Clinical trials: Diseases of the Nervous System
Parkinsonism in Diseases Classified Elsewhere
The Efficacy of Online Exergaming-Integrated Physiotherapy for Parkinson's Disease
To validate the efficiency of online exergaming-based physiotherapy. We will enroll patients with Parkinson's disease in postural instability and gait disturbance motor phenotype in the study and divide them into two groups in a…
- Trial name
- NCT06317792
- Testing
- online exergaming-based physiotherapy programs
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Hearing Loss
Virtual Acoustic Localization Experiment
The present study has the evaluation of a test to measure the localization performance goal . It is about the perception of danger audio signals in everyday listening environments nearby which are reproduced in controlled…
- Trial name
- VALEEvE (NCT02602171)
- Testing
- Oldenburger sentence test, localization test
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Ischemic Stroke
Tongxinluo Capsule in Ischemic Stroke Patients（TISS)
The purpose of this study is to assess the effects in improving life self-care ability of stroke patients after taking Tongxinluo Capsule(within 72 hours after onset) versus Placebos for 90 days.
- Trial name
- NCT01919671
- Testing
- Tongxinluo capsule
- Where
- China
- Volunteers
- 2,007 people
- Sponsor
- yongjun wang
Glaucoma, Intraocular Pressure
Comparing Rates of Glaucoma in Professional Wind Versus Non-Wind Instrument Players
The purpose of the present study is to compare rates of glaucomatous optic neuropathy in professional wind versus non-wind instrument players in the Philadelphia Orchestra.
- Conditions
- Glaucoma, Intraocular Pressure, Optic Neuropathy
- Trial name
- NCT02612571
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Wills Eye
Gaucher Disease
A Study of Eliglustat Tartrate (Genz-112638) in Patients With Gaucher Disease to Evaluate Once Daily Versus Twice Daily Dosing (EDGE)
The primary objective of this study was to evaluate the efficacy and safety of once daily (QD) versus twice daily (BID) dosing of eliglustat tartrate (Genz-112638) in participants with Gaucher disease type 1 who had demonstrated…
- Trial name
- NCT01074944
- Testing
- Eliglustat tartrate
- Where
- 46 sites in United States, Australia and 15 more
- Volunteers
- 170 people
- Sponsor
- Genzyme, a Sanofi Company
Restless Legs Syndrome
Clinical Evaluation of Ropinirole IR (Immediate Release) Tablets in Patients Who Are Diagnosed With Symptomatic Restless Legs Syndrome (RLS) Associated With Chronic Kidney Disease (CKD) Managed With Haemodialysis (Including Haemofiltration and Haemodiafiltration)
This is a multicenter, placebo controlled, parallel group, double-blind, randomized comparison study to evaluate the efficacy and safety of ropinirole IR tablets orally administered for 12 weeks in patients with symptomatic…
- Trial name
- NCT00996944
- Testing
- Ropinirole immediate release (IR)
- Where
- 19 sites in Japan
- Volunteers
- 34 people
- Sponsor
- GlaxoSmithKline
Muscle Weakness
Ventilatory Muscle Training by Breath-Stacking in Healthy Youngsters
In several diseases in which muscle weakness is a determining factor for morbidity and mortality, inspiratory muscle training has been shown to be useful in improving the function of ventilatory muscles, delaying or minimizing…
- Trial name
- NCT03258944
- Testing
- Breath-Stacking
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Stroke, Acute, Stroke
Yield of Implantable Cardiac Monitoring Device in Patients With Acute Ischemic Stroke.
In this prospective cohort study, the investigators aim to investigate the incidence of ICM-detected AF in unselected ischemic stroke patients and its association with anticoagulation initiation and stroke recurrence.
- Conditions
- Stroke, Acute, Stroke, Stroke, Ischemic, Atrial Fibrillation
- Trial name
- NCT05494034
- Testing
- Reveal LINQTM
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- National and Kapodistrian University of Athens
Cluster Headache
CGRP's Cluster Headache Inducing Abilities in Cluster Headache Patients
It has previously been shown that nitroglycerine induces cluster headache attacks in episodic cluster headache patients (ECH patients) in bouts but not in remission phase.
- Trial name
- NCT02466334
- Testing
- Calcitonin-Gene Related Peptide
- Where
- Denmark
- Volunteers
- 37 people
- Sponsor
- Danish Headache Center
Brain Tumor
Brain Tumor Surgery and Postoperative Delirium
1. To explore whether the combined administration of dexmedetomidine during and after surgery in patients undergoing brain tumor resection is an effective and safe modality to prevent postoperative delirium and improve sleep…
- Trial name
- NCT06863064
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Intracranial Hypertension
Comparison of the Effects of Deep and Moderate Neuromuscular Blockade on Optic Nerve Sheath Diameter
Increased intracranial pressure (IICP) is a common problem in traumatic brain injuries and many medical diseases. Early recognition of IICP can save lives.
- Trial name
- MBLONDE (NCT04211064)
- Testing
- Ultrasonographic measurement of optic nerve sheath diameter, Deep neuromuscular block, Moderate neuromuscular block
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Healthy Volunteers (HV), Parkinson's Disease (PD)
Research Into the Safety of a New Agent (VT-5006) in People With and Without Parkinson's Disease
This is a first-in-human (FIH) study of orally administered VT-5006 (also known as AX-5006) in healthy adult volunteers (HVs) and adult participants with Parkinson's disease (PD).
- Trial name
- NCT07310264
- Testing
- VT-5006
- Where
- Netherlands
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Vertero Therapeutics
Prostate Cancer, Pain Cancer
Determining the Effect of Abiraterone on the Metabolism of Oxycodone in Men With Prostate Cancer (the ENABLE Study)
Prostate cancer often leads to bone metastases, which require adequate pain management with opioids such as oxycodone. This study investigates whether abiraterone - a drug used in the treatment of prostate cancer - affects the…
- Trial name
- ENABLE (NCT07001709)
- Testing
- Oxycodone oral capsule 15 mg, Abiraterone Acetate Tablets 500 mg
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Deventer Ziekenhuis
Stroke, Hemiplegia
Usability Testing of Affordable Haptic Robots for Stroke Therapy
Stroke survivors with hemiplegia will be evaluated by rehabilitation professionals and asked to perform a battery of assessments to test the viability and usability of a force-feedback robot that adapts to each individual…
- Trial name
- Theradrive (NCT02772809)
- Testing
- Haptic Robot Therapy with Games
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pennsylvania
Aneurysm, Cerebral, Endovascular Procedures
Comparison of Two Different Antiplatelet Preparations for an Unruptured Intracranial Aneurysm
Perform a randomized comparison study of dual-antiplatelet (aspirin, prasugrel) and triple-antiplatelet (aspirin, clopidogrel, and cilostazol) preparation using P2Y12 assay in patients with high on-treatment platelet reactivity…
- Trial name
- NCT03581409
- Testing
- Aspirin, Prasugrel, Clopidogrel
- Where
- South Korea
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pain, Child, Only
The Effect Of Use Of Raınstick And Kaleydoscope On Paın Anxıety Durıng Blood Draw
Medical procedures are negative experiences that cause pain, distress, and anxiety and are not only uncomfortable during medical procedures, especially in children; negative consequences such as poor recovery, sleep disturbances…
- Conditions
- Pain, Child, Only, Anxiety, Pain, Procedural
- Trial name
- NCT05288309
- Testing
- RAINSTİCK, KALEİDOSCOPE
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Erzincan Binali Yildirim Universitesi
Oculomotor Nerve Palsy, Trochlear Nerve Palsy
A Retrospective Study of the Effects of Ocular Acupuncture on Ocular Motor Nerve Palsy
This retrospective observational study is designed to assess the response to treatment with ocular acupuncture and its relative factors, in terms of diplopia status, ocular motility differences, and clinical features, in ocular…
- Conditions
- Oculomotor Nerve Palsy, Trochlear Nerve Palsy, Abducens Nerve Paralysis
- Trial name
- NCT03461809
- Testing
- Ocular acupuncture
- Volunteers
- 900 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Stroke
TENS and Spasticity in Stroke Patients
study aims to evaluate the efficacy of high and low frequency TENS on spasticity, strength and functional status in stroke patients.
- Trial name
- NCT05075109
- Testing
- High Frequency TENS, Low Frequency TENS, Task Related Training
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Phenylketonurias, Nutritional and Metabolic Diseases
Comparison of Atherogenic Risk Factors and Efficacy of Nutritional Treatment Among Adult Phenylketonuria Patients
Phenylketonuria is a rare metabolic disease that results from the absence or near-absence activity of the enzyme phenylalanine hydroxylase, which metabolizes the amino acid phenylalanine to tyrosine in the body.
- Trial name
- NCT04969809
- Testing
- Ultrasound of the jugular veins, addition of phenylalanine-free protein substitutes
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Obstructive Sleep Apnea
Education Programme on Continuous Positive Airway Pressure Treatment
The purpose of this study is to examine whether an education programme would enhance continuous positive airway pressure (CPAP) adherence.
- Trial name
- NCT01173406
- Testing
- CPAP education
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
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