Clinical trials: Diseases of the Nervous System
Parkinson's Disease
Dexmedetomidine vs Propofol on the Recordings of Deep Brain Activity Measured Through Implanted Stimulators
This clinical trial has been designed to study and compare changes in deep brain activity (field potentials) in Parkinson's disease (PD) patients while awake, and during sedation with dexmedetomidine or propofol.
- Trial name
- DEXPROPAR (NCT02256319)
- Testing
- Dexmedetomidine, Propofol
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Japanese Encephalitis
Immunogenicity of a Commercial Batch of JEV IC51 up to 24 Months Post Filling
The objective is to assess immunogenicity of a commercial IC51 batch at 3 different time points post filling (12, 18, 24 months) in terms of Geometric Mean Titers (GMT) for anti-JEV neutralizing antibodies at Day 56 after the…
- Trial name
- NCT00776230
- Testing
- IC51
- Where
- 3 sites in Austria, Germany
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Trigeminal Neuropathy
Erenumab-aooe for the Management of Trigeminal Neuropathic Pain.
This study is a single center, placebo-controlled, double blind, randomized, phase II pilot to evaluate the efficacy of erenumab-aooe in the management of trigeminal neuropathic pain comparing erenumab-aooe vs Placebo.
- Trial name
- NCT05142228
- Testing
- Erenumab-Aooe
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Maryland, Baltimore
Neurodegenerative Disease, Artificial Intelligence (AI)
ADAI - Home Care in Intelligent Environments Clinical Care Ecosystem for the Management of Home Digital Therapies Through the Use of Assistive Robots and Clinical Predictive Systems Based on Artificial Intelligence Systems
Dementia is a neurocognitive disorder that causes a deterioration in cognitive function, significantly impacting social and work abilities and daily activities.
- Conditions
- Neurodegenerative Disease, Artificial Intelligence (AI), Mild Cognitive Impairment (MCI)
- Trial name
- RAISE_2023_026 (NCT07566728)
- Testing
- CLINICAL INVESTIGATION WITH A MEDICAL DEVICE MARKED CE
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Nocturia, Insomnia
TUCSON Study: Tackling Underlying Causes of Sleep Related Nocturia Nocturia
The TUCSON study is a cross-sectional observational monocentric study. In order to provide a clinical helpful assessment for urologists for possible missed causes of nocturia, the aim is to investigate the voiding and sleep…
- Conditions
- Nocturia, Insomnia, OSA
- Trial name
- TUCSON (NCT05404828)
- Testing
- Polysomnography, Questionnaires, Blood and urine sample
- Where
- Belgium
- Volunteers
- 65 people
- Sponsor
- University Hospital, Ghent
Neurologic Ambulation Disorder
Interactive Intensive Gait Training in Walking Limitations
Gait-MAP is a prospective, randomized, single-blind clinical trial designed to evaluate the effectiveness of an Intensive Interactive Gait Training (IIGT) program in adults with neurological conditions associated with pyramidal…
- Trial name
- Gait-MAP (NCT07899528)
- Testing
- Intensive Interactive Gait Training, Conventional Gait Rehabilitation
- Where
- Italy
- Volunteers
- 112 people
- Sponsor
- IRCCS San Raffaele Roma
Atrial Fibrillation, Stroke
AI-Assisted Workflow for Occult Atrial Fibrillation Detection After Ischemic Stroke: A Prospective Randomized Trial
We hypothesize that an AI-guided AF risk stratification approach, particularly when combined with intensified rhythm monitoring using wearable devices and extended ECG patches, will significantly increase AF detection rates…
- Conditions
- Atrial Fibrillation, Stroke, Artificial Intelligence
- Trial name
- AI-AFIS (NCT07540065)
- Testing
- Active Follow-up Group, Standard Follow-up Group
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Friedreich Ataxia
Safety and Efficacy of Etravirine in Friedreich Ataxia Patients
A drug repositioning effort provided evidence supporting the possible use of Etravirine, a drug approved for the treatment of HIV infections in patients starting from 2 years of age, as a treatment for FA.
- Trial name
- FAEST1 (NCT04273165)
- Testing
- Etravirine Tablets
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Hereditary Cystatin C Amyloid Angiopathy (HCCAA), Hemorrhage Brain
Safety, Tolerability and Efficacy of NPI-001 in Patients With Hereditary Cystatin C Amyloid Angiopathy (HCCAA)
The study aims to measure safety, tolerability and biomarker-based efficacy of NPI-001 (AT-001) in Subjects with Hereditary Cystatin C Amyloid Angiopathy (HCCAA).
- Conditions
- Hereditary Cystatin C Amyloid Angiopathy (HCCAA), Hemorrhage Brain, Hemorrhage Cerebral
- Trial name
- HCCAA (NCT07716865)
- Testing
- NACA
- Where
- Iceland
- Volunteers
- 15 people
- Sponsor
- Arctic Therapeutics
Sarcopenia
(De)Prescribing in Hospitalized Sarcopenic Geriatric Patients
The goal of this clinical trial is to compare the effects of a deprescribing pharmacotherapy approach to the STOPP-START approach (usual care) in geriatric patients with sarcopenia and polypharmacy.
- Trial name
- MEDEGESARC (NCT05757765)
- Testing
- deprescribing pharmacotherapy approach (DPA), STOPP-START deprescribing approach (SSA)
- Volunteers
- 160 people
- Sponsor
- Zuyderland Medisch Centrum
Vision, Low
Mobile Electronic Devices for Visual Impairment
Mobile electronic devices (MED) including, smartphones and tablets, offer a new type of assistive technology for visually-impaired people (VIP).
- Trial name
- MED4VI (NCT03560765)
- Testing
- MED, Buddy
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Manchester
Meningitis, Cryptococcal, HIV Infections
Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis
The purpose of this study is to examine the antifungal activity of recombinant interferon-gamma 1b (rIFN-gamma 1b) given with standard antifungal therapy.
- Trial name
- NCT00012467
- Testing
- Itraconazole, Flucytosine, Fluconazole
- Where
- 9 sites in United States, Peru
- Volunteers
- 60 people
- Sponsor
- InterMune
Delirium
Feasibility of an App to Measure Patient Stressors in an Intensive Care Unit (ICU Feel Better App)- a Before-and-after Study
This study examines the feasibility and efficacy of a mobile application (app), which enables critically ill patients to report perceived patient stressors to their caregivers.
- Trial name
- NCT04880967
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Charite University, Berlin, Germany
Pseudotumor Cerebri
Magnetic Resonance Venography Pre- and Post-Treatment in Patients With Idiopathic Intracranial Hypertension
This prospective study will use magnetic resonance imaging of patients with Idiopathic Intracranial Hypertension (IIH), to determine if the common radiological finding of transverse venous sinus stenosis can be reversed with…
- Trial name
- NCT02394067
- Testing
- Radiological Imaging
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Nova Scotia Health Authority
Sexual Dysfunctions, Psychological
Female Sexual Dysfunction: Prevalence Among Italian Healthy Women
Purposes of this study are: To determine the prevalence of female sexual dysfunctions among Italian general population To determine which sexual domains are more frequently compromised To evaluate which of the factors we took…
- Trial name
- NCT00148200
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Unita Complessa di Ostetricia e Ginecologia
Migraine Disorders
Effect of Metoclopramide Versus Sumatriptan for Emergency Department Treatment of Migraine Headache
The purpose of this study is to determine which drug makes lower migraine headache
- Trial name
- NCT01791400
- Testing
- metoclopramide, injection,20mg, one time, Sumatriptan, injection, 6 mg, one time
- Where
- Iran
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Stroke, Inflammation
Combinating Fingolimod With Alteplase Bridging With Mechanical Thrombectomy in Acute Ischemic Stroke
Proof-of concept clinical trials have indicated that the sphingosine-1-phosphate receptor modulator fingolimod may be efficacious in attenuating brain inflammation and improving clinical outcomes in patients with AIS as a single…
- Trial name
- FAMTAIS (NCT02956200)
- Testing
- Fingolimod
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epilepsy
Medication Adherence in Individuals With Epilepsy
There is an urgent need to understand the psychological and situational factors that influence medication adherence in individuals with epilepsy.
- Trial name
- NCT01566500
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Columbia University
Mild Cognitive Impairment (MCI)
Impacts of Kebbi Robot Intervention for Older Adults With Mild Dementia
The goal of this clinical trial is to examine the immediate and sustained effects of an intensive Kebbi robot intervention on cognitive functions, heart rate variability (HRV), and psychological changes for older adults with mild…
- Trial name
- NCT06606600
- Testing
- Intensive Kebbi robot interventions
- Where
- 2 sites in Taiwan
- Volunteers
- 136 people
- Sponsor
- National Tainan Junior College of Nursing
Spinal Cord Injury, Chronic Pain
VR Mindfulness Training for Veterans With SCI
This study involves delivering a mindfulness program that was developed for Veterans called VA Compassionate Awareness Learning Module (VA CALM) to Veterans with spinal cord injuries (SCI) to develop accommodations to make the VA…
- Trial name
- NCT06587607
- Testing
- VA Compassionate Awareness Learning Module (VA CALM) a mindfulness curriculum.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
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