Clinical trials: Disorder, Mood
Depressive Disorders, Alcohol Use Disorders
Implementing a Blended Care Model That Integrates Mental Healthcare and Primary Care Using Telemedicine and Care Management for Patients With Depression or Alcohol Use Disorder in Small Primary Care Clinics
Integrating mental health treatments into the primary care delivered at Community Based Outpatient Clinics(CBOCs) that are geographically accessible to rural Veterans is a major priority for the Department of Veterans Affairs.
- Conditions
- Depressive Disorders, Alcohol Use Disorders, Post-traumatic Stress Disorder (PTSD)
- Trial name
- Tele-PCMHI (NCT02713217)
- Testing
- Usual Care, Blended Telemedicine-Based Integrated Care
- Where
- United States
- Volunteers
- 318 people
- Sponsor
- VA Office of Research and Development
Dysmenorrhea, Headache, Migraine
Sublingual Tablets With Cannabinoid Combinations for the Treatment of Dysmenorrhea
Sublingual Tablets With Cannabinoid Combinations for the Treatment of Dysmenorrhea
- Conditions
- Dysmenorrhea, Headache, Migraine, Fatigue, Nausea
- Trial name
- NCT04091789
- Testing
- Pure Femme Tablets
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Pure Green
Bipolar Disorder
An Open-Label Extension Study Of Lamotrigine In Subjects With Bipolar Disorder
The precursor study (SCA101469) was an open-label, prospective multicentre study in adult subjects diagnosed with bipolar disorder consisting of 36 weeks treatment with lamotrigine.
- Trial name
- NCT00360126
- Testing
- lamotrigine
- Where
- 3 sites in Australia
- Volunteers
- 11 people
- Sponsor
- GlaxoSmithKline
Unipolar Depression
Thinking Healthy Program - Peer Delivered (Pakistan)
The rates of perinatal depression in South Asian women are reported to be amongst the highest in the world, ranging from 18%-30% in urban areas and 28%-36% in rural areas.
- Trial name
- THPP-P (NCT02111915)
- Testing
- THPP-P, EUC
- Where
- Pakistan
- Volunteers
- 560 people
- Sponsor
- University of Liverpool
Depressive Disorder, Fatigue Syndrome, Chronic
Glucocorticoid Effects on Cellular Cytokine Release
A variety of hormones and immune system processes are responsible for how the body responds to illness. This study concentrates on how the hormone cortisol effects the release of immune system factors called cytokines.
- Conditions
- Depressive Disorder, Fatigue Syndrome, Chronic, Fibromyalgia, Healthy
- Trial name
- NCT00001415
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Subthreshold Depression, Exercise
The Effect of Exercise on Cognition and Preventing Depression in Young People
It is estimated that approximately 30% of child and adolescents manifest subthreshold depression (including other specified depressive disorder and unspecified depressive disorder), which can further develop into major depression…
- Conditions
- Subthreshold Depression, Exercise, Clinically-well, Cognitive Change
- Trial name
- NCT04816617
- Testing
- Aerobic exercise intervention, Psycho-education
- Where
- China
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Major Depressive Disorder, Coronary Artery Disease
Vortioxetine in Patients With Major Depressive Disorder and Coronary Artery Disease
This is a preliminary, open-label, clinical trial designed to assess the efficacy, safety, and tolerability of vortioxetine for the treatment of major depressive disorder in patients with coronary artery disease.
- Trial name
- NCT02454426
- Testing
- Vortioxetine
- Where
- United States
- Sponsor
- Thomas Jefferson University
Depressive Disorder, Major Depression
Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of Vortioxetine
The study is a 6-week, proof-of-concept, open trial of vortioxetine for 20 patients with major depressive disorder.
- Conditions
- Depressive Disorder, Major Depression, Depression, Depression, Unipolar
- Trial name
- VOR-IISR (NCT02969876)
- Testing
- Vortioxetine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD).
- Trial name
- NCT05523817
- Testing
- Intermittent Theta Burst Stimulation (iTBS)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Treatment Resistant Depression
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
Efficacy, Safety, and Tolerability of a single administration of COMP360 in participants with treatment-resistant depression (TRD)
- Trial name
- NCT05624268
- Testing
- Psilocybin
- Where
- 40 sites in United States
- Volunteers
- 258 people
- Sponsor
- COMPASS Pathways
Cardiovascular Diseases, Schizophrenia
Effect of Nutritional Counseling on Anthropometry and Biomarkers in Patients Diagnosed With Schizophrenia/Psychosis or Bipolar Affective Disorder
The goal of this clinical trial is to compare the effect of nutritional counseling versus no treatment in patients with schizophenia or bipolar affective disorder.
- Conditions
- Cardiovascular Diseases, Schizophrenia, Psychosis, Bipolar Disorder
- Trial name
- NCT06197048
- Testing
- Nutritional counseling
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Vestre Viken Hospital Trust
Major Depressive Disorder
Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder
Ketamine infusions resulted in an acute reduction in global depression scores and in severity of suicidal ideation. The investigators therefore plan to investigate the feasibility and efficacy of repeated intravenous…
- Trial name
- NCT01667926
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
Patient Treated With Lithium, With Bipolar or Schizo-affective Disorder, Hospitalized in a Psychiatric Ward
Validation of the French Version of the Lithium Knowledge Test (LKT)
Lithium is a drug used to treat several psychiatric illnesses. This medication requires particular vigilance because it has a narrow therapeutic margin: the dose necessary to obtain an effective treatment is close to the toxic…
- Trial name
- LKT (NCT06033326)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Lille
Treatment Resistant Depression
SAINT for Treatment of Preoperative Depression to Reduce Opioid Use Following Arthroplasty
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for treatment-resistant depression.
- Trial name
- NCT04195308
- Testing
- Active TBS-DLPFC, Open label TBS-DLPFC
- Where
- United States
- Sponsor
- Stanford University
Adjunctive Treatment of Major Depressive Disorder (MDD)
A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder
The study is a Phase 2, double-blind, randomized, placebo-controlled study in Major Depressive Disorder (MDD) participants with an inadequate response to standard antidepressants The objective of the study is to assess CLE-100…
- Trial name
- SOLEO (NCT06340958)
- Testing
- CLE-100
- Where
- 23 sites in United States
- Volunteers
- 99 people
- Sponsor
- Clexio Biosciences Ltd.
Depression, Postpartum, Labor Pain
CSE v. Epidural for Postpartum Depression
The purpose of this pilot prospective randomized control trial is to compare the initiation of labor epidural analgesia by combined spinal epidural vs. epidural for the influence on risk for postpartum depression symptoms.
- Trial name
- COPE (NCT03022526)
- Testing
- CSE, Epidural, Bupivacaine / fentaNYL
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Major Depressive Disorder, Overweight
Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Personalized Approach
This project aims to evaluate whether a dose-response relationship exists between dose of polyunsaturated fatty acids (PUFA), delivered as eicosapentaenoic acid (EPA), and change in markers of inflammation, and whether these…
- Conditions
- Major Depressive Disorder, Overweight, Inflammation
- Trial name
- NCT02553915
- Testing
- EPA 1 g/day, EPA 2 g/day, EPA 4 g/day
- Where
- 2 sites in United States
- Volunteers
- 61 people
- Sponsor
- Massachusetts General Hospital
Cancer
Oncology-patient-reported Anxiety, Mood, and QoL During the COVID-19 Pandemic
ONCOVID is a prospective cohort study investigating oncology-patient-reported anxiety, mood, and quality of life during the COVID-19 pandemic.
- Trial name
- ONCOVID (NCT04340219)
- Testing
- Survey administration
- Where
- Belgium
- Volunteers
- 394 people
- Sponsor
- University Hospital, Ghent
Depression, Depression, Postpartum
Chronobiology, Sleep Related Risk Factors and Light Therapy in Perinatal Depression: the Life-ON Project
In a 3 years longitudinal, observational, multicentre study, about 500 women will be recruited and followed-up from early pregnancy (10-15 gestational week) until 12 months after delivery.
- Conditions
- Depression, Depression, Postpartum, Depressive Disorder, Depressive Disorder, Major
- Trial name
- NCT02664467
- Testing
- Philips EnergyUp EnergyLight HF3419/01
- Where
- Switzerland
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Ospedale Regionale di Lugano
Major Depressive Disorder
Real-life Effectiveness of Vortioxetine in Depression
Worldwide Major Depressive Disorder (MDD) has significant negative personal, societal and economic consequences. Vortioxetine (Brintellix®) is a new antidepressant authorized since 2013.
- Trial name
- RELIEVE (NCT03555136)
- Testing
- Vortioxetine
- Where
- 106 sites in United States, Canada and 2 more
- Volunteers
- 992 people
- Sponsor
- H. Lundbeck A/S
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