Clinical trials: Disorder, Mood
Major Depressive Disorder
Safety Study of F2695 SR in Major Depressive Disorder
The purpose of this study is to evaluate the long- term safety of F2695-SR in the treatment of adults with major depressive disorder.
- Trial name
- LVM-MD-04 (NCT01034267)
- Testing
- F2695 SR
- Where
- 68 sites in United States
- Volunteers
- 828 people
- Sponsor
- Forest Laboratories
Psychoactive Substance Use, Mood Disorders
PrEP and Consumptions
HIV pre-exposure prophylaxis (PrEP) with Truvada®, a combination of two antiretrovirals (tenofovir \& emtricitabine) is a prevention strategy for HIV-negative people at high risk of acquiring HIV.
- Trial name
- PrEP (NCT03449771)
- Testing
- self-administered questionnaire
- Where
- 5 sites in France
- Volunteers
- 237 people
- Sponsor
- University Hospital, Montpellier
Mood Disorders
Efficacy and Safety of TMS and Deep TMS Treatment for Psychiatric and Neurological Disorders
The goal of this study is to examine the efficacy and safety of transcranial magnetic stimulation (TMS) and deep TMS (dTMS) for treatment of different psychiatric and neurological disorders.
- Trial name
- NCT02917499
- Testing
- TMS
- Where
- Croatia
- Volunteers
- 228 people
- Sponsor
- Sveti Ivan Psychiatric Hospital
Treatment Resistant Depression, Depressive Disorder, Treatment-Resistant
Deep Brain Stimulation (DBS) for Treatment-Resistant Depression (TRD)
In this pilot study, we propose to test whether high frequency stimulation of the subcallosal cingulate (SCC) is a safe and efficacious antidepressant treatment in five TRD patients, to compare the effects of left-sided vs.
- Conditions
- Treatment Resistant Depression, Depressive Disorder, Treatment-Resistant, Depression, Bipolar
- Trial name
- NCT01898429
- Testing
- SCC DBS
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Paul Holtzheimer
Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)
Optimization of IV Ketamine for Treatment Resistant Depression
Existing treatments for major depressive disorder (MDD) generally take weeks to months to exert their maximal benefit. There is an urgent need to develop rapid-acting treatments for MDD.
- Trial name
- NCT00768430
- Testing
- Ketamine, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- Baylor College of Medicine
Treatment Resistant Depression
Pulsating ElectroMagnetive Treatment (PEMF) at Treatment Resistant Depression
In this study patients with treatment resistant depression, as defined by Harold Sackeim, is subjected to daily sessions, for eight weeks, with Pulsating ElectroMagnetive Treatment (PEMF).
- Trial name
- PEMFII (NCT01353092)
- Testing
- Re5 Pulsating ElectroMagnetic Fields, Re5 Pulsating ElectroMagnetic Fields (PEMF)
- Where
- Denmark
- Volunteers
- 65 people
- Sponsor
- Hillerod Hospital, Denmark
Bipolar Disorder
Mindfulness Psychoeducation for Bipolar Disorder Caregivers' Mindfulness, Burden, Quality of Life and Resilience
This study was designed to determine the effect of mindfulness-based psychoeducation applied to primary caregivers of individuals diagnosed with bipolar disorder on their mindfulness, caregiver burden, quality of life, and…
- Trial name
- NCT06983834
- Testing
- Psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Anxiety, Anxiety Acute
Anxiety Skills Study
The purposes of this study are: (1) to identify baseline predictors of relative success in cognitive, behavioral, and mindfulness-based treatments for anxiety, (2) explore who benefits from a brief, video-based skill training…
- Conditions
- Anxiety, Anxiety Acute, Anxiety Chronic, Anxiety and Mood Disorders
- Trial name
- NCT07774481
- Testing
- Cognitive therapy, Behavioral therapy, Mindfulness-based therapy
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Ohio State University
Major Depressive Disorder (MDD)
A Study of Flexible or Fixed Dose LY2216684 as Adjunctive Treatment for Participants With Major Depressive Disorder Who Have Had a Partial Response to Selective Serotonin Reuptake Inhibitor (SSRI) Treatment
The purpose of this study is to assess if LY2216684 (flexible dose of 12 to 18 milligrams [mg] or fixed dose of 6 mg once daily) is superior to placebo once daily in the adjunctive treatment of participants with Major Depressive…
- Trial name
- NCT01187407
- Testing
- LY2216684, SSRI
- Where
- 54 sites in United States, Croatia and 5 more
- Volunteers
- 1,480 people
- Sponsor
- Eli Lilly and Company
Bipolar Disorder
Customized Medication Adherence Enhancement for Treating Adults With Bipolar Disorder
In this study, patients with bipolar disorder who do not take their medications as prescribed will receive specialized education and therapy treatment to determine whether the specialized treatment is effective in helping…
- Trial name
- NCT00763919
- Testing
- Psychoeducation module, Substance abuse module, Improved communication/rapport with provider module
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Case Western Reserve University
Bipolar Disorder, Major Depression
Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness
The overall aim of this program of research is to improve the continuity of care for patients with serious mental illness (SMI) by supporting a safer and more efficient bridge from hospital to outpatient care using a mobile…
- Conditions
- Bipolar Disorder, Major Depression, Schizophrenia
- Trial name
- tFOCUS (NCT05703412)
- Testing
- Transition-FOCUS mHealth Intervention, Check-In
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Butler Hospital
Insomnia, Depressive Disorder, Major
A Study of Eszopiclone in Subjects With Insomnia Related to Major Depressive Disorder
The purpose of this study is to evaluate subjective sleep efficacy in subjects with insomnia related to major depressive disorder.
- Trial name
- NCT00368030
- Testing
- Eszopiclone
- Where
- 65 sites in United States
- Volunteers
- 545 people
- Sponsor
- Sumitomo Pharma America, Inc.
Wounds and Injuries, Physical Activity
Swiss Army Physical Fitness Training
The purpose of this study is to determine whether the new sport concept of the Swiss Armed Forces influences the physical and psychological fitness of the recruits.
- Conditions
- Wounds and Injuries, Physical Activity, Mood (Psychological Function), Motivation
- Trial name
- SAFT (NCT02570295)
- Testing
- Swiss Army Physical Fitness Training
- Where
- Switzerland
- Volunteers
- 722 people
- Sponsor
- Swiss Federal Institute of Sport Magglingen
Bipolar Disorders
Open-label Adjunctive Zonisamide for Bipolar Disorder
To study the safety and efficacy of zonisamide as adjunctive therapy for children and adolescents with bipolar I or II disorder.
- Trial name
- NCT00047567
- Testing
- zonisamide
- Volunteers
- 20 people
- Sponsor
- Elan Pharmaceuticals
Major Depressive Disorder
A Study to Investigate Evoked Potentials as Markers of Ketamine-induced Cortical Plasticity in Patients With Major Depressive Disorder
To evaluate if somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) obtained with electroencephalography (EEG) and electromyography (EMG) can be used to detect changes in cortical plasticity in responders to…
- Trial name
- NCT01957410
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Janssen Research & Development, LLC
Oxytocin + Non Specific Counselling, Oxytocin + Social Skills Training
Administrating Oxytocin to Treat Treatment Schizophrenia and Schizo-affective Patients
The objectives of the study are: 1. To evaluate the effect of OT compared to placebo, as add-on to anti-psychotics, on social functioning in schizophrenia. 2.
- Conditions
- Oxytocin + Non Specific Counselling, Oxytocin + Social Skills Training, Placebo + Non Specific Counselling, Placebo + Social Skills Training
- Trial name
- OXY-S-01 (NCT01598623)
- Testing
- Oxytocin, Social Skills Training
- Where
- Israel
- Volunteers
- 48 people
- Sponsor
- Sheba Medical Center
Bipolar Disorder
Development of a Personalized Real-time Intervention for Bipolar Disorder
This three-year intervention development proposal is submitted to the NIMH DATR Mood Disorders/Sleep Disorders Program A2-AID and is led by a New Investigator.
- Trial name
- PRISM (NCT01670123)
- Testing
- Personalized Real-Time Intervention for Stabilizing Mood
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Diego
Depression, Bipolar
Functional and Neurochemical Brain Changes Bipolar Depression
The purpose of the research is to study brain structure, function and chemistry of patients with bipolar disorder who are receiving quetiapine or lithium, in order to better understand who benefits from treatment and why they…
- Trial name
- NCT00608296
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Cincinnati
Major Depression
Relapse Prevention With Escitalopram or Nortriptyline Following Electro-Convulsive Treatment (DUAG-7)
The main purpose of this study is to investigate the relapse preventing efficacy of escitalopram in a dose range and nortriptylin in a single dose in patients having been treated successfully with a course of electroconvulsive…
- Trial name
- DUAG-7 (NCT00660062)
- Testing
- escitalopram, nortriptyline
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- Hillerod Hospital, Denmark
Depressive Disorder, Treatment-Resistant, Memory Deficits
SAINT® Therapy for Memory Problems in Older Adults With Treatment-Resistant Depression
The goal of this clinical trial is to learn whether Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT®), a type of transcranial magnetic stimulation (TMS), is safe and may improve memory and thinking in adults aged…
- Trial name
- NCT07876908
- Testing
- Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT®) with the Magnus Neuromodulation System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- BrainHealth Solutions, Inc.
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