Clinical trials: Disorder, Mood
Major Depressive Disorder
The Neurobiology of Approach Avoidance Training in Depression
The purpose of this study is to test the effects of a computerized approach/avoidance training (AAT) procedure on behavioral, affective, and brain mechanisms that are important for reward sensitivity and well-being in individuals…
- Trial name
- ACTIV8 (NCT02330744)
- Testing
- Approach-positive AAT, Control AAT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
Major Depressive Disorder
Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Major Depressive Disorder
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Levomilnacipran ER fixed doses versus placebo in the treatment of outpatients with major depressive disorder.
- Trial name
- NCT00969709
- Testing
- Levomilnacipran ER
- Where
- 38 sites in United States
- Volunteers
- 724 people
- Sponsor
- Forest Laboratories
Premenstrual Dysphoric Disorder ( PMDD)
YAZ Premenstrual Dysphoric Disorder (PMDD) in China
The purpose of this study is to evaluate the efficacy and safety of YAZ compared to placebo in the treatment of symptoms related to Premenstrual Dysphoric Disorder (PMDD).
- Trial name
- NCT00824187
- Testing
- EE20/DRSP(YAZ, BAY86-5300)
- Where
- 16 sites in China
- Volunteers
- 187 people
- Sponsor
- Bayer
Anxiety, Fear
An Exploratory Investigation of a CBD Supplement's Impact on Sleep, Stress, and Focus
A high-quality broad-spectrum cannabidiol supplement with a bio-terpene complex will be administered once daily. It is hypothesized that this supplement will lead to improvements in sleep, focus, and stress.
- Conditions
- Anxiety, Fear, Stress, Low Mood
- Trial name
- NCT05518019
- Testing
- The Daily Supplement
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Prima CBD
Nutritional Insufficiency
Food Energy Density in Eating Disorders
Nutritional insufficiency is defined as an inadequate amount of nutrition due to decreased food/caloric intake, often due to an eating disorder, such as anorexia nervosa or bulimia.
- Trial name
- NCT01095107
- Testing
- Low fat intake, Increased fat intake
- Sponsor
- The Cleveland Clinic
Depression, Major Depressive Disorder
Noninvasive Physiologic Sensors to Assess Depression
This project aims to use sensors to monitor physiological signals, sleep patterns, vocal characteristics, activity, location and phone usage in study patients with depression who are receiving standard treatment (compared with…
- Trial name
- NCT02568865
- Testing
- Physiological Sensors, Sleep Monitoring Device, Vocal Monitoring
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Schizophrenia, Bipolar Disorder
Illness Management and Recovery (IMR) in Danish Community Mental Health Centres
The aim of this trial is to evaluate the effectiveness of the Illness Management and Recovery program for people diagnosed with schizophrenia or bipolar disorder in according to their level of functioning.
- Trial name
- IMR (NCT01361698)
- Testing
- Illness Management and Recovery (IMR)
- Where
- Denmark
- Volunteers
- 198 people
- Sponsor
- Amager Hospital
Schizophrenia, Stress Disorders, Post-Traumatic
Optimizing Cognitive Remediation
Veterans with mental illness face challenges with community reintegration, including achieving vocational success, attaining their educational goals and going back to school, and maintaining a high quality of life.
- Conditions
- Schizophrenia, Stress Disorders, Post-Traumatic, Generalized Anxiety Disorder, Mood Disorders
- Trial name
- NCT04395157
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder
Light Therapy to Improve Symptoms in Pregnant Women With Major Depressive Disorder
This study will investigate the effectivenss of bright light therapy(10000 lux white)on pregnant women with major depression disorder.
- Trial name
- GZPHBLT (NCT04447430)
- Testing
- bright light, dim red light
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Guangzhou Psychiatric Hospital
Bipolar Disorder, Mania
Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women?
OBJECTIVE: To test the use of two adjunctive hormonal agents in a 28 day three-arm, double-blind, placebo-controlled study in the treatment of acute mania/hypomania.
- Conditions
- Bipolar Disorder, Mania, Schizoaffective Disorder
- Trial name
- NCT00206544
- Testing
- Tamoxifen, Progesterone
- Where
- Australia
- Volunteers
- 51 people
- Sponsor
- The Alfred
Schizophrenia, Bipolar Disorder
Patient Guided Psychiatric Admissions
To meet the requirement for increased patient involvement, several Community Mental Health Centres (CMHC) have initiated a service called "patient-guided admissions".
- Trial name
- NCT01133587
- Testing
- wait list control, admissions contract
- Where
- Norway
- Volunteers
- 53 people
- Sponsor
- St. Olavs Hospital
Low Mood
Effect of a Nutritional Supplement on Mental Wellness in Adults
Trillions of microbes reside in human gut and constitute "gut microbiota". Composition of these microbes and substances produced by them play an important role in human health and wellness.
- Trial name
- NCT06058364
- Testing
- Intervention 1 - Triglyceride
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Pharmavite LLC
Treatment Resistant Depression, Depression
Glutamate Emotion Memory Study
Clinical depression often includes a pessimistic view of things which have happened in the past and an impairment in the ability to experience pleasure or looking forward to things.
- Conditions
- Treatment Resistant Depression, Depression, Major Depressive Disorder
- Trial name
- GEMS (NCT05809609)
- Testing
- Ketamine Hydrochloride
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Parkinson Disease
Effects of Deep Brain Stimulation on Motor, Mood, and Cognitive Symptoms in Parkinson's Disease
The purpose of this trial is to study the mood and cognitive effects of deep brain stimulation in Parkinson's disease.
- Trial name
- NCT00360009
- Testing
- DBS of the STN, DBS of the GPI
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Florida
Major Depressive Disorder, Treatment Resistant Depression
MAO-B Occupancy in Depressed Patients
The study is looking at assessing monoamine oxidase B (MAO-B) occupancy in depressed patients before and after medication treatment using positron emission tomography (PET) scan.
- Trial name
- MOCP (NCT04841798)
- Testing
- [11C]SL25.1188 PET radiotracer
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Centre for Addiction and Mental Health
Dementia, Depression
Pilot Study of Asynchronous and Synchronous Telepsychiatry for Skilled Nursing Facilities
Specific Aims: This study aims to assess the acceptability of asynchronous telepsychiatry (ATP) and synchronous (STP) in rural Skilled Nursing Facility (SNF) population, in a 12-month randomized controlled trial.
- Conditions
- Dementia, Depression, Mood Disorder, Anxiety Disorder
- Trial name
- NCT02537093
- Testing
- Psychiatric Consultation
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Major Depressive Disorder
Study of Electrophysiological Markers of Antidepressants in Major Depressive Disorder
Major depressive disorder (MDD) is a frequent and particularly disabling disorder. The efficacy of current antidepressants is limited, with 50-60% of patients not achieving a sufficient response to treatment.
- Trial name
- MESANTIDEP (NCT06532604)
- Testing
- Electroretinography (ERG)
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Centre Psychothérapique de Nancy
Depressive Disorder and Anxiety Disorders
A Study To Investigate Effects Of GSK561679 On Brain Activation During Emotional Processing In Healthy Volunteers
This study will be conducted in healthy volunteers to investigate the effect of single dose GSK561679 on the changes of brain activation, as it compares to an active comparator, lorazepam.
- Trial name
- NCT00513565
- Testing
- single dose
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bipolar Disorder, Bipolar Depression
Efficacy of Convulsive Therapies for Bipolar Depression
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for Bipolar Disorder (BD).
- Conditions
- Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- CORRECT-BD (NCT03641300)
- Testing
- Magnetic Seizure Therapy (MST), Electroconvulsive Therapy (ECT)
- Where
- 3 sites in Canada
- Volunteers
- 76 people
- Sponsor
- Centre for Addiction and Mental Health
Bipolar Disorder
AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium
Lithium (Li) is the leading treatment for BD, protecting against both maniac and depressive relapse, and reducing the risk of suicide and mortality.
- Trial name
- AMIND (NCT05044611)
- Testing
- Anhydrous Amiloride Hydrochloride
- Where
- 2 sites in France
- Volunteers
- 148 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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