Clinical trials: Disorder, Mood
Late-life Depression, Major Depressive Disorder
Cognitive Behavioural Therapy for the Treatment of Late Life Depression
This study addresses the unmet medical problem of insufficient treatment of late life depression (LLD). Compared with depression in early adulthood, treatment options of LLD are limited.
- Conditions
- Late-life Depression, Major Depressive Disorder, Major Depressive Episode, Major Depressive Disorder, Recurrent
- Trial name
- CBTlate (NCT03735576)
- Testing
- Psychotherapy, Questionnaires, Magnetic Resonance Imaging
- Where
- 7 sites in Germany
- Volunteers
- 250 people
- Sponsor
- University of Cologne
Psychotic Disorders, Schizophrenia
Examining the Efficacy of a Virtual Reality Cognitive Remediation Program for People Living With Psychosis
Individuals living with a psychotic disorder often experience changes to their thinking and social skills that can lead to challenges with work, school, relationships and living independently.
- Conditions
- Psychotic Disorders, Schizophrenia, Schizo Affective Disorder
- Trial name
- NCT05973110
- Testing
- Cognitive Remediation, Active Control
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Generalized Anxiety Disorder (GAD), Major Depressive Disorder (MDD)
AI-Supported Therapy for Depression and Anxiety Compared With Standard CBT
This study is a pivotal, randomised, controlled, non-inferiority trial evaluating "Nook," an AI-delivered, neurosymbolic, clinician-supervised digital psychological intervention for depression and anxiety, compared with standard…
- Trial name
- NCT07620340
- Testing
- AI-Digital CBT, Cognitive Behavioural Therapy
- Volunteers
- 400 people
- Sponsor
- PsyScale
Major Depressive Disorder, Late Life Depression
SSIPP vs. PST vs. WLC
The COVID-19 pandemic and continued lockdown measures have led to social isolation that is likely disproportionately affecting community-dwelling seniors.
- Trial name
- NCT04887350
- Testing
- Student-Senior Isolation Prevention Partnership (SSIPP), Problem Solving Therapy (PST).
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Major Depressive Disorder
Feasibility of a Behavioral Activation Trial
The goal of this project is to train community mental health therapists in behavioral activation (BA) treatment for major depressive disorder and then to conduct a study examining the feasibility of evaluating the effectiveness…
- Trial name
- NCT02992158
- Testing
- behavioral activation, treatment-as-usual
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Depressive Disorder, Musculoskeletal Pain
Multicomponent Program for the Integrated Management of Chronic Pain and Depression in Primary Care
This study evaluates whether the implementation of an integrated clinical program for chronic musculoskeletal pain and depression behave better clinical outcomes than the usual approach in primary care
- Conditions
- Depressive Disorder, Musculoskeletal Pain, Chronic Pain
- Trial name
- DROP (NCT02605278)
- Testing
- Clinical program for pain and depression, Control
- Where
- Spain
- Volunteers
- 330 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Major Depressive Disorder
MemFlex to Prevent Depressive Relapse
A wealth of research has demonstrated that they way in which the investigators recall our personal, autobiographical memories is influential in the course of depression.
- Trial name
- NCT02614326
- Testing
- Autobiographical Memory Flexibility (MemFlex) training, Psychoeducation
- Where
- 2 sites in United Kingdom
- Volunteers
- 70 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Major Depression, Repetitive Transcranial Magnetic Stimulation
Using EEG to Predict Depression Treatment Response to rTMS in Patients With Major Depression
Repetitive Transcranial Magnetic Stimulation (rTMS) is a promising, novel, non-invasive therapy for depression. The study is looking at changes in specific electroencephalogram parameters in depressed patients treated with rTMS…
- Trial name
- NCT04575285
- Testing
- Electroencephalogram (EEG)
- Where
- United States
- Sponsor
- Baptist Health South Florida
Heart Failure, Depressive Symptoms
Effects of a Rehabilitation Program on Immune Activation and Mood in Heart Failure Patients
The aim of this descriptive study is to examine potential changes regarding inflammatory cytokine levels, depressive symptoms and quality of life over the course of the 4-week inpatient rehabilitation program which includes a…
- Trial name
- NCT02358525
- Testing
- multi-modality rehabilitation program for heart failure
- Where
- 2 sites in Austria
- Volunteers
- 16 people
- Sponsor
- Ludwig-Boltzmann Institut fuer Rheumatologie, Balneologie und Rehabilitation
Schizophrenia, Bipolar Disorder
Prevalence of Diabetes Mellitus Among Patients Treated With Atypical and Conventional Antipsychotics
This pilot study hypothesizes that diagnosed and undiagnosed prevalence of diabetes mellitus may differ across antipsychotioc medications in a community mental health center.
- Conditions
- Schizophrenia, Bipolar Disorder, Diabetes Mellitus
- Trial name
- NCT00224276
- Volunteers
- 100 people
- Sponsor
- Yale University
PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder
Ketamine Treatment for PTSD and MDD in TBI
The goal of this clinical trial is to examine the use of sedative ketamine to treat depression and post-traumatic stress disorder (PTSD) in Veterans with mild to moderate traumatic brain injury (TBI).
- Conditions
- PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder, Traumatic Brain Injury
- Trial name
- NCT06228391
- Testing
- IV ketamine, Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Major Depressive Disorder
A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disorder
Major depressive disorder (MDD) is a serious medical illness associated with significant suicidal risk and marked disability. Despite the availability of numerous treatments, achievement of consistent and favorable long-term…
- Trial name
- NCT03538691
- Testing
- Brexpiprazole, Antidepressant therapy
- Where
- United States
- Volunteers
- 1,149 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Postpartum Depression
Online Peer-Delivered Group CBT for PPD
Mothers and birthing parents (hereafter referred to as mothers) who have recovered from Postpartum Depression and are well now, receive training to teach a 9 week Cognitive Behavioural Therapy (CBT) treatment to mothers who are…
- Trial name
- NCT05044455
- Testing
- Cognitive Behavioural Therapy (CBT)
- Where
- Canada
- Volunteers
- 191 people
- Sponsor
- McMaster University
Depressive Disorder
The Effect of Minocycline on Relapse After Successful Intravenous Ketamine/Minocycline-induced Symptoms Response in Subjects With Depression
The purpose of this study is to assess whether the antidepressant effect from intravenous (IV) ketamine treatment can be maintained by minocycline compared to placebo after IV ketamine treatment is stopped.
- Trial name
- NCT01809340
- Testing
- Minocycline, Ketamine
- Where
- 12 sites in Belgium, France and 2 more
- Volunteers
- 29 people
- Sponsor
- Janssen Research & Development, LLC
Major Depressive Disorder
Study Comparing Remission Rates, in Patients With Major Depressive Disorder (MDD)
Tools known as 'depression scales 'are widely used as assessments to evaluate a patient's response to treatment. The purpose of this study is the evaluation of the remission rates for patients with MDD.
- Trial name
- B2411003 (NCT00770289)
- Testing
- Cohort
- Where
- 3 sites in Greece
- Volunteers
- 851 people
- Sponsor
- Pfizer
Insomnia, Major Depressive Disorder
Using Sleep Wearables to Adapt Cognitive-behavioral Therapy for Insomnia in the Context of Depression (CBTiA)
This study aims to better adapt cognitive behavioral therapy for insomnia (CBTi) for people with comorbid depression by using objective sleep measures to tailor the behavioral interventions components of CBTi.
- Conditions
- Insomnia, Major Depressive Disorder, Persistent Depressive Disorder
- Trial name
- CBTiA (NCT05990855)
- Testing
- eCBTi-obj, eCBTi-subj
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of Ottawa
Generalized Anxiety Disorder, Bipolar Disorder
Ziprasidone for the Treatment of Generalized Anxiety in Patients With Bipolar Disorder
This study proposes to examine the potential safety and efficacy of ziprasidone for patients with anxiety and bipolar disorder on anxiety outcomes, bipolar symptoms, and on measures of quality of life and resilience.
- Trial name
- NCT00374543
- Testing
- Ziprasidone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Massachusetts General Hospital
Depression, Anxiety
Bridging the Gap to Improve Mental Health Treatment Utilization
Bridging the Gap aims to improve access to effective mental health treatment in a primary care setting through utilization of single session growth mindset interventions for parents and for youths.
- Conditions
- Depression, Anxiety, Adolescent Behavior, Suicidal Ideation
- Trial name
- NCT04558489
- Testing
- IPR + GMI
- Where
- United States
- Sponsor
- University of Pittsburgh
Bipolar Disorder
Epidemiological Study to Evaluate Adherence to Treatment in Bipolar Disorder: Adherence Study
The purpose of this study is to estimate adherence to treatment in bipolar patients, to characterize patients based on adherence degree and to describe the variables linked to poor adherence to treatment in real-life practice.
- Trial name
- NCT00927420
- Where
- 24 sites in Spain
- Volunteers
- 300 people
- Sponsor
- AstraZeneca
Bipolar Disorder, Schizophrenia
eVAluatIon of OLanzapine TreatmEnT
This clinical observational study aims to investigate the efficacy of olanzapine (Villamos ®) in accordance with the instructions attached thereto in standard clinical practice, followed by the physician to the patient.
- Trial name
- VIOLET (NCT02006862)
- Where
- Greece
- Volunteers
- 468 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
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