenia will be defined as the incidence of sarcopenia compared to baseline measurements at recruitment, using the European Working Group on Sarcopenia in older people 2 (EWGSOP2) criteria
- Volunteers
- 280 people
- Sponsor
- IRCCS San Raffaele
Pain, Postoperative, Genetic Predisposition
COMT Activity and Hypnotizability
Hypnosis is an effective pain management tool for surgery that can reduce opioid use up to 40%. COMT single nucleotide polymorphisms (SNPs) can predict pain sensitivity and opioid use perioperatively, and may also be associated…
- Trial name
- NCT04624880
- Testing
- Giant magnetoresistive sensor (GMR)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stanford University
Stroke
Upper Extremity Recovery Post Stroke Using Virtual Occupations
The purpose of this study is to explore the efficacy of the SaeboVR rehabilitation system for improving functional outcomes related to upper extremity motor recovery in stroke survivors. The specific objectives are: 1.
- Trial name
- NCT03886480
- Testing
- SaeboVR
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Manitoba
Non-valvular Atrial Fibrillation (NVAF)
A Study to Evaluate the Safety and Effectiveness of Rivaroxaban (Xarelto) for Prevention of Stroke and Systemic Embolism in Indian Patients With Non-valvular Atrial Fibrillation (NVAF)
This study is planned to collect prospective data and evaluate the safety and effectiveness of rivaroxaban for the prevention of stroke and systemic embolism in Indian patients with NVAF when used in clinical practice under…
- Trial name
- XARIN (NCT03887780)
- Testing
- Rivaroxaban (Xarelto,Bay 59-7939)
- Where
- India
- Volunteers
- 504 people
- Sponsor
- Bayer
Essential Tremor
1-Octanol to Treat Essential Tremor
This study will determine the optimal dose of 1-octanol that will safely reduce tremors in patients with essential tremor-a disorder in which the hands, and sometimes the head, shake involuntarily.
- Trial name
- NCT00016679
- Testing
- 1-Octanol
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Central Nervous System Diseases
CKD-355 Drug-drug Interaction Study (CKD-355 DDI P1)
The purpose of this study is to evaluate a pharmacokinetic drug interaction between D797 of D324 in healthy volunteers
- Trial name
- NCT03569579
- Testing
- Memantine Tab. 10mg, Memantine Tab. 10mg + Donepezil Tab. 10mg
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Cerebral Infarction, Cerebral Infarction Recovery
D-dimer Prognostic Marker of Cerebral Infarction After Revascularization Procedure
Cerebral infarction is the leading cause of acquired disability in adults. Absence of biological marker used in current practice and identified as a prognostic factor for recovery.
- Trial name
- D-Dimer (NCT04938479)
- Testing
- blood sample
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Spinal Cord Injury
BCI and FES for Hand Therapy in Spinal Cord Injury
This study will assess whether functional recovery of the hand muscles in patients with spinal cord injury is enhanced when electrical stimulation of the muscles is delivered actively by means of using the electroencephalography…
- Trial name
- NCT01852279
- Testing
- BCI-FES, Passive muscle stimulation
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- NHS Greater Glasgow and Clyde
Stroke
Enhancing Prehospital Stroke Diagnosis
Current American Heart Association Guidelines recommend that stroke patients be promptly rescued and identified so that the accepting hospital can be alerted and prepared to receive and treat them promptly.
- Trial name
- AIPO (NCT06427746)
- Testing
- Standard, Video call, Video call + LARIO
- Where
- Italy
- Volunteers
- 2,197 people
- Sponsor
- Agenzia Regionale emergenza Urgenza
Corneal Burn
Modified Corneal EA With Middle LKP for Severe Corneal Burn
The purpose of this pilot study is to explore whether modified corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular…
- Trial name
- NCT03498846
- Testing
- Modified EA and AMLK, LA and AMLK
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-sen University
Alzheimer Disease
Semantic Recognition Task (SRT) in Alzheimer Disease
The goal of this study is to observe the outcomes of a semantic recognition task in Alzheimer Disease and discuss what this might add to clinical practice.
- Trial name
- SRT (NCT05711888)
- Testing
- Semantic Recognition Procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Critical Illness, Muscle Wasting
Indicator Amino Acid Oxidation in ICU Patients
This study will use the indicator amino acid oxidation technique (IAAO) to determine protein oxidation of ICU patients at two protein intakes: 1.3 g/kg/d versus 2.0 g/kg/d.
- Trial name
- IAAO-IC (NCT06104527)
- Testing
- Standard protein enteral nutrition with enteral tracer, High protein enteral nutrition with enteral tracer
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Maastricht University Medical Center
Traumatic Brain Injury
Investigating How Sleep After Training Can Affect the Learning of a Motor Skill in Individuals With Brain Injury
Studies have shown that a period of sleep, even in the form of a daytime nap, after a period of training on a motor learning task can boost subsequent performance beyond that observed after an equal amount of time spent awake and…
- Trial name
- NCT04810442
- Testing
- Nap
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kessler Foundation
Brain Neoplasm
Clinical Study on 5-aminolevulinic Acid Hydrochloride (5-ALA) for Fluorescence-guided Resection of Malignant Gliomas
This study is planned to detect a dose-efficacy relationship between the chosen dose levels of MC506/1 and the extent and quality of fluorescence in the tumour core in patients with newly diagnosed malignant glioma.
- Trial name
- NCT02755142
- Testing
- Gliolan
- Volunteers
- 21 people
- Sponsor
- medac GmbH
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