Clinical trials: Diseases of the Nervous System
REM Sleep Behavior Disorder, Parkinson Disease
A Study of Efficacy and Safety of Idebenone Vs. Placebo in Prodromal Parkinson Disease
To investigate whether 24 months of idebenone may reduce the progression from Prodromal Parkinson disease (PPD) to Parkinson disease (PD).
- Trial name
- SEASEiPPD (NCT04152655)
- Testing
- Idebenone
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Abdominal Pain
Sublingual Analgesia for Acute Abdominal Pain in Children
Acute abdominal pain is a frequent symptom in children admitted to the emergency department . In the past the fear of masking a surgical condition has justified withholding analgesia in patients with acute abdominal pain.
- Trial name
- NCT02465255
- Testing
- Ketorolac, Tramadol, Acetaminophen
- Where
- Italy
- Volunteers
- 210 people
- Sponsor
- IRCCS Burlo Garofolo
Parkinson Disease
Development of Digital Diagnostic Devices for Parkinson's Disease
In this project, ocular motor, pupil and gait data in people with Parkinson's disease (PD) will be collected in order to develop machine learning models for the diagnosis and monitoring of PD.
- Trial name
- NCT06663826
- Testing
- oculomotor and pupillary function assessment
- Where
- Switzerland
- Volunteers
- 116 people
- Sponsor
- machineMD AG
Metastatic Brain Tumor, Primary Brain Tumor
Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System
The NeuroBlate® System (NBS) is a minimally invasive robotic laser thermotherapy tool that is being manufactured by Monteris Medical.
- Conditions
- Metastatic Brain Tumor, Primary Brain Tumor, Epileptic/Seizure Foci, Movement Disorders
- Trial name
- LAANTERN (NCT02392078)
- Testing
- NeuroBlate System
- Where
- 26 sites in United States
- Volunteers
- 1,153 people
- Sponsor
- Monteris Medical
Traumatic Brain Injury
Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheostomy
This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding…
- Trial name
- STBI (NCT06199778)
- Testing
- Rehabilitation therapy, Intermittent Oro-esophageal Tube Feeding, Nasogastric tube feeding
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Zeng Changhao
Alzheimer Disease
Study of Aripiprazole in the Treatment of Patients With Psychosis Associated With Dementia of the Alzheimer's Type
The purpose of this study is to learn if aripiprazole is safe and effective in the treatment of psychosis associated with dementia of the Alzheimer's type.
- Trial name
- NCT00041678
- Testing
- aripiprazole
- Where
- 6 sites in United States
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer
RATIONALE: Taking part in a clinical trial may help children with cancer receive more effective treatment. PURPOSE: Determine why patients who are eligible for protocols made available through the Pediatric Oncology Group do not…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Leukemia
- Trial name
- NCT00002485
- Testing
- psychosocial assessment and care
- Where
- 31 sites in United States, Canada and 2 more
- Volunteers
- 359 people
- Sponsor
- Children's Oncology Group
Huntington Disease
Safety Evaluation of Cellavita HD Administered Intravenously in Participants With Huntington's Disease
Cellavita HD is a stem-cell therapy for Huntington's Disease. This is a first-in-human, non-randomized, phase I study in which participants with Huntington's Disease will receive three intravenous injections and will be followed…
- Trial name
- SAVE-DH (NCT02728115)
- Testing
- Cellavita HD Lower Dose, Cellavita HD Higher dose
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- Azidus Brasil
Stroke Patients With Hemiplegia or Hemiparesis in the Subacute Stage
The Effect of Combined Transcranial Pulse Current Stimulation (tPCS) and Transcutaneous Electrical Nerve Stimulation (TENS) on Lower Limb Motor Function in Subacute to Chronic Stroke Patients With Hemiplegia (COMPENSATOR-Stroke)
The goal of this study is to evaluate the effects of high frequency tPCS + TENS compared to Sham device stimulation + TENS (Control) in lower limb motor function recovery in stroke patients with hemiplegia or hemiparesis in the…
- Trial name
- COMPENSATOR (NCT06999876)
- Testing
- The AscenZ-VIII Stimulator (Investigational Medical Device)
- Where
- 2 sites in Singapore
- Volunteers
- 90 people
- Sponsor
- National University Health System, Singapore
Temporal Lobe Epilepsy, Open Surgery
Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy
Temporal lobe epilepsy (TLE) is a chronically neurological disease characterized by progressive seizures. TLE is the most frequent subtype of refractory focal epilepsy in adults.
- Conditions
- Temporal Lobe Epilepsy, Open Surgery, Minimally Invasive Surgery
- Trial name
- MISET-TLE (NCT05019404)
- Testing
- Functional anterior temporal lobectomy (FATL), Anterior temporal lobectomy (ATL)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Rotator Cuff Tendinosis
Blood Flow Restriction Training in Patients With Shoulder Pain
This study was planned to investigate the effect of blood flow restriction exercise training on shoulder muscle strength and muscle thickness, and to determine the change in pain and symptoms in patients with rotator cuff…
- Trial name
- NCT04333784
- Testing
- Exercise training
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hacettepe University
Epilepsy
Mobile Phone Radiation and Brain Rhythm in Epileptic Patients
This work is intended to assess the effect of -30 minutes- exposure to mobile-phone on the functions of the central nervous system (CNS) in epileptic patients.
- Trial name
- NCT02854384
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
CDKL5 Deficiency Disorder
Study of Adjunctive Ganaxolone Treatment in Children and Young Adults With CDKL5 Deficiency Disorder
A clinical study to evaluate the efficacy, safety, and tolerability of adjunctive ganaxolone therapy compared to placebo for the treatment of seizures in children and young adults with genetically confirmed CDKL5 gene mutation.
- Trial name
- Marigold (NCT03572933)
- Testing
- ganaxolone
- Where
- 36 sites in United States, Australia and 6 more
- Volunteers
- 101 people
- Sponsor
- Marinus Pharmaceuticals
Overweight and Obesity, Metabolic Syndrome
Changes in the Hypotalamic-pituitary Region of Patients With Metabolic Syndrome and Obesity
This study aims to identify new morphological and quantitative magnetic imaging parameters of pituitary gland and sellar region in overweight and obese patient at baseline and after 3 years, dividing patients in 3 groups (weight…
- Trial name
- CHIASM (NCT03458533)
- Testing
- Bariatric surgery, Diet and lifestyle changes
- Where
- Italy
- Volunteers
- 69 people
- Sponsor
- University of Roma La Sapienza
Fragile X Syndrome
An Open Label Extension Study in Subjects With Fragile X Syndrome
This study will enroll subjects who have completed Protocols 209FX301, 209FX302, or are currently participating in Protocol 2202 into a long-term study in which all subjects will receive active drug (arbaclofen).
- Trial name
- 209FX303 (NCT01555333)
- Testing
- arbaclofen
- Where
- 23 sites in United States
- Volunteers
- 357 people
- Sponsor
- Seaside Therapeutics, Inc.
Spina Bifida, Myelomeningocele
Fetoscopic Repair of Isolated Fetal Spina Bifida
The purpose of this investigation is to evaluate maternal and fetal outcomes following fetoscopic repair of fetal spina bifida at the Johns Hopkins Hospital.
- Conditions
- Spina Bifida, Myelomeningocele, Chiari Malformation Type 2, Neural Tube Defects
- Trial name
- NCT03090633
- Testing
- Fetoscopy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Stroke, Acute, TBI
Tracheostomy With Bedside Simultaneous Gastrostomy Vs Usual Care Tracheostomy And Delayed Gastrostomy Placement
There is currently no prospective study analyzing the effect of tracheostomy with bedside simultaneous gastrostomy versus tracheostomy with delayed gastrostomy placement (TSG versus TDG) on the outcomes of neurocritically-ill…
- Conditions
- Stroke, Acute, TBI, Neuromuscular Diseases, Status Epilepticus
- Trial name
- BEGASTON (NCT04758052)
- Testing
- Timing of placement
- Where
- United States
- Sponsor
- University of Mississippi Medical Center
Chronic Insomnia
Cognitive Behavioral Therapy (CBT)-Insomnia for Lung Cancer
The purpose of this study is to determine whether cognitive behavioral therapy (CBT) is effective for insomnia in lung cancer survivors.
- Trial name
- NCT02121652
- Testing
- Cognitive behavioral therapy for insomnia, Healthy eating control
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- State University of New York at Buffalo
Dementia, Alzheimer Disease
The Efficacy of Traditional Chinese Herbal Medicine for Dementia
The Clinical trial is a pilot study for treatment of Alzheimer dementia by traditional Chinese herbal medicine(TCM).
- Trial name
- NCT03838952
- Testing
- Herbal medicine
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Analgesia
Comparison of Standard Epidural and Dural Puncture Epidural Analgesia in Open Gynecological Surgery Techniques
The aim of this study is to compare the effectiveness of standard epidural and dural puncture epidural analgesia techniques used under NOL guidance.
- Trial name
- NCT05408052
- Testing
- Dural Puncture Epidural (DPE), Standart Epidural
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ataturk University
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