Clinical trials: Diskectomy
Cervical Degenerative Disc Disease
Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease
The purpose of the study is to evaluate the performance of the Discover cervical Artificial disc in the treatment of degenerative disc disease in one level of the cervical spine.
- Trial name
- NCT00700739
- Testing
- DISCOVER™ Artificial Cervical Disc, ACDF
- Where
- 8 sites in Australia, Germany and 5 more
- Volunteers
- 60 people
- Sponsor
- DePuy International
Disk, Herniated
A Pilot Study of the InterCushion Disc Nucleus Prosthesis (DNP) in Patients Receiving Discectomy
The primary endpoints of the investigation will include assessment of the maintenance of disc height demonstrated by radiographic evidence based on plain radiographs and MRI and relief of pain as measured by Visual Analog Scale…
- Trial name
- NCT01652053
- Testing
- Disc Nucleus Replacement (InterCushion DNP)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Vertebral Technologies, Inc.
Failed Back Surgery Syndrome, Pain
Spinal Cord Stimulation With Precision® System Versus Reoperation for Failed Back Surgery Syndrome
The EVIDENCE trial is a randomized controlled trial comparing the therapeutic effectiveness and cost-effectiveness of the Precision® Spinal Cord Stimulation with that of reoperation as a treatment of pain in patients with Failed…
- Conditions
- Failed Back Surgery Syndrome, Pain, Back Pain
- Trial name
- Evidence (NCT01036529)
- Testing
- Precision Spinal Cord Stimulator, Back Surgery
- Where
- 18 sites in United States, Canada and 2 more
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Degenerative Instability, Spondylolisthesis
PMCF Study on the Safety and Performance of PROSPACE 3D / PROSPACE 3D OBLIQUE / TSPACE 3D
Prospective, pure data collection of all PROSPACE 3D, PROSPACE 3D Oblique, TSPACE 3D patients in selected centers (not interventional, multicenter
- Conditions
- Degenerative Instability, Spondylolisthesis, Post-discectomy Syndrome, Post-traumatic Instabilities
- Trial name
- PROTONTO (NCT04542577)
- Where
- 2 sites in Germany
- Volunteers
- 208 people
- Sponsor
- Aesculap AG
Diskectomy
Randomized Study of Anular Repair With the Xclose Tissue Repair System
The purpose of this study is to evaluate the benefits of anulus fibrosus repair utilizing Xclose™ compared to a discectomy without anulus fibrosus repair.
- Trial name
- NCT00760799
- Testing
- Discectomy with anular repair
- Where
- 34 sites in United States
- Volunteers
- 750 people
- Sponsor
- Anulex Technologies, Inc.
Cervical Degenerative Disc Disease
PureGen: Radiographic Analysis of Fusion for ACDF
The purpose of this study is to evaluate the rate and quality of spinal fusion utilizing PureGen Osteoprogenitor Cell Allograft in Anterior Cervical Discectomy and Fusion (ACDF).
- Trial name
- NCT01291134
- Testing
- PureGen Osteoprogenitor Cell Allograft
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Alphatec Spine, Inc.
Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis
Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion
The purpose of this study is to evaluate the safety and preliminary efficacy of NeoFuse in subjects with a diagnosis of degenerative disc disease (DDD) at 2 or more adjacent cervical vertebral levels between C3-C4 to C7-T1.
- Conditions
- Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT01106417
- Testing
- NeoFuse, MasterGraft Granules
- Where
- 2 sites in Australia
- Volunteers
- 12 people
- Sponsor
- Mesoblast, Ltd.
Cervical Degenerative Disc Disease
Comparison of DISCOVER™ Artificial Cervical Disc and ACDF for Treatment of Cervical DDD (IDE Study)
This study is intended to treat patients with symptomatic degenerative disc disease at one level of the cervical spine. The patients will be randomized to the DISCOVER Artificial Cervical Disc (total disc replacement) or…
- Trial name
- NCT00432159
- Testing
- Cervical TDR, ACDF with plate
- Where
- 32 sites in United States, Australia and 1 more
- Volunteers
- 500 people
- Sponsor
- DePuy Spine
Cervical Radiculopathy, Myelopathy
Safety Study of Preservon-Treated Bone Implants for Cervical Fusion in the Treatment of Cervical Radiculopathy or Myelopathy
The purpose of this study is to compare the safety and efficacy of Preservon(TM) treated allograft bone dowels to traditional freeze-dried allograft bone dowels (control) for fusion of degenerated cervical intervertebral discs in…
- Trial name
- NCT00344890
- Testing
- Anterior Cervical Discectomy and Fusion
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- LifeNet Health
Cervical Disc Degeneration
Study to Evaluate the Clinical and Radiographic Outcomes of the BEE® HA Cage for Anterior Cervical Discectomy and Fusion
Observational data collection of information after undergoing standard Cervical spine fusion surgery.
- Trial name
- NCT05631392
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Invibio Ltd
Symptomatic Cervical Disc Disease
Safety and Efficacy Study Comparing ProDisc-C to ACDF Surgery to Treat SCDD
The objective of this clinical investigation is to compare the safety and effectiveness of ProDisc-C to anterior cervical discectomy and fusion (ACDF) surgery in the treatment of symptomatic cervical disc disease (SCDD).
- Trial name
- NCT00291018
- Testing
- Total Disc Replacement, ACDF
- Volunteers
- 368 people
- Sponsor
- Synthes USA HQ, Inc.
Disc Degeneration;Cervical
The NanoStrand Clinical Study
A prospective, multi-center, randomized, self-controlled, single-blinded, clinical study evaluating the NanoMetalene implant as compared to the PEEK and allograft implants in ACDF for the treatment of cervical degenerative disc…
- Trial name
- NCT03871400
- Testing
- Anterior cervical discectomy and fusion
- Where
- 11 sites in United States
- Volunteers
- 18 people
- Sponsor
- SeaSpine, Inc.
Failed Back Surgery Syndrome
A Post Market Study on Dorsal Root Ganglion (DRG) Stimulation in Failed Back Surgery Syndrome (FBSS)
18-SMI-2013 is a post market, observational, questionnaire based study to assess the effectiveness of the commercially available Axium neurostimulator in the management of chronic pain following lumbar discectomy (Failed Back…
- Trial name
- SYMPATHY (NCT02335216)
- Testing
- Implantation with the commercially available Axium neurostimulator
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Abbott Medical Devices
Symptomatic Cervical Disc Disease
Novum Vitrium® Cervical Cage in Anterior Cervical Discectomy and Fusion
A prospective, multicenter, randomized, concurrently controlled, noninferiority clinical trial to compare the safety and effectiveness of instrumented Bio2 Vitrium Cervical Interbody Device in anterior cervical discectomy and…
- Trial name
- NCT03828136
- Testing
- Novum Vitrium® Cervical Interbody Device, Allograft Ring or Block
- Where
- 7 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bio2 Technologies
Degenerative Disc Disease in Cervical Spine
Osteocel® Plus in Anterior Cervical Discectomy and Fusion (ACDF)
This is a prospective, non-randomized multi-center study to compare the use of Osteocel Plus in subjects who receive ACDF surgery at one or two levels.
- Trial name
- NCT00942045
- Testing
- Biologic - Osteocel Plus
- Where
- 17 sites in United States
- Volunteers
- 182 people
- Sponsor
- NuVasive
Lumbar Spine Disc Herniation
Lumbar Discectomy Control Study, Risk Factors for Reherniation
The purpose of this 12-month, prospective, multicenter study is to investigate the effect of annular defect size and other risk factors on reherniation and associated costs in primary lumbar discectomy patients.
- Trial name
- NCT02477176
- Testing
- Discectomy
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Intrinsic Therapeutics
Cervical Degenerative Disc Disease
The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery
A multicenter, prospective, non-randomized, historically controlled study. To demonstrate the Synergy Disc is at least as safe and effective as conventional anterior cervical discectomy and fusion (ACDF) to treat cervical…
- Trial name
- NCT05740176
- Testing
- Anterior Cervical Discectomy and Fusion
- Where
- 23 sites in United States
- Volunteers
- 200 people
- Sponsor
- Synergy Spine Solutions
Cervical Radiculopathy, Degenerative Disc Disease
Restore CLINICAL TRIAL
This is a prospective, concurrently controlled, multi-center study to evaluate the safety and effectiveness of the Spinal Kinetics M6-C artificial cervical disc compared to anterior cervical discectomy and fusion (ACDF) for the…
- Trial name
- NCT01609374
- Testing
- M6-C Artificial Cervical Disc, Anterior plate system with corticocancellous allograft bone
- Volunteers
- 258 people
- Sponsor
- Spinal Kinetics
Degenerative Disc Disease
Prospective Study To Assess The Safety and Efficacy of the PROW LIF Procedure
This is a prospective, single-arm, open-label, non-randomized study. The aim of the study is to assess the safety and efficacy of the Prow LIF procedure in Transforaminal Lumbar Interbody Fusion (TLIF) procedures for the…
- Trial name
- NCT01850537
- Testing
- treatment of degenerative disc disease using the PROW LIF
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- NLT Spine
Cervical Stenosis, Spondylolisthesis
Effectiveness of AlloWrap® for the Reduction of Inflammation in ACDF Procedures
The primary objective of this study is to obtain evidence of the effectiveness of AlloWrap Amniotic Membrane in the reduction of soft tissue swelling in two-level ACDF procedures.
- Conditions
- Cervical Stenosis, Spondylolisthesis, Cervical Radiculopathy, Cervical Disc Disorder
- Trial name
- NCT04684901
- Testing
- AlloWrap® Amniotic Membrane
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- AlloSource