Clinical trials: Disorder, Mood
Major Depressive Disorder, Cardiovascular Diseases
Emotion Regulation Training to Reduce Cardiovascular Disease Risk Among Depressed Young Adults in Southern Mississippi
The proposed study will investigate the utility of a single-session emotion regulation training to reduce CVD risk among young adults diagnosed with MDD living in Southern MS.
- Conditions
- Major Depressive Disorder, Cardiovascular Diseases, Inflammation, Blood Pressure
- Trial name
- NCT05425290
- Testing
- Single-session emotion regulation training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern Mississippi
Depressive Disorder, Major
Dialogue to Empower Traditional and Faith Healers to Deliver mhGAP-IG Adapted Psychosocial Interventions in Kenya
The project aimed to create a dialogue between the informal sector (traditional and faith healers) and the formal sector (trained health care workers) in order to increase synergy and communication between the two systems, by…
- Trial name
- Dialogue (NCT03165513)
- Testing
- mhGAP-IG
- Volunteers
- 4,081 people, healthy volunteers welcome
- Sponsor
- Africa Institute of Mental and Brain Health (AFRIMEB)
Post Partum Depression
Effectiveness of Thinking Healthy Program for Prevention of Antenatal Depression
The trial is to evaluate the effect of an evidence-informed, depression focused early prenatal prevention intervention at six weeks' postpartum.
- Trial name
- PAD (NCT04663243)
- Testing
- Thinking healthy Program sessions designed for antenatal period
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of the Punjab
Major Depression, Dysthymia
Implementation of Harmonized Depression Outcome Measures in a Primary Care Registry and a Mental Health Registry
The purpose of this pilot project is to demonstrate feasibility and value of collecting harmonized outcomes measures for major depressive disorder (MDD) in two registries and combining the data to support patient-centered…
- Trial name
- NCT04235725
- Testing
- Harmonized Depression Outcome Measures
- Where
- 2 sites in United States
- Volunteers
- 953 people
- Sponsor
- OM1, Inc.
Bipolar Disorder, Major Depressive Disorder
Sleep Quality, Cognitive Performance, and Computerized Cognitive Training
Poor sleep quality is common in neuropsychiatric conditions and some of the problems associated with poor sleep at night may be due to medication side effects or reduced efficacy of certain treatments.
- Conditions
- Bipolar Disorder, Major Depressive Disorder, Psychosis
- Trial name
- NCT06328140
- Testing
- Lurasidone, FDA Approved antidepressant treatment
- Where
- United States
- Sponsor
- George West Mental Health Foundation d/b/a Skyland Trail
Major Depressive Disorder, Bipolar Disorder
Neurostructural and Biochemical Signatures of Tobacco Smoking in Mood Disorders
Tobacco smoking is significantly more common among individuals with mood disorders, such as major depressive disorder (MDD) and bipolar disorder, compared to the general population.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Tobacco Use Disorder, Mood Disorders
- Trial name
- NCT07910318
- Volunteers
- 240 people
- Sponsor
- Assiut University
Major Depressive Disorder
Home-based Transcranial Direct Current Stimulation (tDCS) for Major Depressive Disorders (MDD)
This is an open label pilot feasibility telemedicine study. This pilot will involve a total of 37 at-home stimulation sessions (30-minutes each) of multichannel excitatory tDCS targeting the left dorsolateral prefrontal cortex…
- Trial name
- NCT05205915
- Testing
- tDCS intervention applied by Starstim device
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- Neuroelectrics Corporation
Irritable Mood, Aggression
Utility of Amantadine Hydrochloride in the Treatment of Post-traumatic Irritability
The purpose of this study is to determine if amantadine hydrochloride given 100 mg in the morning and at noon is safe and effective in the treatment of mood and behavior changes (i.e.
- Conditions
- Irritable Mood, Aggression, Traumatic Brain Injury
- Trial name
- NCT00627250
- Testing
- Amantadine
- Volunteers
- 76 people
- Sponsor
- Wake Forest University Health Sciences
Multiple Sclerosis, Mood Disorders
Study of Brain Activations and Physiological Responses Using NeuroBiofeedback in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by inflammation, demyelination, gliosis, and neuronal loss.
- Conditions
- Multiple Sclerosis, Mood Disorders, Cognitive Impairment
- Trial name
- NBF2023 (NCT06239090)
- Testing
- Rehacor-T
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Sedentary Behavior, Behavior, Health
Stand Up Kansas: An Intervention to Reduce Sedentary Behavior in the Home Work Environment
This project will examine the effectiveness of an intervention to reduce sedentary behavior in Kansas State University employees who are primarily working from home. We will recruit 100 employees to participate.
- Conditions
- Sedentary Behavior, Behavior, Health, Cholesterolemia, Obesity
- Trial name
- NCT04641689
- Testing
- Desk Only, Program Only
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Bipolar Disorder
Study of Aripiprazole in Patients With a History of Bipolar Disorder
The purpose of this study is to learn if aripiprazole is effective in the treatment of patients with a history of bipolar disorder.
- Trial name
- NCT00036348
- Testing
- Aripiprazole
- Where
- 19 sites in United States
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Depressive Disorder, Anxiety Disorders
Measurement-Based Care (MBC) Implementation, Effectiveness, and Mechanisms of Change
Although measurement-based care (MBC) is an evidence-based practice with known benefits, it is not always systematically implemented with fidelity. Questions remain regarding MBC's unique added value compared to usual care.
- Trial name
- MBC (NCT06671158)
- Testing
- Psychotherapy
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Carilion Clinic
Depressive Disorder
Study of the Telomere-telomerase System and the Expression of Candidate Genes in the Leukocytes of Patients With Depressive Disorder: Search for Peripheral Markers of Somatic Stress
The mechanisms of oxidative stress and inflammation involved in mood disorders are factors of chronicity and severity. These mechanisms induce a phenomenon of accelerated cellular senescence and are reflected by alterations in…
- Trial name
- NCT01903655
- Testing
- telomere length
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Major Depressive Disorder (MDD)
Implementation of a Multiple Intervention to Promote Healthy Lifestyles in Patients With Depression
This clinical trial aims to investigate whether an integrative approach combining education on the Mediterranean diet and physical activity (PA) can significantly reduce depressive symptomatology in individuals with major…
- Trial name
- NCT06990035
- Testing
- Mediterranean diet lessons program, Physical activity
- Where
- 2 sites in Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Insomnia
Eszopiclone Co-Administered With Escitalopram for Insomnia in Elderly Adults With Major Depressive Disorder
Research has established the incidence of insomnia increases with age and the possible causes contributing to sleep problems in the elderly are still being explored and debated.
- Trial name
- NCT00813735
- Testing
- Eszopiclone, Escitalopram
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lehigh Center for Clinical Research
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
LHC-CIDI-5 in Hong Kong
The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12…
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), Suicidal Ideation
- Trial name
- NCT06804525
- Testing
- CIDI-5, LHC-CIDI-5
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong
Unipolar Depression
RCT of Psychoeducational Program of Depression
The purpose of the study is to test the efficacy of a psychoeducational group program on unipolar depression
- Trial name
- NCT00319540
- Testing
- Control with depression course (CWD)
- Where
- Norway
- Volunteers
- 155 people
- Sponsor
- Norwegian Institute of Public Health
Major Depressive Disorder, Recurrent, Depressive Episode
Confirmation Bias Towards Treatments of Depressive Disorders in Social Tagging
The study examines whether people primarily want to confirm their prior attitudes in health-related information search, in an online environment using social tags for navigation.
- Conditions
- Major Depressive Disorder, Recurrent, Depressive Episode, Depressive Disorder, Major, Depression
- Trial name
- NCT03899168
- Testing
- Social Tag Popularity, Confidence in Prior Attitudes, Source Credibility
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Leibniz-Institut für Wissensmedien
Major Depressive Disorder
Efficacy of SEROQUEL in Selective Serotonin Reuptake Inhibitors (SSRI)-Resistant Major Depressive Disorder
An open-label, non-comparative, multi-centre, phase II prospective trial to assess the efficacy of Quetiapine fumarate augmentation of selective serotonin reuptake inhibitors (SSRIs) in SSRI-resistant major depressive disorder.
- Trial name
- UNIQUE (NCT00733668)
- Testing
- Quetiapine fumarate (Seroquel)
- Where
- 4 sites in Belgium
- Sponsor
- AstraZeneca
Postpartum Recovery, Mother-infant Bonding
Labor Epidural Analgesia and Mother-Infant Bonding After Vaginal Delivery
This prospective observational cohort study aims to evaluate the association between postpartum recovery quality and mother-infant bonding in women undergoing vaginal delivery.
- Conditions
- Postpartum Recovery, Mother-infant Bonding, Labor Pain
- Trial name
- NCT07582289
- Testing
- Labor Epidural Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ataturk University
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