Clinical trials: Diseases of the Nervous System
Multiple Sclerosis
Promotion of Exercise Through Physical Therapy for Multiple Sclerosis: A Pilot Study
Physical activity and exercise help manage symptoms like fatigue in people living with multiple sclerosis (MS). Despite research supporting physical activity participation, people with MS are often insufficiently active to reach…
- Trial name
- PromPT-MS (NCT06933160)
- Testing
- PromPT-MS
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Michigan
Rett Syndrome
ANAVEX2-73 Study in Pediatric Patients With Rett Syndrome
ANAVEX2-73-RS-003 is a Phase 2/3, double-blind, randomized, placebo-controlled dose escalation safety, tolerability and efficacy study in patients 5-17 years of age with RTT using endpoints including multiple clinical and…
- Trial name
- EXCELLENCE (NCT04304482)
- Testing
- ANAVEX2-73 oral liquid
- Where
- 12 sites in Australia, Canada and 1 more
- Volunteers
- 92 people
- Sponsor
- Anavex Life Sciences Corp.
Obstructive Sleep Apnea (OSA)
A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults
Researchers want to identify which treatments for obstructive sleep apnea (OSA) work best and are easiest for patients to use consistently.
- Trial name
- ADAPT-OSA (NCT07679282)
- Testing
- Positive airway pressure (PAP) therapy, Sleep dental device, Atomoxetine-oxybutynin
- Where
- 4 sites in United States
- Volunteers
- 2,400 people
- Sponsor
- Sairam Parthasarathy
Stroke (Subacute)
Computer Based Cognitive Rehabilitation (CBCR) Intervention for Young Stroke Survivors' Return to Work
Stroke can damage the brain, which may make it harder for survivors to think clearly, solve problems, and remember things. These changes in thinking can make it difficult for people to return to their jobs after a stroke.
- Trial name
- CBCR (NCT07787013)
- Testing
- RehaCom online
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Bournemouth University
Caregiver Burden, Alzheimer Disease
I-CARE 2: Mobile Telehealth to Reduce Alzheimer'S-related Symptoms
This study is a randomized, controlled trial (RCT) to evaluate the effect of Brain CareNotes (a mobile health application) on the burden experienced by unpaid caregivers of patients with dementia and on the behavioral and…
- Trial name
- I-CARE 2 (NCT05733520)
- Testing
- Brain CareNotes, Dementia Guide Expert
- Where
- 2 sites in United States
- Volunteers
- 184 people
- Sponsor
- Indiana University
Rhabdomyosarcoma, Malignant Peripheral Nerve Sheath Tumors
Trial of Dasatinib in Advanced Sarcomas
This study will examine the response rate and the 6-month progression-free survival rates of subjects with advanced sarcoma treated with dasatinib.
- Conditions
- Rhabdomyosarcoma, Malignant Peripheral Nerve Sheath Tumors, Chondrosarcoma, Sarcoma, Ewing's
- Trial name
- NCT00464620
- Testing
- Dasatinib
- Where
- 20 sites in United States
- Volunteers
- 366 people
- Sponsor
- Sarcoma Alliance for Research through Collaboration
Diabetic Neuropathies, Pain
The Effects of the Magnetic Molecular Energizer (MME) on Diabetic Peripheral Neuropathy
This study is intended to demonstrate that exposure to a high intensity, DC electromagnetic field, as supplied by the investigational device known as the Molecular Magnetic Energizer (MME), will create a clinically meaningful…
- Conditions
- Diabetic Neuropathies, Pain, Neuralgia
- Trial name
- NCT00134524
- Testing
- MME procedure
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Advanced Magnetic Research Institute International
Sleep Initiation and Maintenance Disorders
Effect of Device Guided Breathing on Sleeplessness (2BRT01)
The current study is designed to evaluate the effect of device guided breathing (DGB) on sleeplessness. Healthy subjects with mild to moderate sleeplessness that wish to improve their sleep quality will be included in this study.
- Trial name
- 2BRT01 (NCT02521324)
- Testing
- DGB2
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Afeka, The Tel-Aviv Academic College of Engineering
Alzheimer Disease
Senolytic Therapy to Modulate Progression of Alzheimer's Disease
The purpose of this pilot study is to evaluate whether a combination of two drugs, dasatinib (D) and quercetin (Q) [D+Q], penetrate the brain using cerebrospinal fluid (CSF) in older adults with early Alzheimer's disease (AD).
- Trial name
- SToMP-AD (NCT04063124)
- Testing
- Dasatinib + Quercetin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Cerebrovascular Accident
Effects of Combined Resistance and Aerobic Training vs Aerobic Training on Cognition and Mobility Following Stroke
Both aerobic training (AT) and resistance/strength training (RT) have the potential to improve recovery after stroke. Research conducted in chronic disease and healthy populations suggest that AT and RT "combination therapy" may…
- Trial name
- TRI-RAvA (NCT01712724)
- Testing
- combined resistance and aerobic training
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- University Health Network, Toronto
Parkinson Disease
Dance Well Therapy: a Study for Evaluating Efficacy, Safety, and Feasibility
A new and in-teresting complementary approach for rehabilitation of parkinsonian patients is represented by "Dance Well", which is an artistic, multisensory dance intervention based on art and music.
- Trial name
- DWpsVMF (NCT06896123)
- Testing
- Dance Well: an artistic, multisensory dance intervention based on art and music, Conventional motor therapy group
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Casa di Cura Villa Margherita Fresco
Acute intraCerebral Haemorrhage
Prevention of Epileptic Seizures in Acute intraCerebral Haemorrhage
Haemorrhagic strokes represent about 10-15 % of all strokes and 30,000 cases per year in France. The 30-day death rate ranges from 30 to 55% (50% of deaths occurring within 48 hours).
- Trial name
- PEACH (NCT02631759)
- Testing
- Lévétiracetam
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Cardiovascular Diseases, Coronary Disease
Honolulu Heart Program
To investigate coronary heart disease and stroke among American men of Japanese ancestry who were living on the island of Oahu in 1965. Morbidity and mortality surveillance of the original cohort is continuing.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Accident, Heart Diseases
- Trial name
- NCT00005123
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
ALS (Amyotrophic Lateral Sclerosis)
Intermediate-size Patient Population Expanded Access Protocol
The purpose of this Expanded Access Program is to provide tazbentetol to ALS patients who are not eligible to enroll in an ALS clinical trial.
- Trial name
- NCT07088159
- Testing
- Tazbentetol
- Where
- 16 sites in United States
- Sponsor
- Spinogenix
Primary Hyperalgesia
Sensory Function After Wound Instillation of Capsaicin
The use of capsaicin as a potential analgesic drug for postoperative pain relies on the ability of capsaicin to induce membrane lysis of c-nerve fibers.
- Trial name
- NCT00583180
- Testing
- Capsaicin
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Opioid Use, Pain, Musculoskeletal
Naloxone Education in Total Joint Patients
This study examines the efficacy of a brief pre-hospital naloxone education module added to the standard "Total Joint Class" curriculum on patient safety and experience.
- Conditions
- Opioid Use, Pain, Musculoskeletal, Surgery, Overdose of Opiate
- Trial name
- NCT04868552
- Testing
- Pre-hospital naloxone education
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Carilion Clinic
Spinal Cord Injury
Implantable Wireless Brain-Machine Interface System for Spinal Cord Injury: Efficacy and Safety Study
This is a prospective, open-label, multi-center, single-arm study to evaluate the efficacy and safety of an implantable wireless brain-machine interface (BMI) system in patients with spinal cord injury.
- Trial name
- NCT07603752
- Testing
- WRS
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai StairMed Technology Co., Ltd.
Intracranial Neoplasm
The Effect of Cerebral Oxygenation on Postoperative Recovery in Intracranial Surgery
The aim of this study was to investigate the effect of cerebral oxygenation on postoperative compilation in intracranial surgery.
- Trial name
- Oxygenation (NCT03714347)
- Testing
- cerebral oxygen monitoring, routine monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Trakya University
Brain Injuries
Efficacy of Nucleo CMP Forte in Traumatic Brain Injury in Pediatrics
Efficacy of Nucleo CMP Forte in Traumatic Brain Injury in Pediatrics
- Trial name
- NCT04499755
- Testing
- Nucleo CMP Forte
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sherief Abd-Elsalam
Dravet Syndrome
A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Fenfluramine (Hydrochloride) in Infants 1 Year to Less Than 2 Years of Age With Dravet Syndrome
The primary purpose of this study is evaluate the safety and tolerability of fenfluramine hydrochloride (HCl) 0.2 to 0.8 mg/kg/day in infants 1 year to less than 2 years of age with Dravet syndrome.
- Trial name
- ORCHID (NCT06118255)
- Testing
- fenfluramine
- Where
- 12 sites in United States, Belgium and 3 more
- Volunteers
- 25 people
- Sponsor
- UCB BIOSCIENCES, Inc.
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