Clinical trials: Diseases of the Nervous System
Sleep Disordered Breathing
User Preference/Validation Evaluation of the New Philips Respironics Positive Airway Pressure Application
This pilot study is intended to evaluate the acceptance and performance of the DreamMapper application and the Therapist Assist educational tool in naïve patients with Obstructive Sleep Apnea who have been prescribed Positive…
- Trial name
- NCT03748264
- Testing
- Standard of Care, DreamMapper Application, DreamMapper Application with Therapist Assist
- Where
- 5 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Philips Respironics
Cerebral Malaria
Randomized Trial of Erythropoietin During Cerebral Malaria
Malaria remains one of the most common life-threatening illnesses in the tropics with a dramatic toll of more than one million deaths each year.
- Trial name
- EPOMAL (NCT00697164)
- Testing
- Erythropoietin
- Where
- Mali
- Volunteers
- 120 people
- Sponsor
- Claude Bernard University
Sleep Deprivation, Aging
The Peripheral Blood Multi-Omics Study on Sleep Loss
Sleep plays a role in cognitive processes such as memory processing, attention processing, and overall cognitive function. In recent years, the bidirectional relationship between sleep loss and aging, as well as related…
- Conditions
- Sleep Deprivation, Aging, Alzheimer Disease, Healthy Lifestyle
- Trial name
- NCT06492109
- Testing
- Sleep manipulation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Tinnitus, Anxiety
Mindfulness Based Tinnitus Reduction (MBTR): A Symptom Perception Shift Program
This study is a randomized, controlled trial of Mindfulness Based Tinnitus Reduction (MBTR) vs. Treatment As Usual (TAU). This study aims to determine patient's benefit from participating in an 8-week MBTR program as measured by…
- Conditions
- Tinnitus, Anxiety, Depression
- Trial name
- MBTR (NCT01229709)
- Testing
- Mindfulness Based Tinnitus Reduction
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Tourette's Syndrome
Hypersensitivity in Tourette Syndrome
This study will investigate how the sensitivity to touch and smell in patients with Tourette syndrome (TS) may differ from that of people without TS.
- Trial name
- NCT00368433
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
A Mobile Brain/Body Imaging Platform for the Assessment and Optimization of Post-stroke Overground Robotic Gait Treatments
The study aims to identify neural biomarkers that can be used to monitor the recovery of locomotion and movement of post-stroke patients, both in natural settings and with enriched treatment using robotic device.
- Trial name
- COBI (NCT07510633)
- Testing
- overground wearable robotic device
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Franco Molteni
Weakness, Muscle, Muscle Weakness
Short Term Immobilization of the Lower Limb
The purpose of this study is to determine the effects of one week of knee-joint immobilization on muscle size, strength, neuromuscular function, and brain function.
- Conditions
- Weakness, Muscle, Muscle Weakness, Muscle Loss, Muscle Atrophy
- Trial name
- STILL (NCT05072652)
- Testing
- Neuromuscular Electrical Stimulation, Action Observation + Mental Imagery
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Pain
Women's Mammography Study To Improve Comfort During Mammography
The purpose of this study is to determine in a randomized trial whether it is possible to decrease the discomfort of mammography by using the analgesic ibuprofen, or by using a scripted, supportive text informing patients about…
- Trial name
- NCT01716052
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Kenneth A. Kist,
Preoperative Anxiety, Emergence Delirium in Pediatric Anesthesia
Ride-On Toy Car Use During Operating Room Transfer in Preschool Children
The goal of this clinical trial is to determine whether the method of transfer to the operating room can reduce preoperative anxiety and postoperative emergence delirium in male children aged 3 to 7 years undergoing elective…
- Trial name
- NCT07403747
- Testing
- Toy car, Standard Transfer
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Alzheimer Disease, Dementia
SAFE at Home: A Service to Provide Social Engagement to Community-Dwelling Persons With Dementia
The proposed Phase 1 study will involve initial development and evaluation of a new service called Social Activities For Engagement at Home or SAFE at Home (SaH).
- Conditions
- Alzheimer Disease, Dementia, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT05516147
- Testing
- SAFE at Home
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hopeful Aging
Insomnia
Intelligent Diagnosis and Treatment Model for Insomnia Disorder
To establish a multicenter, multi-dimensional cohort on insomnia disorder and to develop an intelligent model for the diagnosis and treatment of insomnia disorder.
- Trial name
- NCT06375447
- Testing
- Routine clinical treatment
- Where
- 5 sites in China
- Volunteers
- 16,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Cervical Radiculopathy, Balance Disorders
Effect of Cervical Traction on Balance in Cervical Radiculopathy
A randomized clinical trial aiming to assess the effect of cervical traction, using different loads, on balance parameters among patients with common cervical radiculopathy.
- Trial name
- NCT06727747
- Testing
- Cervical traction, Rehabilitation
- Where
- Tunisia
- Volunteers
- 36 people
- Sponsor
- University of Monastir
Parkinson Disease
Fox BioNet Project: ECV-003
The goal of this study is to optimize pre-analytical cerebrospinal fluid (CSF) extracellular vesicle isolation protocols for increasing the detection of LRRK2 activity in human CSF
- Trial name
- NCT03775447
- Testing
- Lumbar Puncture
- Where
- 3 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Carpal Tunnel Syndrome
Effectiveness of Carpal Ligament Self-myofascial Stretching in Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS), also known as median mononeuropathy, occurs when the median nerve is squeezed or compressed as it travels through the carpal tunnel at the wrist. It is common in the age group of 40-60 years.
- Trial name
- NCT06229249
- Testing
- Carpal ligament self-myofascial stretching, Conventional physical therapy
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- King Saud University
Parkinson Disease
The Impact of Three Distinct Exercise Types on Fatigue, Anxiety, and Depression in Parkinson's Disease
The purpose of the study is to learn about the impact of exercise on fatigue, anxiety, and depression in Parkinson's disease. It is well established that exercise improves the motor symptoms of Parkinson's disease.
- Trial name
- PDExercise (NCT03833349)
- Testing
- Spinning Class, Yoga Class, Dance Class
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Premier Health
Traumatic Brain Injury, Rehabilitation
Improving Health Outcomes With Resource Facilitation
The purpose of this research is to test a service the investigators of the study believe may increase quality of life after brain injury and reduce the level of disability that might be associated with that injury.
- Conditions
- Traumatic Brain Injury, Rehabilitation, Intervention
- Trial name
- ACL (NCT04462549)
- Testing
- Resource Facilitation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Rehabilitation Hospital of Indiana
Caregiver Burden
SilverBills: A Financial and Legal Tech Tool for Caregivers
Financial and legal management for persons with dementia (PwD) is a crucial responsibility of caregivers. This responsibility adds to the stress and strain of caregiving.
- Trial name
- NCT05382949
- Testing
- SilverBills Financial and Legal Tech Tool for Caregivers
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Marci Lobel-Esrig
Narcolepsy
Metabolism Characteristics in the Children With Narcolepsy
A significant weight gain and obesity are observed for most patients with narcolepsy, mainly at the beginning of the disease and narcolepsy in young children.
- Trial name
- Narcolepsy (NCT02799849)
- Testing
- Sleep and metabolism assessment
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Hospices Civils de Lyon
Polymyositis, Dermatomyositis
Abatacept Treatment in Polymyositis and Dermatomyositis
The aim of this study is to investigate the efficacy and safety of abatacept in patients with Dermatomyositis (DM) and polymyositis (PM) refractory to conventional treatment using a randomised trial design with delayed start in…
- Trial name
- ARTEMIS (NCT01315938)
- Testing
- Abatacept Active Treatment, Abatacept Delayed-Onset Treatment
- Where
- 2 sites in Czechia, Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Demyelinating Diseases of the Central Nervous System, Child
Core Stability, Functional Capacity, Balance, Strength, and Fatigue in Pediatric Demyelinating Diseases
This study aims to evaluate balance ability, core stability, functional capacity, lower extremity muscle strength, and fatigue levels in children diagnosed with central nervous system demyelinating diseases, in order to…
- Conditions
- Demyelinating Diseases of the Central Nervous System, Child, Core Stability, Balance
- Trial name
- PEDI-CORE (NCT07654738)
- Testing
- No ADT
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul University - Cerrahpasa
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