Clinical trials: Disorder, Mood
Suicide, Attempted, Mood Disorder
Functional Imaging of Psychic Pain
Suicidal behaviour (SB) represents a major public health problem, costing life in more that one million people every year worldwide.
- Trial name
- NCT01493323
- Testing
- Assessment of personality traits, Assessment of suicidal act, Assessment of depression
- Where
- France
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Major Depressive Disorder, Alzheimer Disease
Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults
This project aims to explore the feasibility and effects of a symptom-specific, brain-circuit-based, home-based neuromodulation therapy for addressing mood and memory symptoms in older adults with major depressive disorder (MDD)…
- Conditions
- Major Depressive Disorder, Alzheimer Disease, Dementia, Nervous System Diseases
- Trial name
- NCT05976659
- Testing
- Transcranial direct current stimulation (tDCS); Transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hebrew SeniorLife
Depression, Major Depressive Disorder
Stress Generation and Recurrent Depression: The Role of Differential Treatment Response
Depression affects over one million people in Canada, resulting in $14.4 billion per year in costs to Canadian society. In order to prevent this often lifelong disorder, it is critically important to identify risk factors for the…
- Trial name
- NCT00745017
- Testing
- Cognitive Behavioral Therapy, Interpersonal Therapy, Antidepressant medication
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder
The study will assess efficacy, safety and tolerability of 0.5 mg/day and 1 mg/day of sublingual (under the tongue) formulation of agomelatine in patients with Major Depressive Disorder.
- Trial name
- NCT01110889
- Testing
- Agomelatine (AGO178C)
- Where
- 48 sites in United States, Puerto Rico
- Volunteers
- 582 people
- Sponsor
- Novartis Pharmaceuticals
Major Depressive Disorder
Patient Management of Depression Through Technology: a Study of Digitally Enabled Engagement
The current randomized controlled trial is a pilot study that will assess the effectiveness and feasibility of a mobile phone application intervention.
- Trial name
- NCT03242213
- Testing
- Mobile App
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
COPD (Chronic Obstructive Pulmonary Disease), ALS (Amyotrophic Lateral Sclerosis)
Psilocybin Therapy for Psychological Distress in Palliative Patients
The goal of this clinical trial is to evaluate whether psilocybin therapy can effectively treat depression and psychological distress in adult patients with COPD, ALS, MS, or APD who have at least 6 months life expectancy.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), ALS (Amyotrophic Lateral Sclerosis), MS (Multiple Sclerosis), Major Depressive Disorder (MDD)
- Trial name
- PsyPal (NCT06782724)
- Testing
- Psilocybin therapy
- Where
- 4 sites in Czechia, Denmark and 2 more
- Volunteers
- 108 people
- Sponsor
- University Medical Center Groningen
Breastfeeding, Postpartum Depression (PPD)
Telehealth-Supported Breastfeeding Counseling in Primiparous Mothers
Breastfeeding is critical for infant and maternal health; however, many first-time mothers experience difficulties that may lead to early discontinuation of breastfeeding.
- Conditions
- Breastfeeding, Postpartum Depression (PPD), Breastfeeding Self-Efficacy
- Trial name
- TELE-BF (NCT07396415)
- Testing
- Telehealth-Supported Breastfeeding Counseling, Routine Postpartum Care
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Marmara University
Major Depressive Disorder, Anhedonia
Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia
Investigating whether delta-beta cross-frequency transcranial alternating current stimulation can increase goal-directed behavior in participants with major depressive disorder and elevated symptoms of anhedonia.
- Trial name
- DEBRA (NCT05084924)
- Testing
- Cross-frequency transcranial alternating current stimulation via the NeuroConn Direct Current Stimulator Plus
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of North Carolina, Chapel Hill
Cardiovascular Diseases, Coronary Artery Disease
Virtual Reality Therapy in Cardiology
This study evaluates the effectiveness of virtual reality (VR) therapy in the treatment of depression and anxiety symptoms in patients undergoing second stage of cardiac rehabilitation.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Depressive Symptoms, Mood Disorders
- Trial name
- NCT04313777
- Testing
- Cardiac rehabilitation, Virtual therapeutic support, Schultz Autogenic Training
- Where
- 2 sites in Poland
- Volunteers
- 77 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Major Depressive Disorder
NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression.
- Trial name
- NCT06911112
- Testing
- NBI-1065845
- Where
- 39 sites in United States, Bulgaria and 3 more
- Volunteers
- 200 people
- Sponsor
- Neurocrine Biosciences
Postpartum Depression
Mobile Phone Based Peer Support to Prevent Postpartum Depression Among Adolescent Mothers
This pilot study will evaluate the feasibility and acceptability of a mobile phone based peer support intervention among adolescent mothers.
- Trial name
- NCT02818075
- Testing
- Mobile Phone Based Peer Support, Usual Care
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Anxiety Disorders, Depressive Disorder, Major
Auricular Acupuncture vs. Progressive Muscle Relaxation in Patients With Anxiety Disorders or Major Depressive Disorder.
The purpose of this study is to determine whether auricular acupuncture (AA) according to the NADA protocol and progressive muscle relaxation (PMR) differ in their effectiveness of treating people with anxiety disorders or major…
- Trial name
- NCT02340351
- Testing
- Auricular acupuncture, Progressive muscle relaxation
- Volunteers
- 136 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Major Depressive Disorder, Post-Traumatic Stress Disorder
Imaging SV2A in Mood Disorders
This study is designed to examine SV2A density in MDD and PTSD as a correlate of synaptic density, and to determine whether ketamine administration will reverse the synaptic loss in vivo in human subjects.
- Trial name
- NCT02734602
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Yale University
Severe Postpartum Depression
A Study of BRII-296 in Adults With Severe Postpartum Depression (PPD)
The primary purpose of this study is to evaluate the safety and tolerability of BRII-296 administered by 2 intramuscular injections, administered with Depo Medrol as assessed by the incidence of adverse events, changes from…
- Trial name
- NCT06057012
- Testing
- BRII-296, Depo Medrol
- Where
- 11 sites in United States
- Volunteers
- 11 people
- Sponsor
- Brii Biosciences Limited
Bipolar Disorder, Bipolar Depression
Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression
The protocol involves functional Magnetic Resonance Imaging acquisitions immediately before and after Low Field Magnetic Stimulation treatment on two separate days in a sham controlled, randomized trial, in order to assess the…
- Conditions
- Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- LFMSBioMGeri (NCT03484494)
- Testing
- Low Field Magnetic Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mclean Hospital
Pharmacogenetics, Depressive Disorder, Major
Assessment of the Impact of Clinical Pharmacogenomics on Real and Potential Medication Use in Veterans
The purpose of this study is to assess the prevalence of veterans with major depressive disorder (MDD) who are being treated with a medication that has current Clinical Pharmacogenetics Implementation Consortium (CPIC) or…
- Conditions
- Pharmacogenetics, Depressive Disorder, Major, Medication Therapy Management
- Trial name
- NCT04893395
- Testing
- Pharmacogenomic Screening
- Where
- United States
- Sponsor
- Auburn University
Major Depressive Disorder (MDD)
Comparison of Anyu Peibo With Placebo in Treatment of MDD
The purpose of this study is to determine whether Anyu Peibo Capsule in different doses are effective in the treatment of Depression.
- Trial name
- NCT02380066
- Testing
- Anyu Peibo
- Where
- 6 sites in China
- Volunteers
- 120 people
- Sponsor
- Shanghai Mental Health Center
Bipolar Disorder, Rapid Cycling Bipolar Disorder
Evaluation of Patients With Rapid Cycling Bipolar Disorder (RCBD)
Bipolar disorder is a mood (affective) disorder characterized by the occurrence of alternating feelings of excitement (mania) and depression. It is a common, but serious condition, and potentially life-threatening.
- Trial name
- NCT00001772
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Mental Health (NIMH)
Anxiety Disorders, Depressive Disorder
Development of a Model for Shared Care in the Interface Between General Practice and Mental Health Care
Recent research has underlined that mental health of people with depression and anxiety has deteriorated over the last decades in Denmark as well as internationally, and has reached a degree where it is perceived as a global…
- Trial name
- NCT05172375
- Testing
- Shared Care Model
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Psychiatric Research Unit, Region Zealand, Denmark
Major Depressive Disorder, Bipolar Disorder
Mindfulness-Based Cognitive Therapy for Perinatal Women With Mood Disorders
This study will investigate the effectiveness of mindfulness-based cognitive therapy (MBCT) for mood stabilization in perinatal women (preconception, pregnant, and postpartum) with a history of mood disorders.
- Trial name
- MBCT (NCT02150681)
- Testing
- Mindfulness-based cognitive therapy
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- University of California, Los Angeles
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